Conserved Protein Domain Family
PBP1_CcpB_like

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cd06286: PBP1_CcpB_like 
Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species
This group includes the ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species. CcpB is 30% identical in sequence to CcpA which functions as the major transcriptional regulator of carbon catabolite repression/regulation (CCR), a process in which enzymes necessary for the metabolism of alternative sugars are inhibited in the presence of glucose. Like CcpA, the DNA-binding protein CcpB exerts its catabolite-repressing effect by a mechanism dependent on the presence of HPr(Ser-P), the small phosphocarrier proteins of the phosphoenolpyruvate-sugar phosphotransferase system, but with a less significant degree.
Statistics
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PSSM-Id: 107281
View PSSM: cd06286
Aligned: 36 rows
Threshold Bit Score: 262.882
Threshold Setting Gi: 22536948
Created: 10-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    ##  #                                            #                  
P37517        61 TVGVILpysdhpCFDKIVNGITKAAfqheYATTLLPTnynpdiEIKYLELLRTKKIDGLIITSRANHWdsilayqeYGPV 140 Bacillus subtilis
NP_786021     61 TIGIVLpyanhpYFARIVDGIVSAGfakgYKVTLLPTnydmtvERHYLEQLKSKAYDALIFTSRSNSLealeryqkYGRI 140 Lactobacillus p...
AAO80477      61 TLGVMVpytnqpYFDAILSGIIHQAfqqgMMVSLLPTdydkevEKSYLEKMATGAFDGMIVLSKANPLsvf--apyKEQV 138 Enterococcus fa...
EAN10312      82 SIGVILpytnhpYFDQLISGIIEAAfdydYKVTLLPTgyhkekERRYLEEFAAKAFDGLIITSRANTLddllayqkYGPL 161 Enterococcus fa...
CAC98106      61 TVGVIIpyndhpWFDKIVNGILEAAfknrYSVTLFPTgydpkeEEKYLMRLKTKQVDGLIITSRANNWdvilpylaYGPI 140 Listeria innocua
YP_001124627  61 IVGVMLpyihhpYFSAVIEGISKEAlrygYQLLLFQTnydverELEVLERLRMKQMDGLIVCSHEVGWeifdayqeEAPI 140 Geobacillus the...
NP_687799     61 KIGVVIphtrhpYFTQLINGLLDAAkttdYQLVMMPSdynqelELSYLKQLKMEAIDALIFTSRAISLdiietyakYGRI 140 Streptococcus a...
YP_807455     61 TIGVILphtdhpYFEQLVTGILNAAmagnYHAVILPSrydqslEQDYLEDLRRHAYDGLIFTSHGLGLrtiakyqkYGPI 140 Lactobacillus c...
YP_001423350  61 TIGVILpysdhpCFDKIVNGITKEAfahdYVTTLLPTnydpaiEMTYFELLKMKKIDGLIVTSRANEWetavpyleYGPI 140 Bacillus amylol...
AAK92515       5 NIGVVLphndhpYFNQLLNGIMDAAfssgYHIVLLPSeynrtvERDYLEQLKRKNFTALIFTSHELPLavledytrYGQI 84  Lactobacillus s...
Feature 1           #            #                                     #                        #
P37517       141 IACEdtgd-idvpCAFNDRKTAYAESFRYLKsrGHENIAFTCVread-rspSTADKAAAYKAvcgr---ledrHMLSGCN 215 Bacillus subtilis
NP_786021    141 VCCEdpgtsshlaAAYTDRLASYISALMWAKqqGCQNVGVVISrdn--lisASSRVTRMAYQetygk--lpaaNLFTGAV 216 Lactobacillus p...
AAO80477     139 VFCEkied-psyaSIYIDRLTVYRRVFQALKqqGCSEVAITINrap--eksTSARYLVDAYQeiyga--ipenRLFKDCL 213 Enterococcus fa...
EAN10312     162 VFCEeikg-kqasCVFIDREQSITEGLTYLKqqGIKQLGITLGrsg--rlsYNSKITLQLCHqlfps--fdesLVFWDCI 236 Enterococcus fa...
CAC98106     141 IACEyves-kdvsCSYIDRVKAYRAGFQFLQdeGYKKVAFTAGrasrestsTYGKINAYEQVfgpv----genRFLSECY 215 Listeria innocua
YP_001124627 141 VLCEqvte-ydffTVYIDHYQAFAKALHYLVkkGHRRIGYCIGrrt--gpnSQAREAAYQDVlrdvgvtpqrqWIFDGCL 217 Geobacillus the...
