Conserved Protein Domain Family
PBP1_SBP_like_1

?
cd06327: PBP1_SBP_like_1 
Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family
Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family. Solute binding proteins are the primary specific receptors that initiate uptake of a broad range of solutes, including amino acids, peptides and inorganic ions. The members are predicted to have a similar function to an active transport system for short chain amides and urea by sequence comparison and phylogenetic analysis. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus may also be involved in transport of amino acids.
Statistics
?
PSSM-Id: 107322
View PSSM: cd06327
Aligned: 80 rows
Threshold Bit Score: 287.528
Threshold Setting Gi: 146282614
Created: 12-Feb-2007
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   ###  
gi 83311426   30 KIGVLTDLSGtysdlAGKGTIVAAQMAIddfg--gklnGQPIELISADHqnkaDIASGIARKWYDteQVDAIAELVTTaa 107
gi 163705178  38 RIGMIYAKQGpg-asIGEYLQRGSTLAVeqag--rkvlGRPIELVWLDEpn-pQVSQQNMQRLIDenKVVAVVGGNYSss 113
gi 148243967  41 KIGMIDPRTGty-aaAGFSEIHGATMAIdeinkkggilGRPVQMFVEDSeslpGPGVTKAQKLVAedKVNFLMGAVNSat 119
gi 154244387  67 TFGHLTPLTGfl-gpLGAYGQMGVQLAVeelnaagginGRKINLVMEDSvn-pATASSKAERYIErdKVPVIIGEISSas 144
gi 121611607  56 RIGHLTPRTGfl-gpLGEYAVMGISLAVeeinatggvlGRPLELIAEDSvnpsTASSKAQRLLERd-GAVVLIGEISSas 133
gi 69937845   36 VLGHLTPRTGfl-gpMGEYAVMAVDLAVeeinangginGRMLTVVKEDSvnpqTATTKAERLVERr-DLAMIIGEISSas 113
gi 27378774   47 KIGMIWAKTGsi-vdQAEYLAQGGMLALeqrn--ntllGRPAEIVWLDEpnpqGAQQSAERLVGEq-KVVGMVGGALSsf 122
gi 17549517   41 RIGMVDPMTGvy-aaVAQNEVTGARLAVaqinarggilGRPIELLVEDSandvGTGVQKARKLIErdQVSFLIGDVNSgi 119
gi 91974530   31 KVGALLPLSGny-gfLGVTERLGIDMAVeevnsaggilGKKVVVVYEDAgtpaQTTRKATQMLEQd-KVAFFVNGGGSav 108
gi 163724938  25 KFGIVLPLSGpy-aaMAQDMKNGAMLATeqvneaggvlGGQAELIVKDSqlkaDIALRRVKEMVEeeNLTVIGGNLSGai 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          ###                                                  #        
gi 83311426  108 aiavrevskeKGKIDLVSGAASTpltndkcsatgfHWTYDTYALANGTGDAVVkng---gkTWFFLTADYaFGHNLQAQT 184
gi 163705178 114 alammsvanrEKIPLILTGAAASeitgkncnrytfRTQATVPVQMRGLMPFVSqi----gkKVYFLTASYaFGQDILRSG 189
gi 148243967 120 aeslsqfalqHNMLYIDTGGHVDdvtgskchwttfRTCSTTWMLTAGDFETLFkkf---gkKWFFITPDYaFGHAEHRDY 196
gi 154244387 145 alaisqvaarNKVVFVNTGGNSDalrgkdcnrymfHVEGANTQYVKAVGAAMVrdglakgkKLFFLTADYaFGHDLSRVA 224
gi 121611607 134 glaisqvatrNRRIFVNTGCNSDelrgkncsrymfHVEAANTTYVKACGGALLrdnmikgkKLFGLTADYaFGHDLLKAA 213
gi 69937845  114 alsiaqvtarANKLFINTGANSDtlrgsdckrtmfHTEAQNVMYVNAEGQYFLqndmvkdkKWFILSSDYaFGHDLRHGA 193
gi 27378774  123 alaissvakkAKIPYVAANAATGdltgkscnkytfRLQPPVDVHARVLAPYCAai----gkKWYLLTASYaFGQDIKRAF 198
gi 17549517  120 aqaiaqvsneKKVLHIVSGGHTDtitgsdckwnvyRVCNTTSMEANAVANLLFsky---gkKWHFITPDYaFGHTLQKAA 196
gi 91974530  109 satmfefaqrNKVIDLAIDPNAEelvttkagkyafLVPAPSSMIANAVIPEAIkl----gkTAMFLTHDYsFGHAQTGEQ 184
