Conserved Protein Domain Family
PBP1_STKc_like

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cd06326: PBP1_STKc_like 
Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins
The type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins, some of which contain a conserved catalytic serine/threonine protein kinase (STKc) domain in the N-terminal region. Members of this group are sequence-similar to the branched-chain amino acid ABC transporter leucine-isoleucine-valine-binding protein (LIVBP); their ligand specificity has not been determined experimentally, however.
Statistics
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PSSM-Id: 107321
View PSSM: cd06326
Aligned: 72 rows
Threshold Bit Score: 227.079
Threshold Setting Gi: 94312406
Created: 14-Dec-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein complexed with valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                    ### 
gi 83644476  537 VSLGMSAAFSGga-reLGRAMQLGVDLRIReineqGGIHGRYIELRALDDgyepVAARHNAERFIQpdGVFAMLGNVGTP 615
gi 121603214  31 LLIGQSITLEGgk-ndYGTAVLAGMQTYLSavnarGGVNGRQVVLKTLDDdnksAKAETNARQLVEkdKVFALFGSIEGG 109
gi 73540723   37 IVFGQTIGFDSvw-ggPYRSYTEGLLTYFNhvnakSGVHGRRLIVKRREDnyvpEKTVANVQAFLQd-EVFGLVCMAGTG 114
gi 121604595  28 VVFAQIASQSNpasidNAKGLTTGIQVYFEalnakGGVNGNKLKLEVHDDglqaKNMVELTGKLIDnpAIVGLVGFLNTA 107
gi 17548760   26 ITVAQVLPEGSve--mSMRATTEAAECYLRkvsdaGGINGHTFNVVTVDApgrlDAATQRAAETIRqyRPAALLNYSGSA 103
gi 134094329  29 IVIGQAIDLSSpn-aaIGRDYVAGIKTYFDalnaaGGIAGKKIRYIVRDDqatpAVAVKVVSELIEreQVDFLLGGVGDK 107
gi 91789871   45 VTLGQSVAMTGpa-avLALPFAQGARLYFErvnaaGGIHGREIELITADDagnpETTLANTKKLLDq-RVFSLFGYYGSP 122
gi 91787499   30 IVFGQVASQTNpasaaNAKGLAVGIQTYFAkvnakGGIAGNKLKLVTLDDdlqgPKMLELTQQLVAdpSIVGLLGFLNSA 109
gi 17547866   27 VTVAQVLPFAGqa-gsPIRAAADAAALYLRkasrgDGVNGHVIRVVTVNAprglGASVRRTAETLRqhRPAALLNYDGAA 105
gi 94312406   56 LVVGQLVDRTGpq-adLSRDYLAGAKVLFDay--nASNGSLRIVHVVRDAdtnpRGATAQAVALADseHAEVLFGPGDAL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             ###                                                  #     
gi 83644476  616 Taeail--pvalQDRTIVFGTFSGAallrkspperyVFNYRASYEDETSALIRYFVeekevdprMIAVFYQDDgYGLDGL 693
gi 121603214 110 Psvavm--kaanELKVPFFGPMAGSptlrr-pyqplVFPVRAEHREEFFALISHARslg---mrKVAFLRSDSeTGEQHL 183
gi 73540723  115 Ntlaal--pliaQHRLPVVGTFTGApdvrr--daapLFHTRGGYVDEVMRMVQHAAtig---lkRIAVVYQDNaFGKVNA 187
gi 121604595 108 GmtmlakenafgKGAIALIAPMQGDknvv---eadnVFPLRSGYADEIDALLKEAKtwg---kdTVSIVNMNIaFGPILA 181
gi 17548760  104 RiaalirrgvldATRTPVIGANVAStrvrqdpnnrwVFHVRAGVRAEAAKMVSQAVslg---grQVAILYRDDvFGEDGM 180
gi 134094329 108 VtqavlnapafkRSNLVLFAPLVDAveln----dnrALFWRPTYLQEVRHILSHFAplg---itNVGIVYQDGpSTQQAF 180
gi 91789871  123 Qvtavn--sllkDSDLLLFGPMAGAdelrg-slypnVYSVRPGYSEEAIVITRHAEtlg---mrKLAILHARDpESLAAL 196
gi 91787499  110 GlaemakqdlpvKAGIALITPLQGDkhvi---sagnVFPLRSGYADEVTALLKEAKswd---knEVAIVNMNIaFGPPLA 183
gi 17547866  106 RtlallesgalaASRTPVIGALVSStpvrafadnrwVFYLRPGLAAEADRMVREGLaag---rrRAAILYRDDaSGEDGM 182
