Conserved Protein Domain Family
PBP1_LacI_like_1

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cd06277: PBP1_LacI_like_1 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107272
View PSSM: cd06277
Aligned: 16 rows
Threshold Bit Score: 302.272
Threshold Setting Gi: 149793178
Created: 26-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                              ##  #                                             #       
YP_001244535  62 NIHVFAskrilsplqsngilgeFYGVIIRAIEENCgrlgMNVELKM-----------LENFFESNGADGYIFIggdlsek 130 Thermotoga petr...
ABR30626      62 YVGICKsnrlikme-kektspeFYSVILEALEEVG----KTYGIKFe----------KMDIQKPEKCDGYILVggdstke 126 Thermosipho mel...
YP_001306011  62 YVGICKsnrlikme-kektspeFYSVILEALEEVG----KTYGIKFe----------KMDIQKPEKCDGYILVggdstke 126 Thermosipho mel...
NP_621757     77 NICLIIeernf-------kdtnFYTKVIWGIENEAkangYDVLVNFmkkd----lfeIPSCIENRKVSGILVVgtikdef 145 Thermoanaerobac...
NP_470193     61 KFALLAtsfal-------sqrsFFGEIIDNMKQSIiahqAELIIFPvtdee-aeknqLPEQLTTENWTGIFLLshintay 132 Listeria innocu...
YP_001127338  64 NIGLIAsdltf-------sfknFFGEIYLSIEKEVikrgMNLHIQSvnqeq-keqliLPSFIENKMVDGILILshistey 135 Geobacillus the...
YP_001179098  66 TIALIMtknii-------edpyFFSAIVYSVENEIrkegYDFSLYCisse---dewnIEEILTSSSFEGIIIVsaisenv 135 Caldicellulosir...
ZP_01188726   61 NVGIIFskrist----nlvgdpFYGQVMEGVEESLkkynYNLFFKTisgiknedvytINSLIKDQDLAGLILTgyeidke 136 Halothermothrix...
ZP_01575655   62 NLCLIIakstr-------dsigFFSYVQLGIEDEAkknnLNTIIHYydenv--qgfeTPNCVKDGMVSGIITLgrisret 132 Clostridium cel...
YP_001038900  66 SICLMLsndtk-------nsvgFFSFIQYGVESEGkrngLNTILYCfddn---kefqPPVCIRDGIVSGIITLgrisrkt 135 Clostridium the...
Feature 1                       #            #                                   #               
YP_001244535 131 tlkeiksrKKPFVLVDhyipgervdCVISDGYDGALYATNYLIskgfRRIVHIHGplhpygFKMRYDGYKDAmekaglmp 210 Thermotoga petr...
ABR30626     127 iinfyrelEKPFLLLDhyipgekidCIVTNGYDGAYFVTNYLIkkgfKKIYHIHGplysygFKSRFEGYRNAmedanlip 206 Thermosipho mel...
YP_001306011 127 iinfyrelEKPFLLLDhyipgekidCIVTNGYDGAYFVTNYLIkkgfKKIYHIHGplysygFKSRFEGYRNAmedanlip 206 Thermosipho mel...
NP_621757    146 -laeilsyNIPTVLVDhasfmfstdAVLTQNIPGSYRGTKYLIekghKKIGFFGEkdfslsFRERWLGFKEAmrd--agl 222 Thermoanaerobac...
NP_470193    133 -skkvielGMPVVLIDhhdphlkadAVISQNKDGAFTAVEFLIenkhQKIGFLGDttfspsYEERFEGYKKAlqy--hqi 209 Listeria innocu...
YP_001127338 136 -inkviatGIPTVLVDhhhpniqadAVLTNNRFGAYLAVQHLIelnhRDIAFVGNinyspsYEERYEGYLLAlrd--ygi 212 Geobacillus the...
YP_001179098 136 -ikkieekKIPTVVIDnlvdstcidTVNTDNYRSTKAAIEYLIkqgfKHIGFIGDvnhaisYRERWEGFMAAhee--fdi 212 Caldicellulosir...
ZP_01188726  137 lildiknsNIPLVLIDndlwdenidCVVTDNISGARKIVNYLIelghKRIAFFGGplshvsLEERYIGYKQAlkl--agi 214 Halothermothrix...
ZP_01575655  133 -incivgyNLPVVMVDnyfdnlsmdYILTDNHSGGYAATEYLIdcghTKIGFLGDisasisFYDRYQGFLKAlrd--rgi 209 Clostridium cel...
