2LIV,2LBP,1USK,1USG,1USI,1Z15,1Z18


Conserved Protein Domain Family
PBP1_ABC_LIVBP_like

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cd06342: PBP1_ABC_LIVBP_like 
Click on image for an interactive view with Cn3D
Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine)
This subgroup includes the type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine). This subgroup also includes a leucine-specific binding protein (or LivK), which is very similar in sequence and structure to leucine-isoleucine-valine binding protein (LIVBP). ABC-type active transport systems are transmembrane proteins that function in the transport of diverse sets of substrates across extra- and intracellular membranes, including carbohydrates, amino acids, inorganic ions, dipeptides and oligopeptides, metabolic products, lipids and sterols, and heme, to name a few.
Statistics
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PSSM-Id: 107337
View PSSM: cd06342
Aligned: 78 rows
Threshold Bit Score: 243.99
Threshold Setting Gi: 51891306
Created: 2-Aug-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingdimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1Z18; Escherichia coli leucine-isoleucine-valine binding protein (LIVBP) binds valine, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2LIV_A         4 KVAVVGAMSGPvaqYGDQEFTGAEQAVadinakggikgnKLQIAKYDDa------cDPKQAVAVANKVVNd-GIKYVIGH 76
1Z18_A         4 KVAVVGAMSGPvaqYGDQEFTGAEQAVadinakggikgnKLQIVKYDDa------cDPKQAVAVANKVVNd-GIKYVIGH 76
gi 94984727   29 KIATVSPLSGSltpIGSEVKRGAELAVqeqaaafkalgyDLVLTPYDDqa-----sATLAPQIARTIVADk-NVLGVVGA 102
gi 118470564  61 MIAMMGALNGPdaaLGINIKNGVQMAIdkhna--anaqcQVQLKAFDTe------gDPQKATGVAPQIVDepFIIGVVGP 132
gi 152966901  47 SIGFFGALTGPnanLGVNEQNGVKLAVdqhna--esgacQVTVTPYDSq------gDQNQAQGLAQQVVGdeNVLGIVGP 118
gi 145595665  40 KIAIFGAFSGPnsgLVIPSRDGALLAVkqhne--anpdcEVTLQEFDTq------gDPTQATPVANQVTGdeSFLGVIGG 111
gi 108804854  42 KIVSDLPLQGAnraQTISMVNAIRLAIdqrgg--kvaglKIEYESLDDataqsgqwDEGKCAENAQQAAQdeEIVGWIGP 119
gi 28493528   65 SIAYVGIVTGPnaaFGKSINEAFQLAVkqhnd--nnpgcQVTGKVFDTeg-----sPDKAPGVVAQVIGDs-SIVAVLGP 136
gi 51891306  265 VLAAVVPLSGAhgaWGLDLANGVELALrdmeadllrvgyQVSLARYDDq------gRPEEAAAHAQSVAYdqGVIGVVGS 338
gi 159899525  34 TIVSSLPRTGSskgQTDTIVNAIKMRLeeakytacdgnvEIKYEDLDDataakgawDEAKEAENANAAASnkDVMVYIGT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ###                    ##                                                       
2LIV_A        77 LCSSSTQPASDIYEdEGILMITPAAt--------------aPELTARGYqlilRTTGLDSDQGPTAAKYILekvkpqRIA 142
1Z18_A        77 LCSSSTQPASDIYEdEGILMITPAAt--------------aPELTARGYqlilRTTGLDSDQGPTAAKYILekvkpqRIA 142
gi 94984727  103 LNSSVSNVIAQAFGpAKLAMISPASt--------------gDQLTQNGWnhfsRVVAPDSAQGVAAADYIAeelkagSVV 168
gi 118470564 133 AFSGETKATGDVFNqAGLVATTASAt--------------nVQLSENGWrtffRGLANDGVQGPSVANYMKntlenkKVC 198
gi 152966901 119 AFSGESKVADPIFDeAGIVGISPSAt--------------nPALAENGWktffRVLGNDASQGPAAATYISdtlgkqKVY 184
gi 145595665 112 AFSGESKATMAVYEaAGMVMVSPSAt--------------aIELTAGGNkvfhRVVGNDAIQGAAAAVYFRdvvqakKVF 177
gi 108804854 120 FNSGCAAVEIPILNeAGLVMISPANtyvgltke-ggepdepDKYYPTGQrnytRVIPADDKQGRLAAVLMReeg-vrTVF 197
gi 28493528  137 AFSGENQAVGGIFEtARLVHITPSAt--------------lPTLSSHGWktffRAASTDLEQSTGVIALLEkle-akKTF 201
