Conserved Protein Domain Family
PBP1_LacI_like_5

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cd06281: PBP1_LacI_like_5 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107276
View PSSM: cd06281
Aligned: 12 rows
Threshold Bit Score: 311.175
Threshold Setting Gi: 88856046
Created: 26-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                            #                  
gi 121611580  65 TIGCMFSDItNPLYARAFRTLEDAFradGYMLLLAHglndvereleSLRTFQTRGMDGVICApgherapelvalmnsmSM 144
gi 94313872   65 TIGCMFSDVaNPLYARAFRALEEHFrreGYMLLLANglndaereidIIQTFQLRGMDGVILApgnerhpgvldavrrlSM 144
gi 72118306   64 TVGYLVSNIrNPLLAAHFSEVERHLqaaGYSVIVGNtldqphrdreLVSLFETRRLEGIIAApsvesesatdflfgacGL 143
gi 94313569   64 TVGYLTTDIsNPLLAAHFSEVEQHMhaaGYSMLIGTtrnqhhrdrlLVELFETRRLEGIIASlsmessdpaedlfakaDL 143
gi 148557038  58 AVGCLVTDIrLTIAANLVSGAESRLreaGYDLFLASthndpvkeegIWRFFRERQLDAIISVstddqsaeragllqslRM 137
gi 27381489  124 EIGIIVRDItTPVLASFVRAAQDLFeeaGYGLLICSsdnrkdreleLLRRFRQRRIEGLITTtssevdadlaqarndlDF 203
gi 33595248   64 TIGCLLPSIaNPFVAQLLSEVERLAqaaGYSLLVGSseqrs-rdkeLVAFFENRRLEGIIALpaheydpiaaspfaatKL 142
gi 88854860   58 TIGFVAADIgNPLLAQIAMGAERVLrqrGYSMLVANsfnepglaleQLRSMEQRRIDGLLISvsdetdealnkalesaHY 137
gi 88856046   71 TIGVVVADIsNQLFAEISHGAETVLraqGYSTFVANslndpeiavkQLRMLIKRRVDGLLVSvgeedggpivdaiansGL 150
gi 91779725   83 AIGCLISDItQHTAAQMVSAAEERLrarGFEILIANshydlereraILSSLKQRRIDGFIGAisddetpsyfnflhtlNM 162
gi 121607123  67 TIGCMFTDVtNPLYANLYRIYEERFranGYMVLLANslnnpeweleILSMFQSRRMDGIIIApgnernasvlaavqkiDL 146
gi 84502939   40 LIGCLFSDLeNPLYTRLFNSLQDRLadeGFVTLITAsagkldrekqAISIFAERGMDAIVIApghqqdpeivqllekfPA 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #            #                                   #                         
gi 121611580 145 PIVLYDrempdtradALLFDHVRGMKDACNQLFafGHERIALALWnadsrpVRKRIEGYKAAYCAAGMep---pdLILRQ 221
gi 94313872  145 PAVIYDrdla-vdadAVLFDHVAGVKAAIHHLVelGHTRIALALWqvksrpVRRRIEGYKAAFKAAGLpv---pdLILQE 220
gi 72118306  144 PVVILDretp-kpmdAVMLDHRAGVRQSVDYLVslGHRRIALFGPgehirpGREKLLGYQDGLQAAGIpf---dpMLVFM 219
gi 94313569  144 PIVIMDreta-sprdCVLIDHRTGLSLAVRYLKqlGHRRIAFFGPkesirpGREKLLGYQEGLAEVGLlf---dpALACT 219
gi 148557038 138 PVVLWErdgg-enfdSVLTDHYSGCLEACSYLLdlGHERIALVGGrstvwaGREMERGYRAAMAQAGRdv---dpALLFS 213
gi 27381489  204 PVLMFDrevd-gthdIVQVDHASGVNQAVTYLLslGHRRILLLTGpvniypARARVEGYKRAFAAQKLdl---dpTLVRT 279
gi 33595248  143 PTVIMDrdmg-pgfdAVLIDHEPGMRQVMDYLLslGHQRIALFAIgsqvrpGRLKLRSYRAALEAAGLpf---ddRLVYL 218
gi 88854860  138 PITLIDreiaatsaaAVLSDHATGIRAAVEHLIslGHQSIALVNGss---qVRPSRERAETLAKVAGEhpn--itSTIRM 212
