Conserved Protein Domain Family
PBP1_GalS_like

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cd06270: PBP1_GalS_like 
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Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism
Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism. Transcription of the galactose regulon genes is regulated by Gal iso-repressor (GalS) and Gal repressor (GalR) in different ways, but both repressors recognize the same DNA binding site in the absence of D-galactose. GalS is a dimeric protein like GalR,and its major role is in regulating expression of the high-affinity galactose transporter encoded by the mgl operon, whereas GalR is the exclusive regulator of galactose permease, the low-affinity galactose transporter. GalS and GalR are members of the LacI-GalR family of transcription regulators and both contain the type I periplasmic binding protein-like fold. Hence, they are homologous to the periplasmic sugar binding of ABC-type transport systems.
Statistics
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PSSM-Id: 107265
View PSSM: cd06270
Aligned: 46 rows
Threshold Bit Score: 333.695
Threshold Setting Gi: 166007366
Created: 2-Oct-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingdimerization
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:3BRQ_A; Escherichia coli transcriptional repressor (GalS) binds sugar molecule, contacts calculated at 4.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                                   #             
2RGY_A       10 IIGLFVPTFf--GSYYGTILKQTDLELravhRHVVVATGcgestpreqALEAVRFLIGRDCDGVVVIshdlhded-ldel 86
3BRQ_A       21 TLGLVVTNTlyhGIYFSELLFHAARXAeekgRQLLLADGkhs---aeeERQAIQYLLDLRCDAIXIYprflsvdeiddii 97
gi 48526330  95 CIGLVVTNTlynGSYFNELLSQAAKKLedngRQLILVDGkhs---adeERAAIQFLLGLRCDAIIIYprflsvdemddii 171
gi 84386510  61 FIGFVITNElfnGPYFSSLMYHAASYSeksnHQLVITDGkhs---aedEIKAINFLLDMKCAGIIIYpqclaeseiakii 137
gi 90410879  61 TIGLVVSAFe--GAYFSSLLRQASQTAlqagKQLLIMDGghs---stsEQLAIESLVERKVDAVILYtrqipetvlkqlm 135
gi 16120508  61 TLGLVTTSYr--GGFFGALMDFVQTETesqgKQLLVTQGrdn---adkEWLAIQRLYNLRCDGLILHvrflsder-lrql 134
gi 49613880  61 IIGLVVTNTlysGPYFSELLFQTATMTekygRQLIMADGkhs---aeeEREAIQFLLDLRCDAVIIYprflsiealesii 137
gi 16766314  62 SIGLVVSTFd--GFYFGSLLRRASRQAeshnKQLIVTDGhdt---perEQKAVQMLADRQCDAIILYtrymdelailsli 136
gi 15641565  70 SIGLVLPHFe--SSYFGSILFEAEQGAqkagKKLLVMNSkns---eqgEKEAVATLAAQRCDAILLYsrhlnevqllelq 144
gi 59711215  61 SIGLIVSFFd--GYYFGILLKEATRIAeesgKQLIVTDGhnq---vetEIEAINSLVARKCDAILIYsrtmtaddyceiq 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  #                    
2RGY_A       87 hrxHPKXVFLNRAFdalpdaSFCPDHRRGGELAAATLIehGHRKLAVISGpftasdNVERLDGFFDELARHGIardsvPL 166
