Conserved Protein Domain Family
PBP1_tmGBP

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cd06314: PBP1_tmGBP 
Click on image for an interactive view with Cn3D
Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs
Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs from other bacteria. They are a member of the type I periplasmic binding protein superfamily which consists of two domains connected by a three-stranded hinge. TmGBP is specific for glucose and its binding pocket is buried at the interface of the two domains. TmGBP also exhibits high thermostability and the highest structural similarity to E. coli glucose binding protein (ecGBP).
Statistics
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PSSM-Id: 107309
View PSSM: cd06314
Aligned: 11 rows
Threshold Bit Score: 367.121
Threshold Setting Gi: 89899250
Created: 9-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingdimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2H3H_A; Thermotoga maritima glucose binding protein binds glucose, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #                                                                   
2H3H_A         3 TIGVIGksvhpYWSQVEQGVKAAGka-lGVDTKFFVPqkediNAQLQMLESFIAeGVNGIAIApsDPTAVIPTIKKALEm 81
3C6Q_B         3 TIGVIGksvhpYWSQVEQGVKAAGka-lGVDTKFFVPqkcdiNAQLQMLESFIAeGVNGIAIApsDPTAVIPTIKKALEm 81
2QVC_A         4 TIGVIGksvhpYWSQVEQGVKAAGka-lGVDTKFFVPqkediNAQLQXLESFIAeGVNGIAIApsDPTAVIPTIKKALEx 82
gi 15642889   33 TIGVIGksvhpYWSQVEQGVKAAGka-lGVDTKFFVPqkediNAQLQMLESFIAeGVNGIAIApsDPTAVIPTIKKALEm 111
gi 89899250   50 RIAVIPkvavpFFDDCNNGAKAAAdk-lGVQYQWVVPqntqgSTQVRILEDLISkKVDGIAISvnEPKSVEAAIKKAVAs 128
gi 27377380   41 TIALVTnvaadFWTIAGRGLEKAQkehpDYNIELIVTnegtaAGQRRELDDLLVrGVAGISISvdDAPHATEQLNKVAA- 119
gi 14024899   32 TLAFVVngasdFWKAAEAGVKKAQgelpDYNLELKYPeqssvAIQQRLMDDLVTaGVKGIMVSavDPKTSTDGLNKIAS- 110
gi 162451374  50 KLAFVTnnaseFWKIAQAGVRKYEqe-sKVQVDVKMPsngttEEQNQILENLSSqGYDAIAVSaiAPADQVPVLNKVAE- 127
gi 149175858  37 DVAYVTngiasFWVIAEKGAEQAGed-lGVNVEVRMPpq-gvTDQKRMVQELLAqGIDGIAISpiDPANQNDLLKEIAD- 113
gi 118592479  27 QLAFVVnaasdFWKLAEAGVNAAQaelpGYDLQFRYPaqgtaALQNALMDDLVAaGTDAIMISsvDPKTSIDAFNRIAA- 105
gi 162452304  36 KLAYITngvapFWTIAEKGVIDGAke-hNVEVSVVMPsd--vNDQLHRVEDLLIrGVDGIAISpiDAENQVPLLNKAAA- 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                   #                    
2H3H_A        82 GIPVVTLDTDSPdsgRYVYIGTDNYQAGYTAGLIMKellggkGKVVIGTGsltamnSLQRIQGFKDAikds--------- 152
3C6Q_B        82 GIPVVTLDTDSPdsgRYVYIGTDNYQAGYTAGLIMKellggkGKVVIGTGsltamnSLQRIQGFKDAikds--------- 152
2QVC_A        83 GIPVVTLDTDSPdsgRYVYIGTDNYQAGYTAGLIXKellggkGKVVIGTGsltaxnSLQRIQGFKDAikds--------- 153
gi 15642889  112 GIPVVTLDTDSPdsgRYVYIGTDNYQAGYTAGLIMKellggkGKVVIGTGsltamnSLQRIQGFKDAikds--------- 182
gi 89899250  129 GIKVVTFDSDSAnsgRSMYIGTINSAAGETMGESMAkaidgeGEVAILTGqlgaanLNERITGIKKSlskyp-------- 200
gi 27377380  120 KTVLITTDSDAPqsnRLAYIGTDNVAAGRQAGEEIKkalpngGKIALFVGtmdadnARERVQGIKEAiagt--------- 190
