Conserved Protein Domain Family
PBP1_YraM_LppC_lipoprotein_like

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cd06339: PBP1_YraM_LppC_lipoprotein_like 
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Periplasmic binding component of lipoprotein LppC, an immunodominant antigen
This subgroup includes periplasmic binding component of lipoprotein LppC, an immunodominant antigen, whose molecular function is not characterized. Members of this subgroup are predicted to be involved in transport of lipid compounds, and they are sequence similar to the family of ABC-type hydrophobic amino acid transporters (HAAT).
Statistics
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PSSM-Id: 107334
View PSSM: cd06339
Aligned: 110 rows
Threshold Bit Score: 159.008
Threshold Setting Gi: 148555495
Created: 20-Jul-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ligand
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                ###     
2H4A_A         2 QIGLLLPLSGdgqiLGTTIQSGFNDAKgn-------stIPVQVFDTs--xNSVQDIIAQAKQa-GIKTLVGPLLKqnldv 71
gi 114777182 283 TIGVMLPLTGqyarYGREALQGIRVALasle---sdayITLRVEDTasdkTQAIEAYRQLSNe-SVNMIIGPLLAettka 358
gi 86160741  274 VIGVAVPLSGdyqpWGVAIVRAVQLAAeg-------ggVRVAVRDTrgepDGAAQALEALALeeGAIAVVGGVTNaeaer 346
gi 95931195  264 AIGVVLPLSGryapFGELVKQGIELAVkss-----aapIQVFYQDSgadpQSAADAVRRLVRaqRVMAVIGPLTGdaaml 338
gi 42525194  180 TVGVVLPLSGrnapVGQRALRGLEMGLglhi---pgsgFQLAVMDSegnpDSARRGVERLVKedNVIAIVGSLLSktapa 256
gi 115371978 294 TVGVLLPMTGrfkpIGEAVLRGVQLALng-------sdIELIVKDTqgevNLAGQGVEQLAFdeGAIAVLGPLVPdearr 366
gi 116748479 287 RIGVLIPLNGsfarYGDMVLKGLTLANsdwserypgqqVSLVVKDAqadaAVTTRSFEEMVKkdGVLAVIGPLGAqaake 366
gi 77917723  269 ALGVILPLSGrfghYGKMVLQGMQLALeqhnl--qhapVHFLVRDSagdpDLTAQLVTELAAspQILGILGPLTGsaakr 346
gi 91762497   29 RIGLLVPLTGknseIGQSIIKSTRLAIntin----nasIEIIPKDTqsnpEVTLVVAKELANs-GIKIVVGPVFNesliy 103
gi 87200101   31 RVALLVPLTGanaaVGQSIANAATMALldtn----aanMRITTYDTa---SGAGSAASRAISd-GNKLILGPLLGndvvl 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        ##                                              #               
2H4A_A        72 iladpaqiQGXDVLALNAtpnsra-ipqlcYYGLSPEDEAESAANKXWndg-vrNPLVAXPQNdLGQRVGNAFNVRWQQL 149
gi 114777182 359 i--lpylrPGLPVISLTGdtelahrspslfIHTLSPLAQVSAMANYAWqhd-akRMVVITDAD-ENQAEADTFVASFEAL 434
gi 86160741  347 a-aataeeLQLPFISLSKqeglteagphvfQNMLTASAQAKALADFAMgrrgmrRFAVMYPSItYGTELANAFWDEVEGR 425
gi 95931195  339 a-vqeaekAQVPIITLSYrdglpqmgryvfRNSLTPQQQVEALAEYAIeelglnTYAILSPSNkMGQQYAQLFRQAIEMR 417
gi 42525194  257 v-aaksdeLGVPTIALSQrsgltevgptvfRNSLTSGMQVRALVRTAMedmgmkKFAVLYPNDpYGIEFTNIFWDEVLAR 335
gi 115371978 367 a-alvseeLQIPLLTMARqegitgigpyifRNMLTNSAQAEAIADYALnvrgikRFALLYPNLsYGVELANTFWDEVLKR 445
gi 116748479 367 v-apladrYGVPVLTMTQkddegaassfviHIFLDSREIVRSVVKHCRdklghtRFAALYPDDrYGQKLAKIFSEVVPEL 445
gi 77917723  347 a-ahtaerLQLPLLTLSQqtglpqigswifRNSLTSELQVRTLVNYAMyqqnmtSFGILAPETrLGQDLSTAFADEVRAR 425
gi 91762497  104 ----ldelSELTFLALTNkndnf--skniiNAGINATSQLNAIKKFIElne-ikKTIFLTPDVsFKNEIEKAISNSKIKT 176
gi 87200101  103 v-snvarpAKVPMITYSNdsava--srdvfVMGQAPGQSVARVLGFAKskg-igSVAAIIPTGdYGQRAMNAVVDSGRAL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2H4A_A       150 a-------------GTDANIRYYn-lPADVTYFVQENns---------------------------------------nT 176
gi 114777182 435 g-------------GELVKTVKLdkeGLDYRDQLRQLrfdtddeetlaalde------------dlsvflpemdveihmP 489
gi 86160741  426 g-------------GEVRGAETYapdRTTFTPLVKDMvgklhldergdwqeqqrdiakaekdpfrrkkalekardrlapV 492