gi 51891306  339 FTGEATLALAEGLRdSGLVLVAPTAr--------------sEDLVQEGWphvnRLVAHQARLESAAAAFAKarlgvrSVL 404
gi 159899525 114 FNSGAAKISIPILNnAGIVMISPANtypgltkdgkgaegepAVYYPKGTrnytRVVPADDLQGAAAGNWAKelg-vtNVY 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                    #                   
2LIV_A       143 IVHDKQQYGEGLARAVQDGLkkgnANVVFFDGItagekdFSTLVARLKKEnidFVYYGG-YHPEMGQILRQARAAGl--- 218
1Z18_A       143 IVHDKQQYGEGLARAVQDGLkkgnANVVFFDGItagekdFSTLVARLKKEnidFVYYGG-YHPEMGQILRQARAAGl--- 218
gi 94984727  169 VISDNTAYGNGLTRVLMANLkkrkVPVAAYMGAstp-aqIAEAVKRVKASsadVVYFGG-TDDTGSQLVKALRAAGv--- 243
gi 118470564 199 VVDDSTDYGLGLAEAVRTTLgp-vADASCNISVkkgdkdFSAAVTQIKGAapdSVFYSG-YYSEAAPFVQQLKDGGv--- 273
gi 152966901 185 VIDDATEYGKGLADIVRESLg---AKAVKNNTIqtgqtdFSAVVADVQASgadAVFFGG-YYPEGGLLLKQLRESGlsad 260
gi 145595665 178 VINDGTTYGAGIADELTKALg---ALAGGTDQVqekqvnFAATISKIKAAapdAIAYGG-YTNEAAPLVKQLREAGi--- 250
gi 108804854 198 ILDDRETYGKGLADQVQKSAeefgIEVVGRQGIdgsasnYRGLMNRVREAnpdAIYFGGiIENNAGQLVRDKVGAGmpnd 277
gi 28493528  202 VVSDDSAYGKFLGDLVKKGVdlagSDGIITGSRd-----FSSVVAKVVSSgadSVFFAG-YYPEAAAFFTQLRGAGf--- 272
gi 51891306  405 LLLDGSEEAERRAATFSTAAeimgLPIAGRIVVpae-vsGSALAAAVRAYapeAIFYAG-SGQTGFAAVKALREAGv--- 479
gi 159899525 193 ILDDTELYGKGIADVFAATAekngIKIAGRDSIdakasdYKALMSKIAATnpdMIYFGGiTQSNAGQLVKDMRAAGmtad 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                                        
2LIV_A       219 KTQFMGPEGva-nvSLSNIAGESAEGLLVTKPknyd--qvpaNKPIVDAIKAKKQDps-gaFVWTTYAALQSLQaglnq- 293
1Z18_A       219 KTQFMGPEGva-nvSLSNIAGESAEGLLVTKPknyd--qvpaNKPIVDAIKAKKQDps-gaFVWTTYAALQSLQaglnq- 293
gi 94984727  244 TATFMGGDGld-spSFLQRAGIAGAGVVYSTVfgpvs-afsnALDFSDRYRAAYKTkp-sgVAVYAYDATNTLLsaikaa 320
gi 118470564 274 EATFISADGtk-dpEFVKQAGESSKGALLSCPcg------paTAEFAEEYTQKFGQep-gtYSTEGYDLGTILLkgids- 344
gi 152966901 261 KLAFITDDGakdegLITAAGAAAAEGALMTCPclpp---dkaGGTFVADYTEAYGTap-atYSAEAFDAANILLdgiae- 335
gi 145595665 251 TTTFLGFDGly-dpSFPEGAGASAEGVIVTCPclpp---dkaGGTFSADFEAEYGGpp-gsYGAEGYDAANVLIeglae- 324
gi 108804854 278 EVLFIGPDGif-vdTFIEQAGDAAEGAYVTFGgipperlgerGQRFIEEYNAKYPDdpiqaYTAYAYEAANVLLdaiera 356
gi 28493528  273 NGYLVVPDGsl-drNLSKLAGQAAVGVYAVCPctd----dsqVAGFGDAMKKAYGHyp-giYSSSAYDVTTILLrgids- 345
gi 51891306  480 DLPVVGGVEly-npAFETIAGTGWRNIYFTHFtq------gnDARFMRHFEAILGKpt-rgYGMFGYDAARVILealvsy 551
gi 159899525 273 KVKFMGPDGifeqaFIDAAGADNAEGVYATFGgvppaklegkGAEWYNAYKAKFNAep-eaYAVYGYESTNVALaainqs 351
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    
2LIV_A       294 -----------------sddpAEIAKYLKAn-SVDTVMGPLTWDEk-GDLKGFEFGVFDW 334
1Z18_A       294 -----------------sddpAEIAKYLKAn-SVDTVMGPLTWDEk-GDLKGFEFGVFDW 334
gi 94984727  321 agnsrtlptraevsaavrkvnLPACFSADKs-RCATITGAIAFSDs-GERLRSRVMIMRF 378
gi 118470564 345 ----------------gaitrADLLNYVRNy-EGQGVARKYQWTDn-GELTTTLIWMYDV 386
gi 152966901 336 ----------------gnvtrEDLLAYVKSy-DKPGVTKQLKFDEk-GEPSEVSVWAYKV 377
gi 145595665 325 ----------------gnttrEDLLAWVDSy-DKEGVSKSLKFADs-GDVDESRVVIWAY 366
gi 108804854 357 qk-----------adgevnreNVLREVFATe-NYKGVLGTWSFDEn-GDTTLTKLSVQRV 403
gi 28493528  346 ----------------grtsrSSLLDWVRGy-DAYGVSGHYKFKAn-GDLQHTRLYFYRF 387
gi 51891306  552 gee----------hpgqvpdrVELAARVRAtrGLKGWSTQVSFDPatGENQAARVYFFEW 601
gi 159899525 352 c--------------asinreTILKNVFATk-DFDGVLGKWGFDAs-GDTTLTQMSGQQI 395

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