Conserved Protein Domain Family
PBP1_methylthioribose_binding_like

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cd06305: PBP1_methylthioribose_binding_like 
Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily
Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes transition from an open to a closed conformational state upon ligand binding. The sugar-binding domain of the periplasmic proteins in this group is also homologous to the ligand-binding domain of eukaryotic receptors such as metabotropic glutamate receptor (mGluR), DNA-binding transcriptional repressors such as LacI and GalR.
Statistics
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PSSM-Id: 107300
View PSSM: cd06305
Aligned: 15 rows
Threshold Bit Score: 278.057
Threshold Setting Gi: 89054897
Created: 25-Oct-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic transport protein receptor for D-glucose and D-galactose

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #                                                                   
gi 30018927   58 KIALIMqmsigtFSSQYIEGVKKQVelfGGSVQVYNsdndlAKMAANLDTAINsKVDGILIDHGrsealkpgvekalqaN 137
gi 119714669  58 RVAIVQnsgqgdYFQQYLNGTKQQAaalGIDLSVYDaqgdnATQATQLDQAISsGVQGIIVRHGfpdtlcpgvnkaidqG 137
gi 148254055  39 RIAVVNfigggdWLQAFEAGTKRQAdalKVDLRISEarqdpDAQRRLIEDAINqKVDGLIINNGkpealkdvaqkaldaG 118
gi 26989476   36 RIAVSMtgtshyFDIKAFQAQVNEIkrlGGTPITLDagrndRNLVTQLHTVVTqKPDAVIQTLGtlsvidpwlkriqaaG 115
gi 89054897   23 TVAVITpylsqpGTQAYVESFEAAAaanGWDVNVIDtagdvAAVISRIEDAVIqTVDAIVINVDpaqvnvg-llaaadaG 101
gi 52212468   53 RIGITAagtdhyWDLQAYQGAVDEVkrlGGTPIALDagrndSRQIVQIQTLIAqQPDAIIEQLGtasvlepwlrkirqaG 132
gi 77387339   33 TIGITAigtdhdWDLKAYQAQIAEIerlGGTAIALDagrndQTQVSQIQTLIAqKPDAIIEQLGnldvlnpwlqkindaG 112
gi 123442832  38 TIGVAVvgtqhfWDREAFKGASSEVeklGGKVVAVDggrdnQVHADNHDILLArKVDAVISILGdsavepk-fkalqaaG 116
gi 49610870   42 RIAVIRnlgsddNTTQFVSGVLEEGkklGFKVSTFLsngddARFQDFVNQAISqKYDGIILSQGrdpystdlikrivdsG 121
gi 157694244  55 KIKVIRkiggddHTAQFLAGTKAEGealGFTVDVYTangdtAKFHDAISQALEeNYDGFIISHGddeatvadvkkitakG 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                                      #                  
gi 30018927  138 IPVVAFDndlrl---pgvtIIDQDDYSLAWKSLKTLAedlngqGNIAVVWVg--gFAPMERRNVIIDAFykryp-nikev 211
gi 119714669 138 IKVVIYDveiqkc-apqavQTQQSDNKMASLVLDKMAedigtgKPVGYVNVa--gIAPLDRRDLVWQDYlatnd--wtqk 212
gi 148254055 119 IKVVAYDvnldn---pkipQVEQSDADMARLVLDQAVkeqgkgLKGGVVYVa--gFAPLDRRYAVWKEFgkthg--leer 191
gi 26989476  116 IPLFTIDvpsq----yslnNTTSDNVAAGRALAEQLVrdtggkGRILVFNGfy-gVPVCAIRYDELKKVladhpqlqivq 190
