Conserved Protein Domain Family
PBP1_RegR_EndR_KdgR_like

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cd06283: PBP1_RegR_EndR_KdgR_like 
Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR
Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR, all of which are members of the LacI-GalR family of bacterial transcription regulators. RegR regulates bacterial competence and the expression of virulence factors, including hyaluronidase. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107278
View PSSM: cd06283
Aligned: 40 rows
Threshold Bit Score: 256.743
Threshold Setting Gi: 116333106
Created: 6-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                            #                  
gi 1536958    65 LIGVLIGDitnsFSNQIVKGIEDIAsqnGYQVMIGNsnysqesEDRYIESMLLLGVDGFIIQptsnfrky--sriidekK 142
gi 116333106  69 LIAVIVANiddyFSTELFKGISSILesrGYIGVLFDanadierEKTLLRAIGSRGFDGLILQsfsnpqt---vqeilhqQ 145
gi 116332784  64 LIGVVVGDianvFSSLLFKGIYDVLqpaGYDVLLMNanntattEHGELTRLAAQQVDGIILQpsaata-----aayaglT 138
gi 150019460  72 IIGVTIADignpFSSLLIKGINDVCranNYQLLVTNadnlaerEKENIESLLDSQVDGLLVNttgnnykyleefkdsdnF 151
gi 22534847   65 TIGVVIADitnpFISSVMKGIHDTCqqfGYSVNFTNsdndidiELENLNRLNQQNVSGIILDsvdpnhs----fietlsN 140
gi 116617616  61 LIGISVADisnmYTSRLLKGISDYFqntIYQVLIMDgdnsierEYSNLEKMVTERIDGIILQplvhqpdh--yqllideN 138
gi 161702176  65 LIGIAVGDisnfYTSLLIKGILNRLkttQYHSLIMDsdlsrslEKKNIAKLIDEQVDGMIIQpigatse---eykqikeA 141
gi 92089478   47 VVGILVGDisnpFSSLLAKGIDDVLqqaGYDILLMNtnnsrenESRALQRLYQQRVDGIIVQpnsrhfsq--fapaihnD 124
gi 116491638  67 LIGVVVADvenfFSSLLFKGADQVLsdiGFQIILMNsnnsqlkEQRQIERLLELQVDGIILQpmgqlavd--yeflkkqN 144
gi 149905925  72 IIGVTIADignpFSSLLIKGINDVCranNYQLLVTNadnlaerEKENIESLLDSQVDGLLVNttgnnykyleefkdsdnF 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #              #                                    #                     
gi 1536958   143 KKMVFFDsqlye--hrtsWVKTNNYDAVYDMTQSCIekgyEYFLLITAdtsrlstRIERASGFVDAltdanmrhasLTIE 220
gi 116333106 146 MPVVSVDremda--cpwpQVVTDNFEAAKAATTAFRqqgyQHVVVLTSelelsrtRQERYRGILAAaq------dvDVLE 217
gi 116332784 139 IPTIIVDrqlpn--splaQVLSSNFDASYQLGQHLReqgyRRLITVGRavaphtaQTDRLAGLTATg--------lSVIH 208
gi 150019460 152 KPIVLLDrfinp--liydSVTMNNAEVTKNILDELLkneyDHYVYFSEdingissRLERKKAMEEFlsrnpntsgeTNII 229
gi 22534847  141 DRLVMVDrqakd--ikvdTVASDNKESTQIFLEKMQeagyHDIYFVTYpiegistRELRYEGFKEVvss----npdKLII 214
gi 116617616 139 IPVVQVDrytep--ftwpAVVSDNFQKSLEVADLMKsknyEEIIVLSNhingvssRMNRYNGLKTGient--nitiKLIE 214
gi 161702176 142 FPVVQIDrfvep--liwpAVASDNFEKSKELTELIIekgyQRIIVVSPpvihstpRIARYEGLIEAitntd-veikEIIA 218
gi 92089478  125 IPLVIVDrevddqpstvgKVTSANRDACYNLGKILYqngyQNILTVSAhfaeasgQIPRIAGLKVAaadn--glsyHNIE 202
gi 116491638 145 VPTVIVDrkiep--eiwpEIVTDNYECSKKLGELMLqmqyPQILILSEkidentaRQDRYKALDDLqknh--sfnlGLIE 220
gi 149905925 152 KPIVLLDrfinp--liydSVTMNNAEVTKNILDELLkneyDHYVYFSEdingissRLERKKAMEEFlsrnpntsgeTNII 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                                          #                # 
gi 1536958   221 DKHtn---lEQIKEFLQKEIDpde--ktLVFIPNCWALPLVFTVIKELny-nLPQVGLIGFDNTewtcfssPSVSTLVQP 294
gi 116333106 218 VSEssy-nhSEVHQRLTQLITqnd-qktVAFALKERWLLEFFPNLIISglidNQTVTATGFADTdfirrmePKLTLITQN 295
gi 116332784 209 LDMtsh-gaPWLTQQLRQYQQapd--kpVIISLMGPLLFEILASLKAAhlhfPADVGLVSFDDWqwsqyvnDGIYLLQQQ 285
gi 150019460 230 KKNd----iKEIKERIENIINknkdkniCFFANNDEILKVLIECLYDLniriGVDIGIFGFAEEkwarligPGITSIDEN 305
gi 22534847  215 ITEdg--stQRILDIIEHSEQk-----pGFLMMNGPTLLNFMKKLNQStvsyPEDYGLGSYEDLewmqvltPNVSCIKQD 287
gi 116617616 215 IDDn-----KDWQNTLQSMLEspt--kkALYALNGQVLWEIVRFLKKHhiaiPDDVGVIGYDDDmfadmisPEITSVSQN 287
gi 161702176 219 PEAknldvnDDYWKAITEMLNddi--ktAIYTFNGPLLYGCIKFLKEKklriPQDIGLVGYDDEsfgevmgPGITVIEQN 296
gi 92089478  203 TRGhd--qqWLAKTFLQQLNElkg--ktAVVSLMGPILFDLLAIFKELnlsfPEDLGLVSFDDWewsqyvaNGIFLLKQD 278
gi 116491638 221 IKVts--sdDDIFVSLKNRTNnfk-iktAIYALKGPLLLRLMRVLTQRhisvPDQVGLAAFDDWewaklthPLITTIQQN 297
gi 149905925 230 KKNd----iKEIKERIENIINknkdkniCFFANNDEILKVLIECLYDLniriGVDIGIFGFAEEkwarligPGITSIDEN 305
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1                                             
gi 1536958   295 sFEEGQQATKILIDQIegrn--qeeRQQVLDCSVNWK 329
gi 116333106 296 pFLMGASSAEIMLRQLa--------GEKVAPEKMVIP 324
gi 116332784 286 pALMGQLAATTLLHQLstt---pttMTQYVPVAPVVK 319
gi 150019460 306 pYEMGERAAKLLFERIdgsr-kddfVLEEIPVKIHLN 341
gi 22534847  288 sYGIGCLAAQCLIEKIsqgnepttaRLLEVKNQIVIR 324
gi 116617616 288 pQEIGRTAAANLMQIMndkt--tlsKTIRIPSTIQMR 322
gi 161702176 297 lVEIGFQAMDRLLEAIenkt--sklEITTIESKLIKR 331
gi 92089478  279 mELMGSLAANKLLTQInqqs--tisSTTLLPVEIIAH 313
gi 116491638 298 pKLIGSTAANKLLEEIqese--tqaSVITVKSQLMVG 332
gi 149905925 306 pYEMGERAAKLLFERIdgsr-kddfVLEEIPVKIHLN 341

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