Conserved Protein Domain Family
PBP1_LuxPQ_Quorum_Sensing

?
cd06303: PBP1_LuxPQ_Quorum_Sensing 
Click on image for an interactive view with Cn3D
Periplasmic binding protein (LuxP) of autoinducer-2 (AI-2) receptor LuxPQ from Vibrio harveyi and its close homologs
Periplasmic binding protein (LuxP) of autoinducer-2 (AI-2) receptor LuxPQ from Vibrio harveyi and its close homologs from other bacteria. The members of this group are highly homologous to a family of periplasmic pentose/hexose sugar-binding proteins that function as the primary receptors for chemotaxis and transport of many sugar based solutes in bacteria and archaea, and that are members of the type I periplasmic binding protein superfamily. The Vibrio harveyi AI-2 receptor consists of two polypeptides, LuxP and LuxQ: LuxP is a periplasmic binding protein that binds AI-2 by clamping it between two domains, LuxQ is an integral membrane protein belonging to the two-component sensor kinase family. Unlike AI-2 bound to the LsrB receptor in Salmonella typhimurium, the Vibrio harveyi AI-2 signaling molecule has an unusual furanosyl borate diester. Hence, many bacteria coordinate their gene expression according to the local density of their population by producing species specific AI-2. This process of quorum sensing allows LuxPQ to control light production as well as its motility behavior.
Statistics
?
PSSM-Id: 107298
View PSSM: cd06303
Aligned: 11 rows
Threshold Bit Score: 368.613
Threshold Setting Gi: 87121187
Created: 20-Jul-2006
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1JX6; the autoinducer-2 bound form of Vibrio harveyi periplasmic binding protein (LuxP), contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            #  #                                                       
1ZHH_A       47 KISVVYPgq----------qvSDYWVRNIASFEKRLy-----------KLNINYQLNQVFtrpn--adiKQQSLSLMEAL 103
1JX6_A       45 KISVVYPgq----------qvSDYWVRNIASFEKRLy-----------KLNINYQLNQVFtrpn--adiKQQSLSLMEAL 101
2HJ9_A       42 KISVVYPgq----------qvSDYWVRNIASFEKRLy-----------KLNINYQLNQVFtrpn--adiKQQSLSLMEAL 98
gi 56680722  70 QIAMIYPsa----------dtSDFWARNYIAMTKRLe-----------ELGIQFETTEFAsrq---iehSLQSTYANQVV 125
gi 59711314  74 KISFVYPge----------qsSDYWQRNIVALESRLk-----------ALNIQYELTPVStrln--vdfKEQSRSLHKAI 130
gi 78220756  78 RIAFIHPgv----------qaSDYWQRSAASFKARMd-----------ELGLRYELLEFRsrpt--ldvRLQEQQLREAL 134
gi 87120841  67 RIAIIYPsa----------diSDFWVRNYTAMTERLm-----------ELKLPFVIDQYSsrq---iehALQTQHTRAVL 122
gi 87121187  58 QLSLKVKaspaphtlvqerslRILWVVSNAFQARKAfpvidlfkqrmqALKLDYQLKMVRyneg--tsyRQHIDNFNNGM 135
gi 87122525  91 KIAVVYPan----------qiSDYWVRSIKSFEARLk-----------ELNIPYEIESFLtqsthneslRDQAKEILTAV 149
gi 89093783  69 KIAVIYPgv----------qsSDYWRRSLITFKTRLn-----------ELRISHELKTFLsrpg--vdkDLQAEQLTEAL 125
gi 95930397  52 KIVTIYPdq----------qaSSYWRRNLVSMTARLe-----------ELNIRYKWTHFSsqa---hqtRLQEQQLAKAL 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                                          
1ZHH_A      104 KS--KSDYLIFTldttrh-rkfvehVLDSTNTKLILQNITTPVrewdkhqPFLYVGFDHAEGSRELATEFGkffpKHTYY 180
1JX6_A      102 KS--KSDYLIFTldttrh-rkfvehVLDSTNTKLILQNITTPVrewdkhqPFLYVGFDHAEGSRELATEFGkffpKHTYY 178
