4F8J,3TX6,4JB0,3UK0,4DQD,3SG0,4FB4,3UKJ


Conserved Protein Domain Family
PBP1_ABC_RPA1789-like
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cd06333: PBP1_ABC_RPA1789-like 
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type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, RPA1791-1793), involved in active transport of lignin-derived aromatic substrates, and its close homologs
This group includes RPA1789 (CouP) from Rhodopseudomonas palustris and its close homologs in other bacteria. RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793) that is involved in the active transport of lignin-derived aromatic substrates. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).
Links
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Statistics
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PSSM-Id: 380556
Aligned: 95 rows
Threshold Bit Score: 279.047
Created: 2-Jul-2007
Updated: 2-Oct-2020
Structure
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Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:4F8J; Rhodopseudomonas palustris solute binding protein of ABC transporter (RPA1789) binds P-coumaric acid, contacts at 4A
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  • Structure:3TX6; Rhodopseudomonas palustris solute binding protein of ABC transporter (RPA1789) binds 4-hydroxyphenylpyruvic acid, contacts at 4A
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  • Structure:4FB4; Rhodopseudomonas palustris solute binding protein of ABC transporter (RPA1789) binds caffeic acid, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #                                                            ###  
4F8J_A      9 TIGITVTTTGPAAaLGIPERNALEFVAke------igGHPLKVIVLDDggdpTAATTNARRFVTEs-KADVIXGSSVTpp 81  Rhodopseudomonas p...
KWT97483   38 RVGLLVALSGPAAaYGADERAAIEAVTeranaagginGRKIELIVKDTktnpTEAARLANQVILDd-KVIAIIGATTGse 116 Variovorax sp. WDL1
EER62061   36 KIGVLLSLSGAAAtFGIPERDMVKVLAekynaeggfrGRKLELVFHDDqt-nPTESARGATKLIQqdKVVVIIGPTIGsa 114 Acidovorax delafie...
KRF22294   47 KIGVVVPVTGFLSpLGLGDKAAVEQEVkaindaggvlGRKLEVTIKDDksdvPQSVTEFNQLAADk-SYSAILSSSFVsa 125 Phycicoccus sp. So...
PDT50927   34 KVGVILALSGPAApFGIAEADAVRILVdrynkaggvnGHQIEAIYHDDqsnpTEGARGATRLIRQe-GVQAIIGSSTSss 112 Sinorhizobium sp. ...
ABL83624   47 RVGLLFSLTGPAApYGISERNGARVVLdqinedgginGQQIEIFEADDktdpTEAAQQARKLITQd-KVDVIIGTTAGgn 125 Nocardioides sp. J...
KQY15023   14 RIGALLSTTGGLAgLGIPQRDGVLLAQklinanggvgGEPLEILMEDDgsnpDAAMTKVNTLVHSq-GVKAIVGPTGIaq 92  Rhizobium sp. Root...
CNG45995   31 KIGFIESLTGNYApLGGEAKKTVELAVdqintaggidGRKIKLITLDDrtapDQGVLHFNKLKSE--KVTAIIGSTFSnv 108 Mycobacterium tube...
PBI95826   45 RVGALLSTTGGLAaVGLPEREGVLLAQkvvnargginGRPLEIVLEDDgsspDSAVAKANALIHTq-KVRAIIGPSGIaq 123 Variovorax boronic...
OQM76054   31 KIGVSEPLSGAASsLGVPVVDSIKAAAevinanggvdGRKIQLVIRDDqs-rPDIAVQNFRRLSEe-GVYAMIGPNQGsn 108 Pseudaminobacter s...

