Conserved Protein Domain Family
PBP1_LacI_like_9

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cd06290: PBP1_LacI_like_9 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107285
View PSSM: cd06290
Aligned: 9 rows
Threshold Bit Score: 400.944
Threshold Setting Gi: 55773437
Created: 11-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                            #                  
gi 83649520   81 TIGVITqavesPFFNELLKGIEEGLqgsgYASLMASGHWnsqsEIERIRLLIARRVDGIILLtgnlnneqildlatQTPI 160
gi 32472022  102 TIGIVTqnigtPFYDSVVQGVMQGLngtgFSPIVGDAMLnqnlFLDAARTLMGRNVDGLILIagdtpsekieelgeEKPT 181
gi 94972321   70 SIGVLTqdiasPFYGDALGGIERGLmgsgYSPLIISGHWrtdeEEHAIELFMSRRVEALIVLgghlpeeelrqlaqQLPV 149
gi 55773437   65 AVGILLsdfasPFFGPILEALTLELeatpYRPIAVPGHWslvrELEALEFLKAHRVEALVLLgtaldg--ealgelGIPV 142
gi 46255109   72 AVGILLsdfasPFFGPILEALTLELeatpYRPIAVPGHWslvrELEALEFLKAHRVEALVLLgtaldg--ealgelGIPV 149
gi 27367664   70 TIGVLVqhpesPYTSRILNDMEKVLnaqgYSLVIATGHWqrslETHALEYLAKSHVDGVIIVtgslseeqilayaeRIPV 149
gi 149187602  76 SIGVVAasfdsPHIARILKGMDSTVlnhsYQIIVETSHWnkarETEILKQFKQRNADAIVLIgsylndaevktilgKTPV 155
gi 149187603  65 KIGVVApsfdtPYVSRILYGMDRRMrnhsYDIIIETTNWeqsrERHELQDLVSRQVDGIIVVggdlaeediaaltgKIPT 144
gi 159898986  66 IIGVLTqdigsPFYGELLRGIEYGFrgsrYHPIFADGNWqqaeEYNALNILRSRQPEALIILgglmpdaemlaaaqEFPL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #                  #                                   #                     
gi 83649520  161 VAVGhnahs------enaaSIFIDSRMGGYLATKHLIslGHRRIAHIQGpqeqndASNRLHGYKMALEEAGIafdedLLA 234
gi 32472022  182 LVVArempd------wdgaNIATNNFQIGANATQTLLdhGHREIVHIAGpanhidAIGRLAGFRHAMQQAGIevtddHII 255
gi 94972321  150 AVLGrevdfa----spgsiSLALDNRQAAYDLVSYLLdrGHRRIGHIMGpqdhadARDRLDGYRQALEDRGLpfqpsLVV 225
gi 55773437  143 LAFGqrveg------pkawSLCLDNQQAAYEATRYLIdrGHTRIVHISShrggmdVRDRLLGYRKAMREAGLe---aRVV 213
gi 46255109  150 LAFGqrveg------pkawSLCLDNQQAAYEATRYLIdrGHTRIVHISShrggmdVRDRLLGYRKAMREAGLe---aRVV 220
gi 27367664  150 IAVGyqvsg------pnvrSVNVDNVLAGYMATLHLLqqGHVNIAHIKGllnqpdAVARFVGYKKALKEAGIkvqakLIK 223
gi 149187602 156 LLLGspvylaptdsitgipQVLVDNELGGYLATNHLIqlGHTRILHLRGaignndSDERVVGYKRSLEKAGIevldeLIV 235
gi 149187603 145 LLMCrrgk-------gilpLINVDNEMGGYLATNHLVqlGHKKIMHLTGpsgnidSENRIAGYLRSLKNAGLvaepgMVI 217
gi 159898986 146 IIIGrsvps------leeyCVLVDNFQGAYRATQYLIemGHQRIAHITGirshqdTLDRQAGYEQALRDANLpinpdLIV 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #                                                     #                #     
gi 83649520  235 QGDFiePGGLMAMNRLLDkgvsfsAVFCANDQTAYGARLALYRRglrvPEDMSLIGFDDLpmssyttPPLTTIRQPvYEV 314
gi 32472022  256 HGDFhaESAAEAIETLAQrgvpytAIFAANDLMAFGARLALHRRqvsvPDQVSLIGVDDQpeskwmvPPLTTIRQPgKEM 335
gi 94972321  226 QGDFhePSGLIGTQQLLAqhpdmtAIFSANDQMAYGARLALYRLglrvPEDMSLVGFDDLpgsayttPPLTSVRQPmAEM 305
gi 55773437  214 YGDLeeEGGYRAAAEAFRrypdttAIFAANDQTAFGARLYLYEQglrvPEDVSLVGFDDIalsayqiPPLTTVRQPiQDI 293
gi 46255109  221 YGDLeeEGGYRAAAEAFRrypdttAIFAANDQTAFGARLYLYEQglrvPEDVSLVGFDDIalsayqiPPLTTVRQPiQDI 300
gi 27367664  224 QGDFssETGYEKTVELIQsrhyfsAIFAANDQTAYGAIKALHDHglrvPQDVSVIGFDDLpvsqyftPALTTMRQPiEEI 303
gi 149187602 236 EGEFksEQSLEVVKETIEqgieftAIFASNDESAYGAIQALHQKgysvPDDISLIGFDDLpfssyliPQLTTVKQPlEIM 315
gi 149187603 218 DGHFesRNAFQNLTTALKggakptAIFAANDHSAFGVIQALHQYglrvPDDVSVIGFDDLpideyyiPRLTTVRQPfAEM 297
gi 159898986 220 EGTFqeQSGLLAVETLLMranpftALFAANDQMAYGARLALYRRgirvPEDVSLIGFDDLpssayttPPLTTVRQPtFEM 299
                        250       260       270
                 ....*....|....*....|....*....|.
Feature 1                                       
gi 83649520  315 GQTAAKRLLrlirgegaESVNLNVELVIRES 345
gi 32472022  336 GQAAATAIIamingsepDLPKLGGDVVLRES 366
gi 94972321  306 GHWLARFVVaqltgqtvEPFQPRMELRLRES 336
gi 55773437  294 GIALGRALRavlagevpTLPRLELRLVERAS 324
gi 46255109  301 GIALGRALRavlagevpTLPRLELRLVERAS 331
gi 27367664  304 GEISARSILnllngdrsPQRLPPIELVVRES 334
gi 149187602 316 GSIAIRYALdlisgikpNYQVPPVEVIVRNS 346
gi 149187603 298 GEIGVRYLLdlisgnkpNYDIPPVQVIIRDS 328
gi 159898986 300 GMSAAKATLnlidqrpwPLPQLTPDLVIRES 330

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