Conserved Protein Domain Family
PBP1_CcpA_like

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cd06298: PBP1_CcpA_like 
Click on image for an interactive view with Cn3D
Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation
Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation (CCR), a process in which enzymes necessary for the metabolism of alternative sugars are inhibited in the presence of glucose. In gram-positive bacteria, CCR is controlled by HPr, a phosphoenolpyruvate:sugar phsophotrasnferase system (PTS) and a transcriptional regulator CcpA. Moreover, CcpA can regulate sporulation and antibiotic resistance as well as play a role in virulence development of certain pathogens such as the group A streptococcus. The ligand binding domain of CcpA is a member of the LacI-GalR family of bacterial transcription regulators.
Statistics
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PSSM-Id: 107293
View PSSM: cd06298
Aligned: 24 rows
Threshold Bit Score: 341.53
Threshold Setting Gi: 162448029
Created: 16-Feb-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
effectordimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:effector binding site
Evidence:
  • Structure:1ZVV_G; Bacillus subtilis CcpA binds Crh-Ser46-P (effector), contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #                                                         
1ZVV_G        62 TVGVIIPDIsNIFYAELARGIEDIAsmYKYNIILSNSDqnqDKQLHLLNNMLGKQVDGIIFMsgnvTEEHVEELKKsPVP 141
1RZR_A        62 TVGVIIPDIsNIFYAELARGIEDIAtxYKYNIILSNSDqnqDKELHLLNNXLGKQVDGIIFXsgnvTEEHVEELKKsPVP 141
1SXG_F        10 TVGVIIPDIsNIFYAELARGIEDIAtmYKYNIILSNSDqnqDKELHLLNNMLGKQVDGIIFMsgnvTEEHVEELKKsPVP 89
2HSG_A        62 TVGVIIPDIsNIFYAELARGIEDIAtmYKYNIILSNSDqnqDKELHLLNNMLGKQVDGIIFMsgnvTEEHVEELKKsPVP 141
2FEP_A        18 TVGVIIPDIsSIFYSELARGIEDIAtmYKYNIILSNSDqnmEKELHLLNTMLGKQVDGIVFMggniTDEHVAEFKRsPVP 97
1SXH_A        10 TVGVIIPDIsNIFYAELARGIEDIAtxYKYNIILSNSDqnqDKELHLLNNXLGKQVDGIIFXsgnvTEEHVEELKKsPVP 89
gi 41387384   62 TVGVVIPDIsNSIFAEIARGIEDIAnmYHYNIILCNADkrkEKEIRVINTLLEKQVDGLLFMggtvTEEHIQAFQTsAVP 141
gi 3941404    67 TVGVVIPDIsNAFYAELTRGIEDIAtmYHYNIILSNSDlqkDRELQLIETLLEKQVDGLLFLggeiTEAHREIFSAtPVP 146
gi 27315873   47 TVGVIIPDIsNVYYSQLARGLEDIAtmYKYHSIISNSDndpEKEKEIFNNLLSKQVDGIIFLggtiSEEIKSLINQsSVP 126
gi 126698651  64 LIGVIVPEVsDSFVNEVLNGIEEVAkmYDYDILLANTYsdkEQELKSINLLRAKQVEGIVMIswivEQEHINYIQNcGIP 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1ZVV_G       142 VVLAAsiestnqiPSVTIDYEQAAFDAVQSLIdsGHKNIAFVSGtleepinHAKKVKGYKRAltesglpvrdsYIVEGDY 221
1RZR_A       142 VVLAAsiestnqiPSVTIDYEQAAFDAVQSLIdsGHKNIAFVSGtleepinHAKKVKGYKRAltesglpvrdsYIVEGDY 221
