Conserved Protein Domain Family
PBP1_ABC_ligand_binding_like_10

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cd06345: PBP1_ABC_ligand_binding_like_10 
Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions
This subgroup includes the type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine/isoleucine/valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.
Statistics
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PSSM-Id: 107340
View PSSM: cd06345
Aligned: 13 rows
Threshold Bit Score: 322.007
Threshold Setting Gi: 11498567
Created: 30-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 39934810   36 KIGVIAeaq----aiAGASIPQAAQLAAeeinakg------gidgrkIEIVSYDNhss--saDSVRAFQRAVNEdKVNAV 103
gi 55378708   62 TIGHLApln----npLGVGSKRSAEMAVaeinddg------giadqtVELVTKDTras--psEARTVAGELVRQeEVDAI 129
gi 76801383   54 KVGHLAple----ldMGAGSERSADIAVdelnang------gvmdtdVELIHADTsai--psEATRQAETLVQDeNVDML 121
gi 148260325  37 VVGITAwlg----siPGRSIADGATLAAeeinakg------gvngrpIKLVIEDNhns--ttDAIRSFQRMVREdHAVAI 104
gi 116749715  53 KVGVVGprtg-taaaTGKAFEEGIKLATdyvnakg------gvlgkkLEIVFEDTaga--pdKAASGFERLVTRdKVALV 123
gi 27381557   33 KIGVIAevq----siAGAATPGGAQIAAdeinakg------gilgrkVEIVTYDNkss--saDSVRAFQRAVSEdKVSAV 100
gi 148259498  31 VVGITSeig----tiPGKAIANGAVLAAeqinaag------gingrpLKLVIEDDhls--ttDAIRSFQRMVRQdHAVAI 98
gi 149203796  27 KIGATAplsapgavtGGEAMRDAMAIAEadinaag------gvlgceVQVVVADDegl--peRGRAVMERLIAQdQVVAV 98
gi 11498567   36 KVGVLIpetg-lyssAGVAMKNAAELAAeha--------------gnVELVFADCgds--peKAKTAFEYLVSQ-KVDAV 97
gi 163723834  31 KIGVLGpms----ftQGEGHWNGATMAAeevnaaggi--qvgkekreIELVKVDTneflsipDATNAVEMAVSRyKVDFL 104
gi 88601637   37 KIGVVAsmsg-pastTGKDIWQSAELAAqeinaqggvfvkdlnkkipITLVQGDDest--reGGIKAVSKLITQdNVDLL 113
gi 52550143   34 RIGVVApltg-gastTGTDMWQAAVLAAdeinaqggv--lvngtylkVKLFKGDTets--reGGVKAVTKLITNdEVDLL 108
gi 114707765  29 KIGGIAplsppggvqTGESLRDGMRVAVeelnaag------gidgreVELVVEDTsgv--peKGVAAFERLASSeNVVAV 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ###                    ###                                                   
gi 39934810  104 IASYISevvlalmpwasrLKTPFVTPGAAsneitkai-nkdyeknKYTFHGYLTSGELAQSVCdaakdll---------v 173
gi 55378708  130 VGTFSSevtqsimdlvseFNTPFLVTGSAapstvtefvasdyeryKNTFRVGPVNSHFQAEVIsqyashl---------s 200
gi 76801383  122 IGAHASevvlaildfvaeSEIPFLVTGSAapevstnymgddydryEMIFRPGPANSSYQVDELagyaeyl---------n 192
gi 148260325 105 VGDFTSevglalepwaarMHEPFLITGAAsnkltefv-hanyaqhKYIFEPNLNSGELAQNICdaaksvl---------v 174
gi 116749715 124 LGESHSssalaeievaerFKVPFIVVEAWadpit-------aknyRYVFRAGPSNTGVVNESIakwvv------------ 184
