Conserved Protein Domain Family
PBP1_LacI_like_4

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cd06280: PBP1_LacI_like_4 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107275
View PSSM: cd06280
Aligned: 12 rows
Threshold Bit Score: 377.861
Threshold Setting Gi: 120612889
Created: 26-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                            #                  
gi 83593308   69 TVGLILADIgNPFFTALTRAVEDAAYqaGLRVILCNTGEDAeREAMYLRLMQEERVSGVIFAptlayld-hppqsplDFP 147
gi 58582432   54 ILGVIVADIrNPYFTALIRAVEEVAYkaGMRVTLCNTDEDTeREALYLDLMQEERITGLIFAptrvtvg-rmhelslDYP 132
gi 83717472   62 TIGLIVSDVrNPFFTEVSRAVEDAAYaqGMRVILCNTDESPeKEAMYLRLMESERVTGVIYSptydaar-rfdarahAFP 140
gi 120612889  86 IVGLIVSDIrSPFFTDVGRAVEDVAYrnGLRLILCNSDENPaKEQSYLELMADEQASGVILSptmeglr-rlrpgdwPFP 164
gi 17547579   61 TVGLIVSDIrNPFFTSVSRAVEDAAYaaGLRVILCNSDEDPdKEAMYLRLMEEERVTGVILSptrriae-spapvvlGFP 139
gi 146276661  79 TVGLVLADIrNPFFTRLSFGVEDAAYraGLRVFLCNTDEDPaREAMHLEMMAGERVSGLILAptrqlqp--ealkrlRMP 156
gi 34498506   61 TIGLIVSDIrNPFFTSVSRAVEDVAYrsGMRVILCNTDENPdKEAMYLRLMQEERVSGVIFAatratad-sldvaglGFP 139
gi 114327077  83 TIGLIVADIrNPFFTAVSRSVEQIAFasGMRVILCNTDEDPeREAMYLQLMEEERATGLILAptlpais-rlaihrpSLP 161
gi 148259206  61 TVGLIVADIsNPFFTAVARAVEHAAYraGLRVILCNTDENPeKEAMYLQLMEQERVTGVIFAptrasverldqgprpSFP 140
gi 77386748   61 TVGLVLADIrNPFFTRLSFGVEDAAYraGLRVFLCNTDEDPaREAMHLEMMAGERVSGLILAptrelrp--ealrrlQMP 138
gi 21243233   61 ILGVIVADIrNPYFTALIRAVEEVAYkaGMRVTLCNTDEDPeREALYLELMQEERITGLIFAptrvtvg-rmhelalDYP 139
gi 159901223  61 TLGLIVSDIrNPFFTAVSRAVEDTAYahGYNVLLCNTDENPeKELLYLQLMGDEQVAGVIFSptlqtln-rfhelnlSFP 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #            #                                  #                     #     
gi 83593308  148 VVLVDRagpqglyDSVVLDNEAACATLVDHFHarGYRRINGLFGktsaTGVERRRGYDDTmrayGLEPKACAIAPh---a 224
gi 58582432  133 TVLVDRagpgsryDSVVLDNGAAMAELVAHLQaqGYRRIGGLFGststTAAERRDGYLAAmraqGLEPDYREVAPa---a 209
gi 83717472  141 VVMIDRagpagaaDAVTLDNRDAATRLVEHLVehGYRRVAGLFGnastTGRERHAAFVDAlrrhALPADAEFVDPh---p 217
gi 120612889 165 LVLVDRalessrvDRVVLDNHAAARRATEHLLqsGYRRIALLAGihstTGQQRHAGYADAlaahGLAPRPLWLDPt---r 241
gi 17547579  140 VVLIDRagpacgvDAVVLDNQQAAQALAEHLAqhGYRRIGGLFGrtssTGAERHAGVAAGlarhGLAIDARFILPt---a 216
gi 146276661 157 VVLVDRdpegagcDAVTLDNEGAMRALVDHVVagGRRRISGLFGansfTGEARAAGFARAmarhGLPALVHHAPPn---a 233
gi 34498506  140 VVMIDRagpsarcDAVLLDNRTAAAELVDHLIgrGYRRIGGLFGntssTGAERHAGFQEAmeraGLAAAARFVAPs---a 216
gi 114327077 162 VVLIDRegpagclDSVVLDNREASRTLTRHLLqnGYRRIGGLFGmastTAVERREGYEQAmreaGLAFESRQSPAt---i 238
