4RSM,5HKO,4RS3


Conserved Protein Domain Family
PBP1_ABC_ThpA_XypA
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cd06313: PBP1_ABC_ThpA_XypA 
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periplasmic sugar-binding proteins (ThpA and XypA) of ABC-type transport systems
This group includes periplasmic D-threitol-binding protein ThpA and xylitol/L-sorbitol-binding protein XypA, which are part of sugar ABC-type transport systems. Both ThpA and XypA share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge.
Links
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Statistics
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PSSM-Id: 380536
Aligned: 20 rows
Threshold Bit Score: 331.542
Created: 9-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:4RSM; Mycobacterium smegmatis sugar-binding protein binds D-threitol, contacts at 4A
    - View structure with Cn3D
  • Structure:5HKO; Mycobacterium smegmatis sugar-binding protein binds L-sorbitol, contacts at 4A
    - View structure with Cn3D
  • Structure:4RS3; Mycobacterium smegmatis sugar-binding protein binds D-xylitol, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #     #                                                                   
4RSM_A     14 RIGVTVYdm-ssFITAGKEGMDAYAkd---nNIELIWNSanldvSTQASQVDSMINqGVDAIIVVpvqadslaPQVASAK 89  Mycobacterium smeg...
SHF75600   33 RIAAVVQsldteFNVLWANAANSHPlvk-dgTVTLTVLDgrmdaLTQSNQFDTAISeKYDALIFVpvdinagnDPVQRAK 111 Kaistia soli DSM 1...
EIP98730   33 KIGLAVYglrgeFMKMLTNWVQDHPavk-ngDVRITVFDgrydpNVQNDQFDSMIVqQFDGIIFVpidyeagsRSVEKAV 111 Opitutaceae bacter...
ANU46391   63 TIGFSSKtnsdtFVKNIADAAEARAke---lGINLIMMDaagdvNKQISDCETMIAqGVDALVVIpqdvegsaPVVSMAN 139 Lachnoclostridium ...
ONI42795   32 TVGFMNTnlsneYQVTMLDGAKAKAee---mGIKLVEQDgqgdaAKQISQMEQLISqQVDAIVMApydkdacaPAVTKAK 108 Epulopiscium sp. S...
SHE14586   46 RIGVAAQglsheFIKALVEAMQDKAke---lNVELLVMDsqdkiETQLSQVDNLVTqKVDAVILNtvdfvglgPAVDQVK 122 Chlamydophila abortus
CUP14526   30 KIAWVDGnlaneSNAICTDAAKAYAee---nNVDFTLLDgqgsgENQVSQIETLIAqGVDCIIVQpydaaacqVGVEAAI 106 [Ruminococcus] obeum
OXS58848   52 KIGVAAQglsheFIKSLVESMQEKAge---lNVELVVMDsqdkiEEQLNQVDTLVAqKVDAVILNsvdfvgssPAVDKVK 128 Cohnella sp. CIP 1...
KLU69544   81 KIVFSSYsqtaqFQVLLAEAMQDYVsekyadTVDFSVLDgnmdsATQVGQIDNLIAqNVDGILICpmdgdalvPAVEAAN 160 Robinsoniella sp. RHS
KXK65892   54 KIGISTQsweheFLKNMVNALQAIDes--mpDVELVIVDsedsvEKQLNDVDTLIAqGVDGIILNadsvegssQAVVAAK 131 Christensenella mi...

Feature 1              #                                              #     #                 
4RSM_A     90 AkGIPLVPVNaalds-kdiagNVQPDDVAAGAQEMQMMAdrlgGKGNIVILQGplGQSGELDRSKGIEQVlakyp-dikv 167 Mycobacterium smeg...
SHF75600  112 DaGVPVIGSNtlisntdlyksYISSNDVEAGKILAKSVFdkmgGKGNVVIVEGmiGQSAQVQRLEGIEATlkeyp-dikv 190 Kaistia soli DSM 1...
EIP98730  112 AeGIPVVGSNtriskidllaaYVGNNDVRAGEMEAQSVVdrigGKGNVVIIEGpiGQSAQIERRKGNLNVlqkyp-dikv 190 Opitutaceae bacter...
ANU46391  140 NaGIPIIIDNgdiad-kdytaFVGCTDQESGELLGTWFMenvpEGSKVCIIEGpmGQSGQVGRYAGFEKVgmld--hfev 216 Lachnoclostridium ...
ONI42795  109 EaGIPLVIVDstvnnieealtFVGADETIVGALAMDTLVeaigGAGDIMMIRGpiGNSAEVGRSTGALDAlanyp-dvnl 187 Epulopiscium sp. S...
SHE14586  123 GaGIPLVEVItftkn-enydvFVGTDPKQSGIFMGEMLAevlgGKGNVALLQGqiGHSAEITRGQGLQEAlfdkypdikl 201 Chlamydophila abortus
CUP14526  107 DaDIPVLVTKttied-nsicpFVGQDDTVAGEMEMEWMAeqlgGKGNIVIIEGptGISAAIQRNDGIEKTlekyp-dinv 184 [Ruminococcus] obeum
OXS58848  129 EaGIPLVEVItyten-enydvFVGTDPKQSGVMMGEILAdklgGKGSVALLQGqiGHSAEITRGAGLQEAlfdkypdvkk 207 Cohnella sp. CIP 1...
KLU69544  161 EaKVPLITVNaqvns-devlaHVGSDDIVAGELEMQYVAdqlnGKGNIVILHGpnGISAEVLRREGYENIlkkyp-dikv 238 Robinsoniella sp. RHS
KXK65892  132 DaGIPLVELVslten-edydtFVGTDVKASGLLAGEMVAemldGKGKVFEIQGvmGHSAQINRGAGIAEAleayp-diel 209 Christensenella mi...

