Conserved Protein Domain Family
PBP1_LacI_like_7

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cd06285: PBP1_LacI_like_7 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107280
View PSSM: cd06285
Aligned: 8 rows
Threshold Bit Score: 344.775
Threshold Setting Gi: 134099104
Created: 10-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    ##  #                                            #                  
YP_001221888  73 LVGVLVPRLqdyVLATVYEGIDEAAterrISTFVTNsldrpdlqrsRTRSMLDRRVDGMIFGdahlddpl-ldelaeeGV 151 Clavibacter mic...
NP_886234     72 TVSVLVPQLsdlVVATIYEGIDAAAadsrYLTFVANtgdapprqrqLGEMALDRRVEGLIFAdarrddtrfldeiarrGV 151 Bordetella para...
YP_703171     73 LIGVLVPRLedyVLATIYGGIEEAAwesgLSTFVTNsldipanqraRTQMMIDRRVDGMIFGdahldhqf-ldevhdqGL 151 Rhodococcus sp....
YP_887307     70 LVGVLVPRLtdvVLATVYEGIESAAadrgLTAFVANtqdetdrqrnRIDMMLDRRVDGLILGdarsddhtvleeltrrEV 149 Mycobacterium s...
YP_702838     78 TIGVLVPRLsdtVMALMYEAISRAAtrlgYFTVVATtgdnpadesdAARTLLARNVDGLIVAssrrddpl-prelrerGV 156 Rhodococcus sp....
YP_001104765  62 TIGVIVPRLtdtVMAMLYEEITAVAaareLFTVVATtedsveteavAVRSLQMRRVDGLILTtarmgt-----pvttgQT 136 Saccharopolyspo...
ZP_00997754   42 TIGVIVPRLtdtVMAMLYEAISAAAaeqgRFAIVATtddnpdasrkAAEALIRRGVDGLILTtaregdhf-adelrdrGV 120 Oceanicola bats...
YP_702269     76 TLGVVMPRLtdgVVATMFQGIEETAtqagYSVLLSSppddldaqrrAIEFLVSRQVDGLLLSslhspgrefvdslsvgAL 155 Rhodococcus sp....
Feature 1             #           #                                   #                        # 
YP_001221888 152 PFVLVSrrrg-dhvAVTCDDVAGGRLAAEHLIaqGRTRPAVLAGmsfastAVDRTRGFLEAYAEAGmpvppeRVIERGFd 230 Clavibacter mic...
NP_886234    152 PMVLVSrhlg-thcAVTCDDVAGGRMAAEHLLalGHRDIAVLAGeqyastGCDRSAGFIAYCREQGvdipakWILHGPFd 230 Bordetella para...
YP_703171    152 KFTLASrrag-rytSATVDDVKGGRLVGQHLAdtGRRNVAVLAGlefastARDRARGAVEALADNGievptdRIVYSGFd 230 Rhodococcus sp....
YP_887307    150 PFVLVNrsva-dypAATCDNYLGGRLAAEHLLalGHRRVGVIAGlahastGIDRPAGFVDRFREAGievpdeHIVYSGLd 228 Mycobacterium s...
YP_702838    157 PHALVLrtdg-ispSSVGDDEAGGYLATRHLIdlGHTDIAVLSGplfastAVGRLAGARKALREAGiaevpeWIVETTFg 235 Rhodococcus sp....
YP_001104765 137 PCALALrtdg-tspAAIGDDRLGARLATRHLIdfGHRRIGLVGGpgyassAQGRADGYRDALTDAGipvdpaLITGNAFs 215 Saccharopolyspo...
ZP_00997754  121 RFVFALrhng-tsaASVGDDQLGGYLATRHLLdlGHKRIGILAGpdyatsALGRLAGYRQALTEAGipqaqeLIVATTFs 199 Oceanicola bats...
YP_702269    156 PMLQLNrhadvglpFVSGDDHRGGYLAGRHLLdrGFTELAVITGpdhastSRDRLAGFRAALAENGielrpdRVVRSDFd 235 Rhodococcus sp....
Feature 1                                                            #                #          
YP_001221888 231 aAAGREATEEVLRaghaPDALFATNDFAAIGAMGALHDAGLsvPDDVALVGYNDTPLaasgsIGLTSVRSPvHEMGRIAL 310 Clavibacter mic...
NP_886234    231 tRAGRLAGEKLFRsarkPSAVFAVNDFLAIGLMGAVRDRGLraGHDVAIVGFNDTPLaaelpISLTTIRSPmHAMGYRSM 310 Bordetella para...
YP_703171    231 pAGGRAAVEKVLAtgpvPDAIFATNDFAALGAFGALRDRGIhvPDDVALVGYNDTPLaeggaVPLTTIRSPmHELGRHAL 310 Rhodococcus sp....
YP_887307    229 sQGGHYAADRMLDgdapPTAMFAVNDFAAIGAAGAIRNRGLrvGRDVSLIGFNNIALtaemhVPLTSIESHaFDMGRDAL 308 Mycobacterium s...
YP_702838    236 iEDGEEAGNRLFRsasrPTAVFAANDNLALGVMAAAHRSSLtvGDDVALVGYNDIPLsqrlpVPLTSVRTPfDQIAATAL 315 Rhodococcus sp....
YP_001104765 216 iEAGEVAGRQLLDrddrPTAVFAVNDNTAIGVLSAAHRLGLsvPRDVSIVGYNDIPVvsrlpVPLTTVRVPfRQIATDAL 295 Saccharopolyspo...
ZP_00997754  200 iESGETAARTLLAlpdpPTAIFAINDNMAIGSMSAIAQEGLsvPGDISLVGYNDIPIvsrlpVPLTTVRVPfDRVAEVAL 279 Oceanicola bats...
YP_702269    236 vSGGVAAATVLLEsdspPEAIFTVSDTIAIGVLGVARDLGLriPDDLALVGYNDIPVvaqlpVPLTTVRSPaRLIGATGV 315 Rhodococcus sp....
Feature 1                                   
YP_001221888 311 ETLLalvdgreaASRLLEPTLVARAST 337 Clavibacter michiganensis subsp. michiganensis NCPPB 382
NP_886234    311 ELLLerikggrpASERLAPQLMVRAST 337 Bordetella parapertussis 12822
YP_703171    311 RLLLevlagrtpESVLLEPELIVRRSS 337 Rhodococcus sp. RHA1
YP_887307    309 ELLAdtlagaapAQRRTKPVLVVREST 335 Mycobacterium smegmatis str. MC2 155
YP_702838    316 DLMLattp-vddPIRRAMPTLIPRRSS 341 Rhodococcus sp. RHA1
YP_001104765 296 HLLTehk--ghtTTLTTTPTLIPRGST 320 Saccharopolyspora erythraea NRRL 2338
ZP_00997754  280 RLLFedg--qesVVRKITPSLIPRKST 304 Oceanicola batsensis HTCC2597
YP_702269    316 RHLLsiiagndvESVKLPVELIERAST 342 Rhodococcus sp. RHA1

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