Conserved Protein Domain Family
PBP1_LacI_sugar_binding_like

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cd06267: PBP1_LacI_sugar_binding_like 
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Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily
Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily. In most cases, ligands are monosaccharide including lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the domain sugar binding changes the DNA binding activity of the repressor domain.
Statistics
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PSSM-Id: 107262
View PSSM: cd06267
Aligned: 697 rows
Threshold Bit Score: 46.8394
Threshold Setting Gi: 88711387
Created: 26-Dec-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingdimerization
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1BYK; Escherichia coli TreR binds trehalose-6-phosphate, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Citation:PMID 9865945
  • Structure:1JFS; Escherichia coli PurR binds hypoxanthine (corepressor), contacts calculated at 3.5 A.
    View structure with Cn3D
  • Structure:3BRQ; Escherichia coli GalS binds fructose, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Structure:3CTP; Alkaliphilus metalliredigens transcription regulator binds D-Xylulofuranose, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       ##  #                                            #               
1DBQ_A         9 SIGLLAtss---eaaYFAEIIEAVEKNCfqkgYTLILGNawnnlekqraYLSMMAQKRVDGLLVMcseypepl----lam 81
gi 121608366  70 NVALIVpdv---anpFFPPLIRAVEAAAdaagMCIFLGDsdedp-areaRLVGKLSAQVDGLILAscrlaeg------ai 139
gi 134101580  65 TITLVVtdi---anpYYAPLIKAAQSQAlekdYTLVLTDsdesp-rvevSNLRQLLATTSGAILAtsrlsdd------vi 134
gi 31044164   60 HLGVIVpdl---lnpFFADICKGVQARArglgLTVFVSDterde-glelDAIRTLAPQVDGIVLCsphlsgee----lgs 131
gi 116669061  83 TVAVLVpdi---tnpFYFDIIRGTQHQLkaagLTQLLVDteess-emelEALHKMRRSADGFILAasrltda------ql 152
gi 111019782  63 TVAVVVpdi---ghtVFASFVKAAQAQGwhrrQTVLLTDtdgsa-drerEVLGELQGRVDALVVCaprlpas------di 132
gi 25028932   92 IIGMVApdv---snpFFVEIFRGAEHAAaaqgMVVTLLNanest-srarTAIERITPHVDGLLLVssrmdss------ei 161
gi 28379868   82 IIGVIAthv---adyIFPQIIYGIDQVIseggYSLLLGNthnnhqrerkNLINMLNSKVAGLIIEptqsaldnpnmdlyq 158
gi 50841367   70 LVAVCVadv---mnpVFGATVKGIFAGArkrgYMVVLIDsness-eiesETTKRSLATVDGFIFVgsrmsda------gl 139
gi 116253534  61 EVAVVFhdldavnseLYMQVQNGVQREAhrlgMTLRVRWth------dsGQLEELARTCDGLMLVgpharea------va 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #             #                                   #                 
1DBQ_A        82 leeyrHIPMVVMDwgeakadftdAVIDNAFEGGYMAGRYLIerghrEIGVIPGplerntGAGRLAGFMKAmeeami--kv 159
gi 121608366 140 qalsgRLPIVLINrdva---gmdRVLIDSAPGVAAAVRHLHelghrCVAYLAGpasswsNERRRIAVLDTaqesg----l 212
gi 134101580 135 rqiaqHRALVVINreid---gipSLVVDTARGMRKAVRHLAaighrRIAYLSGprnswiNSARWRAVQEEsgalg----l 207
