Conserved Protein Domain Family
PBP1_Arsenic_SBP_like

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cd06330: PBP1_Arsenic_SBP_like 
Periplasmic solute-binding domain of active transport proteins
Periplasmic solute-binding domain of active transport proteins found in bacteria and Archaea that is predicted to be involved in the efflux of toxic compounds. Members of this subgroup include proteins from Herminiimonas arsenicoxydans, which is resistant to arsenic and various heavy metals such as cadmium and zinc. Moreover, they show significant sequence similarity to the cluster of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa.
Statistics
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PSSM-Id: 107325
View PSSM: cd06330
Aligned: 28 rows
Threshold Bit Score: 339.243
Threshold Setting Gi: 76800742
Created: 6-Mar-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   ###  
gi 134093666  41 RIGIIAPRGGvagtIGECGLRGVEWTTARINaag-gigGRKVELVIQEEts-pKDTIDRFRKLVLqeKVDCVQGIVSSgv 118
gi 116749745  51 RIGVLLPTTGsganYSERPIKILPLVAAQINarggflgKHPIELYFRDTqtkpDVGAREARSLILndKVKTIIGTWSSav 130
gi 163699586  41 RVGMPTILSGrvaiLGTSSRAAVQLAFRQINdag-ginGRTLELIERDSkgrpDEAAKVTRDLINndGCEIIIDGEASsg 119
gi 163796812  29 KIGMPTIMSGrvaiLGESSVDAAMVTVRRVNkag-gidGRMLELVVRDSrgkpDEAARMTRDLVNneGCEIILDAEASsa 107
gi 153004040  30 KLGFAYIFSGtnaiYGQFARQGAELAIEEVNrqg-gilGRQVEARFEDEagkpDVGIRVVRKLVFddGVDAVIGLDSSgt 108
gi 72384289   42 KIGLTTDLTGiaaaYARSQVNGVQLAVDQINasg-gllGRKLEVLVRDSqlkpDLGTSHTRDLITreNVDFLIGPDGSav 120
gi 152998415  34 NVGCLFPLTGrgglYGEDSKIGIQLALEQLAnkt--dhYPSLKIIIEDSrskaSRATRLVKELVRnhQTRFICGVVNSsi 111
gi 126666426  44 TVGCLYPMSGragiLGRDSVVGIRLALKYLEqqa-sadSPRLRILLGDTkskvSTATTLARRFIEdeGASFLCGVVNSsv 122
gi 126664341  32 RIGGIYILSGsaatYGEFAQKGINLAVDEINasg-gilGRQVEMVYEDSqgkaSVAIQAARKLVYseGVDALVGLDSSgv 110
gi 27378294   39 KVGMPTILSGrvaqLGTSSRNAVMLEVDKVNaag-glaGRPIEMVIRDSkgqpQEAARVARELVNtdGCEWLIDGEASsg 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          ###                                                        #  
gi 134093666 119 slalapaaedSRMPTIFWDGTTQdgvketmpkpkYVFRSTDNECEAVMASLLAIKhfkg-----kfkRIACVNPDYsYGR 193
gi 116749745 131 amavqeiiheHKVLHLTATSNSSkivhe--nftpYTFMFGPDTRMQSGATVVAVAklike---kgwkKYATIGLDYeWGR 205
gi 163699586 120 afavhevirdLPVLCLHTCSETSsltadpklhvkTAFRSARQGIHDAVAGGTYAAriake---kglkRWMTCSPDYaYGR 196
gi 163796812 108 sfavnevvrdVKKFCIHTNSETSsltadpknrvpWVFRTARQGIHDAVGGGLYAAkvske---kglkKWATVSPDYaYGR 184
gi 153004040 109 aegvapvmpeLETPLIITHAATPhvtga--rcnaWTFRISLSLPQNIAIASTIAAegk-------arRWTTVGPDYaFGH 179
gi 72384289  121 gmtvsavakqYKKVVMMTIPNSPritte--tfhpYVFTVVPSGVMEARAMAAAIGpg--------nkRIAFIGGDYeAAH 190
gi 152998415 112 awqvaqvaeqENAFFIGTDHASSrmtdt--gkrpLYFRVSNNTQQSMLAGAKYIRehfpss-askpiKISYIGPDYeYGY 188
gi 126666426 123 aieitsiaeeTGVFFIGTDHASSrltse--flhdRYFRVTNDTQQSMTAGALFIReyfsdhlsqkplRISYLGPDYeYGY 200
gi 126664341 111 aqgmvptmpeLQKPLIITHAATPdvtgk--lcnaFTYRISVNVAQNMKAAALVAEkld-------atNWTTIGPDYaFGH 181
gi 27378294  118 sfavhevardLGVLCVHTCSEASsltadpkqhipNAFRCVRQGIHDSIVGGSYAAaiska---kglkKWATCSPDYaYGR 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #                         