Feature 1                      # #                  #                           #    #        
4F8J_A     82 TVAVSNVANEAQVPHIALAPLpitp----erakWSVAXPQPIPIXGKVLYEHXKknn-ikTVGYIGYSDs-YGDLWFNDL 155 Rhodopseudomonas p...
KWT97483  117 TLAFADLAMRSKVPVFPMVGTqsvtdpkeafskWMFRMSVPISTDLPASFDRIVadk-rkRLAVFSEEDa-YGQQASAMM 194 Variovorax sp. WDL1
EER62061  115 ALAVLPIAARAQVPVLTPVGTisvtakensffpWVFRTCPNDELLVTASMETAVlkagykRLAVMYQEDa-YGKNSAAFA 193 Acidovorax delafie...
KRF22294  126 STAVGPSAKTAKIPIVALGPVsafad---gsnpYAFTGVAVPEVYARAMVDYLAaqk-isSLAIGYTGKdlYGETGNKAT 201 Phycicoccus sp. So...
PDT50927  113 TLAFAPIAAQAKIPVFAPVGAqsltskshaffpWVFRTAPGSQVTMQSMMLNVVfkpgikKVAIMHQEDa-YGKEEAELA 191 Sinorhizobium sp. ...
ABL83624  126 TLAYAPIAAGLKTPILATNGTisvtdkandfwpWIFRSAPSDLVTMQAMFDQVVaeg-ktRIGIFAEQSa-YGDASVAYL 203 Nocardioides sp. J...
KQY15023   93 TVAIGSVTQPLNIPVLAFTGIgpave---narnCVFHMTPAQGLNARALLSYAKeig-akRVGVLHDSG--YGQVIWGVM 166 Rhizobium sp. Root...
CNG45995  109 GLAVEPLAERERIPYISLSPAdeqvn---pirkYTFVVPAISSTYAEAMLSYFKahq-itKVAVAYDTKsaYAKAGFAGM 184 Mycobacterium tube...
PBI95826  124 TVAIGGLTQAQKLPLVAFSGIgpave---rersCVFHMTPSQELNARAVLSYARdtg-akQVGVLHDSG--YGQVIWNAM 197 Variovorax boronic...
OQM76054  109 TLAVSAIVKQAKVPTCAFNNTiaitk---qnnpYIFRCQTSDADNVKAALLFAHdklkakNIGVLYTSDa-YGSDAYAAL 184 Pseudaminobacter s...

Feature 1                                                  #                        ##        
4F8J_A    156 KKQGea-xgLKIVAEERFarpDTSVAGQVLKLVAANP-DAILVGASgt-aAALPQTSLRERGYkGLIYQTHGaasxdFIR 232 Rhodopseudomonas p...
KWT97483  195 IEVAkksgqVEVVEHASApkaATDLTAQATRIRNAKP-DAVFLATSstgsAGALLRKLQEVGLdVPVYGMAGivqkqIIK 273 Variovorax sp. WDL1
EER62061  194 EKFAke-hgIEIVSLASApaaAVDLSATATRIRAANP-DSVLLWTStpamGAAFVRAARQVGLnVPIIGSGAlvqrsFIE 271 Acidovorax delafie...
KRF22294  202 VAAAke-agIDVVLDEPYdqtATDFSALVSKVKAAKP-AAFLVWGAg---PAPVIISKQFAGSgIPLLMTGAqasqlYVK 276 Phycicoccus sp. So...
PDT50927  192 TRLIkekggIEVVATVSAplsATDLSSAATRVRNSDPdLVLLLTSApa-mAGAFVRGAEQAKLtAPIVGSLSinqqaFVD 270 Sinorhizobium sp. ...
ABL83624  204 EEQVek-agLEIVAETSAavtDTDFTAQATKLRNADP-DVVLLVTGatalGVGIARAVRQGGSdVDMWGGIGlaqqgFID 281 Nocardioides sp. J...
KQY15023  167 SKLGde-fgVEFVQVEKFelsASDATAQAAKVKASEP-DAVIVLSS----LATPFRNLRQVGLtAPIISVHGta-tyEIV 239 Rhizobium sp. Root...
CNG45995  185 QKYAgq-ngVQIVKEETFettASDFSPLFTHVRDSGA-QALVAWASgp-pGVTLAKQYPSSGLkLPLFMTGAqasklWID 261 Mycobacterium tube...
PBI95826  198 KDLGre-ygVTFVQVEKFeiaATDVTTQAAKLRAANP-DAIIVVST----SATPFRNVRQVRIsAPIIAVHGtasyeLVK 271 Variovorax boronic...
OQM76054  185 QKEAea-mgMPVVGAEKVnygATDTTAEWTKLLATKP-DVVILWGSgs-tMSIALRNASQLGNtAPIIGAQGvaasaIIE 261 Pseudaminobacter s...