gi 163724938 104 slvineyackNNLLYMSYCYNSLpvgkef-cgkgfTSAVIPYQNPDALATYAFknl---gkTWMSLSADYrGFHDMMASW 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                    #                          #        
gi 83311426  185 EKVVka-ngGTVKGSVKHpfpnsdFSSFLLQAQSSgaqIIGLANAgadTINAIKQAKEFgitqagQSLAGLLvfitdvhs 263
gi 163705178 190 RGLLke-vgATEVGVDEVpvntadYSSYILKIRQArpdVIVGGLVggdFSNYLKQANEMgmk-drARFAAIAvtdtdfwd 267
gi 148243967 197 VKQLqk-agGKSVGNALAplgttdFSSYLIRARAAkpdVLICLQAgddLVNLLKQAVQFgl--dkQMAIAGAlqemevle 273
gi 154244387 225 KIYIaa-ngGEVVADELVptdatdFSPYLLKIRQVrpdVVISNLAgnqITNFIKQYSEFgl--kyPFGGFGFdtav--aw 299
gi 121611607 214 KRFVta-ngGSFVQDELVatdatdFSPYLLKIRQAkpdVVVSNLSgnqITNFIKQYAEFgl---pYPIAGFAldtal-aw 288
gi 69937845  194 LGFLer-hgGQAVGDELIptdatdFSSHLLNIRNLqpdLIVVNLAgtsGASFMKQYGEFgl---dIPLGGFDynssi-aw 268
gi 27378774  199 TDYIta-ngGTVVGADEVpvgtpdYSSFILKIRAAkpdVVIGGIAasdLTTFLKQWNELgmk-gkIPFAEISvgntdlwg 276
gi 17549517  197 AADLqk-lgGTITGNELTplgttdFSAYLIKARAAnpdVLLVLPQgsdMVNCLKQIAQFgig-kqMHIAGLQqeles-le 273
gi 91974530  185 RRVLkdkggVKEVGEIKIplntrdFSSQIIAIRNAkpeMLIINVAgvdATALLEQIWEFelykqtKIVVPLLdfeds-wa 263
gi 163724938 180 MYNSdq-lgGEFKGNIYHplgtrdFSTYIPRILAEspdILVLNNYgadQIAAIKQFSQLglt-kkMKIVISKthlhiake 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 83311426  264 lgLENAQGMMLTTGFywdm---ddqtRAWSKRWSEKmgggk--mpsmVHAGTYSQVLHYLraaaaaktdegik---vade 335
gi 163705178 268 vgPAASTGIYVKPWYyndpt-ntaaeKKMVADFEKKynqp----psdKTWSGWIGMRALLesieaakstdak----aivt 338
gi 148243967 274 slPKAALLGWWTFEWywnqp-gvphvADFVTAYKRRfgdk---vptaRSWFGYVSAHSIAlaanqaktldslkvvkaleg 349
gi 154244387 300 gaGKGTFGGLWPLIWhhdvp--tadsKAFVAAFVKKfgkp----penQAWGDYVATKVVAramietksttaad--ligyf 371
gi 121611607 289 gaGADNFAGIWPLTWhhevp--apaaQAFVAAFVKKygrp----penQAWGEYVALKAMVqamaetkgtdpak--mieyf 360
gi 69937845  269 atGPQDFKGTWPCIWthqvq--tdasQAFAQAFQAKygkp----aenQAYSDYIAVRIAAeaiaktggtdtaal-iefle 341
gi 27378774  277 vgPEAADGLYTITWWyknpn-nspeeQAMAAAYEKKyhrp----aadKAWMGWLGMKSLLdsiemakstepg----aivr 347
gi 17549517  274 amPPEARVGIWMFEWywkqp-gvpgvEQFVADIRKVnngk---vptaRHWFGFTSVHTLAavanrektldsrklaealgg 349
gi 91974530  264 igREKNQLIALAGIEwhynv-paadaLAFKERYQKQfpkaeypvpttNTVNAYLGVRETLraiqragsldsak--ivaal 340
gi 163724938 258 cgKAYDNNIYGGATYywnmnaageenKKFVEAFTAKygap----psgDAEAAYVGTKAVWqaiaktgaadnvd---alid 330
                        330       340       350
                 ....*....|....*....|....*....|
Feature 1                                      
gi 83311426  336 mrklpindFFAKNGKIRa-DGRMVHDMYLA 364
gi 163705178 339 alekwkntDGDIPAFFRewDHQLVRPAVIV 368
gi 148243967 350 melppeiaLQPGKVHYRagDHQMMANMFPG 379
gi 154244387 372 ekepeldiLKGRKGYFRawDHQLIQEMYTV 401
gi 121611607 361 ekgapievLKARKGSFRawDHQLLQEMYTV 390
gi 69937845  342 dpatefdiLKDRKGRFDaaTHQLLQEVYAV 371
gi 27378774  348 alenwkyrRGNLDIGYRdfDHQMTSRLLVA 377
gi 17549517  350 faladdvkLQPNKCYYRkgDHQLMTSSFVG 379
gi 91974530  341 enhevkdsLKPNPLVIRakDHQWMQDFFVY 370
gi 163724938 331 altsmtiqTPKGSEQFRacDHARQQSILVL 360

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap