Conserved Protein Domain Family
PBP1_LacI_like_2

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cd06278: PBP1_LacI_like_2 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107273
View PSSM: cd06278
Aligned: 50 rows
Threshold Bit Score: 271.74
Threshold Setting Gi: 67155275
Created: 26-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                            #                  
gi 110634279  75 LIAVVTgstrNPFYWDVLRLVDERLqakGMHVMLMTvkese-stdsAVRKVHQYRVDGLLVLsaelsskaidecrefGLP 153
gi 152994227  69 LIGVVVarlsDPFRSSLLEGLLSEIqrkGYQALVTEvrdan-elemTIRRFTQFRVSGVVVTsgqppadlvkecvqhNIP 147
gi 152972930  67 LIGVIVsrisDPFRSTLLDALLNEIqrqGFQALVSEihseq-dlaqTLRRFAQFRVSGVIVTsgqppealvnecvqqHIP 145
gi 16263902   65 LIGVVGanlsSPFISKQLDLLSIGLlrqGKQCLLLNaadarqdiapLIELLFEFRAQAIVVLsgeppasivdecianGVR 144
gi 123442320  68 FIGLVTagfdNPFRSKLLAPLAHHLaiqGFMPLLMNaddpr-qlepQLRELLSYHVAGVILTsgapplslaeeylarKIP 146
gi 77969677   69 MIGVVTagfeNPFRARLLSDLMAALgqrALTPLVTNaedpr-qvrqSLEQLLSYRIAGLVMTsaspplsvaqqylehRIP 147
gi 152969202  85 FIGIVTagfdNPFRSKLLAPLVHQLalnGFMPLLMNaddpq-qlapSLKQLLSYHVAGVIITsgapplslaeeylarKIP 163
gi 118589525  70 LVGVVAadldNPFRSEQIDLLSKGLlecGFRPILLRgekst-dvadLIGSLLQYSVAGVIVTsdtppeeicieclenGVP 148
gi 86360013   55 LVGLVAagfdNPFRTLQIEHLSRALlarNFRPILLPtsqea-dtstVIGQLLHYAVSGVIVTsdappteiceqcaaeGVP 133
gi 90409622   68 LVGLVVtdmdNPFRSQQVNDLSDALlanNYRPLLIPtakdr-dssqIIDMLMCYNVSGVIITsdtppeaifqnciehHVP 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #            #                                   #                          
gi 110634279 154 VVLFNryvetgkvsAVACDNIVAGKDIAQFLYntNHKRFAFISGledsstNKDRFQGYRDQLAKLGcp----ppLVEGGD 229
gi 152994227 148 VVGINrhmdipdvdFVCSDNKMAASLVAEQFIrcGCKSIGWLNYkestwsGINRGEMFYQVMTEKGicdesdllQITAEM 227
gi 152972930 146 VVGINrqptipgvdYVCSDNAAGAELAADQLLrsGCQRFGWLNHhpstwaGRMRGEAFGRALQTRGvdv---erHLAILA 222
gi 16263902  145 LILINqrldrtdtnMVLSDDSHGADLAALRLIesRCKKVAVVTSgsqtpaQLRRAKAFTQRMQAEGvd----vvAWSGGP 220
gi 123442320 147 VTLINrqteldgadQVCSDNAQGATLAAQHLLaqGVTAAGFIGEnahnfsTRQRHHGFEQALTAHGqp----laSIFCEK 222
gi 77969677  148 VVMINreanlpgadIVVSDNAAGAVHAAQRLVraGARRLAFVGPrsasysAQSRATAFEHAIGRGDafdatlahVLDTPS 227
gi 152969202 164 VTLINrhadlagcdRVCSDNAQGAKLVADLFSrrGWRQVGFIGEnrenfsTRQRYEAFIARTSDMAv------sSRFCDG 237
gi 118589525 149 LVVVNkrdpgapvdRVVTAFEDGGRMACEHLIasGCRKLAVVTPerssfsINGRALAFEQAANDRGvp----vlRIARGA 224
gi 86360013  134 IVLINkgndiplvdRIISDDHVAGHLAADHLIdsGARKPAVMAApaksytARRRSEAFIARCKQVGve----aqLLQVRI 209
gi 90409622  147 VVLINklaqhakvdRIICDNEKGVALLIKEFAakKCQNIAIISSknysysIQQRESFFCEYAASENin----ieILRPEK 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                      #                #       
gi 110634279 230 FtyENGRQAVKRLMLrserpdAIFCANDITAIGALDGIRVDlgmrvpedVSIIGFDDIamsswsgIELTTMRQQtTRMVD 309
gi 152994227 228 DgyEGGRQAAHRFCEqgkrvdGVFCANAQLACGFLDGMRENgfda-padFHIIGFDNTpqtaqysYRLTTIHQDvTETAK 306
gi 152972930 223 CkqEGYAGGLQAAALadealeGIFCANAQLACGFLDGMRQRgrea-padFQLIGFDNTpttaqysYQLTTLHQDvAAIAR 301
gi 16263902  221 TsyESGVQAGRELLVdka-idGAFCVTDLLALGFLDAARLEmnrrvpqdVSIVGFDDIpqagwksYGLTTVAQSfQALTE 299
gi 123442320 223 GgyEAGWDAAAALVAqcpdldGLFCATDMLAMGAMDYLHRHlpq---qpVRIIGFDDIpqatyaaYQLTTIRQDtDCLAQ 299
gi 77969677  228 DthASGVEAARHLFAngkrpdGVFCSSDLLALGVIDVARSEfglrvpddVRVIGFDDIpaaeydaYRLTTLRQDtRGLAH 307
gi 152969202 238 GgyQAGYQAARELVAenpgmqALFCATDMLALGAQDGLRDAaa----plPAIVGFDDIpqadwqpYQLTTVQQNtALLAH 313
gi 118589525 225 QtyDGGLVAAEFLHRvrnevdGVFCAADYLALGVLDGLRHIhglrvpqdIQLVGYDDIpqaawkaYDLTTFSQSrQDLCE 304
gi 86360013  210 NdyRSGYDAATDLAAsc--idGLFCANDYMACGVIDRIMQGrsrdeappLPIIGHDDIpqaawtaYDLTTIRQPcDLQAE 287
gi 90409622  223 HcyQGGLTAAQSLLNnptlpdGIFCTNDYLALGVIDGLKEHlgiekitnIAIAGFDDMpqsswvsYQLTTVKQTtSIMAK 302
                        250       260       270
                 ....*....|....*....|....*....|.
Feature 1                                       
gi 110634279 310 SALEIllrridapelkpEFRLEPGKLMIRRT 340
gi 152994227 307 RVLSCleargqdphivqSIEEIPVKLVIRNT 337
gi 152972930 302 QALARlleraadpsqpsRTTWVEVTLIHRRT 332
gi 16263902  300 KVLSAldsd----epetRMQVVPVTLVERQT 326
gi 123442320 300 TAVNLlvnrirrfeqpsVQKTIPVELVVRQS 330
gi 77969677  308 AAVELladrmqtfdgpsRTRIVPVTQVVRAS 338
gi 152969202 314 HAVDLlmtriarfslpsRHREVPVKLIIRHS 344
gi 118589525 305 ATLDLlmqrlenpdlpqQVRVCDVHLVQRTT 335
gi 86360013  288 QTVELlisrmaepeltaRVEFTPVTLITRRT 318
gi 90409622  303 HAVQLlqnridnpeqeaRTIQLDVELVRRST 333

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