Conserved Protein Domain Family
PBP1_allose_binding

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cd06320: PBP1_allose_binding 
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Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis
Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis. The members of this group are belonging to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily. Like other periplasmic receptors of the ABC-type transport systems, the allose-binding protein consists of two alpha/beta domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes transition from an open to a closed conformational state upon ligand binding.
Statistics
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PSSM-Id: 107315
View PSSM: cd06320
Aligned: 9 rows
Threshold Bit Score: 383.013
Threshold Setting Gi: 51857169
Created: 4-Apr-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1RPJ_A; Escherichia coli allose-binding protein binds D-allose, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #   #  #                                                                  
1RPJ_A         3 EYAVVLKtLSNPFWVDMKKGIEDEAkt-----lGVSVDIFAsp--seGDFQSQLQLFEDLSNkNYKGIAFAPlssvnLVM 75
1GUB_A         3 EYAVVLKtLSNPFWVDMKKGIEDEAkt-----lGVSVDIFAsp--seGDFQSQLQLFEDLSNkNYKGIAFAPlssvnLVM 75
1GUD_B         3 EYAVVLKtLSNPFWVDMKKGIEDEAkt-----lGVSVDIFAsp--seGDFQSQLQLFEDLSNkNYKGIAFAPlssvnLVM 75
gi 52424256   57 KIGGVSKtLTNEYWRSLGEGYKNFAdk-----hKVFVAYQAaa--neGDQLGQLSIAETMITeGYSALLFSPqtdvnLQP 129
gi 52306308   57 KIGGVSKtLTNEYWRSLGEGYKNFAdk-----hKVFVAYQAaa--neGDQLGQLSIAETMITeGYSALLFSPqtdvnLQP 129
gi 69934094   57 QIGGVSKaLTNEYWRSLGEGYKNMTda-----qGVGLAYQAap--seGDQLGQLSIAENMILqGYQGLLVSPqtdnnLQP 129
gi 160936560  69 KLGAVAKsFDNEYWRTLREGYGEYQtkaaaagcNITIDVTSaq--geNDEQGQLSIVKDMINkKYTGLLLSPisdgnLTP 146
gi 51857169   35 EYAVVLKvLSSPFWQSMRDGILEEAek-----qGIKVDIYAan--seDDVEGQVTLLENAINkGYKAIGVAPisadnLVP 107
gi 149735308  74 KMGAIAKsFSNEFWRNFKNGYEQSEkvl--kdaGVDVSIKIdgttdeSDEIGQQTMTDNLVNqGYNALMLSPisdsnLTA 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       ##                                                      #   #    
1RPJ_A        76 PVARAWKKGIYLVNLDEkidmdnlkkaggnveAFVTTDNvaVGAKGASFIIdklgaegGEVAIIEGkagnaSGEARRNGA 155
1GUB_A        76 PVARAWKKGIYLVNLDEkidmdnlkkaggnveAFVTTDNvaVGAKGASFIIdklgaegGEVAIIEGkagnaSGEARRNGA 155
1GUD_B        76 PVARAWKKGIYLVNLDEkidmdnlkkaggnveAFVTTDNvaVGAKGASFIIdklgaegGEVAIIEGkagnaSGEARRNGA 155
gi 52424256  130 AAEVAQSKNIPVVNVNDavmp--------tatHYVGNVQkdNGVRVANWFIehs-aegGKVAVVEGqpgvfAAKQRTEGF 200
gi 52306308  130 AAEVAQSKNIPVVNVNDavmp--------tatHYVGNVQkdNGVRVANWFIehs-aegGKVAVVEGqpgvfAAKQRTEGF 200
gi 69934094  130 AMETAASRGIAVVNVNDavip--------satQYVGNVQrdNGVRVAQWFIdnr-pggGKVAAIEGqpgvfAAGQRTDGF 200
gi 160936560 147 GVEDAKKAGIPVINVNDglia--------nadSFVGPKAdqNGELAAEWIAdkl-ggkGKVAIVIGmpkafAARQRTEGF 217
gi 51857169  108 AVAEASKKGIYVINIDEklnleslkglggavqAFVSTDNkaVGRTGAQYIIdri-ggsGQVAIIEGkagaaSGEDRKAGA 186
gi 149735308 152 SVDNAKGKKIPTINVNDglia--------sadYFVGPDAyqNGELAAEWVSkql-gdkGDVAIVIGmakafAARERTAGF 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      #                         #       
1RPJ_A       156 TEAfkka-sqikLVASQPADWdrIKALDVATNVLQrnPNIKAIYCaNDTMAMGVAQAVANAgktgkVLVVGTDGIPEARK 234
1GUB_A       156 TEAfkka-sqikLVASQPADWdrIKALDVATNVLQrnPNIKAIYCaNDTMAMGVAQAVANAgktgkVLVVGTDGIPEARK 234
1GUD_B       156 TEAfkka-sqikLVASQPADWdrIKALDVATNVLQrnPNIKAIYCaNDTMAMGVAQAVANAgktgkVLVVGTDGIPEARK 234
gi 52424256  201 TETinks-gkfeVVASVPANWsrEQAYNVAMTILQrnPDLIGFYVnNDGMALGVVEAVKAAklqgkVAVFGTDGISDAYK 279
gi 52306308  201 TETinks-gkfeVVASVPANWsrEQAYNVAMTILQrnPDLIGFYVnNDGMALGVVEAVKAAklqgkVAVFGTDGISDAYK 279
gi 69934094  201 TTTitea-gnfqVVASVPANWsrEQAYDAASTILQqhPDLIGFYAnNDGMALGVVEAVKAAnlqeqVSVFGTDGIPDAYA 279
gi 160936560 218 ENWmaanakdieIVAKQNADWdrQKSKDLADTWIKqyPDLNAIFCnNDTMALGVVEAVKSSgk--dILVVGVDGIGEAYD 295
gi 51857169  187 TEAflka--gveLVESQPADWdrTKAYDLATNYIAkyPDLKGIYAcNDTMAMGALEAVKNAgk--dIVVVGTDGNEDAVA 262
gi 149735308 223 KGWikdnnsglnVVAEQNADWdrQKAKELASTWIQqnPDLKAIFCnNDDMALGVVEAVEEAkk--dILVVGVDGIGEAYD 300
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
Feature 1                    #                                        
1RPJ_A       235 MVEAGQMTATVAQNpADIGATGLKLMVdaeksgkvipldkapEFKLVDSILVT 287
1GUB_A       235 MVEAGQMTATVAQNpADIGATGLKLMVdaeksgkvipldkapEFKLVDSILVT 287
1GUD_B       235 MVEAGQMTATVAQNpADIGATGLKLMVdaeksgkvipldkapEFKLVDSILVT 287
gi 52424256  280 SILAGELTGTVDSFpVLTGEVAMEVVLrltagqk-lprvvttPQALITLENAK 331
gi 52306308  280 SILAGELTGTVDSFpVLTGEVAMEVVLrltagqk-lprvvttPQALITLENAK 331
gi 69934094  280 SIRAGDLTGTVDSFpVLTGEVAMEVVLrllagqg-iprvvatPQALITADNVA 331
gi 160936560 296 SIRRGELDATIDSFpFYKAQIAGEVMLrrlggqe-iprvlwtPQALIDSENVD 347
gi 51857169  263 SVKAGELAATVAQDpAQIGRRGVQLMIeavkagkaidpnaapAMESVDAILIT 315
gi 149735308 301 SIRAGKLDATVDSFgYYMSQVATEVTLrvlagqd-iprvthtPQALIDKTNVD 352

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