3BRQ_A       98 dahSQPIXVLNRRLrknsshSVWCDHKQTSFNAVAELInaGHQEIAFLTGsxdsptSIERLAGYKDALAQHGIalnekLI 177
gi 48526330 172 ekhKQPIMVVNRKLrkhqshCICCDHKGSSYNATQHLIarGHREIAFITGsldsptAIERLSGYKEALTAANItvrdeLI 251
gi 84386510 138 dstDTPILVLNREMpskpnhAITTDHYQSACLMVEHIIeqGHTDIAVIRGkagsstDELRYQAYQDVLTKQGItldesKV 217
gi 90410879 136 ndlSIPLIIINQQVegfedrCISFNQYEAAQQAAEYLLskGHKEFACITGpessinSRLRLQGFQDTLIKHNLpt--cTA 213
gi 16120508 135 aaaNRPFVLLDRLVpdlearCVTFDHHHASQMATQVLIdaGHRDIACISGssqrqsSVLRIQGFLDAMQLAGLep--vAC 212
gi 49613880 138 eqhEQPIMVVNRTLhqhsdnGICADHQQHCHDAVNYLItqGHRDIAFICGssnsptGTSRLAGYRQALVDNGIpcddrLI 217
gi 16766314 137 datEMPLVIINRNVtqardrAIFFEQETAAFQAVEYLItqGHRDIACITLpvhtptGTSRVAGYRKALEKYGIpwqpaKV 216
gi 15641565 145 qqhPSPLVILNRRLhhpqlhSFGLDQTQIAQLAMQHLLnlGHRQIACITSplvsetGKIRYQVYQQALHEQGIelsssLV 224
gi 59711215 136 kklPIPLVVINRTLpdglghAVAFDQYNASQMAIEHLVglGHKNIAIITLnmtsstGQIRLKGAKETLEKHGIayddnLT 215
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #                         #                           #                     
2RGY_A      167 IESDFSPEGGYAATCQLLEskapFTGLFCANDTXAVSALARFQQLgisVPGDVSVIGYDDDysAAYAAPALTSVHIPTAE 246
3BRQ_A      178 ANGKWTPASGAEGVEXLLErgakFSALVASNDDXAIGAXKALHERgvaVPEQVSVIGFDDIaiAPYTVPALSSVKIPVTE 257
gi 48526330 252 VKGKWTPRCGSLAITTLRDnrisFSAVLASNDDMAIGAIKALDDAgiaVPHDVSVVGFDDIptAPFLKPSLSSVKDPVSD 331
gi 84386510 218 VRGDWTMESGYHTAQALVKskttFTAILSENDDMAIGAIKALTELgysLPQDVSIVGFDNSkvGAFLTPSLTSVSVPLEQ 297
gi 90410879 214 YHGDYFTQSGYHACNELLAskqsFTAIFAANDNMAMGAIRALHDAglqVPQDISVLGFDNDpaGEFTIPSLTTIMLPVEK 293
gi 16120508 213 LEGVYDLESGYLRADEILKqprlPTAIYCCNEEMAIGALLAINKHglqVPQDISLICYDSGerAPFVCPALTSVHFPIVE 292
gi 49613880 218 AQGDWTHDSGYTAAKSLLQrtltFSALVASNDDMAIGAAKALREHglaIPQDVSLLGFDDLpmASWFYPPLTTVHVPVAE 297
gi 16766314 217 KYGDYTLTRGYDACRELLEegvtFSALFACNDDTALGAAKALRQAglrIPQDVSLFGFDDApgATWLEPGLSTVYLPIEA 296
gi 15641565 225 IEGDNTLLGGYQAMQQLLQqgisMTAVFACNDDMALGAMRAMHEHgihVPKQVSIIGIDNEpaAAFAIPSLSSVSLPIGE 304
gi 59711215 216 IIKNGKLEDGYQACKELLKrsqdISAIFCFNDHLALGAIKALKEMnirVPEDISIVGIDNDeiSAFLSPALTTINIPIQK 295
                       250       260       270
                ....*....|....*....|....*....|....
Feature 1                                         
2RGY_A      247 LTQNAVRWLInqcy-gtkwEIFREFPVTVSXRAS 279
3BRQ_A      258 XIQEIIGRLIfxld-ggdfSPPKTFSGKLIRRDS 290
gi 48526330 332 MINEVINRLIamld-ggyfSKDNLFLSELRVRDS 364
gi 84386510 298 MTQKAILQIVget----eqATTINTTGSLVLRDS 327
gi 90410879 294 MAYTAIKQTLqlld-nrkiSPIALFSGSLIVRES 326
gi 16120508 293 MAQYATQLLIdp------lIPAVNFPPAIIMRDS 320
gi 49613880 298 MINYTLEKLLcrle-getvIPAPAFKGTLIIRDS 330
gi 16766314 297 MIATAIDQAVrlan-sepvAPIPPFTGTLILRES 329
gi 15641565 305 LTQQAISLAVeiankkpqdAQHRLYQGSLIARES 338
gi 59711215 296 VTQLAMDKALrlisdkevkATTEILKGNIIVRES 329

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