Conserved Protein Domain Family
PBP1_ABC_sugar_binding_like_1

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cd06300: PBP1_ABC_sugar_binding_like_1 
Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily
Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes transition from an open to a closed conformational state upon ligand binding. Members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes; however their substrate specificity is not known in detail.
Statistics
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PSSM-Id: 107295
View PSSM: cd06300
Aligned: 27 rows
Threshold Bit Score: 244.462
Threshold Setting Gi: 89068578
Created: 9-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic transport protein receptor for D-glucose and D-galactose

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                                                  
gi 14022391   44 RIALANgyi-antWRIQMVQTAKAYAaqkdvaakLKEFKVVSTGedvPAQISAINNFIDs-GYDAIVVNaqnptafgpvi 121
gi 21492834   59 KIGHSHyglagstHTYQTAFEAEYEIkkn--kdrIADYQFRSADlnaSKQVADIEDLIAq-KVDAIIIAplttgsavegi 135
gi 148657167  49 TIGISNpfi-sseYRTQMIQSLIEVNkeymergiTNELVIESADtdvAGQIQQLQNLINk-GVDAILVNpsdvnglndtl 126
gi 108803248  45 TIGVSNgfi-sseWRTQMIQDLERVNkeymeeglTEELVIESADvdvQGQIQQMRNLINq-GVDAIIVNpnsvtglnqvi 122
gi 16263769   27 KIGLSNgwv-gseWRTQMIDEAKAAAaewkekgvDVEVSVQSANvdvPGQIAHIRNFIAe-GVNAIIVNpnsptafdpif 104
gi 14524251   56 VIGMSSfgvnantWTVQVAHEAQAAAdnd---krITKFILLDAGfdqKKQVADIEDLIAq-KVDAIIVQpvtstsanasi 131
gi 10954752   14 KIGMSHfgvnantWAAQMAAESQAAAksd---prISQFVLLDANlsqAKQIADIDELIAq-KVDAIIITpvsptsadagi 89
gi 84500037   64 TVCFSNagv-nnpWRVVGYTNMTEEVenh---dsIGEFIHVDAEgsdDKQIADIDDLLAggDCDVMIVSpnttaalt-pa 138
gi 25169058   82 KVCFSNaal-sntWRQTGWITMNEQLkelqkqgvISQMETRNAQdsdNTQVADIDYFVNqqSCDAFIIApnspqatapav 160
gi 62423329  104 KMCFANasi-snpWRQTGWISMNEQLkelkkdgvITEMETRDAQdndDTQIADIDYFISegDCDGFIISpnstaaitpav 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                                    #             
gi 14022391  122 krakeaGVVLVAFDnildt--kdaiNVNVDQKGLGELWGKWLVshvpngGKVLEVRGVAGtsvDTDRHNGIHEVLdasgk 199
gi 21492834  136 kkakaaGIPTVVYLgrvdt-eeftvQVQGDDFYFGRVMAQFLVdklgnkGKVWVLRGVAGhpiDADRYAGAMEVFsksg- 213
gi 148657167 127 qeainkGIIVISVDqelnt--pgvyNVGIDQKEWAKISARWLAeklggqGNIVLIEGFPGhpaNVARMDGVEEVLkeypg 204
gi 108803248 123 keasdaGIVVISVDqeipa--egaiNVVIDQAEWARRSAEWLVeqlggeGDVVVINGIAGhpaNEARYDAVKEVFsrnpg 200
gi 16263769  105 aqakeaGILVIATDaevss--pdaiYVGIDQTAWGAAGAKWLAetlggkGKVVAINGVAGhpaNEMRVAGYKSVFkdhad 182