gi 95931195  418 g-------------GDIEHQRSYgesATDFRRQLLLLkgedpdapqdaepkvvde-------egdelvveeeeeiaglpN 477
gi 42525194  336 g-------------GEITAVQTYsvkETDFRLVVQRLvgtyfgearqdefnlrlkel--qssgkkhsvrqsnlenvlppI 400
gi 115371978 446 g-------------GVVRGAESYshdQTTFTNEAKKLvgryyledrldyiegvrevnaqeqdsfrrrkaiekvksgldpV 512
gi 116748479 446 g-------------GQVMASVSYkekTTDFKESLQKLitiakkn----------------------------qpptgveT 484
gi 77917723  426 g-------------GQIVAVQSYqpqATDFREQIKRLqgkqpnepett---------------------pedaeaqaaeP 471
gi 91762497  177 lenyiyntdptkltKQIEKITRYeirKQNLEDEINRLekseqsnkell--------------------ierlkkrdtlgS 236
gi 87200101  179 g-------------VTVTAIETYdrgNTSVASAVRRVk----------------------------------------eK 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                 #                      
2H4A_A       177 TALYAVASpt---eLAEXKGYLTNIvp-----------------------nLAIYASSrasasat-----ntntdfIAQX 225
gi 114777182 490 VNFDAIYLalpgrqVALLAGQLAYAdi----------------------rdVALYGSSrwqdgh-------llddrGRYL 540
gi 86160741  493 VDFDAIFIpdfarnVKLIAPALAVEdvvtqtclpddverirkttgradlrpVQLLGANgwssdpsl--fdtapggaGRYV 570
gi 95931195  478 VDFEGLFIpdyadsVALIAPQIAYYgi----------------------enVQLLGINgwnspq-------lidqaGRYV 528
gi 42525194  401 TDFDAIFIpdsaraMGQISAMLSYNdv----------------------rgVKLLGTNlwntkd-------iakraGNFA 451
gi 115371978 513 VDFDGIFIpddwkrVSLVGPALAVEdiitnacdprdlerirkttgkrdlktVTLFGTNlwnspkgqsglpelvergGKFV 592
gi 116748479 485 TPFDALFIpdqvqsVSLIAPQLPYNnv----------------------vgATLLGTNlwseap-------lvqagGVYI 535
gi 77917723  472 PPFDALFIpdtpnrLALIAPQLPFYgl----------------------ddISLLGSAnwdapn-------llpqaGPYI 522
gi 91762497  237 VKFDSVVIsdf-deSLKSVTTSLLYtdit-------------------pkeKYFITLNqwfde---------sllkETSS 287
gi 87200101  206 GRFDALLIa----dGSRIALQAAPLag----------------------kgVKLLGTElwsge--------aaiakSPAT 251
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2H4A_A       226 NGVQFSDI---------PFFKdt-nSPQYQKLAKSTggeyqlxRLYAXGADAWLLINQFnelrq-------------vpg 282
gi 114777182 541 SSARFVASgkeaagendDPLLn--rIHFMLREAWGSda---tsDLLLLAYDSMRIATMLtsrlglsdqa---ilrglrdp 612
gi 86160741  571 RCAIFVDGfyag--ssrPATKa---FVEAFERRHAGqv---ptILEASAFDAAGMARAQlgkaqtrdqm----rdalaav 638
gi 95931195  529 RGSIICDGffaq--spdAPVKq---FVERYERMYGEtp----sILEAQGYDSVRLLLGIltdpaittpqq--lqqylyqm 597
gi 42525194  452 QNLIFVDSm-------tPANQdrsrFVNEYRSLYNEpp----sLIEIQAYDAGLILRQLiaagassree---lvqklgql 517
gi 115371978 593 TCSVFVDGffid--sqrPATRk---FVQAFRAAYKAetgrdpgLLEAIGYDSALMLRQIiekgrpatrga--mrdalatl 665
gi 116748479 536 EHALFATAyy-----peNPSSrakdFRERFQEKFGApp----sYLEAQAYDALMLVLQArsalrstgidrasllqtimta 606
gi 77917723  523 ENAVFVSGfhry--sayPFVKd---FVDRYFERYGAep----sLLEAQGYDVAGIALSLlanptahsran--lrrdltqm 591
gi 91762497  288 QPLYFPSA---------NKDNyd-eFSNEYFEKYNQyp----nQLSFLSYDLVGLVYYLilqnesvid-----kkmftkk 348
gi 87200101  252 RGSWFAAVs--------DGRFg--qFEKSYRTRFGAtp----sRLATLGYDSVLLTLNVarnwkpgttf---ptaklydp 314
                        410       420
                 ....*....|....*....|....*
Feature 1                                 
2H4A_A       283 yrLSGLTGILSADTnCNVERDXTWY 307
gi 114777182 613 egFPAVTGHVRFDDaGVGQKQLDIF 637
gi 86160741  639 rgYVGATGDITMGPrRTPEKPLFFL 663
gi 95931195  598 eaFNGVTGLQGFDRqGEAQRALFML 622
gi 42525194  518 nkFPGSLGNLSINAeREIERPVTAL 542
gi 115371978 666 kdFEGATGRTSFNDqREAVKPLFLL 690
gi 116748479 607 kgFEGIAGKYSFSPmGGLQRNYLLL 631
gi 77917723  592 rhYPGVTGASSFTTtGDADKVLYLL 616
gi 91762497  349 tlFKGKVGVFEIKN-NKINHILNFY 372
gi 87200101  315 qgFIGLDGVFRFTAsGMAERAMEVR 339

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