2H0A


Conserved Protein Domain Family
PBP1_LacI_like_12

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cd06297: PBP1_LacI_like_12 
Click on image for an interactive view with Cn3D
Ligand-binding domain of uncharacterized transcription regulators from Thermus thermophilus and close homologs
Ligand-binding domain of uncharacterized transcription regulators from Thermus thermophilus and close homologs from other bacteria. This group belongs to the the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type I periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding.
Statistics
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PSSM-Id: 107292
View PSSM: cd06297
Aligned: 5 rows
Threshold Bit Score: 372.237
Threshold Setting Gi: 83816364
Created: 14-May-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ligandputative
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on structural similarity to other members of the LacI family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ##  #                                                      #        
2H0A_A      1 TVSVLLPfvateFYRRLVEGIEGVLleqrYDLALFPilsla----------rlkrYLENTTLAYLTDGLILAsydlterf 70  Thermus thermophilus
NP_295607 118 TISVLLPvvtteFYVRLLDGLETAFqearYDVAIFPlldrs----------rlerYLGSHTLAYQADGLVMAtynlttll 187 Deinococcus radiod...
BAD70630   65 TVSVLLPfvateFYRRLVEGIEGVLleqrYDLALFPilsla----------rlkrYLENTTLAYLTDGLILAsydlterf 134 Thermus thermophil...
YP_444503  81 QIAVVAPvvanyFYMHVMRGIQHALadrdMDLMVHApanpqdriheqpdpkslntYMARALQPGRNDGILLLsmpltdew 160 Salinibacter ruber...
YP_445635  73 TIAVALPtfttpFHNELLKGVRDRLddedVDLLLCDlewe-----------apkhSLRSFLEGGAMDGLLLVgvtpdedl 141 Salinibacter ruber...
Feature 1                   #          #                                         #            
2H0A_A     71 eegrlptERPVVLVDaqnprydSVYLDNRLGGRLAGAYLArf-pgPIFAIAVEEEpdrafrrtvFAERMAGFQEALKEAG 149 Thermus thermophilus
NP_295607 188 serrvksQQPTVLVDaysegvdCAYMDNVAGGQVAGEYAAtl-pgTVYAMWVETEldqlfvtrvFEERRNGFLTALNAAG 266 Deinococcus radiod...
BAD70630  135 eegrlptERPVVLVDaqnprydSVYLDNRLGGRLAGAYLArf-pgPIFAIAVEEEpdrafrrtvFAERMAGFQEALKEAG 213 Thermus thermophil...
YP_444503 161 adrlaetSRAVVLVDgehprfeSFAVDSREGGYKATQHLIdrgyeRIGHITVEYDpp------pARYRREGYEQALRDDN 234 Salinibacter ruber...
YP_445635 142 adelrmlGGPVVLVGaelagfdSFYWEDQPGAELAVNHLIdqdytRIGAITTPHDnr------vRNERIAGYRQALEDAG 215 Salinibacter ruber...
Feature 1                 #                                                           #       
2H0A_A    150 rpfspdRLYITRHs------qEGGRLALRHFLEkaspPLNVFAGaDQVALGVLEEAVRLgltpgrdVRVLGFDGHpfaee 223 Thermus thermophilus
NP_295607 267 rplageVTAGFDP--------LSARHAASQLLDeaelPCTVFASaDLLAAALLDEAAARglkvgedVRVIGFDDQpwaaa 338 Deinococcus radiod...
BAD70630  214 rpfspdRLYITRHs------qEGGRLALRHFLEkaspPLNVFAGaDQVALGVLEEAVRLgltpgrdVRVLGFDGHpfaee 287 Thermus thermophil...
YP_444503 235 ravqdkLIAASDErpfa-fseKGGYRAMTTLLGrkprPDAVFAAsDMQAMGAMQAAHENdlrvpedLAIVGFDDLelsrc 313 Salinibacter ruber...
YP_445635 216 iefnsdLVVHGHTskhdgfseESGYEAMQDLLAlddpVEAAFASsDVQAIGAWQALREEgfevpddFAFVGYDDIkvsrf 295 Salinibacter ruber...
Feature 1            #                                       
2H0A_A    224 AGLSTIAQPvEAMGARAAQLLLERmrgy-qgppREVRFEPVLVERAS 269 Thermus thermophilus
NP_295607 339 RGLTTLHQPvESMGHEAATLLLSRlggy-kgpaRARKFMPRLVVRET 384 Deinococcus radiodurans R1
BAD70630  288 AGLSTIAQPvEAMGARAAQLLLERmrgy-qgppREVRFEPVLVERAS 333 Thermus thermophilus HB8
YP_444503 314 AGLTTLRQPaRTMGTRATRTLLRRieaagappvSSTVFSPELVVRRT 360 Salinibacter ruber DSM 13855
YP_445635 296 IGLSSVAQNmHNVGNEGTDLLLDRlekrgpekyTSRLVEPELHIRKS 342 Salinibacter ruber DSM 13855

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