1SXG_F        90 VVLAAsiestnqiPSVTIDYEQAAFDAVQSLIdsGHKNIAFVSGtleepinHAKKVKGYKRAltesglpvrdsYIVEGDY 169
2HSG_A       142 VVLAAsiestnqiPSVTIDYEQAAFDAVQSLIdsGHKNIAFVSGtleepinHAKKVKGYKRAltesglpvrdsYIVEGDY 221
2FEP_A        98 IVLAAsveeqeetPSVAIDYEQAIYDAVKLLVdkGHTDIAFVSGpmaepinRSKKLQGYKRAleeanlpfneqFVAEGDY 177
1SXH_A        90 VVLAAsiestnqiPSVTIDYEQAAFDAVQSLIdsGHKNIAFVSGtleepinHAKKVKGYKRAltesglpvrdsYIVEGDY 169
gi 41387384  142 IVLCAtsdengqyPSVDIDHEAAAFDAVSTLVrhGHREIAMISGtfqdpanGYARFQGYKRAletagiqyqedLVRIGNY 221
gi 3941404   147 VVLAAsrdekkelPYVTIDRIQASKEATLILGheGHKHVGFIGGpltdsvnGYPRYLGYKEAlkemdiafeedLIRLGDY 226
gi 27315873  127 VVVSGtdgkddhiASVNIDFKQAAEEATQYLIekGAKTFSLIGGeys-ikaQDDVLEGLKNVlsqhqlklddtLHLTGNE 205
gi 126698651 144 ATYISktarnydiYTVSTSNEEATFDMTEHLIkkGHEKIAFIMTskddtvlEMERLAGYEKAlsnnnieldksLIKYGGT 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                 ##     
1ZVV_G       222 tYDSGIEAVEKLLEedekptAIFVgTDEMALGVIHGAQDRGLNVPNDLEIIGFDNTrlstmvRPQLTSVVQPMYDIGAVA 301
1RZR_A       222 tYDSGIEAVEKLLEedekptAIFVgTDEXALGVIHGAQDRGLNVPNDLEIIGFDNTrlstxvRPQLTSVVQPXYDIGAVA 301
1SXG_F       170 tYDSGIEAVEKLLEedekptAIFVgTDEMALGVIHGAQDRGLNVPNDLEIIGFDNTrlstmvRPQLTSVVQPMYDIGAVA 249
2HSG_A       222 tYDSGIEAVEKLLEedekptAIFVgTDEMALGVIHGAQDRGLNVPNDLEIIGFDNTrlstmvRPQLTSVVQPMYDIGAVA 301
2FEP_A       178 tYDSGLEALQHLMSldkkptAILSaTDEMALGIIHAAQDQGLSIPEDLDIIGFDNTrlslmvRPQLSTVVQPTYDIGAVA 257
1SXH_A       170 tYDSGIEAVEKLLEedekptAIFVgTDEXALGVIHGAQDRGLNVPNDLEIIGFDNTrlstxvRPQLTSVVQPXYDIGAVA 249
gi 41387384  222 rYESGVEAMKYFLGlkkrptAIFAaTAEMAIGAIHSIQDEGLKVPDDFSIISVDGIrmasmvRPQLTTVAQPMYDLGAVA 301
gi 3941404   227 rYRSGYKAMRELLEsrpeitAVFAaSDEMAVGALHAALDMGRDVPNDLSVIGFENIplasqvRPLLSTVGVPMYDIGAVA 306
gi 27315873  206 sYKSGIKTFEQLQSnl--pdAVLCiSDEQAIGILHSAQDAGVKVPEDLQIISFNNTrlvemvRPQLSSVIQPLYDIGAVG 283
gi 126698651 224 dYESGYNSMKELLDdgiiphAAFVtGDEAAIGAINAICDAGYKVPEDISVAGFNDVkiarmyRPKLTTVYQPLYDMGAVA 303
                        250       260
                 ....*....|....*....|....*....
Feature 1         #   #             ## #      
1ZVV_G       302 MRLLTKYMnkETVDSSIVELPHRIEFRQS 330
1RZR_A       302 XRLLTKYXnkETVDSSIVQLPHRIEFRQS 330
1SXG_F       250 MRLLTKYMnkETVDSSIVQLPHRIEFRQS 278
2HSG_A       302 MRLLTKYMnkETVDSSIVQLPHRIEFRQS 330
2FEP_A       258 MRLLTKLMnkEPVEEHIVELPHRIELRKS 286
1SXH_A       250 XRLLTKYXnkETVDSSIVQLPHRIEFRQS 278
gi 41387384  302 MRLLTNLMkkETVENPRVVLPHETILRVS 330
gi 3941404   307 MRLLTKYMneEQVETGQVYLPYHIQLRES 335
gi 27315873  284 MRLLTKYMndEEIENPNVILPHRIEYRGT 312
gi 126698651 304 IRMVIKLInkELIENKKIELPYRIVDRES 332

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