1ZHH,1JX6,2HJ9,4YP9


Conserved Protein Domain Family
PBP1_LuxPQ_Quorum_Sensing

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cd06303: PBP1_LuxPQ_Quorum_Sensing 
Click on image for an interactive view with Cn3D
periplasmic binding protein (LuxP) of autoinducer-2 (AI-2) receptor LuxPQ from Vibrio harveyi and its close homologs
Periplasmic binding protein (LuxP) of autoinducer-2 (AI-2) receptor LuxPQ from Vibrio harveyi and its close homologs from other bacteria. The members of this group are highly homologous to a family of periplasmic pentose/hexose sugar-binding proteins that function as the primary receptors for chemotaxis and transport of many sugar based solutes in bacteria and archaea, and that are members of the type 1 periplasmic binding protein superfamily. The Vibrio harveyi AI-2 receptor consists of two polypeptides, LuxP and LuxQ: LuxP is a periplasmic binding protein that binds AI-2 by clamping it between two domains, LuxQ is an integral membrane protein belonging to the two-component sensor kinase family. Unlike AI-2 bound to the LsrB receptor in Salmonella typhimurium, the Vibrio harveyi AI-2 signaling molecule has an unusual furanosyl borate diester. Hence, many bacteria coordinate their gene expression according to the local density of their population by producing species specific AI-2. This process of quorum sensing allows LuxPQ to control light production as well as its motility behavior.
Statistics
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PSSM-Id: 380526
Aligned: 11 rows
Threshold Bit Score: 444.891
Created: 20-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingheterodimer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1JX6; the autoinducer-2 bound form of Vibrio harveyi periplasmic binding protein (LuxP), contacts at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #  #                                     
1ZHH_A     19 EQRNLTNALSEAvraqpvplskptqrpiKISVVYPgqqvSDYWVRNIASFEKRLyKLNINYQLNQVFtrpn-adiKQQSL 97  Vibrio harveyi
1JX6_A     17 EQRNLTNALSEAvraqpvplskptqrpiKISVVYPgqqvSDYWVRNIASFEKRLyKLNINYQLNQVFtrpn-adiKQQSL 95  Vibrio harveyi
2HJ9_A     14 EQRNLTNALSEAvraqpvplskptqrpiKISVVYPgqqvSDYWVRNIASFEKRLyKLNINYQLNQVFtrpn-adiKQQSL 92  Vibrio harveyi
4YP9_A     20 EQRNLTNALSEAvraqpvplskptqrpiKISVVYPgqqvSDYWVRNIASFEKRLyKLNINYQLNQVFtrpn-adiKQQSL 98  Vibrio harveyi
SOC13632   67 EERELSARFTQRvqdaaspaadtpptpaRIAVIYPaiqaSDYWRRSIVALERRLdELGIRYEMASEFtlpg-qeiREQTR 145 Stappia indica
CCO23465   42 PAEKRKSNSFDRlvkrnsivalknklkvKIAIVYPgdqvSDYWRRSYKSFAKRLdQYGIKPDLFSIFikpt-aplSEQNS 120 Desulfovibrio hydr...
SIS81454   36 RHAVDDEGFASLidqvslfspvnqekqvKIAIVYPglqsSDYWQRSISALKGRLdDLGVKYVLDIRFskph-ieqALQEE 114 Neptunomonas antar...
OUR96541   33 KQEQLLNDFSKVvtnlpiqvkakqrrpiKISVIYPgkqiSDYWKRSLSSFKARLdLLNIKYQIEEFFtkpg-veiRKQAK 111 Bacteriovorax marinus
SFM30303   47 ALTEAFTRRVRGpalplaereggsrprvQVAVIYPglqsSGYWRRNLVAFRKRArELGLELDLQVFFsgpdsgdvQLQAD 126 Ectothiorhodospira...
SDX12056   49 DERQKMEDFMARvradtvpaegtfdaplKIALMFPsletSDAWARLNISTRARLeEMGIPFEITEFMirp--dehDRQGV 126 Roseicitreum antar...
