Conserved Protein Domain Family
PBP1_FruR

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cd06274: PBP1_FruR 
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Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs
Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs, all of which are a member of the LacI-GalR family of bacterial transcription regulators. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to members of the type I periplasmic binding protein superfamily. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor
Statistics
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PSSM-Id: 107269
View PSSM: cd06274
Aligned: 26 rows
Threshold Bit Score: 309.513
Threshold Setting Gi: 77390126
Created: 12-Jan-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingdimerization
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Comment:based on structural similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #   #                                                               
2IKS_A        22 SIGLVIPDLeNTSYTRIANYLERQARQRGYQLLIACSeDQPDNEXRCIEHLLQRQVDAIIVStslppehpfyqrwandPF 101
gi 53729140   87 VIGLVIPDLtNYGFASTARNLEKLCRENGLQLVIACSdDNPQQEKLVIDRLLDRQVDLLITApthqdpn--yykkiirHT 164
gi 12722273   71 VIGFVIPDLtNYGFACTAKILEKQCRENGLQLIIACSdDNPQQEKLAIERLLDRQIDFLITApthqdps--yyqkigqHT 148
gi 17989330   70 LVGLLLPLHdNRFFSAMAQIFEAHVRARSFCPVVVSAsRDPEEERETAETLISYAIDELFICgatdpdgl-helcekaAL 148
gi 15890250   71 LVGLLVPVYdNRFFSSMAQTFEGQARKRGLSPMVVSGrRDPEEERRTVETLIAYSIDALFIAgvtdpdgv-hqvcaraAL 149
gi 126732415  69 LVALLLPEY-NRFFSQIAQTFSREVRARNLCPVIIATeRDPEEERSTVADLTSWAIDALFFVgtvapedl-srqceaaRI 146
gi 152971084  66 VIGMIIPKYdNRYFGSIAERFEEMARERGLLPIITCTrRRPELEIEAVKAMLSWQVDWVVATgatnpdki-salcqqaGV 144
gi 153010135 144 LIGMILPMLdNRYFSSMAASFETVARSRNLIPVVASTlRDPQQERSTVETLIAHNVDALLIAgatdpdsv-aelcekaHL 222
gi 160896236 106 LIGMVIPTHeDRFFGALSQAFERLAHARGLCPLVVSTlRDGALEVETVRSLIAFRVEHLIVTgatrpdai-saecrkaGV 184
gi 77390126   80 IVGMIMPKYdNRYFGAIAERFEARARAQGLFPVITCTqRDPELEFEAAREMISYQVECLIATgatdpdri-sdfcaaaGV 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ##          ####                                             #               
2IKS_A       102 PIVALDraldrehftSVVGADQDDAEXLAEELRk----------fPAETVLYLGAlpelsvSFLREQGFRTAwkdd--pr 169
gi 53729140  165 PVLHIDrhipnlelnYIISDDTPSVAKLVENIVra---------yQPKEFFYLGGqlslspSASRLEGFYEGleqshlav 235
gi 12722273  149 PILQLDryvpdlalnYVISNDSEHITALICRLCdq---------yQLTEFMYFGGqrtlspSESRLAGFLQGlkqanlnl 219
gi 17989330  149 PHVNIDlpgs--rapSVTTDNFAGGKMLTAAIIeyfge---eaplQPEDLCLFGGrnd-esTRQRICGFHQVkqtvlgad 222