gi 148259206 141 MVLIDRagrasaqDAVVLDNFAAGSMLVEHLAgqGYRRIAGLFGnastTGVERRDGYEAAmlraGLSPSSRFIAPs---i 217
gi 77386748  139 VVLVDRdpegagcDAVTLDNEGAMRTLVDHVVasGRQRIAGLFGansfTGEARARGFVAAlarhGLAALVHRAPPn---a 215
gi 21243233  140 TVLVDRagpgsryDSVVLDNGAAMAELVAHLQaqGYRRIGGLFGststTAAERRDGYLAAmraqGLQPDYREVAPt---a 216
gi 159901223 140 TVLIDRslrsgdvDAVLLDNVSAGYTLAQHLInqGYRRIGAIFGeastTGRERQRGFEDAlrdaGISMQPEYLRFvrprs 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                             #                #         
gi 83593308  225 EAAEVAVSRWLSep--epPEAIVASNSLLLIGALRAVRRAwlrlPDDIALAGFDNELWTelvePGMTVIEQPiEAIGRAA 302
gi 58582432  210 EAAIAELGGWLAnd--trPEAIVTSNSLLLMGALKAARTAglrlPQDLALAGFDNERWTdlvePGITVVEQPvEDMGRAA 287
gi 83717472  218 QAAHARVHAWLAgdaaarPDAIVASNGLLLLGAYRALREHgarvPDDVALAGFDNDAWTelvtPGVTVIAQPvYEIGKNA 297
gi 120612889 242 DAGQRATAQCLAappaerPDALLATNGLLLLGALQAVQAAglrtPQDIGIAGFDNNDWTalpaLDVTTIAQPtYDIGRTA 321
gi 17547579  217 EAAEAETLAWLAsg--erPDALVASNAQSLLGVLRAIRRLsldvPGDIAVAGFDNEPWTelagPGVTVIEQPvYDIGRLA 294
gi 146276661 234 AAGYAALADWLGhe---qPEAVIVSNGLFLEAAVRFCHDRglsiPRDLALAGVDDDPWTgivnPGLTVLRQPaEAMGREA 310
gi 34498506  217 EAAQAAVAGWLRea--gaPEALIASNGLLLLGAVKAVRAAgiavPGELALAGFDNDSWTeladPGMTVIEQPvDEIGRAA 294
gi 114327077 239 PDSEQTAHAWLSsp--hpPEALLVSNSLTLMGVTRAARSLglsiPQQLGLAGFDNDHWTelvgPGMTVMAQPvEEIGRMA 316
gi 148259206 218 EAAEQEIARWFAkg--nlPEAVIASNGLLLMGVVRALRATgrrmPEDLAIAGFDNESWTdlvgPGITVIEQPvAQIGEEA 295
gi 77386748  216 VAGYAALADWLEae---rPEALIVSNGLFLEAAVRFCHDRglviPRDLAVAGVDDDPWTgivnPGLTVLRQPaETMGREA 292
gi 21243233  217 EAAIAELGAWLAnd--rrPEAIVTSNSLLLMGALKAARTAglrlPQDLALAGFDNERWTdlvePGITVVEQPvEDMGRAA 294
gi 159901223 220 EAGHSTTLDLLRlp--qpPEAIFTSNSLLTAGALQAIRERrlqmPEQIGLVGFDDTAWAslvqPAITVLAQPtDEIGRSA 297
                        250       260
                 ....*....|....*....|....*....
Feature 1                                     
gi 83593308  303 MSLLRDRmadPTLPPRQIVLKGRAIIRGS 331
gi 58582432  288 MSLLLERlsnPQLPIRRMVMTGRCVMRGS 316
gi 83717472  298 MQLLTQRladPAMSARTLVLPGELIVRGS 326
gi 120612889 322 AELLLQRmqdPARPARRVVLEGELVARGS 350
gi 17547579  295 MTMLQERlaqPELPTRRVLLTGRLVARGS 323
gi 146276661 311 LSLLLARldaPERPRRKLVLDSELVPRAS 339
gi 34498506  295 MEMLLERlqqPERPLRKVVLAGRLVARGS 323
gi 114327077 317 MDMLFSRlrdPDQPVRKIVLSGRQITRGS 345
gi 148259206 296 MRLLLERldaPEAPVRKTVLGGRCVIRGS 324
gi 77386748  293 LTLLLARlemPDRPRRKLVLESELVPRDS 321
gi 21243233  295 MSLLLERlsnPQLPIRRMVMTGRCVVRGS 323
gi 159901223 298 TELVLQRvadPQRPTRKIILQGELIVRES 326

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