gi 27381557  101 IASYISevvlalepwaarLKMPLITPGAAsneitkai-hndyeknKYTFHGYLTSAAQAQLVCdaakdll---------v 170
gi 148259498  99 VGTFVSevalalepwaarLHEPYLITGAAanelseyv-hkdfkahQYIFHAYMPAAYLAQAVCdatkdtl---------v 168
gi 149203796  99 GGGYHSsvglanmevadaAGIPVVYAETWndgitga---glkhifRIAPLSSEVAAIFSSFAAtvp-------------- 161
gi 11498567   98 VGAYSSpqamvvadaageNKVVYLVSVAStgviek----kvtegnRYVFRTAYNTTYWGVLAAeflsls----------- 162
gi 163723834 105 VGGFRTeavlvmqdiameSKTVFIGCGAAhpqlctrv-lddydtyKYWFRLTPINSSYLGKVDfillgtagai---ikke 180
gi 88601637  114 VGGYSSavvsahqsivadNKVPYIISGGSstsvshr---ddidtsYMFFHRPNTDDSAKASILfidemvrpeiy-kkfnl 189
gi 52550143  109 IGGFSSgityadqvvaaeHKVPFIITGASspiitr----rddidtSYFFHHCPTTDDYPDSTLlfvdeivkpliderynf 184
gi 114707765 101 TGSAHSavcsavgpvaekYDIPFIAGECWsddvt-------aaqiPEVFRITVANSLVYSVAAdwvke------------ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #                                                        #      
gi 39934810  174 darqmkSAVIMSEDAaWTKPLDVGYQECLpk--vgLKVLDHIRFspd-ttdFTPIFNKIEGSk--pDVIITGISh-vGVQ 247
gi 55378708  201 drhgwnTFAVVADDAeWTTVFRNRLVDLLke--adLDVPMVNGLatd-ttsFGSVLDDVDAAg--aDAMFRFFAhinGGP 275
gi 76801383  193 dehgwtTFAQLAEQAaWTQFFTDNLPPALed--rgFDVEYNERIsse-tddFSPILDAIEATg--aDAVFKQFSllpGTG 267
gi 148260325 175 gklhmkTAVVMSEDAaWTLPLDAGFNKCLpk--agLKVLKDIRFapn-tsdFTPIYQQIEAMh--pDVIITGWAh-vGVK 248
gi 116749715 185 -sekfkKAYIVAENTdWGLGIAELSKAALtk--anIPFEMLVTErqs--qdHYTELNKIKAFd--pDVVLAYIYgtgLHY 257
gi 27381557  171 dklkfkTVAIMSEDAaWTKPLDVGYEACLpk--agLKVVEHVRFspd-ttdFTPIFNNIEGKk--pDVIVTGISh-vGVQ 244
gi 148259498 169 dqfhmkTAVVMSEDAaWTKPLDAGYDACLpk--igVKVLDNIRFapn-tsdFTPIYQKIEKLn--pNVIIAGWAh-vGVQ 242
gi 149203796 162 ---gvkKVVMVAENTdYGLPASEQTKAGLd----kAGIASSVYTvdigtqdFSGIIQRIKAEd--pDMIIQLLTgeaSYN 232
gi 11498567  163 -kpdkyYFVGYDPLKtFNQGMLAKINELYge--peLEVYYKSPSvsp--ddYKNVAKQIAERagerDAIILGDPg--GVS 235
gi 163723834 181 lgiekvKVAIVAEKAaWADPIVAAAQKIIpek-mgMEVAGVWRPspv-atdCSAELSAIQRAg--aHIVFTTFSssvGLT 256
gi 88601637  190 pddrplRLALIFQDSpFGKGQQGAVRNLTqdlnlpIEIVAEETFkmg-esdFRTALTSVKAKk--pDIIYAVTFlneLIP 266
gi 52550143  185 penrtlRLGVIYQDSkYGEGVYDGIKKAIeehnlnMEIVSAEKFkms-etdFRTPLTVMKAAn--pDVVYPAAFlneQAL 261
gi 114707765 162 --agfkNIAIISENSdWGFGIIDVFTSNLkd--tgANVTSFTAErtv--sdFTPQLLQLKRAdpqpDLIVAGFTgsnLLL 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          #                                                             
gi 39934810  248 PTVQWKNQqv-pIPMFGIAsqat---netFGKDTNNASDGVLYQGVsgpgv-----avtskSVPFAENFKKKygny---- 314
