Conserved Protein Domain Family
PBP1_GntR_like_2

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cd06282: PBP1_GntR_like_2 
Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators
This group includes the ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor
Statistics
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PSSM-Id: 107277
View PSSM: cd06282
Aligned: 16 rows
Threshold Bit Score: 341.189
Threshold Setting Gi: 116252174
Created: 27-Dec-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                            #                  
gi 77966560   62 LVGVVVPTLsNPVFADCLQGIDELAtaagFKLILMTTEYdaarerhAIETLREQRVEGLILTvadadthp-lldmldhdG 140
gi 115424410  73 TLGVLLPTLnNPAFAECFDGACRDAqklnYSIMVATTDYctkteleSLHMLLDHQVDGLILTlggaqeseaikvlreekA 152
gi 28867715   61 LIGVIVPNLlNPVFAEQFQAMERAArargYNLLLATTDYsaeresaVVEELLRQRVDGLVLTvtdaehnr-vleslvseD 139
gi 33603900   68 TIGLLLPTLtNPVFADCFEGAEQYArragYSVMMATTNYqpaieadAVQALIDHQIDGLILTvgnparna-tlqaleqaQ 146
gi 120612106  60 VIGVVLPTLlNPVFAECLDGIAQAAarggYAILPYTTDYavaqeerAVHLLLAGNVDGMVLVvsqprtsv-alerlaaaR 138
gi 116252174  60 VVGVLIPSItNPVFASSLSSIQNRMlvagHGVLIAQSNYdpareadAVAALLNDRPTGLILTvcdpsts----kallakL 135
gi 149189952  60 TLGVVIPSLiNPVFSEVVTGIQQRArhfgYSVVVVDTQYdsgqeqqAVIDLIRQRVEGVILTiadtsene-alkllrdfK 138
gi 118591728  65 TIGCIVPSLaNPVFAEVVQAAQQEAhlegYQLILACSEYdemqelqAARTLIAKQVDGLVLTvnnasdse-alelirdrR 143
gi 86138231   66 TVGCLVPSLaNPVFAEAVQGVQNELvgtnYQLLISSSNYddkadddAISTLVSKEVDGLIVTmvapersp-alklahqrG 144
gi 99078287   66 TVGCLIPSLaNPVFAEAVQGAQEELrshgYQLLVASSNYddetdndILTTLLSKDVDGLLVTmaapqesv-plaqararD 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #            #                                    #                      #
gi 77966560  141 PHYVLMHndtq--rrpSVSVDNRSAAYDGVRLLTarghRRVLMLAGslaaSDRARQRHLGYAQAleesgvatlPPVEVDF 218
gi 115424410 153 MPYILAYstiq--gvpSVSIDDQLAGRDLAEYVAsfqhKNIAFLSGplhtSDRAARRLLGVRQVarrlklsrfCHYVLPS 230
gi 28867715  140 TPFVLAYhqtdnedysAVSVDNRAGMALATQYLIdaghQRIAMVAGpvmqSDRARLRYEGYRDAmnerglearPVIEMPA 219
gi 33603900  147 VPHVLAYnesg--shpFVSVDNRAAARDMVQRLAdlghRRIALVTGplaaSDRARRRLEGARAAartlglepvAHLAMPT 224
gi 120612106 139 LPYALAYnrhp--dhpCVSVDGEGAVAELVAQLAalghRRIAMVSGqlaaSDRAQQRCRGFMRGmaqaglapaRVVEVPF 216
gi 116252174 136 PPTVLLNnlptaqfpaAVTANNRGAGREITTFLIgmghRRILFLSGnfaaSDRARLRYRGYLDAmaengltplDAVQIPF 215
gi 149189952 139 FPYCLLHnrsd-eqepCVFVDNYQAGIDVAQRVVelghRRVGMLTGrfvsSDRAEQRYKGFKKGlndngleltELLEVDQ 217
gi 118591728 144 LPCCLVYnras-fglpAWAVDNRAAAREVAQAFHdeghVQTGFLALrfhrSDRSRERYEGFAAAcrefgmadpLLLEIEE 222
gi 86138231  145 IPASLMFhdpi-egfaTSYVDNFEAAREVAQRFSeyghRRTGFLALrlatSDRSRNRYAGFHAEcrargmpdpVLIELSE 223
gi 99078287  145 IPVCLMFhdpl-pdwpSAHVSNAQAAAEVARQFAlyghERTGFLALrfstSDRSRNRFDGFRAQcaalnlappKLIEITE 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #                #        
gi 77966560  219 naPELPDAVLAHLTahatrPTALFCSNDLLAMVVMRGLRRAGfsIPDDLSVLGFDGIaigellaPPLASVATPnRDIGRH 298
gi 115424410 231 htQCEPQLVKNWLSsn--pPTAIICSNDLLALSLMSQLHAFGirIPDDIAICGFDGIvfgamytPQLTTVSQPsSDIGRI 308
gi 28867715  220 htNAEFAALEPLLRgp-naPSALVCSNDLLAISLIAELRRHGwgVPERLSVIGFDGIalgtqmhPTLCSVVQPiAELAHT 298
gi 33603900  225 htASNLSTLQQAVQaa-haPTALFCSNDLLATAVIAHLVELGlrVPRDISVCGFDGVaigalmvPTLCTVAQPsRDIGAA 303
gi 120612106 217 v-ETAVQEVAELLRgp-rpPTALVCSNDLIAIRCLRAAHMAGleVPRDLSVVGFDGIalgrdltPVLGTVAQPnVDIGRC 294
gi 116252174 216 vsGYDQLDLGVAMTsl--aPTAIIASNDLLALGVIGALKREGlsVPGDVSVAGFDGIaigrlidPPLTTIEMPdASMGAT 293
gi 149189952 218 nkLDPFGDQEMSVIqreqaPTVWFCSNDLLALKAINAVKANGlhVPSDISIIGFDGMslaqlitPTLATVAVPhLKMGQV 297
gi 118591728 223 qeGNLLELLGTLLAeh-qaLTGIFASNDFLALAAMKAARALGkrIPDDLSLVGFDGIstgllvdPHLATVETDpRTMGQG 301
gi 86138231  224 tdANRPEKLTAILAah-pdLTAIFASNDFLAIAVQKAARLLGwiVPRDLSVVGFDGIeigklldVPLTTIETMpEKMGRQ 302
gi 99078287  224 teANTPSILAQRLSdh-pdLTAIFASNDFLAIAVQKAAPLMGrhVPQDLSVVGFDGIevgrlldRSLATIETTpEAMGRQ 302
                        250       260       270
                 ....*....|....*....|....*....|..
Feature 1                                        
gi 77966560  299 AWQRLVecigg--aaierTSLILPHVVRDGAT 328
gi 115424410 309 ACQKLLaylkq---hiplTSTVVPHRIFPGAS 337
gi 28867715  299 VIEQLLaria----gaaaASHCLPCHIRPGES 326
gi 33603900  304 ACARLLahmeq---gvpiESARLPYRIFPGGT 332
gi 120612106 295 SVELLIeamashrlptreDSLTLPHHFRAGGS 326
gi 116252174 294 AASLLLdmaen---aapaRHLDVAYTLRRGGT 322
gi 149189952 298 AVDILFnakag---asvsTQLALDYQLQMNGS 326
gi 118591728 302 AVQSVLarlldr-ptpdlPSAAATFSFRAGGS 332
gi 86138231  303 AAKSLLtamqg---gvleQLPPLPFRFRAGAT 331
gi 99078287  303 AAQTLLtglqg---gamtELAPLPFTFRAGAT 331

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