YP_001038900 136 -vssiislNLPLVIVDdffddikasYVLTDNLSGGYTATEYLIksghRSIGFFGDifaspsFFDRYMGYLKAhvq--ynl 212 Clostridium the...
Feature 1              #                                                                 #       
YP_001244535 211 RFYECDDt------------eEGTRKVIDIMLNsygtPEAIFTsNDSIAFWTIKRLKEHgirVPEDVSVIGFDDIvdaen 278 Thermotoga petr...
ABR30626     207 RFFEYDDv------------nDNMSEVINSIDI----PEAIFAsNDITAMRIIRELRKRnirVPEDVSVIGFDDIlsakd 270 Thermosipho mel...
YP_001306011 207 RFFEYDDv------------nDNMSEVINSIDI----PEAIFAsNDITAMRIIRELRKRnirVPEDVSVIGFDDIlsakd 270 Thermosipho mel...
NP_621757    223 PVNEDYCvtedverhvlsknyEEVANRLKKLKEf---PTAWVCsNDSNAITLYNALNIMgikVPKDVSIVGFDDIdmcni 299 Thermoanaerobac...
NP_470193    210 PFNEKYAitri------keeqTTLYRTLDELDEl---PTAWFCvNSGLGFILNTYLQSKgynIPKDLSIICFDNTeftvl 280 Listeria innocu...
YP_001127338 213 KPNEDFIfkna------eekeEVIFRYIQQLKKq---PTAWFCaNDALGFLVNSCLQKQgiqVPDQASVCSYDNGqlski 283 Geobacillus the...
YP_001179098 213 EIDKKVCkiegfkd-fsknpePEIQAFLKNLEKm---PQAFFCvSDLSTLLTASVLKEMgfqIPKDVSIVGFDDTelvkh 288 Caldicellulosir...
ZP_01188726  215 EKDDNLIyfckpfs-eiadafKAAYSFFSNVKTl---PSAVFTgNDKIAIGVMKALKELgyrIPQDISIAGFDDIemakh 290 Halothermothrix...
ZP_01575655  210 EINEGYSitdkkl---eelpqEDITGLVNEIRTkaglPTAFFCcNDAEAIVIIKVLKNIgvlVPNKISIIGFDDIenaan 286 Clostridium cel...
YP_001038900 213 PVNSSFSiidknm---avllhEGVDKVVDELKKipqlPTAMFCcNDVEAIALYKAFSVMgisVPDDISIIGFDDIessts 289 Clostridium the...
Feature 1                 #                                      
YP_001244535 279 fdPPLTTLRVFkYEMGCLACKRlhelltginphpVRILVFTQFVKRKS 326 Thermotoga petrophila RKU-1
ABR30626     271 fdPPLTTLKVFkDEMGSLAAKRiyellvghdvhpILISLFTKFIKRKS 318 Thermosipho melanesiensis BI429
YP_001306011 271 fdPPLTTLKVFkDEMGSLAAKRiyellvghdvhpILISLFTKFIKRKS 318 Thermosipho melanesiensis BI429
NP_621757    300 vtPPLTTIHINkELMGIKAVKRllwrmdnpkefhDHIRMEVGFVERQS 347 Thermoanaerobacter tengcongensis MB4
NP_470193    281 snPPLTTMCTNlSFMGEKAVELmynrvrkpdegfVHLALATNLIARDS 328 Listeria innocua Clip11262
YP_001127338 284 atPKTTTVDIDlELYGRRAVELlfwrmenknepvQEILLSSKLIKRES 331 Geobacillus thermodenitrificans NG80-2
YP_001179098 289 fkPALSMIHIDrNYYGQRAVKQllerikcpnkpvEDVRIFCRLNIRKS 336 Caldicellulosiruptor saccharolyticus DSM 8903
ZP_01188726  291 tlPSLTTVRIFkKEMGILAGKRlyelinnitpspIKLVVSVETIIRGS 338 Halothermothrix orenii H 168
ZP_01575655  287 vtPELTTMRVQkEIMGKGAVCKlmekleqeikssEKILLSACLIKRNS 334 Clostridium cellulolyticum H10
YP_001038900 290 vsPELTTMHINkEAMGERAVKKliekmngqesmdEKIVLPVTLIERQS 337 Clostridium thermocellum ATCC 27405

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