gi 14024899  111 QTALFTTDSDAPqtkRVAYIGSSNVDAGKQAAEIAKkampngGKCLGFVGllgadnAKERIQGMKDGlagt--------- 181
gi 162451374 128 KSKLITFDSDAPassRLLYIGTNNHEAGKALGAHIVkllpdgGKMAVFVGtlsadnAKQRLQGIQDAiagk--------- 198
gi 149175858 114 NSILITQDSDAPdspRECYIGMDNYEAGRMCGELVKealpegGEIMLFVGrlgqanARLRRQGVIDEvmdrsndntryde 193
gi 118592479 106 QVPLFTTDSDAPesdRIAYLGSSNTLAGNQAGEIAKkalpngGTCMGFVGflgadnAKERIAGFRETvkgs--------- 176
gi 162452304 112 KTKLITQDSDAPksdRIVYIGIDNYVAGRMAGQLVKeaipggGKVAILVGrlegdnARKRRQGVLDElldrqdtsagndp 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           #                         ##                           #     
2H3H_A       153 --------eieiVDILNDEEdgARAVSLAEAALNahpdLDAFFGVYAYNGPAQALVVKNAgkv---gkVKIVCFDTtpdi 221
3C6Q_B       153 --------eieiVDILNDCEdgARAVSLAEAALNahpdLDAFFGVYAYNGPAQALVVKNAgkv---gkVKIVCFDTtpdi 221
2QVC_A       154 --------eieiVDILNDEEdgARAVSLAEAALNahpdLDAFFGVYAYNGPAQALVVKNAgkv---gkVKIVCFDTtpdi 222
gi 15642889  183 --------eieiVDILNDEEdgARAVSLAEAALNahpdLDAFFGVYAYNGPAQALVVKNAgkv---gkVKIVCFDTtpdi 251
gi 89899250  201 --------kikvVATEGTEDdlAKAVSTTESLFRghpaLKGIFGVSQVGGPAVSKVMATKefgskkgaVKVFAFDDlpdt 272
gi 27377380  191 --------kvelVDVFTDQVdfAKAKANMENVLVkypdIALLSGLWSYETPLIYDAVKAAgka---gkVKIVGFDEdqrt 259
gi 14024899  182 --------kielVDVRGDDIdqARAKKNVEDALVaspdVTCMVGFYSYNTPRIYEALRDAgkl---gqITVVGFDDdpit 250
gi 162451374 199 --------nieiVDKREDNTdrAKARSNVEDIINahpdLKLVAGLWSYNGPAIAAAIEALgkk---gkVLAAVFDEeeet 267
gi 149175858 194 pgkviknekytiLDTRTDDFdfPQGKANAQDAIAkypnLKCMVGLFAYNPPLCLEAVRDAgkl---deIKIVSFDEeaas 270
gi 118592479 177 --------gielVDVRGDDVdfPKARQNVDDVLAanpeVNCMVGFYSYNPPKIYEALQAAgkl---geITVIAFDEdpit 245
gi 162452304 192 lnqelkgakytiVATLTDQIdaAKAKSNAEDMMSahpdLVGLIGLNAYHTPALLEAVKQAgkm---saIQVVGFDEqdat 268
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                      #                                                 
2H3H_A       222 LQYVKEGVIQATMGQRPYMMGYLSVTVLYlmnkigvqntlmmlpkvkvdgkvDYVIDTGVDVVT 285
3C6Q_B       222 LQYVKEGVIQATMGQRPYMMGYLSVTVLYlmnkigvqntlmmlpkvkvdgkvDYVIDTGVDVVT 285
2QVC_A       223 LQYVKEGVIQATXGQRPYXXGYLSVTVLYlxnkigvqntlxxlpkvkvdgkvDYVIDTGVDVVT 286
gi 15642889  252 LQYVKEGVIQATMGQRPYMMGYLSVTVLYlmnkigvqntlmmlpkvkvdgkvDYVIDTGVDVVT 315
gi 89899250  273 VKGVKEGYIQGIMVQRPVTMGKLAVEHLVdqitg--------------kepaPKDVDTGVNVVT 322
gi 27377380  260 LRGVSDGTIESTVVQQPYEFGYLSATNIIktlngd-----------kswipaGGKLIVPTKVIS 312
gi 14024899  251 LGGVKEGTVAATVVQQPFEWAYQGMKLMAaylkgd-----------ksgipaGNLIIIPTKIIG 303
gi 162451374 268 LTAIENGTISATVVQKPFQFGYLASKWAHelsvkpdt--------akaqipaNKSIDTGIDVIE 323
gi 149175858 271 LQGIIDGTVVGTVVQNPYQYGYESVRVLNalangd-----------ksvipeNKIIHIPARKIT 323
gi 118592479 246 LGAIREGSFAGTVVQDPYQWGYQGMHLMAkflegd-----------ksgipgDGLIIVPTKIID 298
gi 162452304 269 LRAIQDGEVVGTVVQNPYMYGKESVRVLAalvrgd-----------nsvvpqDKFISLPARQIR 321

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