Conserved Protein Domain Family
PBP1_GntR_like_1

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cd06273: PBP1_GntR_like_1 
This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators
This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107268
View PSSM: cd06273
Aligned: 22 rows
Threshold Bit Score: 319.157
Threshold Setting Gi: 121611415
Created: 2-Oct-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                            #                  
gi 115421577  72 TVGAVYPTLNNpIYAHSTHSMQQTLwemGYQLLIASHEYHiddEAAVLRATVERGVDGIIMVGtdhseevfalLHQRSLP 151
gi 27381468  106 TLGAIVPTIDNtMFARGIASLQQYLssvGYMLFLTTSGYDldiELQQARNLISRGVDGLVLRGdchhdalrklLADNEVP 185
gi 77965287   79 ITGAIIPTLDDqVFASQVAGMQAVMaehGITLFLGCSNYDpaqALAQVRAMLSRGVEAVSLVGeayppelfelLAMHRVP 158
gi 72123265   65 TIAAVVPTLDNaIFSHAIQGMQGVLaanGYQLLLGSHNYDpqtEIDVVRALSERAVDAMVLVGadhapetlsvLRQSGTR 144
gi 121607796  65 TIGAIIPTVDNaMFARGIEALQSYLslqGYLLLLATSGYDpetEARQAQNMASRGVDGLILRGdthtdalrrlLAAQQIP 144
gi 121607755  70 TVGAVFPTVDNaIFATAIDALGRRLaqsDIQLLIATSGYDvlgEMRQAINLVTRGADALVLCGlcqhpdllhfIARRSLP 149
gi 13471133   67 LVGAIIPTLDHaIYATMVDGLQARLsekDVSLIINTSGYDielEYEQARLLVERGVESVVLVGsthrpatlamFEKKRIN 146
gi 110680950  66 TVGAVIPSMANaMFASGLQAFQEALavdGVTLLVATTGFDseqEFRQIKSLVGQGADGLMLIGndrpdktwdfIDKRRVA 145
gi 121611415  79 TIGAIVPRFGSsSFPTMIQALETRLaahGYTLLLSAPEHKlskEPAILRTLLERGVDAVALLGeeqlthalpmLPASRIP 158
gi 83950289   65 TVAAIIPTIEHsIFAKYIASIEHSLaqrGYSLVIAISHGDldeELAAAQKLLGMGAEAFILSGadhhpdlldlFTQRGVP 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #            #                                    #                        #
gi 115421577 152 YVLTWsvddsnyphCVGISNYTAAYDLARCVLarGHTRVGICGGpierNERARGRRNGVLGAlreqglsvpaeWINEQPF 231
gi 27381468  186 FINVGiyqpdrpypCVGTDNEAAAHRAAAHVIelGHRRIGIVSAlqrnNDRASARVAGFRRAlaenglelpsqWHVEVPY 265
gi 77965287  159 YVVTYayrddsphcCIGFDNRAAFARLTTHLLdlGHRDFAIIMQpsadNDRVQARLRGIHDTlaarglavrpvHQHEGAA 238
gi 72123265  145 TIITWalsn--dypCIGFDNFEIGALAARYLFdlGHRHFGMISGisrnNDRARLRTEGFVNTlralraeiipgAACEQPY 222
gi 121607796 145 FINVGvyhpdkpyaSVGGDNGAAAWRACRYLIelGHRRIGMVAAltrnNDRAAARVAGVRRAlaesglalrasWYIEVPY 224
gi 121607755 150 CVHVMvhepsgkhvNVGFDNAAAMAQATRYLIdlGHRRIAMLAGitqhNDRAMQRVEGVRRAlqaagldfpeqRLVQRPY 229
gi 13471133  147 YVYTYtstataagaAVGFDNEKAGRTAARYLLdlGHTKFAMIAGitqdNDRAAGRRDGFLNElersgidqgmvPVVEGAY 226
gi 110680950 146 HVVSWcnvsregqyFAGFDNARAAGDAAERAMtlGHRRIAVISGqtlsNDRAKARRDGVHAAvarfgdgaritHEVEAPY 225
gi 121611415 159 FVLMWappe-svnhAVGFSEREAAALVVAHLAalGHQRLGFIGGrtgdNARAQRRFHGFTVEvakrgmticeaAMIETDY 237
gi 83950289  145 HVYSSiwqpasaapSIGYDNTALARAAMDYLTghGHHHIAVLHGplteSDRTRDRQAGAQAAqrdg----ltlDFHETSL 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #                #      
gi 115421577 232 SFEGGRQAIREYWSrp---eRPSVIFFGTDLLAMGALHECRRLGIAVPEQLSIVGFDGIdegemmqPELTTVSIPAQEIG 308
gi 27381468  266 TLDDAREAARYLLNlk---dRPTAVVCGNDVIAYGVLLEAERDGFSVPRDLSVVGFDDLdwsrhlrPSLTTIHVPTGETW 342
gi 77965287  239 TIAFGRASLRAIAGsda-atRPTAVICGNDALALGALLEAQALGIDVPAQLSITGFDDIalareiqPPLTTMWVDTDAIG 317
gi 72123265  223 SFAGGRTGLRNILRda--stRPTAIFCGNDVLALGCLFEATALNLKVPDELSIVGCDNLpisaevtPGLTTVALESSLLG 300
gi 121607796 225 HLDDARQGARWLLSspr-edWPTAVVCGNDVIAYGVLLEAERRGLKVPDELSVMGFDDLewsrhlrPSLTTMHVPTDEVW 303
gi 121607755 230 ALADARAGLRQLMAqd---pAPTAVVCGNDVLAFGALLEANSLGLKVPAELSIVGFDDLemarhlqPALTTVRIPTQTMW 306
gi 13471133  227 RLDDGRTCMRRLMEap---rRPTAVFCGSDILAAGAIKYCHAEGIAVPQEVSVVGFDNLeiaeltsPELTTLEVPARDMG 303
gi 110680950 226 LIDDAAAAFDQIMAqa---eKPTVVLCANDALAAGAMMRAREIGISLPDEMSFVGFDDVglarvitPALTTVRVPQIEMG 302
gi 121611415 238 GFEQGYAAMDQIIEdldradRPTAVVCGNDYLAAGALSALDRAAIEVPRALSIISFNDNdfasylhPPLTTVRLPIREMG 317
gi 83950289  221 DVAGGKAATRALLQsa---nRPSAIFCFSDVLALGALFALSEAGLRVPEDVSVMGFDNLdwsgetaPALTTINLPATRMG 297
                        250       260       270
                 ....*....|....*....|....*....|.
Feature 1                                       
gi 115421577 309 RRAARHIVDLIedrepaSSGPLPHTVLERGS 339
gi 27381468  343 QRAGEYLVRSLageqtiMHREIDFSLVVRES 373
gi 77965287  318 RQAAQALLDALengatgPGHAVLPELRTRES 348
gi 72123265  301 KKTAEALLRWLqdgtepGRTEMPISLIQRGT 331
gi 121607796 304 SRAGEYLVNALsgrqttLHHEVDVHLVVRES 334
gi 121607755 307 SSAADRIVAAMggqafpRSTEIDVALVVRQS 337
gi 13471133  304 RIAADYILASPsqrlhlRQRELSIRLIVRGS 334
gi 110680950 303 RAAAQFLLAKIggetdlSSTTFETEFILRES 333
gi 121611415 318 EQAGAYLIARLrgaaqpERVPLHVGLVVRQS 348
gi 83950289  298 AEVGTQLMDHLdngtplGPVRLDGAIVERAS 328

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