gi 88856046  151 PTVLIDrhlgtagasRVLSDHRAGMSAVVEKLIdlGHTRIALINGlpnvlpAMERAAAAKAAAASHPGv------TIEVL 224
gi 91779725  163 PVVLWErdaq-gefnSVLTDHADGCRQAVRYLAslGHRSIALVAGhentwvGREMVRGYQAACEAAGIap---dpKLVLR 238
gi 121607123 147 PAVILDrdmn-vnqdLVLFDHAPAVQQAMEHLIdqGHREIALVISgtqtrpMLRRIEGYQAGFAARGLparadlqVLLPA 225
gi 84502939  120 PIFVLDrdip-iqadRLVFDHFAAMDLAVGHLAklGHRSILPVFShqntrpGLMRHAAFDAAMRGAGLtp----gARVEP 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                       #                #     
gi 121611580 222 PTp--tSSVYEDLLRMLEgpapPTALIAqGTHILVSALRAVARTgrrvPQDFSVVSIGDSdftqthdPPITALRTDaELV 299
gi 94313872  221 PTp--tSSAFDDVTRLLQlpdpPTAFLAqGTHTLTSTLRAIAKQglrvPEDVSVIGIGDTdfaqtydPPLTVLRTPtDEV 298
gi 72118306  220 SRsa-vDSSRTQMSAMLAlekpPTAMIGlGTRLLSGAIYAARKAgldiPRDLSVIGIGTPetlelmyPPLTTLRFNiEAA 298
gi 94313569  220 LPs--mDSSRAAMKQMLAlkqpPTAVIAlGTRLLSGALYEARKAglevPHDLSVIALGTPetlelmyPPPTMLRFNtALS 297
gi 148557038 214 AD----TFTHAACSELLReengVTAIIG-VLDVIVLICKVARAAgrviPKSLSLISIGDSdtlnmnaPAISAIRYDaERH 288
gi 27381489  280 VGfd-aATGFRETAVALEranrPSAIIAgGIDMLPGVLKAIRAThlhvPSDISVIGGADSdlalladPAISVLRWDfTQI 358
gi 33595248  219 TDss-lESARQPMQRMLGldapPTAIVAvGTQLLSGAVHVVREAgmdiPRDMSVVAIGTMqtlelmyPPVTALRYNfQDS 297
gi 88854860  213 GDfs-aEHGYGATKELMTgadaPTALIAgSNQILVGVLRALRELslsiPADVSLVTCDDValsefltPAISTISRDpALI 291
gi 88856046  225 SGafssQHGEEATRALVAraerPTAIVAgSNQILVGVYTALREAglsaPHDLSLVTCDPVplaefmtPALDTIWRDrQEL 304
gi 91779725  239 TS----AFDKDVCRALLTgpgrPTAIIA-TLNDVAIVLEVVRETglsiPADLSVISIGEHeysgiasPALTVVTQNpRDV 313
gi 121607123 226 ST----APAFDLVHELLQrparPTALLTlGTSVLADVLNAIRAQglriPRDISVVSTGEPdfarshqPRISSVTVDlDAA 301
gi 84502939  195 ETp--nTPVFREVQAALScddrPTAMIVqGTHVLPSTLNALANLrlrvPEDISLIAVGDSalaeehvPPITALRLDrSAL 272
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1                                             
gi 121611580 300 AAHAKALlldrlsgrvqivappRTVVAPYALIERASW 336
gi 94313872  299 AAHAVEMllsrlaakgdaslspRKALIQFDLILRESC 335
gi 72118306  299 AQAAAQLmldrleg--vvdepaRQVNVPLDLVLGESC 333
gi 94313569  298 AKTAANLmldrleg--hyageaRRVVIPMDLMLGESC 332
gi 148557038 289 GRTAAEFvldrlgd--sppgnaRRLILPIELIVRQSC 323
gi 27381489  359 GATCARMllerie---apgtepRRLAFAPELVVRDSC 392
gi 33595248  298 ARAVVQLilerier--tappqaRTVVIPSDLILGSSC 332
gi 88854860  292 GRTAAELvlaqf-----sgeagAETHLPTGFRTTDSC 323
gi 88856046  305 GAMAATLmlesl-----rggepREVVLPTEYRAGGCI 336
gi 91779725  314 GGEAADMmlqlidg--sapsgiRRSKHPMRMIVRESC 348
gi 121607123 302 VRESTALlltrire--graaapRRVVVPTIFTLRGSC 336
gi 84502939  273 VEEITARvlarir---gqatevSEKVLGYQLMERASC 306

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