Conserved Protein Domain Family
PBP1_LacI_like_8

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cd06287: PBP1_LacI_like_8 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107282
View PSSM: cd06287
Aligned: 10 rows
Threshold Bit Score: 361.669
Threshold Setting Gi: 16264028
Created: 10-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            ##  #                                      #                
gi 49529399   69 TIALISTIPsaisgGASKLGFMMEVANVAAIYALEHdLYILLVPfidhNNFDGNLMNVDGVILLEPclndpivkkllqyK 148
gi 50083423   69 TIALISTIPsaisgGASKLGFMMEVANVAAIYALEHdLYILLVPfidhNNFDGNLMNVDGVILLEPclndpivkkllqyK 148
gi 72121692   89 CIALLSSMPfavagGTSRLGFMMEVAAIAAEAAMARgLGVVLVPplegAGGLLETLDIDGAIVIEPlagdphiarlrerG 168
gi 16264028   63 IIALASSMPfavaaGPARLGFLMEIAAAAAVTALSRhLALCLVPpl-ePDSNLDALEVDGAIIVEPmvedrlleffsarG 141
gi 118048991  68 MIALMSSMPftvsgGPSRLGFFMEVAAVAASSALERgLVMALVPphrpGQTSLNLLDIDGALVIEPqagdpqlaellqqG 147
gi 134097273  65 TIGLVSSMPfavagGPSRLGFFMEVAAAAAESALMHgFALVLVPpv-eADPPLDSLDIDGAIVVEPdaddsatkrlrdrG 143
gi 126347822  70 AIALASSMPfavagGPSRLGFYMEVAAAAAESALSHgFALVLVPpv-qSGSALYSVDIDGAIVVEPdvedaaaaqlrerG 148
gi 85703909    1 MIALASSMPfsiaaGPSRLGFFMEIAATAAVASLTRnQALCLIPpm-eADSELDAIAMDGAILVEPfaddpmvdrffnsG 79
gi 69935067  108 TIALASSMPfavaaGPSRLGFLMEIAASAAISALTRdLALCLIPph-pAGKGYASVGFDGVILVEPmrddplvahfeqrK 186
gi 16762670   68 TIALLSSVPlaiasGASRLGFMMEVALTSAMMALEKqHALILVPp---GVNPLDAVSFDAAILIEPaendpqlqalaqaG 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #             #                                   #                     # 
gi 49529399  149 IPLVCIGtpgqdnkevPYVDLQSEQTAIKLLEHLVeegaHQIALITGqskRNASLKAEEIYSQYcqqyamteVVYKVEEh 228
gi 50083423  149 IPLVCIGtpgqdnkevPYVDLQSEQTAIKLLEHLVeegaHQIALITGqskRNASLKAEEIYSQYcqqyamteVVYKVEEh 228
gi 72121692  169 VSIVSIGrepltdspvPYVDLQSADTARMLLEHLHthgrKQIGLMIGdaaRQSYVETERVYREFtqanglpcTLVKAPEa 248
gi 16264028  142 VPVVSIGrapg-rediPSVDIQSTATARLMLEHLGan-sRRVGLITGeqrRNSYIETEAAYAAFaaergyspVALRVDEs 219
gi 118048991 148 LPVVSIGrpggdnvnvPYVDLLSGPATQMLLTHMLaagaRQIGLVVGaseRTSYSQAEQAYAAMaaghgmqpVVLRMDEa 227
gi 134097273 144 LPIVALGrqpg--tdlPHVDLHAAAVVRLLLEHLReqggRRIALLVGsarRHSYVDAAHEYRRFahehgmpeLVVLAEEs 221
gi 126347822 149 LPYVSLGrpmapdedaPYVDLRGGRVAELLLRHLHgqgaVRPALLVGsgsRHSSVDALAAYERLaeeydwtpRVARVAEa 228
gi 85703909   80 IPVVSIGrvpg-rddiPFVDLHSYATALMVLNHLRdagaTKVALITGtqrRNSYLETEAAYTAFcenhsiplTLVRVDEa 158
gi 69935067  187 TPIVSVGtvpg-rpdiPAVDMRSGETAAMLLDHLArqgcRHIAALIGsapRTSQIEAEAAFRTLaas---pdRLLKLSEe 262
gi 16762670  145 IPCVTIGrtpgtdtpvPWVELHSAATAQLLLTHLEasgaSKCALFVGntrRTSVLESEAAYQRWcagr-qdpVVYSLNEs 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #                #        
gi 49529399  229 lGEMGGKSAIAEIMKqypktDAILVmiDTFATGVMQYLTEKgisVPKQMKVVTRYNGIRaltsnPPLTAVDLHlDDVAKI 308
gi 50083423  229 lGEMGGKSAIAEIMKqypktDAILVmiDTFATGVMQYLTEKgisVPKQMKVVTRYNGIRaltsnPPLTAVDLHlDDVAKI 308
gi 72121692  249 qGEAAGAEACAQLLAqlpslDALCApvDAFAVGAMEHLNKSgkrVPDDVQVVTRYDGIRartahPPLTAVNLHlERVAAL 328
gi 16264028  220 gGESEAAAAAERLLRnnpdiDALCVpvDAFARGVLDAARLLdrpVPQGLRLATRYDGMRaklatPQLTAVNLHlDQVAEA 299
gi 118048991 228 eGEDGGHAAAQQLLGehpelDALLVmvDAFAVGAARYAQQAglrIPEDLMLATRYDGLRarscePPLTALDLHlEAIAQQ 307
gi 134097273 222 gGTEAGYAACADLLDrhpgvDAVCAtvDAFAVGAVRALTDRglrVPDDVMVATRYDGLRartcePPLTAVDLHlGQAAEG 301
gi 126347822 229 gGEQAGYEACAALLAghpgiDAVCAlvDAFAVGAVRAIRDSgraVPDDVMVVTRYDGLRartcePPLTAVDLHlDRVASD 308
gi 85703909  159 gGETEAEQCCTALLAdhpdlDALYVpvDAFASGATKAAKSLhraVPETLRLATRYDGSRakladPPLTAVDLHlDELAKL 238
gi 69935067  263 eGEEIGYRETLRLLRddpsiDGIFAavDAFASGAVRAAHELgrvIPDQLRIVTRYDGLRaklsqPPLTAVDLHlPAVAEA 342
gi 16762670  224 eGENAGYQAAQQLLQahpdvDGVLVliDTFASGAVRAFQEQdiaIPEQIRVVTRYDGIRareslPPLTAVNMHlDEVARQ 303
                        250       260       270
                 ....*....|....*....|....*....|...
Feature 1                                         
gi 49529399  309 AIDLLItqlned--ietgsLRVMPAPEIIKRTS 339
gi 50083423  309 AIDLLItqlned--ietgsLRVMPAPEIIKRTS 339
gi 72121692  329 AVDLLFahlsg---drsrqTVVGPAPELIVRAS 358
gi 16264028  300 AIDLLIaameg----kepqPHAIAPPQLVVRES 328
gi 118048991 308 AVDLLFehlrg---dttrrMATGPMPALALRRS 337
gi 134097273 302 AVSVLLaemrrgpargeapEVPVPPPVLVPRAS 334
gi 126347822 309 AVELLLgrlrge--tatptVAVSPEPRLIARAS 339
gi 85703909  239 AVDLLIqtieg----qtgrNLISPMPDLVPRQS 267
gi 69935067  343 AVHLLFdrie-----gtsrTVAAELPELVVRQS 370
gi 16762670  304 AITLLFavlsg----ekvsYSDGIMPELVVRAS 332

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