ABR73210   41 RQGPLAEQFTTIvnsppnpirvsqkravRIALLLFgdmnSLENRSILVTFRKRMrELNIDYRLDTYMdgf---esNGDLT 117 Marinomonas sp. MWYL1
Feature 1                                              #                                      
1ZHH_A     98 SLMEALKSKSDYLIFTld-ttRHRKFVEHVLDSTNTKLILQNITTPVrewd--khqPFLYVGFDHAEGSRELATEFGkff 174 Vibrio harveyi
1JX6_A     96 SLMEALKSKSDYLIFTld-ttRHRKFVEHVLDSTNTKLILQNITTPVrewd--khqPFLYVGFDHAEGSRELATEFGkff 172 Vibrio harveyi
2HJ9_A     93 SLMEALKSKSDYLIFTld-ttRHRKFVEHVLDSTNTKLILQNITTPVrewd--khqPFLYVGFDHAEGSRELATEFGkff 169 Vibrio harveyi
4YP9_A     99 SLMEALKSKSDYLIFTld-ttRHRKFVEHVLDSTNTKLILQNITTPVrewd--khqPFLYVGFDHAEGSRELATEFGkff 175 Vibrio harveyi
SOC13632  146 QIAEMLKSDPDYLIFTld-alRHRVLVERLIARGRPKVILQNITTPLrawg--qdqPFLYVGFDHATGARLLADHVVetr 222 Stappia indica
CCO23465  121 AFRKALATNPDYLVFTld-alRHQRIIESILIRNKPSIILQNITTPLkvwd--gkqPLMYIGFDHATGTAMLAGYFIkat 197 Desulfovibrio hydr...
SIS81454  115 QIIEMLELAPDYLVYTid-siRQQRMVEALLQRGKPKLIIQNLTRPIadwy--diqPLIYIGFDHVEGAQKLAKHFMkrf 191 Neptunomonas antar...
OUR96541  112 HILQSLKGNPDYLIFTld-akKHQKIITQILSKGKTKVILQNITTPLklwk--nhpPFLYVGFDHQLGSKLLLDRILqih 188 Bacteriovorax marinus
SFM30303  127 QLREVLLQDPDYLVYTldtdlHRELIDRILARGDGPRLILQNITTPVrawe--grqPLIYVGFDHAQGSRILAKHLRgi- 203 Ectothiorhodospira...
SDX12056  127 QVEQVLGGDFDYVVIGps--eYQVQKSNIARLSEAMPTLVMNVVNPFvdtlgtarqPITHVGFDHTIGAEALCRWVIaet 204 Roseicitreum antar...
ABR73210  118 SYFKMANAQPDYIIMTkl-gsVQRRFLERFLYSGKPKVILYDFASPLthwm--nhpPLMYVGFDQKKATTMLASYLErql 194 Marinomonas sp. MWYL1
Feature 1                        #                                                 ##         
1ZHH_A    175 pKHTYYSVLYFsegyiSDVRGDTFIHQvnrdnnfeLQSAYYTKAtKQSGYDAAKASLAKhpdvdFIYACSTDVALGAVDA 254 Vibrio harveyi
1JX6_A    173 pKHTYYSVLYFsegyiSDVRGDTFIHQvnrdnnfeLQSAYYTKAtKQSGYDAAKASLAKhpdvdFIYACSTDVALGAVDA 252 Vibrio harveyi
2HJ9_A    170 pKHTYYSVLYFsegyiSDVRGDTFIHQvnrdnnfeLQSAYYTKAtKQSGYDAAKASLAKhpdvdFIYACSTDVALGAVDA 249 Vibrio harveyi
4YP9_A    176 pKHTYYSVLYFsegyiSDVRGDTFIHQvnrdnnfeLQSAYYTKAtKQSGYDAAKASLAKhpdvdFIYACSTDVALGAVDA 255 Vibrio harveyi
SOC13632  223 pQPESFAIFYGlkgyvSYARGEPFRLAmaeqpgkrLVASYYVGFdREKAREAAAELLKRhpnlgFIYSCSTDIALGVADA 302 Stappia indica
CCO23465  198 gGKGKYAVLLPdpgylSQERGKTFISYldrhssleMVSVFQTGInKEKARKATLELVRKhpdikFIYACTTDIALGTIEG 277 Desulfovibrio hydr...
SIS81454  192 pENTQYGIIFWgegvvSDQRGLTFEREign---yhQLKTSYFAVdPLQAKRAVLAMLNDypdlkYIYVCATGAALGAIDA 268 Neptunomonas antar...