2HJ9_A       99 KS--KSDYLIFTldttrh-rkfvehVLDSTNTKLILQNITTPVrewdkhqPFLYVGFDHAEGSRELATEFGkffpKHTYY 175
gi 56680722 126 QDadLYDFVIFGpselaiqadnidkMAASEGFSTFVWAFHTPLkdl-knqPDGWFDFSSAAGALTMCDYMLgrlgNDVTM 204
gi 59711314 131 EQ--KSDYLIFTlnttrh-rkfiehVLQNPETKIILQNITTPVkawhgsqPLLYVGFDHVIGTKLLANYFQhrfpEHANY 207
gi 78220756 135 QA--DPDYLVFTldvgrh-kkmieqVLERGRPKIILQNITTPLrswedrqPLLYAGFDHISGTRLLADHFMlnrpQGGTY 211
gi 87120841 123 SSekAYDFVIFGpselalqsvniqkLAASEQFKTFIWAFHTPNprw-ehqPDAWFDFSSAMGAEVLCHYVIerlgDNIEF 201
gi 87121187 136 AF--EPDYVISSltssvn-rklieqVLAKGKSKVIITDLSSPVigwlhssPLMYVGLDERAIARRFAQYVDsiypLDAKI 212
gi 87122525 150 NS--EADYLILTlykkqh-kaiierLISNQKTKVILQNITTPIkawgnlqPFMYVGFDHVKGTQLIADWYIkqeiRHKRY 226
gi 89093783 126 AW--QPNYLIFSadaldh-qntiqrILLQGKPKLILQNITTPLklwashpPFLYTGFDHEIGTQLLAERMIt--pDHSQY 200
gi 95930397 108 QL--KPDFLVINidssri-rkllgrVLYRGTPKIIVPNQTIPNtqwqdypPLLYTGFDHEEGSRMLATHLFdtygNDARY 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #                                                 ##               
1ZHH_A      181 SVLYFsegyiSDVRGDTFIHQvnrdnnfeLQSAYYTKAtKQSGYDAAKASLAKhpdvdFIYACSTDVALGAVDALAELGR 260
1JX6_A      179 SVLYFsegyiSDVRGDTFIHQvnrdnnfeLQSAYYTKAtKQSGYDAAKASLAKhpdvdFIYACSTDVALGAVDALAELGR 258
2HJ9_A      176 SVLYFsegyiSDVRGDTFIHQvnrdnnfeLQSAYYTKAtKQSGYDAAKASLAKhpdvdFIYACSTDVALGAVDALAELGR 255
gi 56680722 205 AMNRGipgitDDQRSGDFKACveekgnwtTIYEHYGEYqREGGFEGTSLILQAypeatVIHNANTAMAMGSVEAQISVGK 284
gi 59711314 208 GMLYYsygylSTARGDVFVQSmdsd-kytLTSSFYTEAtEESAYAATQDILKDnpdidFIYSSSTDIALGAIDAINDNKN 286
gi 78220756 212 AMLYFsqgyvSTMRGDTFKAFvhp--hwkLAGTYYTDGiRAKARQATLDILSSqd-vdLIYACATDTALGAAEAMEQTGM 288
gi 87120841 202 AANRGipgitDTQRSQGFIDCvekkadwlNMYEHFGQYqKLGGSDGVKLFLSNfpevkMVHNANTAMTIGALDTLVEESK 281
gi 87121187 213 AAVMLpvgyiNHARCDAFIDAmhar-grqMTKIFYSDAtEMDAYQFVSEMAENnnpaeYIFSCSSALAAGVLRAIKQHNI 291
gi 87122525 227 GLLHFpkgyiSQVRGDSFIEYtnahselnLVSSYYTNStRQNAYQNAINMLNEnrhlgFIYASSTDIALGVSDAIAEQKR 306
gi 89093783 201 AMLFFapgyvSKMRGGTFISEakqqkglsPVASFYTGGnRGKARAATLKTLSKnpdvdMFFACSTDIALGVSDALDELKL 280
gi 95930397 185 AIICGtngqvSQLRTQGFHQIaidrqappPLVEFFTDQtPDKIYRAASDIVNSynqvdFIFCTTTDIALNTSRALKDLGR 264
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1               #                    #                                    
1ZHH_A      261 e-dIMINGWGGGsaELDAIQKGDLDITVMRMNDDTGIAMAEAIKWDLEdk--pvPTVYSGDFEIVT 323
1JX6_A      259 e-dIMINGWGGGsaELDAIQKGDLDITVMRMNDDTGIAMAEAIKWDLEdk--pvPTVYSGDFEIVT 321
2HJ9_A      256 e-dIMINGWGGGsaELDAIQKGDLDITVMRMNDDTGIAMAEAIKWDLEdk--pvPTVYSGDFEIVT 318
gi 56680722 285 ekeVFSTGWGGTglELDAIRRGELDATPMRMGDDVGAATAEAIKAHLEgrsdelPFVFLGRITVAH 350
gi 59711314 287 t-kTVINGWGGGslELKAIENGELDVTVMRMTDDTGIAMAEAIKLDLEnk--pvATVYSGEFELVT 349
gi 78220756 289 qgkVLLNGWGGGsaELQALLAGKLDVTVMRMNDDNGVAMAEAIRLDLEgrpheiPVIFSGEFVLVR 354
gi 87120841 282 lsdIFVTGWGGTakEIEKIKMGELGATPMRMSDDLGVATAESIKFHIQkresdiPHTYLGRIVVVH 347
gi 87121187 292 e--STTNSWRYTsiEQRALDDGRLVVTLERDVKEFSFVIAETIQSDLTgl--dlPNLYIPSSALIS 353
gi 87122525 307 qnkVLVNGWGGGsaELDAIAQGKLDVTVMRMNNDNGVAMAEAIKLDLTgnktqvPVIYSGDYELVT 372
gi 89093783 281 hdqILVNGWGGGdaELEALLAGKLDLTVMRLNDDASVAMAEAIKLDLNgsshlvPQIYSGDIVLLD 346
gi 95930397 265 kdaIAINGWGGGekELEALQQGDLAATVMRMNDDSGVSIAEAVKFVLEdrqqqiPRLFCGTMKLLS 330

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap