Conserved Protein Domain Family
PBP1_LacI_like_10

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cd06292: PBP1_LacI_like_10 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107287
View PSSM: cd06292
Aligned: 14 rows
Threshold Bit Score: 334.673
Threshold Setting Gi: 77970046
Created: 24-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    ##  #                                             #                 
NP_631078     59 LVGLVLPelqNPIFPAFAEVIGGALaq-qGLTPVLCTqtkggvseaDYVELLLQQQVSGVVFAggglfaqadap---hdh 134 Streptomyces co...
YP_001626255  65 LVGLVLPelqNPIFPAFAEVVSGALaq-gGYTPVLCIqtaggiseaDYVELLLQQQVSGVVFLggmyaqqdss----hdh 139 Renibacterium s...
YP_833241     72 QVGIIVPdltNPIFPAIAQTVVSLLsq-eDFIPILCAlpgggrsedEYIEMLVAQEASGIIFIcsshadgqas----ler 146 Arthrobacter sp...
CAA80383      59 LVGLVLPelqNPIFPAFAEVIGGALaq-qGLTPVLCTqtkggvseaDYVELLLQQQVSGVVFAgglfaqadap----hdh 133 Streptomyces am...
NP_828443     54 LIAVITEyvsNPFFADVCERIESTLap-hGLKTVLCPcfpggvqelDFVTSLADRGVAAVVFLsssntiegad----pea 128 Streptomyces av...
YP_001103911  75 VIGLLVPelsNPVFPAFAEALEARAvg-aGYASLLCNtrvg-mseeDYVRMLIARGVEGMVFVspeiantegeqrisrsy 152 Saccharopolyspo...
P23823        70 LIGLVTPeltNPIFPAFAQVVEQALag-yGYTPVLCTqipggatedELVEQLEERGVNGIVFLsglhadttad----prr 144 Streptomyces li...
YP_001632431  62 ILGMLVPttsNPSFGQLAVAVEEVAqrkhDYRVLVCNtyrdkqleaKVLDELIGLGIRAVIVIsslnderh--------- 132 Bordetella petrii
ABB11425      62 LVGLLVPsmaNPMYGYIAREVEACAqeryGHRVLIGNtyrdakkeaSFFDDLFAHGVRRVIVIssladesh--------- 132 Burkholderia sp...
YP_001476358  68 MLGLLVPsivNPSFAALVREIELAAkqnyGYQVLLGDthrqqeeeiRFLDDLLALGIRGVVVAstfydrph--------- 138 Serratia protea...
Feature 1                      #                  #                                   #          
NP_631078    135 yrllaerNIPVVLVNasipd------lgfpCIACDDAVAVEQSWRHLTslghERIGLVLGpsdhipSRRKLTAAREAaqa 208 Streptomyces co...
YP_001626255 140 yrrlierKLPTVLVNaaapg------lefpTVSCDDAVGMEQAFGHLVqlghRKIGILLGpadhapSQRKLASARSIaek 213 Renibacterium s...
YP_833241    147 yhrlrgrGIPFVLVNgarpe------lsaaSVSNDDAAAISTAVHHLAslghRKVGLAIGphrfipSRQKLAGFRSAlae 220 Arthrobacter sp...
CAA80383     134 yrllaerNIPVVLINaaiad------ldfpCIACDDAVAVEQSWRHLTslghERIGLVLGpgdhlpSRRKLAAVRAAggs 207 Streptomyces am...
NP_828443    129 yellrsrRIPFVGVNgqfeg-----vseapVFSTDDLLAAELAVDHLYrlghRRIGMASGpvgnrpADRRVSGFVSSlar 203 Streptomyces av...
YP_001103911 153 yeklladGVRMVFVNggapt------ldvpDVAVDEHLAGYTATRHLLdlghRRIGFVSGparavpSRLKRAGWAAAlee 226 Saccharopolyspo...
P23823       145 yarlterGVPFVLINgyner------irapFVSPDDRSAVRMAVRHLAdlghRRIGLAVGpdryvpSRRKAEGFADAlae 218 Streptomyces li...
YP_001632431 133 ieaaidrGLAVVSYDlgidpa---rpakhdHVLPDNRLAGQLAASHLIahghRHLAFVKPkgatisRREKIEGFMQAvrq 209 Bordetella petrii
ABB11425     133 leraaerGMTVVSYDrratpg---elskveHVTADNEAAARLATRCLVdaghRRLAFATVagmtvsRSDKIRGFLETard 209 Burkholderia sp...
