Conserved Protein Domain Family
PBP1_CelR

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cd06295: PBP1_CelR 
Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators
This group includes the ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators. The binding of CelR to the celE promoter is inhibited specifically by cellobiose. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107290
View PSSM: cd06295
Aligned: 45 rows
Threshold Bit Score: 269.815
Threshold Setting Gi: 23007680
Created: 7-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      ##  #                                           # 
gi 5327256    69 NRTDAIDLVVpepetr---------ffaepYFSDMLRGVGAELadteMQLLLIFagsdrerqrLAQYLAAHRVDGVLLVs 139
gi 29828237   63 KRHDAVAVVIaepetr---------vfadpFFALQLRGISKELtahdCQLVLLLtegrddharVGRYLAGGHVDGALVFs 133
gi 29827870   68 GRSDSIGFLLtepqer---------ffedpNFNVLLRGCTQALashdIPLLLMLagtkderrrITRYITAGHVDGVLLVs 138
gi 23007680   65 RRTGSVALVVsepseqrspspflerlftdpYIGRVTAGAQQVLrprdIHLAILPadpp-ahdqVVRYVRQGHVDGVLLVt 143
gi 119961804  65 NRANSVAFLLtetqer---------lfedpNFAVLMRGAADALavhdIPLVLIMagtddeqrrATDFLTAGHVDGVLLIs 135
gi 134103128  63 RRTDAVALVLsepenk---------ffddpFFASTVRTVSQHLsaadTQMVLLLvhreddherIARYLSGGHVDGALVLa 133
gi 145592891  62 QRTDSVALVMseaatr--------vfsddqYFPGIIRGAAQELetadKQLVLMLagspagherVERYTTGQHVDGVLFAs 133
gi 145594108  67 QRTDSIALVVsesgdr---------vfaepFFAGIVRGVSSGLlgtpFQLWLVMvqsptererVEHHLTNQHVDGVLLLs 137
gi 7387564    62 RRTDTVALVVsennqk---------lfaepFYAGIVLGVGVALsergFQFVLATgrsgieherLGGYLAGQHVDGVLLLs 132
gi 158317216  68 RRTDTIVLIVherpdt---------vfadpFFASVLRGVNQALsvtqLQLVLLQvqgdrqrdrALRYVGNGHVDGVLLIs 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #                  #                                   #  
gi 5327256   140 vhaddpl-pdllaqlEIPAVISGprsaa------etltSVDSDNYGGARSAVEHLLsrGRRRIAHITGrldvygAQRRAD 212
gi 29828237  134 lhlddpl-pglirgaGVPTVFGGrpgwgdgtrdaapavYVDCDNRGGARAAVRHLVglGRTRVAHLTGpldqtsAVDRLD 212
gi 29827870  139 shsgdpv-aeelreaGVPLVACGkpigl-----gskvsYVAADDRDGARDMVRHLLslGRRRVGVVTGpldtpgGVERLA 212
gi 23007680  144 ssasdpl-sariaalTVPVVLSThldgvd---eaagvsWVDLDQAAGGRIAAERLVadGRTRLATVAGpsdvpfARGRRD 219
gi 119961804 136 shgsrkgiiadiisaGVPAIACGaplgf-----ekkmgYVAADDYEGARDVLRYLRdgGRQRIATIAGpadtsgGTRRLE 210
gi 134103128 134 phlddpl-peavrdlPLPIVFGGrvgip-----etglhLVDHDNVGGGRLATEHLVglGRRTVVTVAGpvdeyaGIERLD 207
gi 145592891 134 lhgadpl-pgrlarlGIPVVCSGrplgg------tsvpYVDVDHIGGVSRAIQHLIdsGRQRIATIAGpqdmvgGIERLT 206
