Conserved Protein Domain Family
PBP1_ABC_ligand_binding_like_6

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cd06340: PBP1_ABC_ligand_binding_like_6 
Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions
This subgroup includes the type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine-binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Statistics
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PSSM-Id: 107335
View PSSM: cd06340
Aligned: 19 rows
Threshold Bit Score: 387.403
Threshold Setting Gi: 83311560
Created: 20-Jul-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 116063233  37 KIGVILPLSGrlaeTGADLRRGIEFAVDEInsqgg-----------vkacgGAKLTVVYGDSagkpeTGAAEAERLISQe 105
gi 158423733  39 KVGVLQPVTGalamDGEYGRTGAEFAIAAVnaagg-----------ikslgGAKLEMVFGDArs-npEAGTQEVERMQGe 106
gi 27378033   61 VIGVIYPFSGgsaqQGVDAQKAYETALEVInkdtdfdlpl-akgeglpglgGAKVRLVFADHqa-dpQKGRAEAERLITq 138
gi 71083359   27 KIGVLYPLTGpvaqVGKDAVAAVQTALDIInnshnipgmplakdaglkglgGGKISIVVGDHgg-kpDIGVGETEKMLNs 105
gi 108803214  36 KIGSLHPLTGplavDGKRMDQAVKMAIEDInkagg-----------iealdGAKLEFISGDTkg-epETASSEAQRMIDe 103
gi 83311129   46 KLGVLLPRSGhlalIGQACQRGAEIGLPMLrd------------------mGYSVELMNADTes-npDVGRTQAEKLIRe 106
gi 83311560   58 KVGLLLPLSGglarEGQSCKRGAEVTPGLLad------------------mGMPVQLMIADTet-niDTARTRAEKLIAd 118
gi 157363981  23 KIGAIFPLTGpaaaTGVKIKYAIEVAQEIIngvypdidldlaksqglsnlnGAKIQFIFADHqa-npELAMAEAERLIQn 101
gi 148257255  38 KVGLLQPISGafalDGDLAKIGAEFAIKEIndagg-----------ikalgGAKLELVVGDSrs-naEAGAQATEELQSa 105
gi 115422033  33 KIGVLHPVTGalaySGQQCRLGALLAIEDInkagg-----------ikslgGAPLEAVLGDAqs-rpEAGSAEVEKMNEa 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 ###                    ###                                             
gi 116063233 106 -GVIALVGAYQSsvtktasevaerYQVPFINPDSTspaltergykWFFRVTPHDEMFAAQQADFIDwlnqkyglnlrTFA 184
gi 158423733 107 -GVVAVVGGFASgiclaasqtaarYDLPYLVDVGVsdqivqrglkNTFRFGPGFGVCTRSALDNLArineaagkpakTVV 185
gi 27378033  139 eKVSAIIGTYQSavavtvsqicerYQIPFVSADNSspslhrrglkYYFRAAPHDEMYSAAMFDFFDamkkk-gtkieTLS 217
gi 71083359  106 dKVHAMFGAYYSsvtgaasqvserAGIPWVNGESTspklttrgfkYFFRVTPHDGEFTQLMFEFMDdfntkngnklkTLG 185
gi 108803214 104 -GAVALVGPYTSataatiartaerSQVPFIIDVATadsilaqgyrYTFRIQPGSQTMGEYGARYLKeiseaqgspveSVA 182
gi 83311129  107 -GANMLMGCFDSattlavagvaeqKGVPFVVNIASepklteqgfkYVFRNFPSAGMLGKGGLLLYKdifaatgvtpkTAV 185
gi 83311560  119 -GAQVLIGAFDSahtlavaqvceqRGVPLVVNIAAapniteqgfkTLFRNFPTAPKLVTEGLALMKdvfkvtgttptKAV 197
gi 157363981 102 eKVVALIGCYHSsatkpasqiaekYGIPFVAGSSSsaalterglkWFFRIAPHDGMETDFFFLYLNylkekyganlsRVA 181
gi 148257255 106 -GVAAVLGGFASgialtatqtaarYDLPFVVDCAVadtiterglkNTFRFNPNFSMATAVALKNLVklnddagkpikTVA 184
gi 115422033 101 -GVSAIVGAYASaiclattqtaakYNLPHVVDVGVadqiverglkNTFRFGPGYRASSERAITDLAalndaagrpakTVM 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                      #                 
gi 116063233 185 IIHEDTeWGSKVAEAWKKYFtq--hgYTLVEEVSYhaatvtsLDSEVQKLKAAnpdILLAASYiqdAILLVQTMKAQnfa 262