gi 14524251  132 ekavaaGIPVVLHTgries-eayttEIQGGAEHFGKVMGDFLVkelggkGNIWVLRGLAGhpeDTNRYNGLKQSLegte- 209
gi 10954752   90 ekavnaGIPVIVHTgltkt-dkytvDIQGGGENFGKVSGEFLVkelggkGNIWVLRGLPThpeDINRYKGLLEAIkgtd- 167
gi 84500037  139 veraceAMPVIVFDrgvntdcpvtfIHPVGGYGFGIQGAEFIVdnveegANVLMLRILPGvdvLETRYSAGRRILdeag- 217
gi 25169058  161 eracntGKPVIIFDrgagtdcattfIHSVGGMAWGIDSATFVTenvkpgGHVVALRTAPGvdvFEQRWAAAQHIFsea-- 238
gi 62423329  183 eracktDKPVIVFDrgvetdcavtfIHPIGGFAWGIDTSQFLIdnlnegDKVVALRILPGvdvLEQRWAAADKLFgea-- 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     #                  
gi 14022391  200 kwaVTEVVGKWddGVAQKASADAIAtngpfDGVTGQGG--DTGIVQAMIDAKh-pFVPFGGETEngfrkfc--aahaadG 274
gi 21492834  214 lqiTSTQHGSWsyEDSKKIAESLYLsdpdvAGIWTDGAnmSLGVLDALQEAGastIPPITGEALngwmr-----rwndeK 288
gi 148657167 205 ikvLGRETGKWdeATGQQVMSNFLAsfpnlDGYWTQDGm-AIGAMQAVMAANppkWPILVGEGRcqflqlwdqrlkedpN 283
gi 108803248 201 ievIAEANANWdqATGQQKMSNILAsetgiDGVWTQDGm-ARGVLQAIVASDperFPVVVGEARlgymrlwhelrqqdeD 279
gi 16263769  183 iqvVNEVNANWdqAQGQQAMQNILAtypdiNGVLVQDGm-AAGAWKSIMDAGkagQIAATGEIRkdfid-----lwikeK 256
gi 14524251  210 ikiAAEEHGDWqyDKAKKVCETLYLsdpnvDGIWSSGAdmTRACVDVFKQFGs-pIPPISGEGNngffg-----qwiadG 283
gi 10954752  168 ikiVAEDAGLWsyDYGHKVCETFYLenpkvDGIWSSGAdmSRACMDVFQQYGa-kVPPITGEVNngflq-----kwiesG 241
gi 84500037  218 mniVGAEFTDGdnAKTKSIVEDYLMrg-diDAVWMDAGatAVAAIEAFEDSGy-dIPVFVGEDQqdflr-----kwqdkG 290
gi 25169058  239 glkYTDYITGAdpTKIKAVVADELAkg-tvDAVWVDLGdqSVPAIEAFEDTGk-dIPVVTGEDNlsylr-----awknkG 311
gi 62423329  261 gieVVDYFTEGdpAEIKKVVSDELAkg-dvQGIWMDAGdgAVSAIEAFEDAGk-dYPVMTGEDElsflr-----kwkdtE 333
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
Feature 1              #                                          
gi 14022391  275 LKCSSAGTGPAQVAVAIKTAIAALEGnv---------vpQSVKLPLAIV 314
gi 21492834  289 LSSIGPICPPALSTAALRAAFALLDGkpi--------qrNWTNRPKPIT 329
gi 148657167 284 FETIAVANPPGVSPTGLRIAVNMLMGkqvdksklggangLSFVIPVPVI 332
gi 108803248 280 FSSYGVINPPGVGASGLRVAVEMLRGkelkegvlsgeanNTIYVPIPGV 328
gi 16263769  257 LNSGATVNPPGVMASALNVAVLMLQGkelkepakagqygNALYLPIPFI 305
gi 14524251  284 FKSISSEYSPAQGAAGIRAAVALLEGkal-------hkhYDYNPPGWDL 325
gi 10954752  242 VDAVATEYGPEQGAAAVRAAVALLEGkai--------hkRYVYEPDGWD 282
gi 84500037  291 LTAIAPTYPTYQWRTAVIAAARVIEGeal--------pgPEWVLPQPAI 331
gi 25169058  312 FKGFASVYDAYQWRTALLAAASLFRGes---------ipKDWVLPQVPV 351
gi 62423329  334 MTALAPVYSNFQWRTPLLAAEKIFKGee---------vpTEWVLPQSPI 373

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