Conserved Protein Domain Family
PBP1_ABC_uncharacterized_transporter

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cd06325: PBP1_ABC_uncharacterized_transporter 
Click on image for an interactive view with Cn3D
Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions
This group includes the type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine/isoleucine/valine binding protein (LIVBP); its ligand specificity has not been determined experimentally.
Statistics
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PSSM-Id: 107320
View PSSM: cd06325
Aligned: 88 rows
Threshold Bit Score: 213.973
Threshold Setting Gi: 6647972
Created: 9-Aug-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ligandzinc binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein complexed with valine.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                              ###       
2QH8_A         4 KVAVSQive-hpALDATRQGLLDGLKakg-yeeGKNLEFDYKTAqgNPAIAVQIARQFVGe-NPDVLVGIATPTAQalv- 79
gi 83310454   63 KVVVGVlnh-aiVAEEALDGFKAGLGglg-wpeGGRVTYHYRGPl-AGAALDAEAERLAEl-KPDLFLTLSTPAAKsafk 138
gi 78042725   32 TVGILAas---gIKAEKIVGLKQGLAdlg-iieGKDINYIILNAegEREQLLPLARKLVQe-KPDVLVATGGVEADalkr 106
gi 148240904  31 GIGFLGagt-aeTTAPLLQALKQGLReng-lieGKEYVLEPRWAegDYKRFPAFAHELAAq-GARVIVVTTIAAAGaaq- 106
gi 27380310   80 RVIRLAp----vHIPVQVEGTRNALRelg-yveGRNIRLEFLNAagNVDALPAVAQEMVRdgGVDAIIAISTPAALaay- 153
gi 39983212   30 VAAVLTsd--meRYRDAYRSFLKALAakg--yeEGAVEVVTQTPnpDPISWANSVRKFDAi-KPDLLVTFGAPVTLaak- 103
gi 145619456  18 VAALLTcd--lpRYRDAHKAFVKALVlkg--ydQSNVEVITQTPnpDLISWSNSIRKFNAi-GADVIVAYGTSAALaal- 91
gi 89893290   43 TVGILMgs---dLRTNKVNGVIEGLKkyg-yeeNVNIRFRIVSAqdRIDDLPELAQELVRq-NPDLLIGTGERETLalqk 117
gi 27382862   39 RLGVLSvtaaddAIGQTRSAILVEALaahgwkeHGNLRIDWRSGagDRARIAGLADELIAl-KPDILLAVGTPSVEelr- 116
gi 163699764  29 VIGYLGpes-pgRYASRLHAFREGLAetg-yaeGRNVAIEFRWAegRYDQLPRLAADLVNr-QVAVIVAPGGAEIVlaar 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ###                                                        #        
2QH8_A        80 -satKTIPIVFTAVTDPvgaklvkqleqpgkNVTGLSDLSPVEQHVELIKei--lpNVKSIGVVYNPGe-aNAVSLXELL 155
gi 83310454  139 vaknAGIPLIFAPASDPiaiglaenlgrpgrNATGVTFGIQEPVRLQWLKtm--lpDLKAILVPYNPDd-lSPLASLLKI 215
gi 78042725  107 aakdQDTPIVFIGAASSvegglvksfiepggQITGVDNYHAELAGKRLELlkkllpSVNKVIVLYDPKv-pPSYTSLKIV 185
gi 148240904 107 -ratSVIPIIMTGLNDPvgnglvtslalpggNITGMATLNQDVTPKLVEFlhallpNATSTAVFFNPAn-pSNVTYLDSV 184
gi 27380310  154 -katQTIPIVALTAVDPvgsgladslahpgrNVTGVTMFSEETTVKRVELmrevfpRAVRLGTVTTRLt--SGAQSLSPV 230