NP_687799    141 VVCEklqeynhlsSAYLDRYSSFLEAFSDMKlrGLEHLVLLFSrnne-ssaTYQSALLAYQEvygql--sspyMVVGNVH 217 Streptococcus a...
YP_807455    141 VVCEnpgk-iklaAAYADRTPAYQEAFQWMGsqGYSKIALLLSrpy--aqsATSKLTINSYVdvfgk-rpsdeMIVYHMR 216 Lactobacillus c...
YP_001423350 141 VACEytqh-qeipCAYNDRQAAYRESFLYLKnrGHQDVAFTCVreaekspsTADKVTAYKAVfgsl----detRILVGCH 215 Bacillus amylol...
AAK92515      85 VCCEnpgq-hhisAVYSNREPAYLAAFNYLKslEVQQIGLLLSrnla-kspTWVAVTGAYQQifhqk--pdqqLMIGGMR 160 Lactobacillus s...
Feature 1                                                              #              #          
P37517       216 dmNDGELAAEHFYMsg-rvPTAIYANSDEVAAGIHLFAKKNnw----dVEIIGEGNTsisrvLGFPSLDLNlEQLGIAAF 290 Bacillus subtilis
NP_786021    217 tfEDGYRAGRYFAKlk-psVDAILANGDDIGAGIQDYYRVHql---tpVKIIGQENLlssrlMQFSTIDHHlEALGKAAF 292 Lactobacillus p...
AAO80477     214 tyEDGCEVGRHCGQdp--tLQAVVTNGDEIAAGIQAVIERP-------LFLVGQEQTllseiLNFSTICHPlMELGEKAT 284 Enterococcus fa...
EAN10312     237 daEKGKQAGFFFKEl---gVDGVFTNSDMVAAGILQSYLQDk-----tPVVIGRDNLliselLGFPTIDHHlEACGEMAF 308 Enterococcus fa...
CAC98106     216 tlEDGVKAGKYFFAegkdwPDAIYANGDEVAAGVMYHVKELglrvpedVAILGQENLpigkaLEITTLDHNlKKLGENAF 295 Listeria innocua
YP_001124627 218 flEDGKRVIEQWMAme-erPSALLVTSDQVAAGIVLEARRIgvripeeLTIIGFDNDplaemLGITTVALPhFTLGEKAF 296 Geobacillus the...
NP_687799    218 dfNDGLNLSYQLVKev--sIDGILATSDEVAAGLIKGYEESrk---kcPYIIGQECLlvgqlLKLPTIDHKsYYLGKLAF 292 Streptococcus a...
YP_807455    217 tfEDGYQAGARLVNe---hPDFILGNGDDITAGLRQYFVDHhl---piPPLMGQENQlssrlLQMSTIDHHvTAIGAAAL 290 Lactobacillus c...
YP_001423350 216 dmDDGKRAGEHFWGfd-kaPTAIYAHSDDVAAGLYQFAKEQkw----dAEIIGEGNLsvsraLNIPSLELHlERVGKEAF 290 Bacillus amylol...
AAK92515     161 sfEDGYRAAEQLIArq-paLNCYFTNGDDIAAGVRQYHLDHql---pvPILIGQEKQlssllLKMPTIDHHfFTLGQKAF 236 Lactobacillus s...
Feature 1                                  
P37517       291 SLflq------depADIKIQHKFKKK 310 Bacillus subtilis
NP_786021    293 ELsis------hgqKHQLIKSEFIER 312 Lactobacillus plantarum WCFS1
AAO80477     285 HLfqe------krpKTIQLTSTFINR 304 Enterococcus faecalis V583
EAN10312     309 QLflt------ekkDKVKIPYTFIQR 328 Enterococcus faecium DO
CAC98106     296 SIfeq------gklQRIKVEHELIRR 315 Listeria innocua
YP_001124627 297 RLlhhwletgnvprKQEELPTRLVVR 322 Geobacillus thermodenitrificans NG80-2
NP_687799    293 KQala------ekiSQEVLFSEFLSQ 312 Streptococcus agalactiae 2603V/R
YP_807455    291 KLalr------ddiAQTVIQSDLILR 310 Lactobacillus casei ATCC 334
YP_001423350 291 LLffh------eetAKKQIMHQFQRK 310 Bacillus amyloliquefaciens FZB42
AAK92515     237 ELals------nqhHECAFESEFIRP 256 Lactobacillus sakei

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