Conserved Protein Domain Family
PBP1_MalI_like

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cd06289: PBP1_MalI_like 
Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria
This group includes the ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria. They are members of the LacI-GalR family of repressor proteins which are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107284
View PSSM: cd06289
Aligned: 37 rows
Threshold Bit Score: 295.612
Threshold Setting Gi: 119469877
Created: 11-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                            #                  
gi 2506563    66 VIGLIVrdlsapFYAELTAGLTEALeaqGRMVFLLHggkdgeqLAQRFSLLLNQGVDGVVIAgaagssdd---lrrmaee 142
gi 89069232   63 TIAMCLhtitnpTFSAILTSAERVFweeGWTVMFGDseddlakQRAFIARSIESNIAGLVVSpaagtrsa----dleefr 138
gi 14025056   49 IVGVVVhdimnpFFAEILRSIESELdrsRQTFILSNhydqlekQRTFIDTLLQLGADGVIMSpaigtpaa---dilmaee 125
gi 89056418   64 LVGLVIndlrnpFFTEFATVLQMTLaakGYATVIANsdedadlQAKLMGSMIEHGVSALVVSpayddggd---afdqver 140
gi 91795299   64 TVAVCLndlsnpFFTEFLGHMETRFreaGRMMLFCHahetpsiQARFIRQMAEHGAAGLILVpvegtsradlegprvrhl 143
gi 118593813  64 LIGLIIndlrnpFFTEFAASAQMTFarkGYSTVIANtdedpeiQAQVIDSMIEHGVSAFVISptyggdes---pfdrier 140
gi 118588449  81 IVGVAVhdilnpYFAEVFSALEDVLeeqGQMIFICNhrddvkrQRAFVNTLLQHRADGLILCpsvgtsae---einrlvd 157
gi 163759752  66 LIGLVIndlrnpFFTEFATSLQMALaghGYSTVVANtdespelQDQVVGSMIEHGVSAFIICpaygedss---tfdmiak 142
gi 114048872  69 LVAIVIndltnpYSAQLAVGLEANIrrmGLFSMLVNsgedkdtQSQLVQSLKEYNVAAFVICpapgtdpe----wvnrla 144
gi 71145448   69 LIAIVIndlknpYSAQLAVGLEQQIrqmGLFSMLVNsaenvdtQTSLVRNLKEYNVAAFIICpapntsad---wvnslve 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #              #                                   #                    
gi 2506563   143 kAIPVIFASrasyl--ddvdTVRPDNMQAAQLLTEHLIrnghQRIAWLGGqsssltRAERVGGYCATllkfglpfhsdWV 220
gi 89069232  139 gHVPMVLASrevea--teldLVRIDYVKGIELAVAHLAelghRRIAWIGRgaetgaRPPGFASFVAAlearglafeprHG 216
gi 14025056  126 nGLPAVLIArtveg--advpVFRGDDSYGTGLATNHLIslghKRIAMIGGtdqtstGRDRYQGYVNAmeaaglevrpsWR 203
gi 89056418  141 aGIPAMQVLrktdprtglfpFASFDYASGSAKATRHLMnqgaTRIAFVGGmegraiTEERKSGYLAEikra---gaepFV 217
gi 91795299  144 rDFPLVLISrdvad--tafdRVINDDERGIRLLFEHLYalghRRLAWLGGggdtstAHDRERSFRREmdaaglpiddaTM 221
gi 118593813 141 aGIPTMQVLrqldertdlfpFASHDYAFGGEAAAQHLIdtgcRRIAFAGGladrpiTLERMSGYRNVmqan---glapTI 217
gi 118588449 158 qGIPVTLVArevpg--vwapCVRGDDLAGTYQITKHLIkqghRNIAMVGGrrgsstGRYRNAGWRKAleeagidpasqLD 235
gi 163759752 143 aGIPAMQMLrrvddrlklfpFTAPDYRAGSEVATRHLIsagaKRIAFIGGlegrrvTEERKAGYLDVlhei---dmdpVI 219
gi 114048872 145 sSVPVIHIMreveg--aavpTVLPDNQGGTLAATRHLItqgyRCIGFLGGnkrisdYGERLAGFKEAlaeag-lepagIW 221
gi 71145448  146 qGFPVVHIMreiag--akvaTVLPDNFTGTKLATQHLImkgyKKIAFIGGnesisdYHQRLSGYIEAmtlakvpfskkLC 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                                                              #            
gi 2506563   221 LECTSsqKQAAEAITALLRhnptisAVVCYNETIAMGAWFGLLKAgrqsgesgvdryfeqqVSLAAFTDAtpttlddIPV 300
gi 89069232  217 HFCDPdrRSGYDGMTRLLEtapeitAVLCFSDMIAIGALRALHEAgrap---------grdVSVVGFDDLdeaqyatPPL 287
gi 14025056  204 IAGPRtkQAGFEAAGQFLAlkdrptAACCWNDLVAIGLMNGIARAglvp---------gidISVTGYDDLeeaaiatPAL 274
gi 89056418  218 LHGRSsrAFGLEAAMALPMdv---dAAICFNDLVALGMLSGFAREgvel---------grdFRLVGFDDIedcaqvwPQV 285
gi 91795299  222 HHGPTslAFGDSMLDELMAlptpptAIVCFSDVIAFGVLAACYRRglrp---------gidLSVTGFDDMgaaaysaPAL 292
gi 118593813 218 FHGRPsrQFGREIALKILQehdgleAAICFSDLVALGMLSGFAELgikv---------gqeFKIIGFDDIeecslayPRL 288
gi 118588449 236 LPEMMtqADGRAAVPKILEaehrptAIVAFNDLVALGMMTTFRRAgvep---------gpdMAITGYDDIdgadartPAL 306
gi 163759752 220 LTGKAsrKFGKESAGRLMSehpdvnAVICFNDLVALGMLSGCHELgvsv---------gtdLLIVGFDDIeeiahayPSL 290
gi 114048872 222 ETALTnrHGGRVAMAELLEsiqrpeALVCFTDIIAYGAIEQLRQQglkp---------gedMAIIGFDDLedsslmtPAL 292
gi 71145448  224 VQSNTtrNGGRSAMKEVLTltsdieAVVCFSDVIAYGAIEQIRASgrqp---------gkdIAIVGFDDLedsrlmsPAL 294
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
Feature 1            #                                     
gi 2506563   301 TWASTPaRELGITLADRMmqkitheethsRNLIIPARLIAAK 342
gi 89069232  288 TTVRIDlPELGRAAARTLldrmadpaapqRLVKIDAVLVPRG 329
gi 14025056  275 TTVWNGqREVGRRAASALldklngqtvrpSQELIKPELHVRQ 316
gi 89056418  286 SSVACDiSGFAQGIADGLlawmqdgvtppPEHRAPVHLVART 327
gi 91795299  293 TSVRVRtDLIGDRASELLlariagdrqpaVREMMPPELVVRE 334
gi 118593813 289 SSVRCDtALFGRNAAEAMlawivdgirppDTKHYPVELMKRQ 330
gi 118588449 307 TTVSAQpDKIGRLAALTLlrqiagdrvpnTPIVIEPDVRIRE 348
gi 163759752 291 SSVHCDiAGIGSQAAANVvgwlekgqvpaPETRTPISLCIRQ 332
gi 114048872 293 SSIAIDaDAVGATVCGVLdnirk-glqeqGLQRLPVQLKVRG 333
gi 71145448  295 TTIHVDaNQIAIAVCQILtnin---ngnrNKILVGVDLIERD 333

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