Conserved Protein Domain Family
MAM

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cd06263: MAM 
Click on image for an interactive view with Cn3D
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.
Statistics
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PSSM-Id: 99706
View PSSM: cd06263
Aligned: 86 rows
Threshold Bit Score: 78.1885
Threshold Setting Gi: 146328566
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:putative adhesion site
Evidence:
  • Comment:mutation of these conserved charges resulted in a reduction in adhesive interactions in RPTPmu

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ##                                                                           
2C9A_A          7 CLFDEpy------stCGYSQseg-----------ddfNWEQvntltkpt-----------sdpwxpsGSFXLVNAsgrp- 57
gi 82270257   211 CDFDDg--------sCGWFEltpg----------dgfDWVRgtsaevpphfygy-pppldhttssteGHFMFILKnsss- 270
gi 166159334  277 CSFELg--------sCGWSAadt------------qsSWRLvsgqqliedth-----llgttlkntqGHFLFLKVrghg- 330
gi 147742916  475 CDFEEqcaggedeqaCGTTDfespeaggwedasvgrlQWRRvsaqesq------------gssaaaaGHFLSLQRawgq- 541
gi 82265848   183 CSFEDg--------dCSWKPiag-----------rtlSWKRlqssakpp-----------rqscpssGATFSVEGghak- 231
gi 21358251   288 CNFETp---------CSWTWgnys----------dgfQVITgtelskrnltgll-pgpaadsiddanGHFLYARVnps-- 345
gi 122068816   18 CNFETe---------CAWKAdetn---------pnsfQVVTganltasnrtgmm-pgpssdilgdanGHFLHLRLtsn-- 76
gi 146328566  480 CNFEDg--------fCGWTQgtls---------phtpQWQVrtlkda--------------rfqdhqDHALLLSTtdvp- 527
gi 166159334   53 CDFESp---------CSWTLssh-----------stgGEWFitsaqqhrsnrrdtqpirdystgkseGHFLLLKPssshl 112
gi 146328566  266 CSFDFp---------CELEYspplhd-----lrnqswSWRRipseeasqmdlld-gpgaerskemprGSFLLLNTsa--- 327
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
2C9A_A         58 --egqRAHLLLPQLKen--dTHC---IDFHYFVSSksnsppGLLNVYVKVnngp--lgnPIWNISgdp--trtWNRAELA 126
gi 82270257   271 --lypQAVLQGPWFRqs--aSGCt--MTFWHYNSGis---vGAANMNLRIkgdp--nntVIWRTLydq--gpqWKQTTVQ 337
gi 166159334  331 --derEALVQSPALPstisnQDCq--LQFSLYRYGdf---nGTVLLSVVEsgas--apaLIWERSghw--kdaWQEITLP 399
gi 147742916  542 --lgaEARVLTPLLGps--gPSCe--LHLAYYLQSqp---rGFLALVVVDngs----reLAWQALsss--agiWKVDKVL 606
gi 82265848   232 -gqrgSALLRSPLFPpplrnSPCt--VRFWLCSRGlh---kGSLSLWLLEnstgpeeqrPLWSSAseakseksWKLITLP 305
gi 21358251   346 ---srPLNLTSPEFStt--mEKCf--LEVYMHQSDm----sHGLSRVVVEllht--aesSWVPAEilgdnvrqWTRKVYR 412
gi 122068816   77 ---stQHILTSPMFGat--rEHCy--LEMMTHQSSmg---hGTLRIVIETsgn---qdpSWVPAEvfgndlskWQRTTFR 143
gi 146328566  528 --aseSATVTSATFPapiksSPCe--LRMSWLIRGvl---rGNVSLVLVEnktgkeqgrMVWHVAayeg-lslWQWMVLP 599
gi 166159334  113 saarcSFHMTSPVVLss--gPFCh--LQLARFQPEph---aGNISAFVKHtdsidikpiDLTIKEqesd-ssqWEVLEAV 184
gi 146328566  328 ---dsKHTILSPWMRss--sEHCtlaVSVHRHLQPsg---rYIAQLLPHNeaa----reILLMPTpgk---hgWTVLQGR 392
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
Feature 1                                                 
2C9A_A        127 ISTfwpnFYQVIFEVITsg----hqGYLAIDEVKVLghpC 162
gi 82270257   338 LGRlt-qPFQISLSKISlgv---fdGVSALDDVTFSn--C 371
gi 166159334  400 ITEil-nGFHLKVQAFWtsg---skADIALDDISLSa-aC 434
gi 147742916  607 LGArr-rPFRLEFVGLVdldg-pdqQGAGVDNVTLRd--C 642
gi 82265848   306 LYGla-dWFWLQFSTENgpg---pgSSVSLDNISFSm-dC 340
gi 21358251   413 LGRvs-rDFRIVFEVVPdlrv-gqkGHVALDNLRMVn--C 448
gi 122068816  144 IDRis-kDFQILFEVVPnrlggrarGHVSIDNLKLVn--C 180
gi 146328566  600 LLDvs-dRFWLQMVAWWgqg---srAIVAFDNISISl-dC 634
gi 166159334  185 IGQln-ePFQVTVQYSAcss--hevGFLAFDSLELKn--C 219
gi 146328566  393 IGRpd-nPFRVALEYISsg----nrSLSAVDFFALKn--C 425

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