gi 94312406  133 Lpalaa-stelsRRGVQIVAPLSGLsln-----aenVWFTRADYQSELDAAVRQLRgfg---ltAVTLAVSPD-FAAGTL 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #                      
gi 83644476  694 KGVEDALSDYgvrPHEIAKFSYqrn----taqIEGAAQGMLGRlsd---iqAVVAISTyt-aSARMTKRLRQAgf---tG 762
gi 121603214 184 ANVRLICQRLg--MTLVADLPFksdi--tdaqLGAMVTQLEQAga-----qMVFNHGGvg-iYEKLIRKARDKam---qT 250
gi 73540723  188 DAAVDAARKY---GAEIATMVVhsvk---gddVAAVVAKLQGAra-----qTTLLFTApq-sVADILTAHQSRhgplpyP 255
gi 121604595 182 ELAQKRATDLg--LKVVSRSVVdfspdaqaasVSAAVKSVVAAhp-----kAILVLAAgm-pAFEFIKAVRAVpe--glG 251
gi 17548760  181 HSSVDALSASg--LEPAAVLPMpt------dmMDSAALTQLAEdvlrvdagAILMFSDsv-nIGGFLRAYRERgg---iA 248
gi 134094329 181 RSVSSELRGRg--LNLSGTLRLsdn----ekqNAQEVAHLAATkp-----gFVIVIADti-gTSLFLKEFRKFss---qT 245
gi 91789871  197 DSAERTMTGMg--ANLLLKAPLe---------GTDKVLAVKAE--------SVLLISApk-gAAIAIRDLRSKgy---kG 253
gi 91787499  184 QLAIQQANAQg--LKIATHQVIdvs----paaFDASVKAAVAAvsks-qpkAVLVLAAgk-pASEFIRAFREApg--gaT 253
gi 17547866  183 RASTAALRTRg--LQPVLHLPFavpmm-dtpsLDRVAEQVLGAd------aDVILIFAdslsIGGFLRAYRARgg---hA 250
gi 94312406  203 AAGTPWLSRLe-kAMSVQTVPLtg-------nFDESARRIAAGrp-----gAVIVGGDtl-aYGSLGRALAAQnw---yG 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                                                          
gi 83644476  763 PFANVSfvgaralaeqfkelgAEYGEGVIVSQVAPPYdsy-atGVLRYREALSRFypn-eqpDFISLEGYIVATLFFHAL 840
gi 121603214 251 AFYAVNsasaq-----lvkrlGELSHGMVFTQVVPSPwerksaITREYQTEFARFmpg-qefSYGSLEGYVTAKALVAAL 324
gi 73540723  256 WILSVTsarqv------fekaGDLSRGVAVTQIMPNPasrvvpLVREFQDVLDQAgvs-dnrTYEAVEGFVTAKVVVEGL 328
gi 121604595 252 QIYGLSvlrhsd---liaitgVNKARGIVLSQATPYPftstkpVITEYQAAMKAHdpk-aalSFSSLEGFLGAKIAAEAV 327
gi 17548760  249 VVTTDStpsade---lvrassVELARSVHLTEVMPPIgkrnvrLVRAFVADMTAAgrpdlarSVTALEGYVAARLFVEAV 325
gi 134094329 246 FVAGTSlinldt---lrelagARAVEWTVFSQVVPNPnagksaIQLEHLTMMKKYrde--ppSSLTLEGFVIAKALTRTI 320
gi 91789871  254 PIYGFSntgesl----ladqlGAAGSGVVVVRVTPKSdnakssLVRELQAEAAAAklg--ksNVYMLEGYIAAWAYTEAL 327
gi 91787499  254 QVYGLSvllhda---lvnavgADKARGIVLSQAVPYPfipskaVINEYLTDMNKYaag-qplSFSSLEGYLGAKIAAEAV 329
gi 17547866  251 LIATDStpsapa---lvrassVALARGVRIAQPMPAPgerrtrLVRAFVADMRGGgrpdlagSAEALEGYASARLFVEVL 327
gi 94312406  266 FLVGLSavspvs---areilgTGYAGGMVVTQIAPGPqestlrVVKEHVARMKQYlde--ppSPATLAGYIGAAWLVRAA 340
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
Feature 1                                                    
gi 83644476  841 EkagrhfdteslvntlesfdgvdLGIGETITFRASNHQGSHRVW 884
gi 121603214 325 Rlagtspsreg--fvtalegatlDLNGLRASYDSSNHQGLAFVD 366
gi 73540723  329 Lacgtnpsrelf-iskleafgkrEFGGLRVHYDRNRHSGPDYVE 371
gi 121604595 328 Rraganpsrerv-lgalktmqeyNLGGISVNYSAQARKGWGGVD 370
gi 17548760  326 Rrisgpvtgeav-rtallqrgpfDLGDFEIRFGPAQYEGSRYVG 368
gi 134094329 321 Qkskrplhmal--qdflaqdsniDLGGLAISSSGRNNHLSNYVD 362
gi 91789871  328 Rkagkeptrvkl-rkaldtmqemDLGGFRIHFDGDRVGSKLVEL 370
gi 91787499  330 Hragsqptrakv-laaltnlgefDLGGLYVKYTPVKRQGWGGVE 372
gi 17547866  328 Rrirgpvtgeav-rtalqtrgpfDLGGFEVDYGPSQYEGSRAVG 370
gi 94312406  341 Sgikapgpve----lrralqtrvDVGDFMLDFTRGLRGSQYVQL 380

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