Conserved Protein Domain Family
PBP1_ABC_ligand_binding_like_11

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cd06346: PBP1_ABC_ligand_binding_like_11 
Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions
This subgroup includes the type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine/isoleucine/valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.
Statistics
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PSSM-Id: 107341
View PSSM: cd06346
Aligned: 24 rows
Threshold Bit Score: 337.694
Threshold Setting Gi: 22298336
Created: 29-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                  ###   
gi 86607235   41 KIGALLSLTGdlqaYGENCLKGIKLALDQINaaggvlgspIQVVEADDqtsaQPAIDAAQRLVNveKVAAIVGALGSgit 120
gi 110668131  51 RQGYLLPLTGdlgsLGTAMRDAGMMATAQVQdadi--qisVETQEEDTqtevPAAIDGANALVNs-DFPMMVGSATSnie 127
gi 82617351   32 TIGVLYPFSGdlgtYGKPETDAMKLAVKEVNenggvlggrLKLLIKDTetseDEAVAKVHELLDwyNVSVIIGTAGSetc 111
gi 148508228  45 SLGILLPETGdlasVGQPMIQAAQLPVMQVNdsnp-agisVNAQTEDTqtspSAGVSAAESLIGa-GVPSVCGTASSgvn 122
gi 55380247   42 SMGILMGVTGglseVGPAIRDAAELAVKQVRdadn--gfsVDTQFENTetkpSRGVSGAEALVNg-GYPIICGGLASsvt 118
gi 56752242   36 KLGSLLPLTGdlaqYGRPMQDTAELLVQTVNacggvqglpVRLIPADDetkpDRGVAAMTKLAEvdRVAGVVGAAASnvs 115
gi 67922813   55 KIGALLPVTGdlasIGANMPEAVKLAVEEINacegvngepVTLVTEDSqtdpAAGGAAMTKLAEvdRVAGVVGAFGSsvs 134
gi 17229326   57 KIGSLLPATGdlasIGQQMAAAVPLVVETVNacggvngqpVSLVAVDDqtdpKAGAAGMTKLATvdKVAGVVGSFASsvs 136
gi 119510719  54 KIGYLLPATGdlasIGQQMSGSVPLLVETVNacegvngkpVNLVAVDDqtdpRAGAAGMTKLATldKVAGVVGSFASsvs 133
gi 158337446  35 KLGTLLPITGdlaqYGTPMQETANLLIKTVNacdgvlgkpVTLISADTqtdpAQGTQAMTKLVEadQVVGVVGAASSass 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          ###                                                     #     
gi 86607235  121 ipvattvtvpSKIPQISPASTaptittl----ddngflfRTVPSDAFQGVALAQITReen--leRLAIIYINNdYGKGLA 194
gi 110668131 128 ign--rvfvpNGMLACSPSNTlptlstf----ddddlffRTTPGDQYQGFAMAQAAGerldnieTVATTYINDdYGQLLS 201
gi 82617351  112 kai-igyttsNGVLQISPSVTgveftty----pdndlffRTCPSDALQGIAMARLAIqqg--ykTASTLVVWNpYGVGFE 184
gi 148508228 123 vpvsqqvfipNEVVGCSPSSTalsvtnl----ddndyifRTAPSDFLQGRVMAQVMAerl-evgSVSTLFVNNdYGQQLS 197
gi 55380247  119 lqvaenvaipNQTVMCSPSATspdvssl----edndfvyRTPPTDKLQGSLLAQIAAerl-ekeSAAILFLNNaYGNGLS 193
gi 56752242  116 daa-ltlavnNRVVMISPSSTsprfterarrgdfkgywfRTAPSDALQGPALAKLALdqg--wrSVSVIAINNdYGNGLL 192
gi 67922813  135 gaa-vgiaaqNKVMLISPGSTspvftdqakngdfngywaRTAPPDTYQAQALAALAKkqg--fnNVSTVAINNdYGVAFE 211
gi 17229326  137 taa-vsiaaqNKVLLISPGSTspvftekaqkgdfngfwaRTVPPDSYQGPALAELANkkg--fkRVSTIVINNdYGVGFE 213
gi 119510719 134 taa-vsvavpNQVMMVSPGSTspvftekaqkgdfkgfwaRTAPPDTYQALALAQLANqkg--fkRVSTVVINNdYGVGFE 210
gi 158337446 115 saa-lpiavrGQVVQISPASTspvfteraekgefegfwaRTAPPDTFQSQALAQLAKqkg--ykSVAILAINNdYGNGLV 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                           #            
gi 86607235  195 DSFKAAFek-rgGTITKSVPYepg---qasYRGELDQLKEGdp-----------------qALVLIGYpenGAIILRQAL 253
gi 110668131 202 QWFTKHFeqgygGTVQEQVVHdpv---qssYSSKLQTALSGdp-----------------dLLVVITYpqsGVQMFNDYY 261
