Conserved Protein Domain Family
PBP1_ABC-type_HAAT_like

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cd06333: PBP1_ABC-type_HAAT_like 
Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids
This subgroup includes the type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids. Members of this subgroup are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine-binding protein (LIVBP); their ligand specificity has not been determined experimentally, however.
Statistics
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PSSM-Id: 107328
View PSSM: cd06333
Aligned: 52 rows
Threshold Bit Score: 283.684
Threshold Setting Gi: 159039786
Created: 2-Jul-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                  ###   
gi 113866605  41 TVGVSLSTTGPSAsLGIPQKNSLAYLPqk------igGEAVRYIVLDDasdptQGAKVARRFVSEdKVDIILGSSAVaps 114
gi 56421561   33 KIGAIFSASGGAApLGKPEMETVKMLVeqwnkqggidGKKIKLIAYDDksnqnEAVLSTKKLIEQdKVTAIIGGTISgns 112
gi 116751482  38 KIGAVFSITGVGSfLGEPEKKTAEMIRdeinkqgginGHPVELIIYDDesdttKCTLAVKKLIKKdEVPVIIGPTRSges 117
gi 39996834   27 RIGALFSITGPASfLGEPEKNTLEMLVkdanarggigGRKLELVVYDTqgdvtKAVQLANKLIKNdKVSVIVGPSTTget 106
gi 39996833   29 RIGALFAVTGPASfLGEPERNTAQMMVnkinaaggikGRKVELIVYDTqgdatKAVQAANRLIKDdKVVAIIGPSTTgdt 108
gi 116749116  33 KIGGLFSVTGPSSfLGDPEKKSLELAIdeinarggidGHLLEAVIYDTegdpgKTNLNASKLMTKdNVIAIIGPSLTptt 112
gi 95930553   25 KLGAFFDLSGRAAfIGTPTKLVAEMVVdkinsegginGKQLELVIGDTeanpaKAASLAKKFIYKdNVVAIIGPTMTdtg 104
gi 163723099  34 KIGGIFSVTGGASfLGAPEKLSMQMVVdqinaaggidGHMLEAVIYDTkgdptEAVNFANKLINKdRVLAIVGPSTTptt 113
gi 158520850  30 RVGCIFSVTGKASwLGEPEKKTAEMLAekinaagginGHKLKLYIEDDqgdntRAVNAAKKLINRdKVCAIIGPSVSgat 109
gi 116747826  35 KIGAFFALSGPASsIGTPTKLVAQMVVdkinkegginGTPLELVVGDTesdptKALMEAKRLIEAgKAAALIGPTRTdeg 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          ###                                                 #         
gi 113866605 115 iai-aevadeAQTVQLAFSPIelkp-----grggWTFRLAQPVRLMANAVAATAKtngvkTIGFIGFADaYGETWLKDFT 188
gi 56421561  113 lam-ipliekAGIPYISLAASkqivnpsdgssrhWTFKTAQGDNIVIQKLLGFLKekgwtNVAWLNVANaYGTSGHEEFV 191
gi 116751482 118 iav-atvaeeSKVPLISCATSykivtp--iesrkWVYKVAGSDAHVVGKMYDYMKgkgvkKVAIMTDSSgYGASGREELL 194
gi 39996834  107 mav-iplaekEKIPLISCAAGikitd----pvkkWVFKTPANDHVAAEKILIQAArlkqkSLAIITVSDgFGSSGREQLK 181
gi 39996833  109 mav-ipivekAQIPLVSCAAGskite----pvkkWVFKTAQNDGLAVAKIYEQLNrlrmsKVAILTVSDgFGSSGREQLK 183
gi 116749116 113 lai-vplaekQPVPLISCAAGilite----pvkpWVFKTAQSDVLAVAAIYGHMQkknikKVGIITVESaYGESGRDQLT 187
gi 95930553  105 mtv-kamagkGKTPIFMTVGGdpvimggkfgpfdWVFKSPQRSSIAVQRLFDYLRakgltKIALLSAADgFGKDGARWIK 183
gi 163723099 114 mav-iplcvrARLPLISCAAGngivn----piqpYVFKTAQSDIQAVATIYAYMKeqgmkKIAILCVDNgFGASGAVQLR 188
gi 158520850 110 mai-lpvmqeAEIPLVSCAAAavivep--vaerkWIFKTPQKDSDAVRRIYEHMIsrgikDVGLITGTTgFGNAGRTQLK 186
gi 116747826 115 mavkayiedtAHIPIVMTIGGdpviaggkfgpfkWTFKAPQRTSVAARKTYDFIRslkltKIAVLTATDgFGKDGLTWLE 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  #                        #            
