Conserved Protein Domain Family
PBP1_FucR_like

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cd06276: PBP1_FucR_like 
Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability
Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability. FcuR acts as an inducer of fucRRIAK and as a corepressor of another locus that regulates production of fucosylated glycans. FcuR and its close homologs in this group are a member of the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107271
View PSSM: cd06276
Aligned: 14 rows
Threshold Bit Score: 163.216
Threshold Setting Gi: 71850939
Created: 7-Mar-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   ##  #                                             #                  
gi 88711387   91 RLALLLfafqsFQEEFYNTFREEMGNRFqIDVFFHHNNv---aIFKTILANIQGKYGMYVIAPiqhssi----------k 157
gi 126647485  90 KVLLLFnklssYKKIIYYTIIETLGEHAtVDMHVHHYNv---dLLEDLIHQNVGKYNYYVIAPhffdkethp----isgy 162
gi 60491239   80 NVLLLLdeyspFKYALYNSFVKRLSIRYkVDLLFHQYNe---rLFNTIIRESLGRYNKYIVMNfdnekl----------s 146
gi 146299759  89 KVLLVLdtfkaYKEVLYHSFVNNLPDNViTDVQFHHYNi---dVFKTIINNGIGKYYKYVVMNfdhkei----------a 155
gi 60491338   80 NIFLLFnefneFKEDLYNSFISSIRKTAnVDLYFHNYNr---kVFETLINEANYKYTTYILMPgkftni----------- 145
gi 86143603   90 NVFFLVnkpssYKMMIFNHFVNTLGVNAhVNLYIYHCEe---sLFVNAIEKNLGAYNYYVIMPhfkdndfnhvsftpevl 166
gi 146301953  88 NILFLTnklssYKMKTYSAFINTLGANAhVDLQIYHCDe---tLFLNILDKFEGAYDYYVITThfktdelkhlsftdevv 164
gi 149279080  93 KIFLLFnklsaHKKIVYDSFIAALGDDVsVDFYIYNNDf---tLFKRFLSNAKEEYSHYVIIPhfiegeey-------ar 162
gi 88806588   88 KVFLLFnklsvHKKIIYDAFARTLGDRAtVDFFIYENNy---rHFKDLIEYGKNRDYTHYVVIchfeegged-----lcd 159
gi 29376450   60 TFVLLLns-heTFEAWVTSFIDKAQENG-YNCLILNSHgsleqELKNITSPTLKQASGIIWDPinenskq---------y 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #              #                                        #         
gi 88711387  158 sllktIEPKKLLLVDryldl-gveysFIAQEFEEAIYLSLVKLLpaitKYKKFILILNkdt--dhsPPSIRRAFERFLv- 233
gi 126647485 163 ellkkIPKDKLLIMDraikghenefpGVFQDFAKDIFAALETGLshlrKYKKMILVFPkgd---myPLEIVDGFKRFCf- 238
gi 60491239  147 pnlykINPSKLLLLDfgkfe-kegfsYVCQDFDQGFYNALFQLAdrlrKYQKLVFVLVdds---mhPRSSRDFFERFCa- 221
gi 146299759 156 palsaISKDKLLLIDwniqa-dkannYVFQDFGKAFYNSLTEAVdlfkKYKKIQFVYPdft---nhPKETVEFFKKFCa- 230
gi 60491338  146 aplleSLSGRVFLLDhfhpelagkysSVAQNFEKDTYEALVYGLphlkKYDHIIMVQKee----kePIERYNGLCAFCe- 220
gi 86143603  167 kaierIPKDQLLMVDntkpeikgnygSIYQDFKEDIYNALIEGKeklkKYEKLILVYPekls-hpyPRRILHGFRQFCm- 244
gi 146301953 165 daikrIPQEKLVILDniklgtgddviKIYQDFENDIYNALKEGLekiaKYKRLILVYPdkav-ypyPRRILHGFRKFCv- 242
gi 149279080 163 dvinaLPKEKLILLDkkipgidgeyaAAYENFEQNIYDALEQARkqlsKYHTLKLIFPrks---yfPKEIVEGFGRFCq- 238
gi 88806588  160 flqasIPKQKLIVLDkklpddciqvaTVFQEFEKNIYDALVELNpklrKYKKIKMLLRqrt---yhPVEIKKGFIRFCg- 235
gi 29376450  129 akfieELTIPYYFVNhstn----elpSLAGLYEEASYVLTQELLq--nNHKKISYFVTnpkykeaiIAGYKKALFDVNlp 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                                                #                #    
gi 88711387  234 --DYKIEGKV-KNKYKLGSVKKD-NLYFIlSDTFLWDVLRDCEQKNYkiGQNIGILSQDDNvakeivfGGITTISTDFKE 309
gi 126647485 239 --FHDFENMI-LDGIDDAPISDG-DLFLVlAESDLVNIIKKAREQMLtlGQDVGLISYNETplkeildKGISTISTDFIH 314
gi 60491239  222 --DQHLGCEV-VSDIEGLQVRRG-EVYIAiRQIDVVSIIKKSRVEGLqcGVDFGLIGYNDTpayevidQGITALSVDWEK 297
gi 146299759 231 --DFGFEYEV-ITDPKKFNIEKG-IAYISvSDRILGHFLEQCKEKDYepGKDVGFLSYNETpmkkfiyKGISVVSTDFKE 306
gi 60491338  221 --EYHFTHEY-TDSVRNREIRQG-ETFMVvNDRDLVDLLKQAQLQNFapGKDFGIISYNDTplkeilaGGITTLSTDFKQ 296
gi 86143603  245 --QYDFEYEIlNEIYEDMEFEGK-DVYITiEEMDLVNLVRQIRERNLtmGKDVGVISYNETplk--elLGITVISTDFKA 319
gi 146301953 243 --EHEINFEIlSEVYDDMILKKG-DLFITiEESDLVNLMKQIRDEEFvlGKDIGVISYNDTplk--elLGITVMSTDFNI 317
gi 149279080 239 --QYAFNHKV-ISSIATEPIDKG-EVYISlMEDDLVVLLERLIGLKLmiGKEVGVISYNETplkkiilNGITTISTDFRF 314
gi 88806588  236 --EFAYDFGI-VEKIEEEELEPD-TVYINlKEDDLVILIKKINASGLvlGKQVGIISYNDTpvkeilrDGITVISTDFEN 311
gi 29376450  203 fsKENILTTI-PADFSNQLITDGiTGILTdDYTQAVFLEQLLKQSGLrtPDNYSLLAIKRKidrsflpDHISSVLLDTET 281
                        250       260       270
                 ....*....|....*....|....*....|...
Feature 1                                         
gi 88711387  310 MARLTAQHvkf---gdyTQIIIPTKLI--KRNS 337
gi 126647485 315 MGKSIGRQimge--edkIPIKNPFRLI--VRKS 343
gi 60491239  298 MGDKAAEFvlq---gktIQDYLPTEVR--LRAS 325
gi 146299759 307 LGTKAAAFith---deeTQCYVPTNLI--IRES 334
gi 60491338  297 MGQTMASLitq---keiKTIENPWKLD--IRNS 324
gi 86143603  320 MGETAAYMvlk---nkkEKVKNVFKYI--ERNS 347
gi 146301953 318 MGETAARLiln---kekGHFKVPFNFI--DRNS 345
gi 149279080 315 MGTMAANLile---nsrKHVEIPFYYT--RRPS 342
gi 88806588  312 LGRQAADMvle---kgtRSVANPFYVI--SRNS 339
gi 29376450  282 FGSKLALLllnkrkektALINEAEKLVldHKNT 314

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