gi 82617351  185 KAFTKEFkt-lgGKVLQSVKYdpd---tttFNSEVEQVTAAnp-----------------dCVMLCAYpetGSGMLKTAY 243
gi 148508228 198 DRFTSVFteeydGEVFETVGFnkg---assYSSAIETALSGstatessgstgtppgssgpeGVVVIGYpesGIQLFRDYY 274
gi 55380247  194 NGFTKTFeeeygGEVLNQVSYsag---rssYTSQLQNTLDGdp-----------------eTLVIIGYpesGNKIFRNFY 253
gi 56752242  193 RSFIPAFeq-agGVVFNRDQPvlytpdassFDSEVEQVFRDrp-----------------dAVVLIGYpdsGALILKSAY 254
gi 67922813  212 QQFVGAFek-sgGKILSKDKPvrydpkaatLDSEAAAAFADkp-----------------dAVAGVLYpetGSILLQAAY 273
gi 17229326  214 KAFVQAFek-lgGTVVNKNNPvrydpkattFETEAAAAFAGkp-----------------dAVLGVFYvetGSLLLKSAY 275
gi 119510719 211 KAFIEAFek-lgGTVINKDQPvrydpkaqtFDTEAAAAFAGkp-----------------dAVIAVLYaetGSLLLKTAY 272
gi 158337446 192 SAFIPAFka-mgGTVVNETRPtfydpntstFDTEVNQVFKGqp-----------------dAVLLVSYpetGSLILKSAQ 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #                                                                 
gi 86607235  254 EGgl---fDRFVFTDGmrspdl-----atqvgADKLEGSIGTSPqaltdskayQIFAEAYKAAygelpptpYIDTAYDAA 325
gi 110668131 262 AEfd--tdRPIMLTDGakdpt------lpqkvGNSMEAVVGTMPaaag--pnyDSFTTAYEEEygns-aiaFTAQTYDSS 330
gi 82617351  244 KNgym-dsIDWLLSEGlksdgladmvgkdeagNYIIAGLKGTTPdsrg--payETFRQKYLAEygkv-peaYCANSYDAV 319
gi 148508228 275 SQsd--gsEEILVPDGlrdgt------mpgqvGNDMANVTGTAPaagg--psqEAFNSLFQDEyges-pgvFTSQSYDSV 343
gi 55380247  254 ENfdr-adMDILVPDGlradd------lpgnvGHDMTNVRGTNPssag--pgiEYFKSAYQDEydsa-pgpFNQQSFDAA 323
gi 56752242  255 EKgllgqsTQMLLTDGlktdqlaelvgrnpqgRYIVQDLVGVAPssgg--pgrEAFLKRYQERfqrs-pqvFDANTWDAA 331
gi 67922813  274 KQgls-egVTVLLTDGvysqdfveqvgktpdgTFILEGALGTVPgadg--ealEAFTSKWNEKtgkd-vtaFVPHSWDAT 349
gi 17229326  276 QQgva-qgVQIMLTDGmksdefpaqvgktadgKFIASGIIGTVPgsdg--kglEALTKLWQSKkgsa-pgeFAPQAWDAT 351
gi 119510719 273 ERglt-egVQILLTDGvkaptfpeqvgkgadgKYLLAGALGTVPgsdg--kalADFNKLWQEKkggs-pgeYAPQAWDAA 348
gi 158337446 254 ELgfldgnTALITTDGmketsladlvgknaqgEYLVSGMLGTAPsagg--palVAFQKRYQDAfqre-psvFDPNTWDAT 330
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                                                     
gi 86607235  326 FVLALAiqkagsadgtairdalrqvanppgteilpgewakavellkkgedidYTGASGSLNFDEnGDVAg-TFAHWT 401
gi 110668131 331 AITLLAnaaagentgsaisdqmanvanpggtavsidnlaegvqmaangeevhYEGAASAVDFDEnGDLQsgSYEIWE 407
gi 82617351  320 AVVALAiekagdtsgtairdslrdvanppgnkdvsdigealdtirkgfysinYLGASGEITFDEhGDVMg-SFCEWT 395
gi 148508228 344 AIQILAnaaagendgtavrdqmrrvanpegmtvtpdnliegveaaangeevnYQGASSATNFDEnGDPAsaAYAIWE 420
gi 55380247  324 AVLMLAraaageddgtairdqmravtdsggeavgpenlgegvslaadgneinYQGVSGPVEFDDnGDLAsaVYNYFR 400
gi 56752242  332 ALLVLAaekskslegeklkdsvaaiang--pgepvsdicqalalvragkpinYQGASSELKLDNnGDVSg-RYDFWQ 405
gi 67922813  350 VLLMLAaeaakantgegiqskirevana--pgtevsdpceaialirngedinYQGVSGNVDIDEnGDVVg-SYDVWT 423
gi 17229326  352 ALLVLAaqaakentgvgiagkirdvssa--pgvevtdvceglkllqegkdinYQGASGNVDIDAnGDVIg-VYDVWT 425
gi 119510719 349 ALLVLSaqaarentgvgisnkirevsne--pgtevtdvceglkllregqdinYQGASGNVDVDAnGDVVg-VYDVWD 422
gi 158337446 331 ALLVLAaeaakeptgtgireqlqavana--pgeevtdvcealallregktinYQGASGTVDLNPqGDVTg-SYDIWS 404

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