Conserved Protein Domain Family
PBP1_LacI_like_11

?
cd06293: PBP1_LacI_like_11 
Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors
This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
?
PSSM-Id: 107288
View PSSM: cd06293
Aligned: 7 rows
Threshold Bit Score: 425.307
Threshold Setting Gi: 77390112
Created: 25-Jan-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                            #                  
gi 152970283  69 TLGLVLPDItNPFFAELADAAEEAAsasGYSLVLCITRNnpekecQFIRWLDTCQVDGLLFTTNRPdngllrkevqrHER 148
gi 63254739   64 TIGLVLPDIaNPFFAELADAAEEEAsahGYNLVLCVTRNlleresTFVRWLDSRNVDGLLLVSNRPddgtlasqlmsYRN 143
gi 66044032   64 TIGLVLPDIaNPFFAELADAAEEEAsahGYNLVLCVTRNlleresTFVRWLDSRNVDGLLLVSNRPddgtlasqlmsYRN 143
gi 159185589  66 TIGLVVPDIgNPFFGMLVAAVEEEAdrrGLALSLFATLNrkgrelSYLRLLARNHVDGLVFITNHPntdelaelintTGK 145
gi 116249675  66 TIGLVVPDIaNPFFATLVAAVEQAAdekKLAVSLHATLNrpgreiEYLQLIERNHVDGLIFVTNHPddgalaalingSGK 145
gi 77390112   61 TIALVVPDIaTPFFATFVAAVEAEAdarGLSLALHATLNrpdrelKYLDHIRQGHADGLIFITNHAgsralaekvnsGGP 140
gi 121608452  64 MIGLVMPDVaNPFFAELADAVEQAAfegGFGLALCITRNqlareaLYLGWLDTQHLDGLIFATNRPddgslgkligeRSN 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #            #                                    #                       # 
gi 152970283 149 IVLLDEDIPgskvpKVFADNVQGGRIATEKLIaaGHRHIAFVGGpdklmsVRERYQGFCTAMEQAGlswppeWVMYGDYq 228
gi 63254739  144 IILLDEDVPgtsqpKVFADNHQGGRLATDYLIrhGHRRIAHVSGpsalmsARERYAGYREALALASiaevpeYLCFGDYs 223
gi 66044032  144 IILLDEDVPgtsqpKVFADNHQGGRLATDYLIrhGHRRIAHVSGpsalmsARERYAGYREALALASiaevpeYLCFGDYs 223
gi 159185589 146 VVVVDEDVPgatvpKLFCDNEQGGRLAGAHLAehGHSRVLYVGGpedmisTERRFRGMTSALAERKceaelsITRYCGAy 225
gi 116249675 146 VIIVDEDIPdskapKLFCDNEQGGHLAGRHLAeqGHRHVLFIGGdermisARRRYDGLLKALRERHggearaDRYAGEYt 225
gi 77390112  141 CVVVDEDIAearvpKLFCDNAEGGRLAGRRLAraGHRHVLFIGGvdqmisGARRYAGFLEGMREIAgpdvriERSCGPYt 220
gi 121608452 144 IVLIDEDVPgvdipKVFVDNIEGGYLATRHLLdaGHTRIAHVTGpaalftVRERLAGYRRALDTAHipfdasLVLFGSYe 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #                #        
gi 152970283 229 -rEFGQQALRYLFSqq-vrPTAVFAASDYLVLGLLDGLRASGlqAPEALSLVGFDDAnyadftqPRISTIRQPaRELGRT 306
gi 63254739  224 -rEFGRIATAQLLTlp-dpPEAIFAASDFIALGVLDVLRERTisVPGAMSLVGFDDAvyaslltPPLCTIRQSsRELGRL 301
gi 66044032  224 -rEFGRIATAQLLTlp-dpPEAIFAASDFIALGVLDVLRERTisVPGAMSLVGFDDAvyaslltPPLCTIRQSsRELGRL 301
gi 159185589 226 tvEFGRAAARRFLDeg-rpATAVFASSDEIAIGFVEVLRSEGvrIPQDVSMIGFDDVgplhlfaPPLTAIRQPvSAIGQR 304
gi 116249675 226 -iEYGRAAALDYLSgd-rkATAIFASSDEIAIGLVEVFRSRGvsIPGDISVIGFDDVgplhlfaPPLTAIRQPvRQIGRR 303
gi 77390112  221 -fEAGRAAAQAFVArgpdrPTAIFATSDELTIGLYEVLREAGlsIPRDVSVVGFDDVgplhlfaPAVTAVRQPvRDLGRR 299
gi 121608452 224 -rRFGQTAAAELVArd-daPTAIFAGSDYLAVGMLETLRDCGldVPGDMSIVGFDDMefasllmPPITTLKQSaREMGSA 301
                        250       260       270
                 ....*....|....*....|....*....|....
Feature 1                                          
gi 152970283 307 AVNIMMrllnd----dpdipAETRLPVEWIGRDS 336
gi 63254739  302 GVAQLLqrmtg----gdcaqDIVRVPVELVCRGT 331
gi 66044032  302 GVAQLLqrmtg----gdcaqDIVRVPVELVCRGT 331
gi 159185589 305 ALSLLLetnwde---gapplSEELLPVEIVVRES 335
gi 116249675 304 SLELLLetnwhe---wkpsaSEELLPVEIVVRNS 334
gi 77390112  300 ALELLLapppvd---perlpPEELLPVTLIERES 330
gi 121608452 302 GVAILLamladhspapatgaPVQRLPVRLIERAS 335

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap