Conserved Protein Domain Family
PBP1_ABC_ligand_binding_like_4

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cd06337: PBP1_ABC_ligand_binding_like_4 
Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions
This subgroup includes the type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine-binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Statistics
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PSSM-Id: 107332
View PSSM: cd06337
Aligned: 11 rows
Threshold Bit Score: 348.628
Threshold Setting Gi: 54293487
Created: 30-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       #
gi 148256554  30 KIGWVGCLSGirapFAEPDPWIQERMKthlkdg--lkiggkTYNVELVIRDNqs-epNRSATVASELVLreKCDLILVQD 106
gi 56708888   37 RIGFISPLSGprasFGTSDQWMVETISkhlsgg--lisggaSHEVEIIVKDNqs-nmNRSISVGNELLLrdQVDMLLIND 113
gi 83701634   31 KVGRVVPITGpladVGKDTPWVDENKLgpinkagglvvggqRCKIQYQIYDSkstvaGSAEAATRAILSd-KVDFLLAQG 109
gi 158317736 114 RIGMVSPRTGslrlYSEVDAHVVETMRtifkdg--irvgrsTLPVEIFVRDGqs-drNRAAAAATDLIFtdQVDVVLVGG 190
gi 111220606  18 RLGYVTSRTGtlssYSVVDSYVVQTMRslladg--vkvggrSYPVEIFVRDAes-drHRAGIAATDLIFkdKVDIVLVGG 94
gi 118592793  42 KIGHVSPRTGplagFAEADDYVLAGIRqalagg--ienngkTYQVEIISKDSqs-npNRAAEVASELLLgeEVDLIVAAS 118
gi 13476001   33 KVGFVSPRTGplagFGQTDGYVLDLARkalagg--idiggkKYSVEILDQDTqs-dpSRAGQLAKDLINnqAIDLMLAVS 109
gi 118592413  11 KVGYISPVTGlfatFAEADPFLLKQIRtalndg--ivnngkRYEVDIIDVDDqt-npDRSTSATQQLINsdEVNIVLAQG 87
gi 54293487   43 HIGIYAPFSShs-aFIGRNILAAMEMGserl-------qssDIHYSFYTLDQlp-knKNAGLVLQKFIDthHINVLVTGG 113
gi 27381518  134 RIGYISPKTGpfapFAEADDFILDQVRkslagg--lsvggsKYEVEIIARDDqsspdRQSNLAAELINKe-NIDLMLAQV 210
gi 116248775  35 KLGYVSPQTGplaaFGEADKFVIDSFLatt--------ksmGLNYEVVVKDSqs-npNRAAEVAKELIVtdEVNLILVAS 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##                    ###                                                       
gi 148256554 107 GDaqipvg-eladaRGVPAISTMLPWQAWMFPRKSTPdkg-----fpYTFHFFWGADDVVKNFIGMWQsve--tnkKVGT 178
gi 56708888  114 GDaavalg-eiadiHGVPTMSTMQPWQAWMFPRGSNPeqg-----fpWTFHFFWGADDAMSTFTRLWDqid--tnkVVGD 185
gi 83701634  110 TPdttnapsdlcerNLVPCVMTNTPVEAWLFGPDGKPkt------ykYAYEFFFSVPDLVANHLGMIKslpggfngSIGY 183
gi 158317736 191 TSdnanpvsdaceaNGVPCISTEAPWESWFYGRGGNVqap-----fsWTYHFYWGMGDLRGAYTTMWGqld--vprVVAL 263
gi 111220606  95 TSdtaipvadqceiNQVPCISTSAPWQSWWNGRGGNVdmp-----fhWTYHFYWGMEDVVATYVAMWRqlg---itKVGL 166
gi 118592793 119 TPdttnpvsdqaelNEVPCITTDCPWQPYFFGRNGDPqtg-----fdYTYHFFWGLEDVINAFLDLWQqsg--vakTVGG 191
gi 13476001  110 TPevinpvadaceaAGVPCLSTVMPWEAWYFGRGAKPgaps---pfkWTYHFGFGVGEFFKTYISQWNlie--tnkKVGV 184
gi 118592413  88 ALgiknvs-aqcefAGVPSITTMDPWQGWLFPQGGTPetg-----fqYANHFFWGIEDIISTYVGMWSsle--tnkKIGS 159
gi 54293487  114 KEt----------gLIAAPIAKKNNLIHFSLTNNTEVad------grNNFIVWSPAYDQAKVLVNELKrqh---vhHLGI 174
gi 27381518  211 SIgpavs--qqcelNGVPCISTMGPWQAWMFPMKGDPakg-----fkNVFHFFWGIEDIAAVYLDIWKdad--tnkVVGS 281
gi 116248775 106 TPettnpvattceaEEMPCISTVAPWQPWFIGQQGNPgdpgswkpfnFAYHFFWGLEDVIAVFTNMWAqie--tnkKVGG 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                                       #                 
gi 148256554 179 LYIDNsPGVAFADPSEGLPagla-qagYREVPAGLYKLTtddFSNQISALKNEGvDIVSGFAYgphWVTLWNQAAQAgfk 257
