3H5T


Conserved Protein Domain Family
PBP1_LacI-like

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cd06279: PBP1_LacI-like 
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ligand-binding domain of an uncharacterized transcription regulator from Corynebacterium glutamicum and its close homologs from other bacteria
This group includes the ligand-binding domain of an uncharacterized transcription regulator from Corynebacterium glutamicum and its close homologs from other bacteria. This group belongs to the LacI-GalR family repressors and are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding.
Statistics
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PSSM-Id: 380502
Aligned: 56 rows
Threshold Bit Score: 210.528
Created: 26-Dec-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ligandputative dimer
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ##  #                                             #            
3H5T_A     70 AIGVLLTEdltyaFEDMASVDFLAGVAQAAg--dTQLTLIPaspassvdhVSAQQLVNNAAVDGVVIYsvakgdphiDAI 147 Corynebacterium gl...
SOB87686   67 AIGVLFNDqlsyaFTDPHDIAFLRGISSVCeeegANIVLIPlq-----dkRPAQRDQLAAIVDGFILNapyrshptiRAA 141 Sphingomonas sp. 9...
PCI60817   98 SIGIIFNDqlsyaFSDPHDIEFLRGVSTVCeeegSNLVLVPlk-----hsDLQDFEAIDAMVDGYILNapyknnittQRA 172 Gammaproteobacteri...
SCF03347   33 NLGVVLGErlsyaFEDPQAARFLAGVADVCaaegVGLTLVPit-----gePSDAQRVAQAAVDGFVVWttsdddpvlDAV 107 Micromonospora mir...
AJR09476   65 TIGVIFNQemsyaFSDPHATRLFRGISEVCqehgLNLLLLP---------LSSNEQILNVMVDGYIFNatfkndpiiEKI 135 Photobacterium gae...
SEQ50651   71 VIGIVLPDclsynLNDSVANQFLNGVTTELesqhLSMLLIHsre----lsSTNQVRRLQSTVDGFIVYghieddaifDQL 146 Amphritea atlantica
EXJ12899   68 IVGVLLADslsycISDPVASQFLAGLADVLdqrqCNMLLLPgqd----esTSYKSRQMESMVDGYIVYgglhpskrfQRL 143 Nitrincola sp. AK23
SMB96906   90 VLGLILGEhltyaFEDPQAASFLAGVAEVCaqwgYGLLMVPvt-----gaADDPKRVVGAAVDAFIVWtttdddpvlDAV 164 Deinococcus hopien...
GAB59129   64 IVAVILSDsleymVSDPVASQFLQGVSRELerhqLHLLLFSg--------SSTNLEAISDFVDGFICYgaprnlgliKQL 135 Rheinheimera nanha...
AEX54076   67 AIGIIFNDtlsyvFTDSHDVQLMQGIAGECdrkgVSIILIPlh-----ngQGARASVINTAVDGYILNathnndqiiAKA 141 Rahnella aquatilis...
Feature 1               #            #                                                     #  
3H5T_A    148 RARGLPAVIADqpareegmpFIAPNNrKAIAPAAQALIdaGHRKIGILSIrldranndgevt-rerlenaqyqvQRDRVR 226 Corynebacterium gl...
SOB87686  142 LARGLPTVVVDfdap--dlsSILTNDrAAMRAVVDHLLalGHRHIAIVTFpreegngeigs--laddfsdeshvVHERIE 217 Sphingomonas sp. 9...
PCI60817  173 LAKGLPTVVVDfdsp--ehiSILTNDtEMMCQITEHLLalGHKKIAIITFpvhenshelft--lsrsldsdnyvVNQRLK 248 Gammaproteobacteri...
SCF03347  108 ADTGLPAVVHAgphg-rgmpVIGIDDrAAAVAIGQVAFa-GARRPVVLGFpldrrrarllls-gdqvgevrfpvTRHRWT 184 Micromonospora mir...
AJR09476  136 INKAPPVVTIDldlp--gfgSVSINNkQAAYEIAQYVFskGHKEVAVLTFpfsrnpkglvk--lfdhiqgdnqvSLDRLC 211 Photobacterium gae...
SEQ50651  147 TLQSKKLIAVDcamg--dhsSIASDNfGGAFNSADLALqhCPKYPAILGLriinskhvcrvyndndlfsntisvAALRLQ 224 Amphritea atlantica
EXJ12899  144 LQQSKPIIAVDvdtt--dfiTVNIDNqDGAYRSACLALdhRPQKVAIISLrltpvstvswat-cdacyaspasvSRSRWL 220 Nitrincola sp. AK23
SMB96906  165 VTAQRPAVIHGsssq-kspySVSIDNrAAAFAMATQTFa-HAKRPAVISFpldrtrapvltt-gidpetalfpvTRERLL 241 Deinococcus hopien...
GAB59129  136 ASSPKRVLTVDfdlp--grpSVNIDNeQAAYQSAMAVLqpGDTVAILGLRlidaadsrpvl--daplwdnqssiAHRRLD 211 Rheinheimera nanha...
AEX54076  142 LSKNLPVVTTDfkip--phsSVSIDNyRAMREICLHLLekGHREFGIISFpslqgrkgivp--lsqdisgdndvMITRVK 217 Rahnella aquatilis...
Feature 1                           #                                                      #  
3H5T_A    227 GAMEVFieagidpgtvPIMECWINnrQHNFEVAKELLEthpdltAVLCTVDALAFGVLEYLKSVgksaPADLSLTGFDGT 306 Corynebacterium gl...
SOB87686  218 GCRDAIdaagv-praaVLVCETVNseDGGARAASWLLRrrpeltALVCFSDRLAHGAVTGATALgravPTQLSVTGFDGI 296 Sphingomonas sp. 9...
PCI60817  249 GCQQAIkhcdi-emdsVLVQETSNneHGGAEATKILLAlnpnitALVCLSDSLAFGAMSECLRQklaiPEHISITGFDDT 327 Gammaproteobacteri...
SCF03347  185 GLRDAWtlaghpaerlRLAVCPVNdsREGERFALELLDgadppdAVAAMSDELALGVLRAAAGMglrvPDNLVVTGWDDS 264 Micromonospora mir...
AJR09476  212 GVRDAHvdagldpnksVVYEVPDN--MTGNEAAKKILEehpnttALICFSDKLAVEALRYCKSRgikiPEEISITGFDNI 289 Photobacterium gae...
SEQ50651  225 GYRRALsehnmilpneRLWHIPDNteASALLAVREALHctprpdALFCMTDTYALTAIKEATRMgiriPQELKIIGFDGV 304 Amphritea atlantica
EXJ12899  221 GYMQALqeynypleqlSVVDVPVNthRNACLAAFMLLNqeerpdVIICMSDRMALGALQVALQQqisvPNDLKIVGFDGI 300 Nitrincola sp. AK23
SMB96906  242 GYRDAAqtlgipwssvLVGVSATNntREAQALAAQMLAldppidAIAAMSDQQAIGVLNAAKAArvsvPDRLTVSGWDDA 321 Deinococcus hopien...
GAB59129  212 GYLRAMaeckltlqpdYLWHIPEStqPHAQLAAKAVLAltprptVLLCMSDLIALSAMREALQQgiaiPQQLKVVGFDGI 291 Rheinheimera nanha...
AEX54076  218 SCVETFrewnieldncFLCETSHHe-TFGEIAAQELLNvnpgitAFICLSDRFAQGAINYCRQSglrvPQNIAITGFDNI 296 Rahnella aquatilis...
Feature 1                     #                                       
3H5T_A    307 hm----aLARDLTTVIQPnKLKGFKAGETLLKMidke--yvePEVELETSFHPGST 356 Corynebacterium glutamicum
SOB87686  297 dppggapSPLQLTTVRQNaVEKGRRAAEMLLMPdgr----evRTVSIDAEFVVGDS 348 Sphingomonas sp. 9NM-8
PCI60817  328 qpksthmTFPALTTVKQNaFEKGRKAAEALLKRevkqdqkinKRINIEARMIIRGS 383 Gammaproteobacteria bacterium
SCF03347  265 da----aTPAGLTTVAQSlREQGAHCARAALGRpg------rTDPRHEWQVVQRTS 310 Micromonospora mirobrigensis
AJR09476  290 pms--gdKDICLTTVNQSaVQIGRLATLNLINGk-------rDKITVEHDLVIRAT 336 Photobacterium gaetbulicola Gung47
SEQ50651  305 pes--ltSSPSLTTVKQDnFAKGEIAASLFTKPtp------pRETILPTELLIRES 352 Amphritea atlantica
EXJ12899  301 aes--qfTHPTLTTVQQYnELKGQMAGNMFLGLap------rQNVILPTDMLMGET 348 Nitrincola sp. AK23
SMB96906  322 pa----aAQHLLSSVKQDlRAQGVACARLALGEp-------sPSFTDDWSIVIRSS 366 Deinococcus hopiensis KR-140
GAB59129  292 eet--lrYHPTLSSVWQFsDAKGEAAVKAFLSAq-------dSPQLLPYELRLGES 338 Rheinheimera nanhaiensis E407-8
AEX54076  297 pr---peNEIGLTTISQDpVRKGEIAAALLLEGkn------nIHFDLEFTLIIRGS 343 Rahnella aquatilis CIP 78.65 = ATCC 33071

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