YP_001476358 139 frealkrGLVMINYDeraltapgetalpidSVSMDNGAAGNMAARHLIaqgcRRIAFATAsgmtssRANKIAGYRQAlea 218 Serratia protea...
Feature 1                         #                                                             #
NP_631078    209 sng---tlpdaHVERAMFs--------lEGGQAAATRLLDrg--itGIICASDPLALGAVRAARRRghrvPHDVSVVGYD 275 Streptomyces co...
YP_001626255 214 agl---elsddLVVHAHYs--------lEAGQAGASRLLQsg--atAIVCASDPMAIGAIRAARRLelrvPQDVSVIGFD 280 Renibacterium s...
YP_833241    221 yld--tqdpepHTATSMFt--------vEGGQSAANELLDsg--htAIVCASDVMALGAIRAVQARglrvPEDVSIVGFD 288 Arthrobacter sp...
CAA80383     208 l-------gddLVERSMFs--------lEGGQAAASRLLErg--vtGIICASDPLALGAVRAARRRglhvPRDVSVVGYD 270 Streptomyces am...
NP_828443    204 rgv---edpeqWVVRQSYt--------vEGGQSAAISLLGrg--atAIVAASDYMALGAIRGARRQgydvPGDVSVVGYD 270 Streptomyces av...
YP_001103911 227 adi---apdprLVAHAPFg--------aEGGAQAMAELLEtag-ptAVMCSSDVMALGAMREAKRRglatPEDLSVVGFD 294 Saccharopolyspo...
P23823       219 ilgtprdqaeqHVRRTLFs--------vEGGHAAAGSLLEqg--ctGLVCGSDLMALGAVRAARERgldvPADLSVVGFD 288 Streptomyces li...
YP_001632431 210 sg----eqcsaQIIDIDDgtrfgdgelgQLGFQAAQQISRlaqrptGIAAVNDMTAIGLMAGLRHCglsvPEDVSVIGMD 285 Bordetella petrii
ABB11425     210 ag----ieahaQVLDGGPaneygdavivDVGRALGVALAAdparptGIVAVNDLFALGLMAGLRDGglrvPDDVSVVGMD 285 Burkholderia sp...
YP_001476358 219 agl---pvrviEGKAQFAygda---emaELGKTLAEQICQseprpdGVVALNDMLAIGMISAFQRLgvrvPEDISVVGID 292 Serratia protea...
Feature 1                        #                                           
NP_631078    276 DSafmtctePPLTTVRQPiEAMGRAAVDLLcaqiqg----tevphRELLFEPELVVRGST 331 Streptomyces coelicolor A3(2)
YP_001626255 281 DSalmnsidPPLTTVRQPiEPMGKMVIKYLldqidg----ssrasDELLFEPELVLRAST 336 Renibacterium salmoninarum ATCC 33209
YP_833241    289 DSplmaltnPPLTTLRQPvAAIAHAAVHALaaeiag----eqstrSPVVLASDLVVRGST 344 Arthrobacter sp. FB24
CAA80383     271 DSafmtctePPLTTVRQPiEAMGRAAVDLLwaqiqg----tevphSELLFEPELVVRGST 326 Streptomyces ambofaciens
NP_828443    271 GAmimdfvdPPLTTVRQPaDRLASEVARSIlalvgn----rdvpvGELLFDPELVIRAST 326 Streptomyces avermitilis MA-4680
YP_001103911 295 DIalasycqPALTTLAQPiEEMAAAAVDELsrrldpdqpgrattsFSRMFRPNLVVREST 354 Saccharopolyspora erythraea NRRL 2338
P23823       289 DSqlvaftdPPLTTVRQPvHAMATAAVGALleeiah----qtvqrTEFVFQPELVVRGST 344 Streptomyces limosus
YP_001632431 286 NIsmsefawPPLTTVATPvADVAETMVEQAiarirq----pslapREFSFPPRLVERQSV 341 Bordetella petrii
ABB11425     286 GHflsaisnPALTTVQLPvTEMAEDMVRRVmrsdgd---tplapeSHVFSGVTLIERASV 342 Burkholderia sp. 383
YP_001476358 293 NMflselfnPTLSSVAPPlREMAVKIVDRLigrlen----pelpvEEFLFAPSLVCRQSV 348 Serratia proteamaculans 568

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