gi 134093666 194 NTWTAFQALLkkygieHEVVSEQWSkig---nldLTSNVAALKAAkpdLIFSSLLfadLPVFMKQAHNAGLTe-gTRFVL 269
gi 116749745 206 DAQKVFVENLkaaspgTELMKELWAklg---etdFTSYITAVMSLkpdFLFGAIAgkdNETFLQQAKAAGLFk-sVSYPG 281
gi 163699586 197 DNTAEFLEFAkhfepsIEAVDQVWPklf---apdYTESITKILQVkpqAIYSALWggdLVAFVEQGNLYRLFg-nIGFFS 272
gi 163796812 185 DNTKEFMEYVkifapdVEIVEQTWPkif---qpdYTENVTALLNAqpqAVYSALWggdLVAFFDQASLYGLFd-qFQAFA 260
gi 153004040 180 ESWEYFKKDLarkkpgVTFVADGEAafppskttdFSPYITKVMASdadGVLVSLWggnLIDFVKQANELGFFk-gKREIL 258
gi 72384289  191 QGLKYFKDWLakvnpsAEIVSEAWPklg---epdYSSYITSLMSSkpdVIFSYLWgadLIGFVKQGKPYGVFt-kTKVAS 266
gi 152998415 189 TMWDDLEDALkqqqvnYEVVTTLWPkly---epnYFTFIQALLEKptdLIVNAMWggdLVTFIQQANSTNLFq-hARFAN 264
gi 126666426 201 QVWADFREALerfnvdYEIAGVLWPrln---epdYSHYINELIKEkpdLVVNSLWggdFVAFVTQATNTALFq-gSRFAN 276
gi 126664341 182 QSWEFFGNYLkelkpdVNLMSETNFprfg--aedFTPFIDRVMDSdadGVLISVWggdLVNFIRQANNRGFFekdYELLF 259
gi 27378294  195 DTTGEFTLYLkrfapdVEVISESWPklf---qpdYTEVVTKILQAkpqALYSCLWggdLTSYIDQANIYAMFs-qMEVFA 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                              
gi 134093666 270 PAagwqh--tamkkEFTPEGIVWGHNTmyfddpkasatqKEFVKWYADKyk--dyPHWEADRAYFSMMVYKagvekalaa 345
gi 116749745 282 VFlpvte--lmqqrQTLPRGIIGLNRCpffahm-dnpimQNYVKIYQEKfgkddyPDDFACMYADSLNALDqavtkastv 358
gi 163699586 273 GGlgdpp--vltaiKQLPPGLNTAYRYnrnyp--mkpanTAFADGFAKIag--hdPTNWAWQCSLACSFIAealkrtggr 346
gi 163796812 261 VNlgdyp--vitaiKSRPEGVHSGSRYhkdip--dtaenEAWYEEFIANsk--vlPTNWSWENATGMDFIVaalqetggn 334
gi 153004040 259 MTlgaate-vltalGDRMPAGLWVGTRywfqgs-aspmnKAFVEGYRKKfg--vyPSYNAHGAYAAVLAYKaaaekakst 334
gi 72384289  267 LVflddl---kalgDEMPDGVIAQMRApffal--tgdrmTKFTEQFRAKyn--dyPADWAIMGYEGMQILAqaiksansl 339
gi 152998415 265 FDtganfevlaalgEDMPEGLILASRHhnnwp--dtafnQWFVSRFHELsg--ryPSYAAEGAYSGIMAIAeavhlagvd 340
gi 126666426 277 FEkggdyeifaqlgNQMPLGLLLASRHhnnwp--etdfnHWFVEEFRRKtg--yyPSSGAQGAFTGIVAIAeavkkagan 352
gi 126664341 260 TVgaate--vlsalGDEMPEGVHLSTRywyday-dndvnAHFVKAYVDAyd--vpPSYNAEGAYAAIYAYKkameaagtt 334
gi 27378294  271 VNmadyt--altvvKNLPKGIHSGNRYiktfp--ttpenAAWGDAYKSKyn--eyPTNWSWQNATAVMFLAeaakkanat 344
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
Feature 1                                                      
gi 134093666 346 kkswptpeeicaaipgvqvesLGGKGAMRA--DHIAN-QTFHQGLS 388
gi 116749745 359 etea-----irkaltgatvdtCRGKLPLRDc-NNQLD-APSYVGEV 397
gi 163699586 347 tegtal-aaelkgmklaspfaVDDAITMRDs-DHTIIgYPVAWGRT 390
gi 163796812 335 tdaekm-aaatagrtidspfgVGGKLTMREa-DHTLVnYMVGYGKT 378
gi 153004040 335 dkaa-----vakaleglavevPLGKIVIRAe-DHQAV-QDGVWGRT 373
gi 72384289  340 esda-----ivkaveqvkydgLRGPISFRAl-DHQGT-VGSYIGTV 378
gi 152998415 341 atneel-qtvlenlviklpedPVGFSSYMDanTHQLQ-QVISIGTS 384
gi 126666426 353 yqdptaiqqafetltlttpedPIGFQSYMDpnSHQIQ-QVMAIGET 397
gi 126664341 335 dasa-----vakalsgmsmeaPNGTITFRKg-DNQAM-VSPNWGIS 373
gi 27378294  345 dgkki--aevlagltikcpfgADGTVTMRGd-DHTLVgYAIGWGTT 387

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