Conserved Protein Domain Family
PBP1_ABC_ligand_binding_like_8

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cd06343: PBP1_ABC_ligand_binding_like_8 
Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions
This subgroup includes the type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine/isoleucine/valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.
Statistics
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PSSM-Id: 107338
View PSSM: cd06343
Aligned: 41 rows
Threshold Bit Score: 376.928
Threshold Setting Gi: 91783060
Created: 2-Aug-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 27376090   91 GASDTEIKIGNVEAYSGPasaYGVIGKTEEAYFKmin-dqGGINGRKINWISYDDgys-ppKTVEQVRKLIESdEVFLVF 168
gi 163724691  27 GITDDEIVIGSHLDLSGPiagWGTQAKLGMEMRAkecndaGGIHGRKIRLVIEDNayd-pkKAIMVTNKLIARdKVFMFV 105
gi 86139742   13 GVTDDMITLGTYTDLSGPlavWGVPEANGLRMRVdeinaaGGIHGRQLEIIIEDTqyq-vpRAIQVANKLMRRdQIFAMV 91
gi 51891941   60 GVTDTTVKVGGFAAQSGPvapIGISVRKGFEAYIkhvndqGGVHGRKIEIVNIIDdqfdgsKALTAAKQLVESdKVFALA 139
gi 160901984  22 GVTDDKILVGTFQAMSGPvapIGRPMAQGMQAYFnyindnGGIYGRQIELIVADDqfn-paKTVVEVRRMVEQdGVFSIV 100
gi 27383038   47 GISATEIVIGTHQDLSGPikgWGVPVSNGMKMAVeevnaaGGVNGRKIRLVVEDSgyd-pkKAVLASQKLIERdKIFAMV 125
gi 157363932  21 GVYSDKIVVGSFQALSGSyaiIGQEMSKGMKAYFnwvnknSGVYGRKIELIIADDqln-psKTVVEVKRLVESdKVFAIV 99
gi 56476955   25 GVSRDEIVVGSIQDLSGPialLGVPVRDGMLMRFedanaaGGVHGRTLRLVVEDSgyd-pkKAVLAARKLIQRdHVFAFL 103
gi 39934310   30 GVTDNEIVIGTHMDLSGPlkaWGVPATNGMKLAIaqinddGGINGRKIRLVNEDDgyd-pkKAVLITQKLIELdKVFAIV 108
gi 89902269   24 GVSPTEITLGSIQDLSGPlagFGKQARLGMLLAVdeineqGGVSGRKLKLLVEDSgyd-pkKAVLAAQKLVNQdKIFMMV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ###                    ###                                                    
gi 27376090  169 NALGTptqtavqkyhnaKKIPQLFLATGaskwndp----qnfpwtmGFQPSYRVEARIFAKYILkekpdaKVAIFYANDD 244
gi 163724691 106 GNMGSptagatkplisgKKIPQIFPITAaslffdp-----ydrysfGGWVPYYDQVRAAVKWFVenkgakKIGMMYQDDE 180
gi 86139742   92 GALGTpmnlaimpqqieAGIPNMFPMSAevemyep-----ldpmkyAFFRSYTDQFRAGVAYFKengdfsTPCIAQLANE 166
gi 51891941  140 PILGTagfmasydyfveKRIPVIYPMTGveqtahp-----pqenifAVQPNNYDEAKILTQYLVdelglkKIAVLWQNSD 214
gi 160901984 101 GGLGTpgilavqdylndNGVPFVYQGGGsiefslp-----preyifPVQPNYIVEANIVMNYLVekg-heRIAIVYRNAE 174
gi 27383038  126 GPMGSptvlaaqdilldAGVLQLFPLTAaeftfkfdpakpqerlkfNNLLPYVESTRAALKYMMewksfqKPCIMHQDDE 205
gi 157363932 100 GGLGTygclavmdyleqNKVPFVYQGAGtsllvmp-----pkkyifGVQPDYTLEGQLIAKFLVkelgkkKIAILYMAND 174
gi 56476955  104 ANLGTpvvmatmpivvgAGRPHLFPFSPhestyap-----rhplkfQMFAPYQDYMDAATRFMMqtrryrQVCVLYQDDD 178
gi 39934310  109 SAMGSattlapmplvqsAGLLHLFPITAaeftfkmdpakpedrlkfNMFSPYYDTMRLGIKYVIektqpkKPCIVYQDDE 188
gi 89902269  103 GHIGTaqnmaampvqfdKNVINFFPITAaremyep-----fhklkySFAATYYDQMRRAVPQMVkdkgikKVCTIYQDDD 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                                     #                        #
gi 27376090  245 FGKDYVAGIKDVFgdkasKLIVAEESYetwepsIDSHIVKLKGTga-dVFVNISTpkfAAQAIKKIAELEWkPMHLMTDV 323
