Conserved Protein Domain Family
PBP1_sucrose_transcription_regulator

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cd06288: PBP1_sucrose_transcription_regulator 
Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107283
View PSSM: cd06288
Aligned: 35 rows
Threshold Bit Score: 295.648
Threshold Setting Gi: 86360780
Created: 10-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             ##  #                                             #        
gi 608709     63 TLAVLAqdta--------ttpFSVDILLAIEQTAsefGWNSFLINifsed--daarAARQLLAHRPDGIIYTtmglrhi- 131
gi 13474146   65 VIGFAVdqla--------tspEAVVAIEGARQASwnaGNVLLVAQtmgda-vmeprAIQALTRRGISALIYMtiftreit 135
gi 116249576  67 LIAMLInevt--------sspHVAGLIDGAGEAAnelGYLLSVMPtdade-eaeqaALSHLATLPAAGIIYArlitqqv- 136
gi 86360780    8 LVGLVAddli--------tspFATEIIRGLDGAVraaDMAVFAMTlgghr--siasILDEMRRFRPRAIAYAamyhksv- 76
gi 57545639   43 TIGVLAldtv--------ttpFSVEITLSIEETArayGWNSFVVNmftdd--npddIVDLLLAHRPGGIIFTtmglrev- 111
gi 28868104   63 TIGVFAldta--------ttpFAVELLLSIEQTAqqaGWNVFILNllsnp--ptdqNIDLMLSHRPDGLIFSamglrev- 131
gi 86360634   61 TFGIITdyvs--------ttpYSVDIVRGIQDWAnanGKTILIANtggss-ereveIWKMFQSHRIDGVLYVtmyrriv- 130
gi 89068785   61 LIGLITgaisqeigpavqsglPEMNIVQAIQREMsaqGKILMISDtggra-daapvLARTFAQHRVEGLIYVadhhrei- 138
gi 51590030   63 TLAVLAwdta--------ttpFSVEILLSIELTArefGWNSFLVNltsre--dsqrALNQLLAQRPDGIIFTamglrqv- 131
gi 52306915   63 TIGVLSlgta--------ttpFSVEILLGIEQTVrqhGWNSFVINtfendsqamedAVEQMLSHRPSAIIIArnglknv- 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #             #                                   #              
gi 608709    132 -tlpeslyGENIVLANcvadd-palpSYIPDDYTAQYESTQHLLaagyRQPLCFWLpesalaTGYRRQGFEQAwrdag-- 207
gi 13474146  136 apdylyslDIPVILLNcytad-yafpAVVPSEIAGGQSSTRHLIshghRRIATITGepwmqaAQDRLKGYRRAlatadip 214
gi 116249576 137 -tlapqlaEWPTVLLNcytvd-kplpSVVPGDLSAVMKATLSLIdaghTRIAYIGGedaieaSRERIKGYRRAltmrdip 214
gi 86360780   77 -dlppefaDAVGVMINcrdan-drvtSLVPDESGAAIEITNYLIdagrRNIAFINLpgl-laGELRELGFRQAlehagid 153
gi 57545639  112 -sipprllELPCVLANcenkg-epvaSYIPDDEHGQYTAVQALLaagySRPLCLHLpvnhlaTRRRRRGLDRAcreasid 189
gi 28868104  132 -sipqrlkSKPLVLANcvadd-sslvSYVPDDETGQYRALHHAFnqgyRRPLFINLpkqslaWEIRQAGMQRAclafg-- 207
gi 86360634  131 -dpesgdvSIPTVMINcrpqtrellpSIEPDDYQGARDLTRYLLerghRRIGYIRLnpillgAELRLDAFRRTtsefglt 209