gi 89054897  102 IPVVGMDagsdp---lvavNVTSNGYGMAAETSVYVAnringqGNVVMFVFd--aFPPVQLRGVVADAVfgnfpdievld 176
gi 52212468  133 IPLFTIDtasp----sslnVVTSDNFAIGSQLALKLVndirgeGNVLVFNGfy-gVPVCAIRYDQLKAVlkwypkvkiie 207
gi 77387339  113 IPLFTVDtatp----hainNTTSNNYSIGAELALQMVadlggkGNVLVFNGfy-sVPVCKIRYDQMKYVleafpdvkiie 187
gi 123442832 117 IPIFTVDhvsp----ysinNTTSDNYTIGSTIGRYTAdalggkGNIAVFNAfsnsLRICGIRYDLWKYVlqdypgikiiq 192
gi 49610870  122 IAVSVFDtavngq-ipgvtVTQQDDASLTNESFGQLVkdfngkANIIKLWVa--gFPPMERRQLAYQQIlkanp-gikel 197
gi 157694244 135 IPVVAFDsnpklkgikgvtVTSQDDEQLAKKSLDALVsdfkgkANIAYLWVd--gFPPMVRRNKVYQETlkqhs-gikel 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                         #              
gi 30018927  212 ARFGTASNntpLDTQTQVEALLKKYPkkgdlqAIFAS-WDEFAKGTVKALEQAGRt--dIKVYGIDLSnedlqlmqkens 288
gi 119714669 213 FKTGKFTNstaTDTAPMVDSVLKSNPdv---vAVYAP-YDELTKATLSALKQNPSlqgkVKVYGADIStadielmtnpds 288
gi 148254055 192 AVWGVVNDsvpASVADQTKAVLRAHPei---tAIFTP-WDEFARGVKLAIDELGVge-kVKIYGVDIStsdiqaiiepks 266
gi 26989476  191 PELRDVIPntvQDARSQIAALLNKYPkgd-iaAIWSA-WDIPQLGASQALIDAGRs--eIRTYGVDGTpevlellahdds 266
gi 89054897  177 RVTPDVSDggiADSRARMEAILAANPepgsiaAVWAA-WDQPALGALQAIEDAGRgdegIVITGIDANpqarda-iaagg 254
gi 52212468  208 PELRDVIPntaQNAYAQISQLLQKYPkgt-isAIWAA-WDIPQVGATQAVDAAGRr--eIRTYAVDGSpeavalvrnpts 283
gi 77387339  188 PELRDVIPntiQSAYSNVTDMLTKYPnegdvgAIWAC-WDVPMIGATQALQAAGRt--dIRTYGVDGSpefvemvadpes 264
gi 123442832 193 PELAEQYAnspEDARKKTLELLSQHPkgt-ldAIHVAcWDQPAIGIVQALEESGRag-dVKVTAIDAGpetleimaekgs 270
gi 49610870  198 ESIGAVSSdvqGDTANKVGAVLAKYPkgk-idAIWGS-WDAFSQGAYKALKENGRt--eIKLYSIDISnqdlqlmreass 273
gi 157694244 212 DRFGIASSdtsVQTQNAVAAMLNKYPkgk-ldAIFAT-WDAFAIGAARALKEAGRt--eVKIYGIDVSnadlqemtakds 287
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
Feature 1               #                                  
gi 30018927  289 PWTATAATDPAEVGKVQVRFLYkkIAGEQTPdiYSLEPYLVK 330
gi 119714669 289 PWVATGATDPNAIGAAVVRTLAlhMAGELDGlnVEFPPILVT 330
gi 148254055 267 PWVATAATNASVVGEVSVRAVAllIAGQDPGhsVLVQPRLVT 308
gi 26989476  267 PIGAVVAQQPDLIGRTAVRNVAryLAGQRDLpkETHVAALLT 308
gi 89054897  255 SFEASIAQDFTGIGQAAADVVGrlMAGEEVResVIYVPTMLV 296
gi 52212468  284 SAAAVVAQQPALIGRTAVRNVAryLAGDRSLpaYTFVPSVLV 325
gi 77387339  265 PAGAVAAQQPSEIGKLAVQNVArhLAGQEVKp-FTFAPAVLI 305
gi 123442832 271 PLVANVAQQPNLIGKTSADNVAryFAGEKLLp-QTFVPVLPV 311
gi 49610870  274 PWKVSVAVDPKLIGKVNLRLVAnkIAGEPTPatYEFRAASIP 315
gi 157694244 288 PWKYTAAVDPKLIGAVDVRILAkkIAGEKTPssYDLEASLIS 329

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