gi 145594108 138 lhgadpl-pmlleerGLPTVLGGrparmpq-pntepawLVDADNVGGARRAVEYLVgrGRRQIATVAGpqdmgaGLGRLT 215
gi 7387564   133 lhrddpl-pqmldeaGVPYVYGGrplgvp----eeqvsYVDIDNIGGGRQATQRLIetGHRRIATIAGpqdmvaGVERLQ 207
gi 158317216 139 lhgddim-pmsvsgaGVPLVMAGrlltg------dpvdSVDADNVGGARQAVRHLVatGRRELATVAGpvdmsvGVDRLA 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #                                                     #   
gi 5327256   213 GYRDAlrdaghpadelLIEPGDFteEGGRRAMTLLLSrhpdlDAVFAGSDVMAAGARQVLREAGrrIPDDIALVGYDDSa 292
gi 29828237  213 GFRDVmvda----dprLVVQGDFtpAGGERAMRELLErcpdvDAVFAANDLSASGALRVLREQGrrVPEDVALIGFDDMl 288
gi 29827870  213 GYREVlaeagleyderLVVPGDYsrASGAAGAERLLErapeiDAVFVASDLMAQGVLTVLRQAGrrVPEDVAVGGFDDSp 292
gi 23007680  220 GFLEAvraag--laepVVVEGDFtrAGGEAAARALLAarpdvDGVFGASDLMADGASLVLQEAGrrVPQDVAVVGFDDSt 297
gi 119961804 211 AYRDDqgad---ideeLIAQGDYsrDSGAKAMRELLGrtkniDAVFAANDLMALGAMDVLREAGltIPGDVAVVGFDDIs 287
gi 134103128 208 GWRQAtgldd-qkaanRSERADFteDGGERAMTALLQrvpelDAVFAANDLMAAGALRALHAAGrrVPQDVAVVGFDDQp 286
gi 145592891 207 GYQAAvapa---glpeWVAYGDFtrESGMAATRRLLAehpdlDAIFAASDLMAHAALRTLRATGrrVPDDVAVIGFDDIe 283
gi 145594108 216 GYQEAvaktpsggrpdLIAYGDFseGSGEAAMRQLLAacpdlDAVFVASDLMAFGALRALREAGrrVPEDVAVVGFDDAp 295
gi 7387564   208 GYREAllaagmeydetLVSYGDFtyDSGVAAMRELLDrapdvDAVFAASDLMGLAALRVLRASGrrVPEDVAVVGYDDSt 287
gi 158317216 212 GYTQAardanlpasatRVETGDFteASGQAAAARLLAehptiDAVFAASDLMALGVLRALRAAGrrVPDDVAVVGFDDAa 291
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                      #                                            
gi 5327256   293 iar-hmdPPLTSVRQPiQEMGRAMIDLLLtdiadrrppasrgldrRQAVLPTELVVRAS 350
gi 29828237  289 pvaeqtdPPLTTVRQDiEEMGRLMARLLLsgldrrgeaagpagtpAGVVLPTTLVRRAS 347
gi 29827870  293 aat-astPSLTTIRQPwDRISNEMVRVLLaqig--------gedpAAVILPTELVRRES 342
gi 23007680  298 var-qahPPLTTVRQPvEEMAAEMARLLLaaidd------pdadaRSVLFEPHLVVRDS 349
gi 119961804 288 tsq-eaaPPLTTVRQPfDRISEEMVRLLLdvis--------gkrpAAVTIPTELVIRES 337
gi 134103128 287 avaprtdPPLTTIRQDpSLRTEHMVDRMArliag------epvptGRTVLPVELVRRES 339
gi 145592891 284 taa-ytdPPLTTVRQPiQQIGRRMTRQLLrlaag-------epiePAVVLPTELILRES 334
gi 145594108 296 iar-qsdPPLTTIFQPiEEMGRQMAQLLVsrirg------eeratTNILLDTELVERAS 347
gi 7387564   288 vae-haePPMTSVNQPtELMGREMARLLVdritg------ettepVRLVLETHLMVRES 339
gi 158317216 292 pav-yadPPLTTVRQPvERLGAEMVHQLLrriad------ptgdtASVILPTELVIRSS 343

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