gi 89068785  139 -emdltsgNCPVVLVNcyda--aatpCVLPDDEAGEAALVARLIeaghRRIGFLPPdrtqpaARLRLDGYRTAlaaagla 215
gi 51590030  132 -tiperfrDKNIVLANcvses-hsipSYIPDDFDGQYQAMKLLLqrgyQRPLCIYLpectlaGKARRAGVEKAwqesalp 209
gi 52306915  134 -sipeklrSFPLVLANcqtqd-mavaAYIPDDYQGQRVVVDRIVakgyQRPLFLHIpknyiaTAKRRQAFEDAwanhs-g 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #                                                                 #   
gi 608709    208 rdlaEVKQFHMat------gDDHYTDLASLLNahfksgkpdfdVLICGNDRAAFVAYQVLLAKGvriPQDVAVMGFDNLv 281
gi 13474146  215 fdpdLVVEGDWs-------aSAGYAATVKLLAlkd-----rptAIFCQNDRTAIGCYEALKEAGlhiPQDISVVGYDDEe 282
gi 116249576 215 vdnhLIIKGRWt-------iQGGYAAFKRLQAldd-----rptAICCFCDRIAMGVYEAAKEAGlsiPRDLSVIGFDNEs 282
gi 86360780  154 gagaIVLPAVSkaiysdrahSLVSAHVQELMIgpr-----rpdAILCGNDRVAMEVYAALRRAGaaiPDDVAVASFDNQv 228
gi 57545639  190 pdtlEHCYMQFg-------dEHYRDIPEMLLAhieqg-kprfdSVICGNDRIAFMVYQTLLTQGiriPQDIAVLGYDNLv 261
gi 28868104  208 laadEHMQYNLs-------eHDAYWETAAILErhmidgrpqfdILVCGNDRIAFCAYQLLLGRGlkiPADVAVLGYDNMi 280
gi 86360634  210 endlSISLGMDgpvg--aenNYVFAAATEMLKqdd-----rptAIMSGNDEMAIQIYIAAMALGlriPQDVSIVGFDDFr 282
gi 89068785  216 ydpdLVAHVHDpd------aDRARALLTEALDallsl-dappsVICCTNDEMAMRLYGLLRSRGlrvPDDISVAGYDDHk 288
gi 51590030  210 teqlNQCHIAWg--------DEHYQDVIPLLErhcpkgkpnfdVLICGDDRIAFLAYQVLLAKGvviPQQVAVIGYGDMv 281
gi 52306915  211 qkpvQFFMRRDg--------EDYFEGAQPLIDylekpdplpfdVIICGNDRIALVAYQLLLAKGyriPEDVAVCAYDNMv 282
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                      #                                        
gi 608709    282 gvghlflPPLTTIQLPhDIIGREAALHIIegr------eggRVTRIPCPLLIRCS 330
gi 13474146  283 iar-hlfPPLTTSILPhMAMGQWAIEQLEaptap--gqgryPITKLECPLVERES 334
gi 116249576 283 ysg-dmlPPLTTMQLPhADMARYAVEKLAemiaaprmrhdnHKVKLECEMIVRQS 336
gi 86360780  229 eiasrldPPLTTMALPhRAMGRQAAQILLaedr-----apvGVQKLPFQLVERAS 278
gi 57545639  262 gignlflPPLSTVQLPhYEIGRLSTLHIIngd------thrDKVIVESPWLPRES 310
gi 28868104  281 giaelfiPALTTVQLPyYEIGRNAARHLIegl------dvsGTQPVDCPLVVRES 329
gi 86360634  283 tvtmalkPELTTAALPyYDLGREGAKWLNdliag--ekiypGSRVVSCKLVERSS 335
gi 89068785  289 tisemlyPQLTTVVLPySEMGRQAARLMLeliegk-plaspGPTLVDGPVVWRSS 342
gi 51590030  282 gigelylPPLTTVQLPyYDIGRQAALHLIrgr------esrAIHRLPCPLLERGS 330
gi 52306915  283 giaqlfiPPLTTVELPhYQMGQEAALHLIegr------kdrDIHQLPCPLIEGES 331

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