Conserved Protein Domain Family
PBP1_LacI_like_3

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cd06279: PBP1_LacI_like_3 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107274
View PSSM: cd06279
Aligned: 32 rows
Threshold Bit Score: 259.097
Threshold Setting Gi: 94986342
Created: 26-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         ##  #                                            #             
gi 134097068  71 AVGLLLTENLsYAFRDPGAISFLEGLSLACedagHGLLLIPasp----ereDVASVHRAGVDGFVVYsvpeddph-laav 145
gi 163839242  62 TVGVVLTKKLsYAFSDPYAVTYLAGLTTACeakgYGVLLIPaie----egtQISALERASVDAVASFclspgdaa-lava 136
gi 111021536  62 AVGVIVPDSPvQALEDPSVTLLMKGIAEIGnsadIALTLFPasrggspdspPNSLVLRGLVDGVVIHnvpdghpl-veai 140
gi 159898004  73 AVGVLFAERLpYAFRDPAVLMVLEGIATTLeqagLGLLLVPgr------ddDTTTVQQALVDGFIVYsmmetdpl-vqaa 145
gi 13476917   72 AIGVATAEPLsYFFDDPFARVMMAGISQACdatgAGISLVSaan----neqLAWNIQSALVDGFIVFcieggsrl-vqla 146
gi 111021522  62 ALGLMITDSLrYAFDDPATSQLLKGISEVGelaeVALTLLPcplestrvaeGSGVLVRGAVDGFLAYampdghpg-mqta 140
gi 16122699   68 TLGVIFNDNLsYVFSDRHDIALMRGIAEECekngINIALMPlkt----nnaLKKRMMGALVDGYILNatynndev-vqaa 142
gi 134100972  72 IVGVVIGERLlYAFRDPVAVALLDGLTEELapagFGLLLLSgssg--rtgpAPEQVERAPLDAVVVEscggddapavstl 149
gi 84494301   61 TVAVIVEDRLlHAFRDPFALAVLDGLAQELdamgTSMLLIAdhg-----daQPHPLAAHAIDAAIFPlcgrtdsplvshl 135
gi 148656680  70 ALGVLLPLDIaATMANPFFPLFLRGVGAVCgatgMTLMLVPplw-----gsMLKAIPHATVDGFIVIgleidrge-vqql 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #            #                                                       #
gi 134097068 146 lerPVPVVVCDqprl-dnldWVGPDDARAIKSMADHLIklGHRRIGVSCMrlargrndglas---vqrqanasfhvQKSR 221
gi 163839242 137 ksrNVPIVYEDadsg-pntsWVSIDEQAAGRSLGKHLErlGHRNVVVVTNlrggdqqncqw-----adggeitqlnDFGR 210
gi 111021536 141 iarGIPAVVVDsprs-aglpFVAIDDRHGAYLQMDHILslGHRRIGIIVDklgqdsdcrmvt---addvgaaternARER 216
gi 159898004 146 lkrRLPTVLLDqppr-pdvpSIIVDDEAGARMATEHLLslGHRQFAIITDrlvetnlrpssapinvhdqskptffvTQLR 224
gi 13476917  147 rerKLPFVALDlasedgsvaTIGIDNVAGAAMAARHLTdlGHRRFAVLALqfvddrtgpvs----peqvqtavyagTRDR 222
gi 111021522 141 msrRLPIVVIDgpnp-gglpRVGIRDRQAAKEIAEHVLslGHRRVGFLVDrlvpdgkggpvd---aartraardhvMKER 216
gi 16122699  143 ltsGLPVITTDiklq--nftCVSIDDGAAMQAICHHLLaaGHKKFGIVSFpvkrlpgeltsl---aefstdydngvAFGR 217
gi 134100972 150 hhrGVPIIGVEgtrl-pdvpMVSIDNHGATVELTRHLVelGHRRISVVTLpmrqpgthrgpl--ddsrratatsttGIDR 226
gi 84494301  136 larRIPMIGAGaplh-dgvtHVLVDERGASAAATQHLVdlGHTRLAHVLMpigpgrpthria---vaelehaaypdARER 211
gi 148656680 144 rrrRVPFVMVDgdap-edipAINVDDRRGARAAIMHILslGHRRIGIVSLeswhhry-------------edftgtLAAR 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #                                                     
gi 134097068 222 LTALAESfseagv--dwtkvPVVERFDHtaASGASAARQLLDldp--ditAIVCTSDILALGALNEARSRglrvPEDLTV 297
gi 163839242 211 YRGLTESmpe-------atiRVFNSAPNnsDAGRLAGELILDrhd--rptAIVCLSDVQALGVLEAMNVRglqaGKDISL 281
gi 111021536 217 LAGYYAAardhhl--pveelSIVVAGNIdrAAGAEATRILLDaar---ptALVATSDVHAVAAWQVLRERgltvPDDMSV 291
gi 159898004 225 LQGYRQPleaagi--dwrsvPIYDCNDNneADGAAAIQILLAhnp--rptAILCLTDRLALGAIAGAQQAgyqvPQQLSI 300
gi 13476917  223 LTGYFQElsrvg---vdtskVPVYETANdaTSTIAALEAIFGaae--pptAILAMSDRMALVALEWLSARklnvPNDVSV 297
gi 111021522 217 LAGYASAcrkytv--pwsstVVVEAGGFdyELSRTAVETLLDagp---vtAVIAASDLLALAAIDVAHERglrvPQDLSV 291
gi 16122699  218 ISACITAlsdag---idlhtSYVAEQPHseTGGEKAAKALLAkep--gisAIICLSDRFAFGVYQFCQDHnipvPGQIAI 292
gi 134100972 227 LRGVEDAlgh--------avAAWEASDGliEEGHRAGLELLAgsphqrptAVVAQSDLLAVGVVHAARELglriPQDLSV 298
gi 84494301  212 ARGFLDVadp--------asPLVEAEQPdvAAGELAGRILLDvaadnrptGVVAQSDLLAAGVIRAAEGLglrvPEDVSV 283
gi 148656680 210 FAGYREGlaeygrtiddpdiQVVTVSTSr-AGGVEAFTRLWRses--pptAIVAMSDITALGVLEAAKAHgvrvPDELSI 286
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
Feature 1           #                #                                      
gi 134097068 298 TGFDGIada--erAGLTTVRQPvLEKGRAAGRLLLetse--pgrpREVVLETQLITGTT 352
gi 163839242 282 TGFDDIpaa--aaAGLTTVRQPaFERGRLTGELLIdqe----lpnRQILLETELIVRSS 334
gi 111021536 292 IGFDDApva--elLGLSTIHQPiVEKGRAAATILLdrlg--ggtrTRSLMKTSLVVRAS 346
gi 159898004 301 VGFDDIpqasqsvPSLTTIRQDhRQKGLSAGQALIellag-qsptSYQRLAVELVVRDS 358
gi 13476917  298 VGFDGVpeaevsePPLTTVAQPiAEIGRLAVKAILend----gttSRRQLPVELIVRAS 352
gi 111021522 292 VGFDDIpaa--raAGLTTVRQPlVDKGREAAQLLLdiig--ggagREITLPTELVVRES 346
gi 16122699  293 TGFDDIdiq-dppVGLTTIRQPtVLKGREAARALIsgq-----ldNDISLDFELVVRDS 345
gi 134100972 299 TGFDGIdtpwlgdLRLTTVEQPmTEKGRAAGRMVVdvla--garpDPVMLPTTLRVRSS 355
gi 84494301  284 TGFDGVdlp-wldRQLTTIDQPgEAKGRLLGDLTRrala--gespRSEPFDVSLRVGDT 339
gi 148656680 287 VGFDDLpeaayatPPLTTVHQPiEEKGRLAAEMLVaalddeesepVHHLLPTELLVRGS 345

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