gi 31044164  132 lgdftDKPIVLLHrkep---gfgSVTADLVEGMTDALTHLHalghrRIAYVGGprsswaARERAAGVEAVaasgl----v 204
gi 116669061 153 advsgSQPLVTINrasa---napTVVIDTPSAMIQALEHLAslghhRICYVSGpptswsNLRRWKIFEEDsahrg----l 225
gi 111019782 133 vqlagDTPLVLVNrssp---ecdCIVADSEDGIRQAIDYLValgheHLAYVQGspqswsNQRRVAAVEEFckard----v 205
gi 25028932  162 qkiarAVPTVVVSrpis---gipSMMVDNYDGAVKALVHLVdqgcrSITYVSGphrswsDSTRWRGIVDAatalg---tl 235
gi 28379868  159 eikdnGIPVLFINasypn-ldfqAVTTSDQEAEQRMIEYLFemgheSILGIFQvdd-aqGVHRMNGFVKAyqeqpeisyk 236
gi 50841367  140 rhlagIKPVMTVNrkvp---gvsSVTPASDEGLGDALTHLVsegrsTVTYLAGptaswqSGVRWRSLLERarrdg---kv 213
gi 116253534 129 avsatGVPIVRFGwvdal-eqidHVGGTDHEAGQAVVEYLVglghrSIVYVYGmpglrgRQERHYGAREIaery------ 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                                                                      
1DBQ_A       160 pesWIVQGDFe----------------------------pESGYRAMQQILSqph-rptAVFCggDIMAMGALCAADEMg 210
gi 121608366 213 eviQIAPRRPs-----------------------------YEGGMAAATIVRstr--atAVIAfdDLVAQGLLAGMARMg 261
gi 134101580 208 daaFVGPHVPn----------------------------lSGGHEAADALMLqr---atAAIAynDLIAIGALQRLQTAg 256
gi 31044164  205 eivQVGSVAPh-----------------------------FDGGVTGAADVVlas-gasAVLAfdDIVAFGLISRFTVRg 254
gi 116669061 226 ethRIGPFTPk----------------------------tTSGAAAADAAVRtg---atACIVfnDLLAIGMLQRLRERg 274
gi 111019782 206 qlsLLGWQQEt-----------------------------LAGGHAAAASVIatg--asAVIThnDPMAIGVMNGVRAMg 254
gi 25028932  236 agdQAGSASLrvsrtvtvqpsrmrhltrptvrqlpadepsLVGGRRAFGEWAkep--tdAVICfnDMVAVGFIQQAESTg 313
gi 28379868  237 sniLMYQSGDp----------------------------fEKLAHRLDTYLQnne-rptAIACynDQLAIRVMDYLKGKg 287
gi 50841367  214 tvhQLACPTPt-----------------------------IRGGIEAFDMWRahp--tsAVIAynDLIAIGFMRRAMACg 262
gi 116253534 202 pdvSLHVMQFd----------------------------eENGFSTAFRALVekgirptAFFCahDGLALTVVSELLGQg 253
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                    #                #                                      
1DBQ_A       211 lrvpqdVSLIGYDNVrnaryftPALTTIHQPkDSLGETAFNMlldriv----nkreepQSIEVHPRLI 274
gi 121608366 262 vhapagISVVGCDDVlat-rtyPALTTIASRpELAGRMAMEVlleqla----agkssgAAHMLNTELI 324
gi 134101580 257 isvpadFSLIGCDDIfgadlttPGLTTIAGPtERLGRSAVDVlhaqlt-----hrtrtDSTLFDAHLV 319
gi 31044164  255 vrvpeeMSVVGCDDIalsgmaaPPLTTVSVPkAHGARAAVDLlcrilatp-aaegeqpPQRVLPTHLV 321
gi 116669061 275 irvpedMSIVGCDDIfgadfcnPPLTTISSPiEQAGRVAVSMllsqlnp--lhggttrRLAVMPTHLT 340
gi 111019782 255 fsvpadLSVVGIDDSplaelasPALTSINVPmARAGVLSLDLvfqran----epdsdiREIHLPTQLV 318
gi 25028932  314 irvpadVAVVGFDNTeisvlvsPSLSTVAGPlRSVGRVGTANliaiing--mkaplmaKPRELPTRLI 379
gi 28379868  288 lniptdISIVGFDDYhmsrymsPGITTMNHEkTTMGEDTGRQmlrll------hkqpvESIVYTPKLI 349
gi 50841367  263 lripndVAVIGFDDIpfsalvsPALSTVRVNqFQMGVVAVNRlldmvekpshherqapSEDVVPVSFM 330
gi 116253534 254 yripddISVVGFGDYspatqisPALTTVRMEgQECGAVGLRLllerienp-rlpgmpaRRIMIASRII 320

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