Conserved Protein Domain Family
PBP1_hexuronate_repressor_like

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cd06272: PBP1_hexuronate_repressor_like 
Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators
Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107267
View PSSM: cd06272
Aligned: 9 rows
Threshold Bit Score: 289.252
Threshold Setting Gi: 15896789
Created: 2-Oct-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     ##  #                                            #                 
gi 56908317   62 TIGLVWpti-ervALSALVTRVNQHItnsgRTMILSIn-----hALEAVELFSRMRIDGILLFeeeipqd--klpnniGI 133
gi 118726267  70 IIGILWpsvysseLIVSFFDGIQNSIlndkLNVEVVFkpyqyseISKMEDVFKNQLFNGVIIVgasdrdvdymytiksAM 149
gi 15896789   67 TIALYWssdisvnIISRFLRGLQSKLakqnYNYNVVIcpyktdcLHLEKGISKENSFDAAIIAnisnydleylnkaslTL 146
gi 73663493   62 TIGLIWpsv-drvAVTHLITEINLAIkslgYVMFVSId-----dVAAASKKFVEFGCDGIIIFdedettn-lppeiynNV 134
gi 52003704   62 TIGLVWpti-eriALSALVTKINEVVeknnYSMILSVn-----rAKEAVDLFKSFRVDGIMIFeeggetq-lsddtglTI 134
gi 90021828    5 HLCVIApyl-qggYMGEIINHIRRACatreYRFTLIRtn----sLGEFSLNLGASEFDGVITIrnaaspkmveylqnrAI 79
gi 90021826   11 HIAVFSpyl-qgfYLGEIVDQIRQLCsinhYKFTAIRtd----sLATFDIPLGVSHFTGVIILknaispaladriltmGI 85
gi 22779099   62 TVGLIWpav-drvAVTTLASQINEAVkkagYFMVVSId-----dPITAAGKFLELRFDGVIVFdegeetr-lpakisnNI 134
gi 126698376  60 KIAFYWqdegfelASTNILQAINHIIslehLNINIIIrpykvghLCDDEYFFANNYYDGIVLTginaddieylvknkpKI 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #            #                                    #                        
gi 56908317  134 PLLSYGvpai-eqfpTVGVQHELAMELAVKEFVeiGHQSIAYAGVingtgrrQQAKQIGYEEAmrkrg----lksqRIDT 208
gi 118726267 150 PIILFNrqnd--kygSVCIDNYDTGKKVAGLLAarKHKKVGLISPnll-srnFSMRRTGFLDGcqkygi--svlpeHIIQ 224
gi 15896789  147 PIILFNrlsn--kysSVNVDNYKMGEKASLLFAkkRYKSAAAILTesl-ndaMDNRNKGFIETchkngi--kisenHIIA 221
gi 73663493  135 PVVAYGvdrd-ipypIVNVNHAEAMIIAIKELLakGIDRIDYIGDihtndarQIAKKDAIANYceqhh----iqyrMIDS 209
gi 52003704  135 PILSYGvsge-hthpIIDVNHKKAIYKAVAYLYqlGHKNISYVGDlspadkrQVEKSKGFEEVmmeagl-klsrnsILNT 212
gi 90021828   80 PVVAIAhdyfpldvpIITSNNAKGMDLAFNYLLerGHKKITFIGDlsq--ydLRKRFERFCELldenkl-qltdksLICV 156
gi 90021826   86 PVVSIAydyypleipVVGCDNEQAVALAYNYLKelGHNQIAYVGDfsq--ydLRKRFEYFGKLcdqdkdsnsdldtFYPV 163
gi 22779099  135 PVVAYGveqk-ldypIINVNHDKSMQLAVDTLIdkGNREIDYIGDletkdirQIIKKETFIRYceekk----inyrLIDS 209
gi 126698376 140 PVVVVNreip--gfsSVSIDNEETGRIAALHAIqnGKNDIAVVFNpts-ftcMTLRGKSFLKTckehgi--hlsdsIYYC 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                     #                  #    
gi 56908317  209 RGLDACDADSAIERLLTeptlptAIICSSYDIAIGTLRALRRNgiqvpndLSLISYDNIpqla--eadVPLTAVGVPIDK 286
gi 118726267 225 ETIDSEGGYRSAEKLLRseslptALFLLVSGYSHGVYSVFQKNgvripedIEIIGCSDIvssr--ilkPSMTVIDLPVQK 302
gi 15896789  222 AENSIHGGVDAAKKLMKlkntpkALFCNSDSIALGVISVLNKRqisipddIEIVAIGMNdreytefstPPVTIVDIPIEE 301
gi 73663493  210 SGLNAIEAETSVKHFLQesslapGVICGSYDITVGTINAMGSDe-----qPIIYSYDNIpqik--kidYPVQAIGVPTAE 282
gi 52003704  213 NGLSWYNGYTAAKKLLQqtpkptAIISGSYDISVGILRAVKEQqlsipedLSLISYDNIpqma--sleTPLTSVGVPIDQ 290
gi 90021828  157 DDTLFTGGREAAAQFIKhvdqvdAVICGAGNTGMGFVKQLKAQgvnlpekLEAISFDDVafme--litPGMPRIDQNLDQ 234
gi 90021826  164 DNSLYRGGLNAAKAFLKrgdtstAVICGAGLTAIGFYEKINKSnr----kIDVVGFDATsitp--iyaPNIIAVDQNLHL 237
gi 22779099  210 EGLSEEVTSNSLRKFLMkntlkkGIICGSYDITMGLLHHMDKQae----kPMIVSYDNIkkfd--aidTPVHTVGVPSEK 283
gi 126698376 215 SNKIDSGYDIAQKMLAKnsl-kkVIFCNHDVVALGMMNAFHESgivigedIQIFAASNGpsrlmarsiPPLTVIDLKMEE 293
                        250       260       270
                 ....*....|....*....|....*....|....
Feature 1                                          
gi 56908317  287 LAKELVETllalie--geqaatGRKLTPELVRRN 318
gi 118726267 303 MVKKSLLLild--------minGYIQDPHIIFEE 328
gi 15896789  302 MAGTCISLvek--------linRDIENPTSILFD 327
gi 73663493  283 IAQQVVAIldkvik--gepienTYHLHPSLSHNQ 314
gi 52003704  291 LAHKMVDSllslire-pgsiplTQKMDPELNVRM 323
gi 90021828  235 VAAHALEAlealitq-tpltthTLHVDPTLIIGK 267
gi 90021826  238 IAHKALAVikniqq--qeevqrEEQVPARLILPN 269
gi 22779099  284 IAESLVQMlmkhieaegvvedqVMQLYPEVTFPE 317
gi 126698376 294 TAERSLRMiidtvtg-ringiqQQVIYPSIIYRQ 326

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