Feature 1                                                       #  #                          
4F8J_A    233 IAGKSAEGVLXASGPVXDPEGQDdsaltkkpGLELNTAYEAKygpnsrsqFAAHSFDAFKVLErvvpvalktakpgtqEF 312 Rhodopseudomonas p...
KWT97483  274 NGGKAAENLIAPALVNPDEAGPLvd----lfDLLKNKGGVAGfgallganAMATVVQGLKAGA---------------TD 334 Variovorax sp. WDL1
EER62061  272 TAGSAAENVTILAFANWDDPSPKlkk--lgaLLRTNGKTPSGfgelltatGMAALTAALAKVEg-------------pVT 336 Acidovorax delafie...
KRF22294  277 PAGAAAEGVVMTSSIAVPGRELPagpl-kdlVDAFTGPWAKTnagy-ppqFAFDGATGVQLLKaaie-------eagsTD 347 Phycicoccus sp. So...
PDT50927  271 AAGKAGNGVMSVTLGNWFEPTPKqie--lgkLLHEAGKQPAGygeiigssSIMILAEAVKAVQg-------------eIT 335 Sinorhizobium sp. ...
ABL83624  282 GAGPDAEGVHMVAMNNWNDPSEDe-------QQLKDLLEAAGfeatsfeaAGANGAQVVAAGAekv---------egeIT 345 Nocardioides sp. J...
KQY15023  240 KAMGDAADNIVHAEFLIAEDPLPy-------QVEFVAEFQKEygrl-pkhFEAAGYDAVMATVaalkr------assnAA 305 Rhizobium sp. Root...
CNG45995  262 PVGKAAEGVYVQSAIGVVADHLPdgkl-kqsVEEMSGPFKQKygye-ppqFAMDGYAGVKLLAaaig--------kagTD 331 Mycobacterium tube...
PBI95826  272 AMGDAADNVIHSEFLVAEDPLPA--------QKEFVDAYKKEygkl-pkhFSAAGWDAVMALAesika------ngadTS 336 Variovorax boronic...
OQM76054  262 GAGAAAEGIYMVTLTAPDQVTEGqk----dlAKIYKEKNGDDyql---tiYDTIGWDALHLVAkaie--------nagGD 326 Pseudaminobacter s...

Feature 1                                              
4F8J_A    313 REAIRKALvsekdi--aasqgVYSFTETDRYGLDDRSRILL 351 Rhodopseudomonas palustris CGA009
KWT97483  335 GPSLRDKVetmgpi-kgyaaaPIRFSATDHDSWNKDTLIYV 374 Variovorax sp. WDL1
EER62061  337 GARIRDALekvcgidnpyvdgKFCYSADSHEGFGSDALQAV 377 Acidovorax delafieldii 2AN
KRF22294  348 RAKVRDALesldv---ltptgRFTFSKTDHAGLDTDAVAIV 385 Phycicoccus sp. Soil802
PDT50927  336 GQAIRDAAekicgfegtysegKVCYSTEQHEGFDAETVNIV 376 Sinorhizobium sp. NG07B
ABL83624  346 GEKLRDAMatvcdlntyaigeSVCYTEDERDGMGTDALALL 386 Nocardioides sp. JS614
KQY15023  306 PDALCQEVrtpyq----gafaQYDFTAKDLGGLTLSSFSYS 342 Rhizobium sp. Root1334
CNG45995  332 REKIRDALegltl---vtpcgQYTYSETDHSGLKPTDISMN 369 Mycobacterium tuberculosis
PBI95826  337 NEKLCAAMrrpya----gvttRYDFAAPDMGGMTLAGFTYS 373 Variovorax boronicumulans
OQM76054  327 REKMLEGFekisnyqlaagtyTYTSDNHEGLGVDSVWIVQV 367 Pseudaminobacter sp. JH-7

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