gi 55378708  276 MAARWAQGey-eFGIEGVHvasm---lpaYYQLTEGAAAYETTTQSgaagvt----ditskTVPFTEAYMEAygdaddpp 347
gi 76801383  268 MLSEWRNSey-pFGQEGVSvpsm---speYWDDTDGGCQYETTAESggagas----pitdlTQPFTEEYEAVadgerp-- 337
gi 148260325 249 PTTQWAEQnv-pIPLMGISsqat---sttFWKATNGATQGVITIAPaaagv-----aitpkTQPFMKAYQAKfhts---- 315
gi 116749715 258 FVAQAGEVkl-tPKAIVLDgag----ppsLWPDYWKNVGDYGDLECfvssmhe-kveltklATEFRQAYVKAfggp---- 327
gi 27381557  245 PTVQWKNQqv-pIPMFGISaqal---sptFWKDTNGAADGIPSLAVatpdv-----avtskTKPFAAAFKAKfgsp---- 311
gi 148259498 243 PTVQWAQQkv-pIALAGINaqag---ssvFWKATNGATEGVITGSTsapgv-----aitpkTLPFTDAYQKKfgys---- 309
gi 149203796 233 FTQQSAEAgi-gPQDLPTTcdqaalesgaFWQNVPDGNLCFVNAVGlpral------yndkTNAFVAAYTAKtgks---- 301
gi 11498567  236 INFLKEYRan-gGKGIIYSvgg-----alALPATLKKLNAGYTAFQaaalee---tektdlTAKYFADYKAKfged---- 302
gi 163723834 257 FAKQMGELkv-pAAPVGINvesq---ksgFWEATNGAGNYVLTINTynpvk------isefTIPFVEDYRKRyge----- 321
gi 88601637  267 LTQQARRDv--gLDTLILSienn---ddpDYYSGVGALGDYTLMESrfspyaipkgstserTKKFLEDFQTKyggf---- 337
gi 52550143  262 IVSQGRRDv--gLDTIYLSvecn--ddsdYYTGVERWGEYSIQESRfgpyvip-agqissaVVKFKADFENKwgap---- 332
gi 114707765 236 MLRQAYDLgvapSPQTAIFaagsdvlepeFWNVMGDAGTYVIGNPAglpgk-----pdtelSRSFSKAYEEEfsrp---- 306
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                                                
gi 39934810  315 --psyAGYTAYDEVYYIAeaVKRAGSTDgeklvea------lektdyeGTIGRVQFYGk--DEPFtHGLKYG 376
gi 55378708  348 skpmyMGFVTYDAIHVFKnaAERAGTVDqennldtiv--dallqtdftGVAGQIQFYGa--DETYaHDLREE 415
gi 76801383  338 tlpmyMGYCTYDGLMLYAeaVERAGTFDyrnnlqdil--delratdftGTTGQIVFGEe--GSEFpNDVIAG 405
gi 148260325 316 --payTGFTTYDAMYALAaaIERAKSTKagplvaa------laktdrvGTEGPMQFNGp--KARFaNGIVYG 377
gi 116749715 328 -ptdyKSRSIYDSILIAAdaINRAKSTDpeklvea------lektsleVTRGTVKFGLe-kGGTTyHQWEPP 391
gi 27381557  312 --payTGYTAYDEVYFITeaIKRAGSTDpdkmvae------iektdyeGTIGRIQFYGk--DDEFtHGIKSG 373
gi 148259498 310 --paySAYSTYDAVYALAdaLKRAKSTKalaivha------lektnmvGTQGRIAFQGa--KSKFaHALKYG 371
gi 149203796 302 -aaesYAMEAYDSIMILAeaMKIAGSTEgdaivta------lenityqGVLGEITFPY---NSAN-PPATAG 362
gi 11498567  303 -annyAGLLTYDSIMILSqaFEKGGKEKlietle---------sgsfkGAAGIYRFNEn--HQAL-WGSEEL 361
gi 163723834 322 --mpnYTAGTHDAIKILQvaIEKAGTINsdevvkm------lettdlnTAAGRVVFDKs--HDVT-WGPNYV 382
gi 88601637  338 --agmMGAATYESVYIAAkaIENAGTVQkdavrkalse-ismdhmievMKDQVIRFSPdyqESSFdLYVEQM 406
gi 52550143  333 --psmMGASTYEGVYTAAeaIKNLGGTLdkekirasltelempqiievMQNEVITFSPdyrESKFdLYMEQL 402
gi 114707765 307 --anaVAMEGYDGVMVIAeaIKAAGSTEgpalqea------lrnlrwsGTRGEIYFPQt--TDPA-WQYQQW 367

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