gi 39983212  104 -qetSGIPVVFVDVYGPvetgisrsmsqaggSLCGVSSKVPVATLIKAMGdi---rPIRTLGVLYNTRe-aGSILQLKEV 178
gi 145619456  92 -resHDIPIVYADVYGPvetgvaksmvssgrNIAGVSSKVPLVTLVKTAMdl---kPIRSLGVVCASRe-eGSQVQLKEA 166
gi 89893290  118 aaadSQIPIVFIGVGFAeelglvdsythpggKITGVDNYYLQLSGKRLEYlkrllpDVQKVMVLYDETi-tPVEPTMDFL 196
gi 27382862  117 -rrtAMIPIVFAVVTDPvsqgfvqnlahpggNITGFTDYDGPLAGKWLEMltqvtpKVSRVFVVYNPAtapFAALMLRTI 195
gi 163699764 106 -satTTIPIVFELGGDPialgvvgslarpegNLTGVSSLSVGVTPKRLEFmhellpSAGAFAVAVNPTs-pTAKSQVRDL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  #                        #            
2QH8_A       156 KLSAakhGIKLVEATALKsaDVQSATQAIAEKs--dVIYALIDNTVASaIEGXIVAANQAkTPVFGAATSyverGAIASL 233
gi 83310454  216 TPLAgelGIRLDHAHVRNgaELDAALSAMASDv--gAVFVPVDAYVASqVPRIMLATLKRgIPLSTPQRRgvqeGAFMSY 293
gi 78042725  186 KDTAkdlGIEIKTIAVSSraEFKTKLNQHSLKgf-dAILPLSSFLLETlTQDLLNLSLQYkIPVMGIFEQeadrGYFAAY 264
gi 148240904 185 RVRTaplGIAVHDFVVSTpnELNAAFDTIAARrp-nALLVVPDAAILDlGPRIAALALQHrIPVVSVDADltrdGGLIGY 263
gi 27380310  231 LETGralGFRVEHVDIDEpvDIAKALSPKILAgfdvLVFVPDVVLDAHmADIIKMIGLSK-TPAIFASPDwvtnGGLMSF 309
gi 39983212  179 KRVAaqqGFAVVEANVSSaaGLDTALTYLLGRad-cLFVSESSVIGRGfDRIVRKATDAR-VAVISLTPGsserGALVSL 256
gi 145619456 167 RRIAaqaGMVVVEANLASsaGFDAALASLFASrv-dCIYVTECTVGSRnFEKIVHRATDLrIPVISQMPGaahkGATISL 245
gi 89893290  197 NRVAaqlDMTVIPVGVKNeaETLKAINGILPGea-dGVMLLCSLLMESvTDSISPLIQEKrLPAFGVSANqtkkGFLASY 275
gi 27382862  196 EDAArtlHVTVEPAPVHDaaSIAALASRKDGG----LLILPDFFTMANrAHLLAAVREAR-VPAVFWSRTfvdeGGLMSY 270
gi 163699764 184 QRAAtslGVELHALHASTeqEFEALFTAVPRLra-gGLVFTSDPYFAYrSQQLAALAARHaVPAITQSRDfpnaGGLMSY 262
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                           
2QH8_A       234 GFDYYQIGVQTADYVAAILEGkepgslDVQVAkGSDLVINKTAAEQLGITI 284
gi 83310454  294 GLDMHALGAQGARLAAQVLGGvpagdlPVETA-EFRLTINMDTAGRLGISL 343
gi 78042725  265 GVSMYNQGYQGARIVAKVLQGqqpeqiPVETPdNLELVVNLRTAKKLGLKL 315
gi 148240904 264 GLSRRETYRRSAYFVKKVLDGlkpadlPVEQPtRILMSVNLKTAKALDIEI 314
gi 27380310  310 GPDFSNANHHLILQLDRVLKGakasdlPFERPtKFDLRINLRTAKTLGIEL 360
gi 39983212  257 EISPTEQGQLAADYASKILSGrkpgelPVYTPrKVDLVLNMGVARTLDLHV 307
gi 145619456 246 EADPVEQGQVAAEYVARILAGkrpgqlPVVTPkRVDLIVNMKAAKSMDLNV 296
gi 89893290  276 GMDYREQGIQASRIAAKILQGqdpgiiPVEAPaRVDFIINTKVAEVFKAGI 326
gi 27382862  271 STDSAEQLRRAAGYIDRILKGaqaadlPVQNPtKFELAVNLKAAKALGVTI 321
gi 163699764 263 GGDFEQSHRHTGIYAGRILKGerpsglPVQLVtKVELFINLKAADSLGLTV 313

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