Conserved Protein Domain Family
PBP1_CatR_like

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cd06296: PBP1_CatR_like 
Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation
This group includes the ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group belongs to the the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Statistics
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PSSM-Id: 107291
View PSSM: cd06296
Aligned: 24 rows
Threshold Bit Score: 323.803
Threshold Setting Gi: 31559718
Created: 7-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  #                                                 #             
gi 31559718   69 LVDLVLpavgdsWASALIGGVERVAaqnsLDLVIIMvrage-----sqgrsWVERLVDHRSRGALIAvvqptaserrlle 143
gi 29828656   67 LVDLVVhslessRSGAVLHGVEEAAheagLEVVVSAgltrtrg--grpergWLDKLSARGSSGVLFNlaeltppqyawld 144
gi 121607937  65 VIGVIAlqldipFIIGVVNSVVRAAaaagNEVLIYShpere-----kqpssNVLQLLQQFTDGVVALppyqpgf-veala 138
gi 94972164   65 TLGIVVpsigpqYISEVVRGADLVAyeagLDLLISTtqedt-----sherqNVGRLSRGLVDGLLMVlprsldryadalk 139
gi 156740911  67 VIGVIVqdmwhpFISMVIKGINQVAaahdYDLLAYAsarrtaetlaqweqrQVAQLNGAVTDGIIVVtprsa------ty 140
gi 159898293  67 VIGLLVpelievYYHEVIKGVGAAIensgYDLLIYTsgsptrnkraswereHVALLSSGLTDGCIIVspsap------tf 140
gi 119961632  67 LLQLVVnnfdspWVLETMEGVEAAAtrlgYTVAYTRavnat-----aenwqKLREPSGNRLDGVMLLaprqgsplvelar 141
gi 119961058  66 LIDLVFpgmgseWACEIIEGVERVAqeagYGTVVSSlsldg-----srirpWLANLAERKSDGVLLAvyeldskqiqrik 140
gi 148271474  64 VIGVLVagf-epFSAEILKGVGAALrssrYDLLAYSgsrqmdn--tgwerrSLSRLSGTLIDGAIMVtptvv------ta 134
gi 159898919  94 AVGLLVrdlgssYMGEIVRGIDESLsaaqYNLMLYTthrrk-----ikeriYVNNLIQGMTDGLLLVlpenleayletld 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #             #                                    #                   
gi 31559718  144 raRIPFVLIDpagtperaapSVGASNWAGGADAASFLLdrGHTSFAVVAGdph-slnCRERAGGFLSRirell-pdsrpT 221
gi 29828656  145 qhRIPYVLIDpeleppagvvSVGAANWQGGMSATEHLLalGHERIAAIGGhrr-kmcGGARIAGYRSAlaaagvrhrpeY 223
gi 121607937 139 rgRFPVAMVDspldh-aqlpCVTADDYGGARSAMKHLAelGHKRIAFIAGseq-lgsAGERLRAYHEAvavhglvrdpaL 216
gi 94972164  140 qaEVPVVVVAsantt-mpfpLVDADHYHGARLAVAHLLglGHRRVGFIAGrrd-ttaSLERLRGYREGlltagltpdpvL 217
gi 156740911 141 rtAFPVVAVDpnqad-tefpAVISTNRQGVLEAMRYLLalGHRRIGFITGrmd-lqsAVRRFDGYRSAlaeagipldpaL 218
gi 159898293 141 qeNAKIVVIDphgag-aevpSVVATNHEGAIQAVDYLVslGHRRIGFVQGhps-awsALQRFEGYKDGlakagisfeaaL 218
gi 119961632 142 tlNIPAVAIDpegsqglqipSVSPASFSGALRAVSHLLelGHERIGIITGrvhspghGRARYAAYAAAlheaglpvlpeF 221
gi 119961058 141 slGIPVILIDpvgqpgpdlmTVGAANWDGAFSATEHLLklGHTRIGMIGGred-lqcSSAREDGYLAAlrrggveadsaL 219
gi 148271474 135 qtDIPVVSIDphtgp-adlpSVESDSLGGALQATRHLLelGHRRIGFLAGrpd-lrsASLREAGYRRAlqdagiafdpaL 212
gi 159898919 169 qtNFPYVLIDhqgld-ertpVVITTNWQGGYDATRYLIelGHRRIGFLTGmmd-mrsSQDRLSGYQAAlrdhglpadpqL 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                                     #                #   
gi 31559718  222 VLYGGWlmETTAQVVAELLGspsrPTAVFACNDNMALGVYAAAHALELRIPEQLSVIGFDDLvearlasPPLTTVRQPvP 301
gi 29828656  224 VRHGNFdpAVARRRMREFLDlpepPTAVFVCSDRMALGVYEALAERGLRVPDDISVVGFDDLpearwasPGLTTVRQPlA 303
gi 121607937 217 VVPGRYslEGGRAAALALLAlkkrPTAIFAANDLSAFGVMAVLQEQGLKIAQDMSVVGFDDVpaalhvhPALTTVRQPmE 296
gi 94972164  218 IRPGEYtqPGGFAAARSLLDlpdpPTAIFAANDLSAFGAMEAIKDRGLRVPDDVSVVGFDDIpqanqvhPALTTVRQPlV 297
gi 156740911 219 IVEGDYtrENGFAGALRLLTqprpPTAIMASSDDTALGVYDAAAEIGLRIPDDLSVIGFDNTpagallnPPLTTVDQFiE 298
gi 159898293 219 VCEGDFtsACGKNATYRLMNqpnpPTAIFAANDRTAIGVLEAAKELSLNVPQDLSVIGFDNIpetmqttPRLTTIDQSiR 298
gi 119961632 222 VRDGDFsiESGLRLGGELLDlperPTAIFTGSDLQALGVMNAAGQRSLKIPGDLSIVGFDDIaqaaltsPPLTTVRQPlA 301
gi 119961058 220 MVPGDFstESGARGTEALLAlperPTAIFTGNDAQALGAYRAARSAGLRIPEDLSIIGFDDIpaaewiePGLTTIRQPvV 299
gi 148271474 213 VRAGLFltAAAREPARALLSmpdrPTAIFAANDLSGIAILQVAAELGIRVPEDLSVIGFDDIpeasqmsPALTTIRQPmQ 292
gi 159898919 247 VYEGTYyqPEGYAGAQSLLRlpepPTAIFASNDVMAFGVMEAVRDAGLRIPSDISVIGFDDIaqasqvaPPLTTVAQPlE 326
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1                                             
gi 31559718  302 EIGAAALRSlldlrg--gypvaRRLELATELIARDSV 336
gi 29828656  304 EMAATAVRLlvrmma-gerpegTRTELSTRLVERAST 339
gi 121607937 297 GIGRAAVSTllsqia-glapdsARVTLPTELIVRQST 332
gi 94972164  298 EMGTAGTRQllnllh-gvgpvtDRLVLPTELIVRAST 333
gi 156740911 299 KMGALAAEVllqhiq-glpgetRIHKVPTRLVVRQSC 334
gi 159898293 299 EMGSLGVQLlidmlq-nressqLLHTVPTRLVIRDSC 334
gi 119961632 302 QLASMAVGMlteqieqqglatsAALEVATELVVRGST 338
gi 119961058 300 QMAETAMRAllrhle-gdeelpQRIELGTELVVRGST 335
gi 148271474 293 RLGTTAVDLlmslms-gtgpeaMHVQLPTRLVRRATT 328
gi 159898919 327 QLGREAVRMllarin-npeqpiARTILPTTLIIRQSC 362

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