gi 163724691 181 MGHIMMKGLKDQLav-hgLEVAAAESYkrgatdFSSQMAKLKKAdv-dLVCLGTVireTVGGVKEAKKLNWdVDMVCFSP 258
gi 86139742  167 AGESMALGVTQQLae-ydMKVAAKTEHsatesdMLSSVTTLKNAgc-dIVFLAGGvrdTILVVATSKKLGFePTFVTGMV 244
gi 51891941  215 MGEQGLKGVKDYIge-lgAELVYDAPHdagsvdFTTPVLNLKQKgaegVVIMTTLa-eTIGIVKEMHKQGVtAVPITSYV 292
gi 160901984 175 DGQEFSNSAVGTLka-lgMEPVANIAVdpfksdFTSEVTRLLSVkp-dAVAVMLFlpqSVGFVRQAKQFGMtDQRYLLTY 252
gi 27383038  206 YGKNVLDGFNQQLav-mkVQPASITSYkrgasdFSAQVAKMKSDgc-dLVVLGAVlrePIGAMTEARKLGWdVTFLGATP 283
gi 157363932 175 IGKEGYAAALSRLqs-ynLKPVVEISYnpaetdYSALAVDVLNAnp-eAIIIYGLitdTIRWIKTLRDYGVtSDIVTIYP 252
gi 56476955  179 YGLEVMKGVERALaa-lnQPLAAKTSYkrgatdLSSQIARLRGAgc-dFVVLATVvreTVAAVAEARKTGWtVDMLVTAS 256
gi 39934310  189 MGKNFTDAYTDQLka-mnIPSATMVSFkrgatdFNSQVARMKADgc-dMVALGSVvreSVGITTAAQKLGWkPTFVVSSP 266
gi 89902269  178 FGLEVLRGGEAGLkt-inMDFTEKTSFkrgatdFSSQVAKMKAAac-eMVVLGTIireTIGTIGESRKTGFnPIFLGSSA 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 27376090  324 svsiga-vmkpagLEASEGVLSAGYlkdasdp----qwkddegMKKFMAFIDKYmpgan-isdaNLVYGYAAAQTMVqvL 397
gi 163724691 259 gynsyvvglclkaGFSPDGLYATGQsnyvyp------dselesIREFCKKHKEWygkd---pdlPTSAGWGGMDYLIkvA 329
gi 86139742  245 symda---vataaDGAMDGLYLVSPfvfana------gdsegeAKRILESYSEIygek---mapQAQLGYVFIDLIAvaL 312
gi 51891941  293 nadpvn--vpalaGEAAIGLYAGGWvpvad--------pddpnIQKFWEIYGRYnnge--lpdaYGTAGFIAAELLVkgL 360
gi 160901984 253 snadvs--ylqlaQEAGDGVEVMAWvavdft------npeepaIKIWQEYYEGIpn-------aYAIAGMIAAEVFVegV 317
gi 27383038  284 vnvme---vpmlgKEAVEGLYAASGfeipye------dtakgkVHDWLVNYKKMfntd---antQAIIGYNAVMTFAfyA 351
gi 157363932 253 nadps---fvtlgGKYVEGIYLTGWvplatpdkpefvrdyeraVAIFQETYPKEip------ssYAVAGFIAAEVFVqgL 323
gi 56476955  257 gysaq---thelgGKTVEGLYGVSVlphpya------egasrpLAEWIERYRKRfgaa---pnvWSVMGYAAADLFVkaA 324
gi 39934310  267 syvpd---fpqlgKETTEGIYGVGQteifya------dtatgeVKKFVEDYKKMfgid---anqQSTAGYNGVMVFAhfA 334
gi 89902269  256 aytdl---ihklgGKAMDGLYATMTvqnpy---------tdeqSPQIRFWANKYktkfnedpsvFSVYGYLIINTFAnvA 323
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                                        
gi 27376090  398 KQAGDNLTRENVMkqaaslkdf--------apdtlipgiKINTSPTdFAPIEQLKMWRFKNGQW 453
gi 163724691 330 EKAGPDLTREKWIdtaesygvy---------kdpifggvDVEFTSEqHQGAFDAILSQVKNNKF 384
gi 86139742  313 EAAGRDLTTEGFLaateaits----------yvdpiggqSVSFGPEdHQGIESLIMAKVEDGKW 366
gi 51891941  361 EDAGRDLTYESFIqalenlnd-----------wsgimarNLTYGPGeRAGVKAFYLNKVIEQDG 413
gi 160901984 318 KRAGPDLTRESLVsaletldnwkgnyitlgdenhglsykPVSSGFDsRMGMTSMYVLKSVLTDQ 381
gi 27383038  352 QKAGKDLTGQKMLdslesgek----------fldifnspPTKFSKTdHLANTITQVQQVKGGRW 405
gi 157363932 324 LRAGSDLTREGLVkalesfdh-----------wngilakDITWGPNlRRGKSSMYFIKIENGVF 376
gi 56476955  325 EQAGPELSVERFVaameslht----------prdffgspEYRFGPDdHLGNRHGRIAQIRDGRW 378
gi 39934310  335 KKAGKALTTESLMtalesget----------fddifggaPISFSKDnHLGVSAAVIGQIKDGRW 388
gi 89902269  324 SKAGKNLSTDSFIkvmdtltv----------ppdifgstTITFSPTkRLGSDASRLSQIQDSKW 377

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