gi 158423733 186 LVHEDGlFGSGLAKVMQAELpk--lgFEILDTIPVptp-srdLSNVVLRLRSLnpdIVMPSTYygeTVLLARTMQQQrvr 262
gi 27378033  218 LFHEDTiFGTDSGNAQAKIAge--raYKIVTDIKYran-spsLSAEVQQLKTAnadVLMPSSYttdGILLVKTMAELgyk 294
gi 71083359  186 IIHEDTlWGADSGGTQNTMAkd--kgYKVVEKISYkak-ttsLSSEVQRLKAKnpdVLLPSSYtadAYLFLNTAKELdyn 262
gi 108803214 183 YIHESSeFGTSVFEAFQKEAqr--lgIEVVREITYdalnvsdLTSELTQAKAAdadVIVATGYyrdGLLLAQAAANVkpd 260
gi 83311129  186 LLHINDsFGMAMLGGINALMpkldmpFQIVETIAYdpk-ardLSIEVAKAKAAkadFVMTVTRlndAILLVREMVKQqve 264
gi 83311560  198 FLHNNDtFGTAMAGAVNKLFptldmpFPLVETISYdgn-ardLAVEVGKAKATgadLVLLVPHgddCIRAIREMVKQrfe 276
gi 157363981 182 VVYIDNeYGVHASLMVKEKIkky-sgFNLVADIKYpan-vtnVDIEVQKIRAAkpdVIIHASYigdMTMFVKKYKEFnvm 259
gi 148257255 185 IVHEDGlFGSGLAKIMQEKLpp--lgFQIVETIAHptp-ardMTNVVLRLRALnpdLIVPSHYfneFVLMARTLQQQrvr 261
gi 115422033 180 IVHEDSlFGTGTAALLSKSLpq--hgFEVKDVVKHpnp-trdFNNIVLRMKSLnpdIVIPANYyneYALLLRAMRQQkvq 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                                                         
gi 116063233 263 PKVVLAQDAGfinps-yvsqvGKDGWYIFSREVfspdlidkiprLKEVNDRYKKKygvd-lngNSARDYTGIWVLYyale 340
gi 158423733 263 PKAVYGVLNGaasnmrfvkefPEAADKIMDCNHwydp---rkagAQALLKAVADAgkg--wnyNLPMNYSCVGLLAdale 337
gi 27378033  295 PNAIVAQDAGfseka-lydavGDKLEGVISRGTfsldlaqkrpmVGKINEMFKARsgkd-fndLTSRQFMGLIILAdais 372
gi 71083359  263 PKLLVAQNAGytdpk-fiatmGSKAEGVITRSPfntdlattipmIGTVNEIFKTHsggrdlsdVPARAFTGFMALAnain 341
gi 108803214 261 VKAVYGVANGafdldtfpedaGDNGNYYLSSNYhyda---tsdrARKLRQRFEERtges-mrtAAVFSYQAVEVIAdale 336
gi 83311129  265 TMGIISPGAPgmydkqffkalGKYAEYCTTNVPwfdp---kqemAKTLEKTFEKAfpeescdlNVGFTFEAVLIAAdahk 341
gi 83311560  277 PKAVVSPGSPgmyetqfyktlGKYSDYCMTNLPwinp---ksamSQALLKAFSKShpdalfemNIGFTFEAILIAAdaak 353
gi 157363981 260 PKVVLSFCGGyqdpq-fvinlGKDANFFSGTNAttsalfskmaiLARINQLYKAKsgvd-idgPTLEDFASAMVIAeain 337
gi 148257255 262 PKGIYAVFGGaassyrfvnefPEAAQGVMDCNHwgdp----kspITAKLRETVTAagkf-yayNTPINYSLVKVFAqave 336
gi 115422033 257 PKAIYSVLGGaassykflkefPDIANGIIDCNHwfnp---kdarVAPLKARVEEKgay--fsyEVFMTYTAMMLLAdale 331
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                               
gi 116063233 341 dackkaspsnpeefrralrdslvnlqlspdqiimpwKGVKFDEkGQNILGQGLIV 395
gi 158423733 338 ragstdrakvi----------dalaastwadhvmpyGPTKFVD-GQNQGAAPVSL 381
gi 27378033  373 rakstdgekvrd--------alaatdipgeqtimpwKRVKFDEmGQNNDADPVLL 419
gi 71083359  342 nagstdpekirq--------alvdldmssdslivpyRGIKFGAdGQNEKTRGILM 388
gi 108803214 337 ragssepqelrd---------aiaetslqtelfpfdGPIEFDDrGQNVNAQPIVM 382
gi 83311129  342 ragsndpqalt----------ealratnlskramlgGAIKFEAnGQNMNLISAAV 386
gi 83311560  354 ragsndpkail----------aalpttniaehvmigGPIAFDAkGQNTNTRSATI 398
gi 157363981 338 iakstdpskil----------eilqtqtfsapyfvsGKIKFGPdGQNLYSASVMT 382
gi 148257255 337 kagsadrakii----------ealaanefdsgimpyGKTKFDAkGQNASALPLNT 381
gi 115422033 332 raksadraait----------ealasstfadhimpyGPTKFVDgQNTGAQPLLTQ 376

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