gi 15890250  150 PHVNIDlpgk--fasSVISNNRHGAEILTAAILahaak---ggslGPDDVILFGGhdd-haSRERIDGFHAAkadyfgve 223
gi 126732415 147 PHVFVDqpca--rapSVVTDNRTGAQVLTREILasmtalggvgtgPRETVYFIGGdrrlpsTANRVEGFSEAlyshvgrv 224
gi 152971084 145 PTVNLDlpgs--lspSVISDNYGGAKALTHKILansa----rrrgELAPLTFIGGrssdhnTSERLRGFHDAhrelglsv 218
gi 153010135 223 KHINVDlpgk--hgaSVISDNYEGARVLTQQIAsrr------shrKENSFYFIGGvdsdhnTRARVLGYQDElaalniai 294
gi 160896236 185 RHVNVDlpgk--kapSVTSDNRWGAAELTRLLLarsrp---pagaPQDAVCFLGGvrkeyaTEQRLAGFREAlapht-pv 258
gi 77390126  159 QAINLDlpgg--rapSVVSDNFGGARDLAHLLLer---------aPHEALLFIGGrpsdhnTAERIRGFRAAhadrgipl 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                              #            
2IKS_A       170 evHFLYANSyerEAAAQLFEKWLEth-pxPQALFTTSFALLQGVXDVTLRRdgkl---psdLAIATFGDNeLLDFLQCPV 245
gi 53729140  236 ksDWILHKDyqpESGYQMFAEVVErlgrlPEAVFTASYTILEGVLRYLTEHkqmaklmnqeLHLATFDDHhLLDALPFHI 315
gi 12722273  220 kkEWILHRTyqpESGYQMLAETEAklgrlPQAIFTASYTLLEGVLRYLTEQkkmdlllnrqLHLATFDDHdILNALPFHI 299
gi 17989330  223 peGCVFKTGyspANTLVALNDYRArhgrlPRGLFVNSSINLEGLLRFMAEHpgep---lndIVIGCYDYDpFASFLPFPV 299
gi 15890250  224 ggDDIEITGyspHMTEMAFERFFGrrgrlPRCFFVNSSINFEGLLRFMGRHdgea---fgdIVVGCFDYDpFASFLPFPV 300
gi 126732415 225 apSQIIAETydiDAATETIAALYArlgglPRGLFINSDSVFEGVLRFLATLpehe---ldaCAFGCFDYEpLGQLLRFPV 301
gi 152971084 219 pqANILAPGyskGHVEDCLQERFGsaktlLQGIFVNSTISLEGVVRWLSQVgltg---seqPPMGCFDWDpFVYLLGHDI 295
gi 153010135 295 haDTIVTNGygpDTAAVTIRDIYGklnglPEALFVNSTSPFEGVVSFLKTLpvde---vreCSIGCFDWDpFIEVLHFPV 371
gi 160896236 259 adEHIVCCGydpEAARLAMAALYQrlgglPRALLFSSGITLQGAIRFLRALpdae---laqCSFGSYDWDpYAECLRFPV 335
gi 77390126  228 peSAILACGyaaEKAEAALEARAGd---lPRGLFVNSTITLEGVVRWLRRQspp-----apVEIGTFDWDpFAALLPDCV 299
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
Feature 1                                                
2IKS_A       246 LAVAQRHRDVAERVLEIvlasldeprkpkPGLTRIKRNLY 285
gi 53729140  316 HSIAQDHDQIALRTFQLmrekl---qrktINNAKVDCEII 352
gi 12722273  300 HSIKQNHPQLAHQIFQHimryf---agkkSPNQKIDCDVI 336
gi 17989330  300 ISILQDVEGMIAKAFDLmerr-----vtePELHLIMPKLI 334
gi 15890250  301 YMIKPDIAQMLEKGFELleen-----rtePEVTIIEPQLI 335
gi 126732415 302 HMMRQRHKMLVRRAFALlge------dgkPVIEQVQPELY 335
gi 152971084 296 DMVQQDVPAMLDAVFSIidag-----easQQRIEIPPRLM 330
gi 153010135 372 VMVRQNVQAMIERAFKLldep----vqttDLPEMIPTELI 407
gi 160896236 336 HMVRQNVEGLMAEAFRAidge----glraGQVVQVRPQLV 371
gi 77390126  300 GMVEQDVAGMLEEVFRLigha-----pdaGLRIEVPTILR 334

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