gi 113866605 189 AAAsangIRLIATERYgraDTSVTAQAIKLIAAKPDAILIAGAgtgAALPHTTLRERGYg-GTIYHTHGaat-kdLIRIG 266
gi 56421561  192 HYApeygVKAVIEEEFeatVDDAKAMLTKVKKANPQAIIVWGTaqeSAVVTKNIRQLGIe-APIVESHGigt-ksFIDLA 269
gi 116751482 195 RLApeygFTIVADERFdpkDTDLTAQMTKIRGTQPQAVVNWSIgptQILAIKTWRDLGMdaIPLFQSHGfgs-lkNLELA 273
gi 39996834  182 ALAgqkgFRIVADEVYgpkDTDMTAQLTKIKAAKPDAVICWGTnpgPALIARNMKQLGIk-VPLYMSHGvaskkfIELAG 260
gi 39996833  184 AQAaqhgIQIVSDDTYgpkDTDMTAQLTKIRSSGAQAVICWGTnpgPAVIARNAKQLGLa-IPIYMSHGvss-kkFIELA 261
gi 116749116 188 AQApkfgIQVVQAETFgakDTDMTAQLTKVRSAQPEAVICWGTnpgPAVIARNFQQMGFk-IPLYQSHGvas-pkFVELA 265
gi 95930553  184 KLApeygIEILAEESFgtrDTDMTAQLTNAKNANPQAIVTWTIgpaGSIVAKNKAQLGId-LPLFQCHGlpd-pkYIELA 261
gi 163723099 189 EQAakfgLEVVSDESYggkDTDMTAQLTKARKAAPDALVCWGTnpgPAVVAKNAKQLKLd-FPLFMSHGvas-pkFIDIA 266
gi 158520850 187 DLApeykMNIVADETYgpaDTDMTAQLVNIRNAKAQAVINWSIvpaQSIVPKNMKQLNMt-IPLYQSHGfgn-ikYVEAA 264
gi 116747826 195 QLApefgLEIVAKEAFgvtDTDMSPQLLKIKASGAQAVICWTIgpaGARVAKNVKQLALg-IPLVQCHGqpd-pkYIELA 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 113866605 267 GRMVNGAILPAGPVIVPEQLPagdpvrkpGLDYVTRYEKQygad---srtqFGAHAYDAGLVLErivpvalrharpgtpa 343
gi 56421561  270 GEAANGVWFPAGRILVADQLPdsdpqketLLKYKEQFEKAygya----pttFGGHAWDAFHLLVnaikeggadqekir-- 343
gi 116751482 274 GKAAEGVLLPLARVNVGSLLPdsqpqkkiILEYTRAYETLykep----issFGGHAWDSMHLAMaalkavgpdpakir-- 347
gi 39996834  261 ADAAEGIMLPAGKLAIFDKLPkndpqyklLKSYDESYRKAygve----astFGGYAYDSFLLISgamkkgtspqqird-- 334
gi 39996833  262 GDAAEGIILPSGRVIVADLLPaadkqkksLMAYVKDYQKQfkae----gdhFGGHAWDAVMLLKgalerggdrpaair-- 335
gi 116749116 266 GEAAENIVLPAGKILVTDQLPdsdpqkavLKRYVEQFTGRfkqp----vspFGGYAYDAMMILAkalegtegkkdavr-- 339
gi 95930553  262 GSASEGDRMPSTKLLVADALPdsdpqkavIQEFIQLYKEKgydkq-fpintHSGYAWDAIMIVAnamkqvgtdkaalr-- 338
gi 163723099 267 GDACEGVMLPTGAVLIADTLAadyhqkaaLDKYIGDYKAAykag----vsgFGGYAYDAMKILEialkgtngdkakir-- 340
gi 158520850 265 GEAAEGIIFPAGRLLAVDTLSgdnpqkalLAAYKAEYEARynep----vstFGGHAYDALSIVVkalekagddpakir-- 338
gi 116747826 273 GDAAEGSIMPSTKLMVVDQLPdsdpqkavIMEFIKLYTDVyhfdkqypintHSGYAWDAIYLAAnamrkvgtdaeklr-- 350
                        330       340       350
                 ....*....|....*....|....*....|....*....
Feature 1                                               
gi 113866605 344 frqalrqaleterdivvshgVLNYSGQDHYGFDQRGRVM 382
gi 56421561  344 ------salentrkfigisgVFHMSKDDHTGLDADSLVM 376
gi 116751482 348 ------dhieqtkgfvgmhgIFNFSPQDHCGLSKDDLEM 380
gi 39996834  335 -------gleqtrklvsvsgIFTMSPSDHNGLDLSAFEM 366
gi 39996833  336 ------dqlektrnfagiggIFNYSAADHAGLGKDAFVL 368
gi 116749116 340 ------krieevrglvgvtgTFNFSPQDHNGLGPDAFVM 372
gi 95930553  339 ------eaientkgyvgvsgIYNLTAEDHNGLDTSSMVI 371
gi 163723099 341 ------dnieaiqgyigvtgTFTFSPTEHNGLGADSFIM 373
gi 158520850 339 -------dtietiefvgtggVFKFSAEDHTGLDKNAFEM 370
gi 116747826 351 ------aaieqtkgyvgvsgVFNLTPEDHNGLGTDSLVM 383

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