Conserved Protein Domain Family
PBP1_sensor_kinase_like

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cd06308: PBP1_sensor_kinase_like 
Periplasmic binding domain of two-component sensor kinase signaling systems
Periplasmic binding domain of two-component sensor kinase signaling systems, some of which are fused with a C-terminal histidine kinase A domain (HisK) and/or a signal receiver domain (REC). Members of this group share homology with a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily and are predicted to be involved in sensing of environmental stimuli; their substrate specificities, however, are not known in detail.
Statistics
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PSSM-Id: 107303
View PSSM: cd06308
Aligned: 24 rows
Threshold Bit Score: 358.864
Threshold Setting Gi: 117925671
Created: 25-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic transport protein receptor for D-glucose and D-galactose

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #                                                                   
gi 29347164   34 RIGVAQcsd-dsWRHKMNDEILREAmfynGVSVEIRSagddnSKQAEDVHYFMDeGVDLLIISaneaaPMTPIVeeayqk 112
gi 156740872  40 RIGMSQannaepWRQAMNDQIAAAAarypHIRIEFTDarqnnAQQVADVETFLQqGIDLLIISpneatPLTNIVaqafqr 119
gi 134097541  50 TIGMSQanlaepYRVRMDEDIRKAAekvpQFDVQFADaakdnSKQVSDVENFMTkKVDLLMISpneaaPLTDVVkkayne 129
gi 149832222  36 VIGMSQcnlgepWRVAMNDQIAMAAekhpEFEVIFADaaqdnSKQIADIENFVQmGVDLIITSpneatPLTNAVsaayda 115
gi 149275793  30 LIGFSQcvgsdlWRKTMLDEMKMELslhpGAKLVYADadnnsNTQIKQVKEMLDqGIDLLIISpneakPLTEIVeqtysd 109
gi 13476788   45 VIGFSQannaepYRQHVNDELTAAAkavpGFALQIADgagnvNTQTSQVDNFITqKVDLLLISpfeaaPLTPAVkramda 124
gi 116625233  30 VVAFSQannaepYRAAQNALMEKLFaaqpDVKLVISDaqqdnSKQVAQVETFIRqKPDLLIVApneraALTAVMgqamea 109
gi 150019274  39 IIGMSQanlyepWRISMNKEIQEEVkkhsNIKIIFKDaggdvEKQREDIEDLMNfGADLLIVSinnskELTPTVrka-ye 117
gi 149905739  39 IIGMSQanlyepWRISMNKEIQEEVkkhsNIKIIFKDaggdvEKQREDIEDLMNfGADLLIVSinnskELTPTVrka-ye 117
gi 162148225  51 VIGFSQanfkepYRAHVDHELQRLVknypQFKLVIADgqandNTQVSQVENFLTqQVDILFVSafeaaPLTPAVsavydk 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                           #            
gi 29347164  113 GIPVILVDrkils---dkytaYIGADNYEIGRSVGNYIAssl-----kgkGNIVELTGLSGstpAMERHQGFMAAiskfp 184
gi 156740872 120 GIPVIVLDrkvrg---dqytmWIGADNRLIGRKAGEYTArwcre-qqrspCNVIELRGLEGstpAQERGDGFREGiagnp 195
gi 134097541 130 GIPVVVLDrkveg---eafttYIGADNVQIGRQAGEYFKntll----pqgGKIVQLKGLSGstpAAEREKGFMEGiags- 201
gi 149832222 116 GIPVILLDrkidg---dkytqFIGADNVDMGRIAGEYIAdtll----pdgGKVCEIKGLEGtsgGIDRDNGFREGikknd 188