OUR96541  189 pNGGKFAMLYLtdgyvSKMRGDSFIGNlkqhkkwkLVGRYYTDNdENKIKKALEDLTTNekdiqLVFSCSTDIAITSAKF 268 Bacteriovorax marinus
SFM30303  204 lPGGDLVILYGtdgyvSRARGGAFLKAlegs-glrIREGYVTDFlAPVVRRATRDALARypqlkAVIACATDMALTAAGM 282 Ectothiorhodospira...
SDX12056  205 gGEGTFALVRYipgliDSQRSDHFADCvtensnmtMVDEFEANGdRELAFSGGQALLSRhpdltMLHAGNTAVALGVLAA 284 Roseicitreum antar...
ABR73210  195 pEETKISALVLptgylGHMRCDLFLDEmaky-krhISRIRAVSDdRRSAFEAARIILKEns-pdFIFSCSQNISEGVIEA 272 Marinomonas sp. MWYL1
Feature 1                   #                      #                                          
1ZHH_A    255 LAELGRe-dIMINGWGGGs--aELDAIQKGDLDITVMRMNDDTGIAMAEAIKWDLEdk--pvPTVYSGDFEIVTkadspE 329 Vibrio harveyi
1JX6_A    253 LAELGRe-dIMINGWGGGs--aELDAIQKGDLDITVMRMNDDTGIAMAEAIKWDLEdk--pvPTVYSGDFEIVTkadspE 327 Vibrio harveyi
2HJ9_A    250 LAELGRe-dIMINGWGGGs--aELDAIQKGDLDITVMRMNDDTGIAMAEAIKWDLEdk--pvPTVYSGDFEIVTkadspE 324 Vibrio harveyi
4YP9_A    256 LAELGRe-dIMINGWGGGs--aELDAIQKGDLDITVMRMNDDTGIAMAEAIKWDLEdk--pvPTVYSGDFEIVTkadspE 330 Vibrio harveyi
SOC13632  303 IEAAGLtgkVATNGWGGGs--aELDYLAQGRLDVTAMRINDDNGVAMAEAISLDIQgrsdevPLVFAGSFALVSsddapQ 380 Stappia indica
CCO23465  278 LRETGMlnkIMVNGWGGGs--pELAAIRKGEMTVTVMRINDDNGIAMADAIILDMLgqkkklPLVFSGRFELVEkgidpV 355 Desulfovibrio hydr...
SIS81454  269 LQELGRs-dVDINGWGGGq--aELDAFQKGQLDVVLMRMNDQNGIAMAEAIRLDMQgw--siPNVYAGDFRLLTqgmetD 343 Neptunomonas antar...
OUR96541  269 SKKNKLd--FTINGWGGGsaelESLSLKKNGIDLTVMRINDDNGVAMAEAIKYELEdrssliPRVFSGEMVIIDksttkE 346 Bacteriovorax marinus
SFM30303  283 LQEAAPereILVTGWGGGs--eELAALEAGRLAATVMRMNDDAGVAMAEAVALDVAgkgdqvPTVYAGDMVLVTrqtpvQ 360 Ectothiorhodospira...
SDX12056  285 ATERGKlddVIINGWGGGa--dELKSIKDGGLKVTAFRVNDDWGVAVAEAIRAHAAge--evPVVLAATIKPIDytmsaE 360 Roseicitreum antar...
ABR73210  273 LQAEGFdtqIQTNAWGGSs--sGIADLESRKVKASVLFMKDDLSIAIAEAIKLDLEgr--nmPTLYVANSMLVPaeldsE 348 Marinomonas sp. MWYL1
Feature 1             
1ZHH_A    330 RIEALKKR 337 Vibrio harveyi
1JX6_A    328 RIEALKKR 335 Vibrio harveyi
2HJ9_A    325 RIEALKKR 332 Vibrio harveyi
4YP9_A    331 RIEALKKR 338 Vibrio harveyi
SOC13632  381 RIEELKRR 388 Stappia indica
CCO23465  356 RLERLQNE 363 Desulfovibrio hydrothermalis AM13 = DSM 14728
SIS81454  344 IVEKLIKE 351 Neptunomonas antarctica
OUR96541  347 EIEKLKKR 354 Bacteriovorax marinus
SFM30303  361 VLRGLEAR 368 Ectothiorhodospira mobilis
SDX12056  361 AIDAETDY 368 Roseicitreum antarcticum
ABR73210  349 SLRLMVQQ 356 Marinomonas sp. MWYL1

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