Feature 1            #                           #                          #                 
4RSM_A    168 LAKDTANWkrDEAVNKMKNWISgfgp-qidGVVAQNDdmGLGALQALKESgr--tgVPIVGIDGIEDGLNAVKsgDFIGT 244 Mycobacterium smeg...
SHF75600  191 IEQKTANWsrAEALSLVENWLTahpd-eiqGIIGENDemAIGALEAVKGHgldpkkIPIAGVDGVTDALLAVQr-GEMMS 268 Kaistia soli DSM 1...
EIP98730  191 LDMKPGNWdrALALSLMENWLTaypg-kinGVIGQNDdlGLGAIQAIKAAglkvsdFAVVGVDGIKDAFAAARa-GEIVS 268 Opitutaceae bacter...
ANU46391  217 LSTQTANWkrDEAMALAEDWLTtygd-dlkAIICENDdmGLGALAACKAAgr--tdIVIGGVDGLEDAVEAVKngEYGVS 293 Lachnoclostridium ...
ONI42795  188 VIDEPADWdrEKALKLMENKLHgdf--divGVLAQNDemAIGAQKAIEAAgkq-dqIKVIGIDAIPDALTAVAegKLLAT 264 Epulopiscium sp. S...
SHE14586  202 ITQQTANWnrDEAMRITEDWLQrfp--eidAIAAQNDemAMGALQAVEAAgk---dIVVMGIDGIPDALKAVKegRLAAT 276 Chlamydophila abortus
CUP14526  185 LHTQPADWnrDEGMSLMETWLQegk--eidGVVAHNDemALGAYDAIADAgka-geIKVIGIDAIDAAKKSVAagELDAT 261 [Ruminococcus] obeum
OXS58848  208 ITEQTANWnrDEAMSITEDWLQrfp--eisAIAAQNDemAMGALQAVEAAgr--sdIIVVGIDGIADAMKAVKegRLAAT 283 Cohnella sp. CIP 1...
KLU69544  239 LSEPTCNWsrEEALSTTENLLQgad--eiqAIVAQNDemAMGALQAVLDNdmg-dkIIVTGIDAIDDAKAAIEagTLSAT 315 Robinsoniella sp. RHS
KXK65892  210 VESQSGEFtkDKAMSVTEAWLAkypageidAIIAHNDgmALGAMNACISAnr--teIKIIGIDGDAEALQAVIdgTMAAT 287 Christensenella mi...

Feature 1       #                                                              
4RSM_A    245 SLQNgTVELAAGLAVANrlakg--------------------epvnKEPVYIMPAITKDNvdVAI 289 Mycobacterium smegmatis str. MC2 155
SHF75600  269 TLQDaDAQAQGAIDLALaavqgesyqpkakvwdvnggklaweggksQHYSVPWVPVTGENveALL 333 Kaistia soli DSM 19436
EIP98730  269 VLQDsKAQGQGALDVLLrhiigpeykpqsdiwefygdrmpwnggneKHYDIPWTLITAQNadSLA 333 Opitutaceae bacterium TAV1
ANU46391  294 VLQDsEGQGKGGVDVAYqivtg--------------------qeyeEDTRIPFRPITKENvdAYL 338 Lachnoclostridium sp. YL32
ONI42795  265 IYSSpELKAATAVQVAVdaang--------------------qeleREYYVDFVLITQENvaDFQ 309 Epulopiscium sp. SCG-B05WGA-EpuloA1
SHE14586  277 VLDNvTAEGKRAVEVAVglikg--------------------ekfeKKELIDYVPVTAKNvdEYL 321 Chlamydophila abortus
CUP14526  262 VLQDvETIGKKTVEVAIemckg--------------------ekvdDVYNVDPVLLTKDNiaDYV 306 [Ruminococcus] obeum
OXS58848  284 VLDNvTAEGKRAVEVAVglikg--------------------ekfeKKELVDYVPITGDNigQYL 328 Cohnella sp. CIP 111063
KLU69544  316 VFQDaKGQAEAGIDEILdivk---------------------ggepKDVSIPYVLVTKDNiaDYK 359 Robinsoniella sp. RHS
KXK65892  288 VVDDvETESRLAVEEMVsilng-------------------sepkgQILAEYIPVKTAEEakVWL 333 Christensenella minuta

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