gi 149275793 110 GIPVIVIDrktts---nlytcYVGADNYQIGYMASQYLGnti-----sgpANILEVMGLPGsspTIERNKGFNDGlkkfp 181
gi 13476788  125 GIPVIELDrktvgdpgkdytaFIGGDNYKIALEAGKYTAktll----pdgGEAAVLEGLPSstpAVERLNGFKDGvkena 200
gi 116625233 110 KIPVICLErdilq---pnytsYIHSDNVAIGRLAGQFIVghltkkygkpaGNVVAMRGLLGvegEINRDRGAKEIldkyp 186
gi 150019274 118 SLPVILLDravdg---ydytlYIGADTRSIGVQAGELIAnlag----nnkANVIEVQGILDsstDKEITDGFKEAisnyk 190
gi 149905739 118 SLPVILLDravdg---ydytlYIGADTRSIGVQAGELIAnlag----nnkANVIEVQGILDsstDKEITDGFKEAisnyk 190
gi 162148225 131 GIPVIELDrrttg---ekftsFVSGDNRAIAHEAGLYAAsll-----pdgGDVAILEGLPSsspAIERLEGFKAGistnp 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                        #               
gi 29347164  185 diklIDKADAAWerGPAEIEMDSMLRrhpkiDAVYAHNDRIAPGAYQAAKMAgre-keMIFVGIDALpgkgnglelvldS 263
gi 156740872 196 dvriIASQNADWlaERAAPLSRAMLEanpvvDVVYAHNDPMAIASFTMARDLgrdpdsILFIGIDALptpdggiqavrqG 275
gi 134097541 202 kievVDTADGEWerSVGQQKMDALLKahpdiQAVYAQNDPMAEGAWLAAQAAgr--kdLKFVGIDGLpiesggikaveqG 279
gi 149832222 189 kieiVAVNNADWlrEKAITVAEEMLQtndeiDLFLALNDPMAEGAYIAAKNAgre-gdILFVGFDGLptpdggirsvmdG 267
gi 149275793 182 nlkiKSQVYGDWmkPNAERQLSKISDqlndiDVVFAHNDNMAFAAQSVFKKLgia-sqAKFIGIDATpgaggglqmisnG 260
gi 13476788  201 kiqvVAEQAADWvpDKAQTAFAAMLQahpdiKVLYASNDMMAAGALLAAKGAgk---qVKIIGTDGLpgpaggieavakG 277
gi 116625233 187 eikiVADPVADWiqAKAKDRMTEVLRaqpkiDVVYGHNDPMAIGAYLGAKELgre-keMIFVGVDGLggpaggikkvmdG 265
gi 150019274 191 niaiDRTIVGNWqkNETEDKLEEILKddkdvNIIFAHSDYMALGAYYATVSTns--knIKIIGVDGLegpqggidlvrnG 268
gi 149905739 191 niaiDRTIVGNWqkNETEDKLEEILKddkdvNIIFAHSDYMALGAYYATVSTns--knIKIIGVDGLegpqggidlvrnG 268
gi 162148225 203 kvkiIAVQPVDWmqDKAVEVFSAMLQahpdiKLVYTSNDLAAAGAYIAVKQAgkl-gqVKIIGTDGLpgpsggiravaeG 281
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
Feature 1              #                                  
gi 29347164  264 VLDATFIYPTNGDKVLQLAMDILEKkp--ypKETVMNTAVV 302
gi 156740872 276 QLDVTYVYPTGGAEAVEWAIRILERget-ppREVILDTEEV 315
gi 134097541 280 RLSATNLYPTGGEEAVEAARKLLIDcqp-vpKEQTLPTELV 319
gi 149832222 268 RLSMTQVYPTGGTEAIESAYQLLVEgke-ldKTLTLTSEIV 307
gi 149275793 261 LIDASMLYPTGGKEAITTAIKIMDKip--fsKELILPSLVI 299
gi 13476788  278 DWAATFTYPTGAKEAIEMSKKILLDcatsvePTVTVETTAI 318
gi 116625233 266 VLAATFVYPLWVDKAVEIGTRILREpgfvpaKDYVLESVMV 306
gi 150019274 269 ILQGTFTCKTGGKEAVDYAIKILNKkdd-ipKKVLLKCNKI 308
gi 149905739 269 ILQGTFTCKTGGKEAVDYAIKILNKkdd-ipKKVLLKCNKI 308
gi 162148225 282 QWTATYVYPTGAAEALDLAKKILIDcassvpRLVTVPTQRI 322

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