Conserved Protein Domain Family
YdcF-like

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cd06259: YdcF-like 
Click on image for an interactive view with Cn3D
YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.
Statistics
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PSSM-Id: 99750
View PSSM: cd06259
Aligned: 448 rows
Threshold Bit Score: 58.4791
Threshold Setting Gi: 169778635
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative active
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:highly conserved residues within the family; YdcF has been shown to bind AdoMET

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3CA8_A        38 DCVILAGNAvm--------------------------------------------------ptIDAACKIARDq------ 61
gi 81753334   77 TVFVVFGLGtqtvneqghnt---------------------------------vepltfsygsIFAAARFYHEcqss--g 121
gi 153007464  68 TAFIVFGMGtqtvdgdgqk----------------------------------vveplafsygPILAAVAMNRqcve-kg 112
gi 81543915    6 PIYVVLGKRlnanqltl--------------------------------------egksrvdgLISALQCHENt------ 41
gi 86144371    5 HLLIVLGKRlnenklt-----------------------------------------negisrVDALVEYLAGplaeesn 43
gi 81755874    5 RLVIVLGKRlfknalt-----------------------------------------pegvsrVDALVDAMASgki---e 40
gi 149191683   8 QLIVVLGKRlnnnaltl--------------------------------------egmsrveeILRHVGSSDCs------ 43
gi 81726369    5 NVVIVLGKRlvnnqls-----------------------------------------aegisrVEALAAKIREmpm---- 39
gi 148652582  86 TAYVVLGGGlteadhkpnrqksaiankgsdthvanrppsspaqkntpqlspnsivlnqyslnrMQTVIWHYKKk------ 159
gi 187476600  42 SAAIVFYTPdeav----------------------------------------------ratyVRRAHDLYRAgq----- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               #  #     
3CA8_A        62 -qIPLLISGGighsttflysaiaqhphyntirttgraEATILADIAHqfwh-----ipheKIWIEDQSTn-CGENARFSI 134
gi 81753334  122 vsCTFITTGAdvag-------------------tgvsEAASTAAELEkagv------dsrAIIQDDRPHn-AWTTARNVA 175
gi 153007464 113 frCKFIASGAdvag-------------------tgvsEAASIATQLEkagv------dpaSVLLDEKSRn-SWQNSRNVA 166
gi 81543915   42 -aARVVFCGGitlg-------------------qtvsEAKRMHEYFEqrrqqlglsfpqiDVLLEQESTs-TVENIEHVA 100
gi 86144371   44 qqTAVAFCGGvtqg-------------------qtvsEADMMHEYFRelenqleypfpigAVLLEQHSTn-TVENIQNLA 103
gi 81755874   41 pgSRIAFCGGitqg-------------------qtrsEAIAMFDYFQqrchannltfsaqNILLEERSTs-TVENIFEVS 100
gi 149191683  44 -sSIIAFCGGvtng-------------------qsvsEARLMFEAFEaglssm-dnsnigAVLLEEESTs-TVENIIHLS 101
gi 81726369   40 enTALVFCGGktqg-------------------qsisEADAMYAYFQtlntslakpfptsQTLLENRSLn-TFENMRNAA 99
gi 148652582 160 -pLPIILTGV---------------------------EAPWMRDWLLnyg--------idNIITENASMn-TCENARFTA 202
gi 187476600  71 -vGMIVCVGGarpg-------------------rnyfGSAVMADELErsgv------pagALHCGDRVSddSRSNIQAAW 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #   #  #                                                  
3CA8_A       135 ALLNqaver------vhtaIVVQDPTMQRRTMATFRRMTgdnp---------------------daprWLSYPGfvpqlg 187
gi 81753334  176 ATLRelk----------paRVVVLQPAPMMGRTLLYLAHf---------------------------gIKPEPVatsylt 218
gi 153007464 167 AILReir----------paKVVLLQAAPMMKRDLLYLAHf---------------------------gVKPEPVaagylt 209
gi 81543915  101 QVLLesgvvqr--getlalTLVSNDYHLKRIFEIQQLMDeqgllrkliercaqsgvrleiardlkahlCVPYPHqnpqg- 177
gi 86144371  104 SEMIesglftr--gqsvtvTFVSNDYHLQRIFEIQSLMDeqgllkvlvekcsalgvelqidpqreahvAVPYPHqteqg- 180
gi 81755874  101 RLLNqsgqcsa--gsvlkvTFVSNDYHLKRIFEIQQLMDeqgllrvlrercaqhgvhldihhdleahvSVPYPNvggea- 177
gi 149191683 102 EVLLesellqn--gakievKFVSNDYHLERMFTIQSLLDsqgllrylksecqraglnltissdikshfPVPYPHhcvng- 178
gi 81726369  100 KVLCesglfplpsqatvevILLSNVYHLERILEIQTLMDeqgllrviksqcasvgldlhisldiqkhiSVPYPHqgpqa- 178
gi 148652582 203 KRLNls-----------dvYLITDAYHMTRTRRQFALNNiht-----------------------spiVAPLPMqkswlh 248
gi 187476600 125 AVLNardf--------qdaVLVADRLHGFRLRYLAHMLTgqs------------------------prWAAAPDylswe- 171
                        250       260       270
                 ....*....|....*....|....*....|..
Feature 1                                   #    
3CA8_A       188 nnadsvifinqlqglwpverylslLTGELPRL 219
gi 81753334  219 vngsth------fstslsflamdlALNEEIGA 244
gi 153007464 210 gshtnm------sspglyflmtdlALHEEIGV 235
gi 81543915  178 --------------------lrflWVDELTTY 189
gi 86144371  181 --------------------qlflLMDALTTY 192
gi 81755874  178 --------------------qlflLIDELTTY 189
gi 149191683 179 --------------------qlflLLDELTTY 190
gi 81726369  179 --------------------eaflLLDELTTY 190
gi 148652582 249 pk--------------dnaqhsrrTLYELAAY 266
gi 187476600 172 -------------------qallrAYWELLAW 184

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