gi 56708888  186 FYLDNpVGNAFADPAMGLPgfie-rggYSRVDGGMFKIDaddYSGQVSRFKEAGaDIVTGFGFpphWITFWNQAGQAgyt 264
gi 83701634  184 LYPNDpDGTVFASLFDPAYkk----egWKPTDPGRFAQGlpdFSSIINQFKRNKvEVVTGVLAppdLQNYLQQAAQAgfk 259
gi 158317736 264 LLPNDqDGATFSNGVFGLPalaq-agfRILSDVPPYSVGerdFSAQIQKIIDNDvEIVAGIPNpddFAAFWRTLNDRnyl 342
gi 111220606 167 MYPADdDGQAFANPDFGIPtirnfdfqLTSPATSGYQVGapsFDSYLSAFKAAGvQAVVGIAQaadFATFRRQTRTAdft 246
gi 118592793 192 LFPNDaDGNAWGDEIHGFPpala-gegYALTDPGRYQPLtddFSSQISAFKEAGcDIITGNMIppdFATFWAQSAQQgft 270
gi 13476001  185 MYPNDaDGNAIRANLAPLLak----qgFTIVDPGAYETGttdYSSQIALFKQEGvEIFNSFPIppdFAAFWRQAAQQgli 260
gi 118592413 160 CFTNDpPGQTFFSDTIGFPpalr-dagFEMVDVGLFEPGsndFSRQIAAFRDSGcDIMTGLFDppdWVVFWRQAMQAgfk 238
gi 54293487  175 ITANQpSSTALTHSVIKQLqad---shIDVAASEYFEPGnkdFSRLTNRIKRKNaDMYLVMASpedIKLIQEQMEADkqh 251
gi 27381518  282 VFSNDvPGNAMGDAKLGMPgafa-kagYKIVDVGRFPVGaddFSTHIQAFKKEGvEIVTGLFNppeWATFLNQSAQMgfk 360
gi 116248775 184 LFPNDgDGNAWGDKVVGFPpvle-rmgYGLIDPGRYQNMtddFSAQINAFKSGQcEIITGVVIppdFTTFWNQAKQQgfa 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                                                         
gi 148256554 258 PQICTIAAAflfps--avnalGDRGDGMSTEVWWTPAYPFKSsltgqsAAELAADWEKTTgrqWTQPIGYAHALWEVGIa 335
gi 56708888  265 PKACTFAAAflfpq--aieamGDRGDGMTTEVWWTPNVPFASsltgqtARELADAWEAESnaqWVQTLGYSHALFETGLn 342
gi 83701634  260 PKMYVIDKAtgype--pmnaiGKPGYGILSVNFWSPAYPGRSkfggydGQGLVDAYEKATgkqYIPPLGYDDASYDILLd 337
gi 158317736 343 PKVVTMSKAlsfer--dvenlGATANGFTTEVSWSPKHQFRSyltnrtAEELASEYVDQTgrpWAPSLGFTHALYEVLAq 420
gi 111220606 247 PKALTVSKAlnfqe--dvralGSNGDGLTTEVAWSPAHPYRSslnnktSQDLASDFASARgrgWTQSLGFSYALFEVAVk 324
gi 118592793 271 PKVVTIGKAllfps--vieslGDRGDGLTSEIWWSPNHPFSSsltgvsSKELADGYMAASgrpWTQPIGFKHALFEVATd 348
gi 13476001  261 KQIKIAQVAktglfpsdiealGDLGVKISSAAYWHKAFPYKSpltgvsGTELADGYEAASgkqWTQQLGASMSLLDAGFe 340
gi 118592413 239 PKVVTVAKAllfpa--gvqslGIEANGMSTEVWWTPSYPFRSsitgqsCAELASAYEAETgkrWTQPIGVVHALLEAGIn 316
gi 54293487  252 VPITSIVERa-----------TPEVVKVFEGQWYVDSHEMQPd-----FINEFKQNYLNY---PVTEAGYAFDLFQLLNk 312
gi 27381518  361 PKVCTVAKAllfpg--gvaalGPRAEGMSTEIWWLPSYPFRSsltgqtAAELAASYQQATkreWTQPIGVAHALFEAGVq 438
gi 116248775 263 PKIASIGKAllfpq--tvealGNAGHNLSSEVWWTPSHPFKSsltgesTAQVADAFTKATnrpWTQPIGFAHALFELAVd 340
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                               
gi 148256554 336 alrnsdpkdkk-slrdaiagldlqTVVGPVNFKDs-----pIKNVAvtSLAGGQW 384
gi 56708888  343 alvqsgapkdraavrdvfastrldTVVGPVNFADs-----pIRNTArtQLAGGQW 392
gi 83701634  338 aiqranvega----sshqenelpsSSFMSIDHGNam----pLDAVA--VLHQSQN 382
gi 158317736 421 alvnvdsidnargiadaiarvkanTIVGTVTFGGaq---nvPKNVGsiPLVGGQW 472
gi 111220606 325 alggaasldre-aiaaavkevdaqTIVGPVAFGSqs---nvPKNVArtALVGGQW 375
gi 118592793 349 virrsadledpnaileaiqktklsTVVGPVDWSNg-----pVRNVTktPLVAGQW 398
gi 13476001  341 alkastdakdkaavakalstlkteTMIGKVDFTSg-----pVANVSpgPIIGTQW 390
gi 118592413 317 alrtaddptdpdsvadaiknmtldTVVGTLDWANs-----pIKSVAkmAIAGGQW 366
gi 54293487  313 sivmai------------rtqgspTSQEVVHQLHn------IANGT--GVMGTMV 347
gi 27381518  439 alkasgdpkspnkvveslrklktdTVIGNLDFGGs-----gIANVSkiRVVGGQW 488
gi 116248775 341 amkragdptdgdavaeaiaatkldTLVGPIAWDGkglppfaAKNIAktPLVGGQW 395

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