Conserved Protein Domain Family
PBP1_ABC_ligand_binding_like_12

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cd06347: PBP1_ABC_ligand_binding_like_12 
Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions
This subgroup includes the type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine/isoleucine/valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.
Statistics
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PSSM-Id: 107342
View PSSM: cd06347
Aligned: 60 rows
Threshold Bit Score: 346.083
Threshold Setting Gi: 139437974
Created: 21-Mar-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       #
YP_148833     47 KIGANLELSGgvasYGQSIAEGLDLALeeinke-----gingkkLELVKVDNkse-aaEATNGAIKLISQdKVVAIIGSA 120 Geobacillus kau...
YP_001210627  38 KVGLVAPLTGdvqsFGEYTKNGFLLALeeagyk------agdykIEPVIVDDrnd-anEGANVATKLVSQdKVKAIIGPV 110 Pelotomaculum t...
ZP_02091030   50 KVGVMGPLTGdasvYGQAVVNGANLYMkqvnadg----gvngkqLEIIAMDEqgd-etQAVTCFTKMVDQ-GITALVGDV 123 Faecalibacteriu...
EDK89843      37 KIGAIGPLTGpvaiYGISATNGLKLAIdeinang----gilgkqVELNLLDEkgd-stEAVNAYNKLVDW-GMVALVGDI 110 Fusobacterium n...
YP_001560624  45 KIGGIGPLTGeaasYGISVKNGATIAIkeindaggvtvgdknyiLEMNFADDqas-peIAVTAFNTVMDW-GAQAILGSV 122 Clostridium phy...
NP_604326     36 KIGAMGPLTGavaiYGISATNGLKLAVdeinang----gilgkqVELNLLDEkgd-stEAVNAYNKLVDW-GMVVLIGDV 109 Fusobacterium n...
EDM89044      34 KIGVIGPMTGdyaqYGLGVYHAVQLAAeevnang----gfngynVEVLAAGDdqgdpeKAVNAYNDLLDK-GMQMLCGTV 108 Ruminococcus ob...
YP_521259     45 KIGGTGPLTGgaaiYGNAAKNGAQIAVdeina-------lggiqFELKYEDDehd-aeKAVNAYNKLKDW-GVQMSLGSV 115 Desulfitobacter...
ZP_01771527   46 KIGVIGPLTGaaatYGVSAEKGAKLAAkdfst--------kdlkLSLKSEDDvad-geKAINAFNALCDW-GMQALVGPV 115 Collinsella aer...
EDK23504      40 KIGGIGPTTGdaaiYGTAVQNGIQLAIdeineag----gingyqIEFKFEDDqsd-seKSVNAYNTLKDW-GMQMLVGTT 113 Ruminococcus to...
Feature 1        ##                    ###                                                     # 
YP_148833    121 TStntlaqvqvandNKVPLITPTGTNPTITnkdgkv--nefvfRTCFIDPFQGTVAAKFALnelkvkNAAVLIDSSsDYS 198 Geobacillus kau...
YP_001210627 111 TTrsaipvsdiansNKVVMIASTATNEKVTvadgkr--keyvfRACFIDPFQGTIGAKFALdtlkakTAAVLYDQTnDYT 188 Pelotomaculum t...
ZP_02091030  124 TTaptlavaaesadYNMPMVTASATAEAVTydaetdtvngnvfRACFTDPFQGVKMADYAYeklgytKAAVIFLKGkDYN 203 Faecalibacteriu...
EDK89843     111 TSkptvavaevaaqDGIPMITPTGTQLNITeags------nvfRVCFTDPYQGEVLAKFAKeklgakTVAIMSNNSsDYS 184 Fusobacterium n...
YP_001560624 123 TSgsclairkdtfeTGIFQLTPSGSAAECTeye-------nafRLCFTDPLQGVTLANLAKelg-yeKIAIIYNNSdEYS 194 Clostridium phy...
NP_604326    110 TSkpsvavaevaaqDGIPMITPTGTQLNITeags------nifRVCFTDPYQGVVLAKFAKdklgakTVAIMSNNSsDYS 183 Fusobacterium n...
EDM89044     109 TSgaciav-gaeaaESTFLFTPSGTAVDCItsgs------nefRMCFTDPAQGTKSAEFIGkhklatKVAVLYDSSaDYN 181 Ruminococcus ob...
YP_521259    116 TStpgvatsaemfsDRIFALTPSASAPAVIegkd------niyQMCFSDPNQGSASAQYIAdkklgtKIAIIYKNDdVYS 189 Desulfitobacter...
ZP_01771527  116 TTgaavav-sgeiaDDMLMVTPSASSLDVTkdkt------tvfQVCFTDPTMGASAAKFLAekyadaKIALFYNSGdTYS 188 Collinsella aer...
EDK23504     114 TStpctavveethaDNMFQLTPSATAVESIqyd-------nafRMCFSDPDQGKASADYISennlakKIAVIYNSSdTYS 186 Ruminococcus to...
Feature 1                                                           #                        #   
YP_148833    199 KGLAASFKDAFtqggGKIVAEEAYvak-dtdFRATLTRIKSKNPEFIFLPGYYeeVGLIVKQARELGl-nVPIMGGDGWd 276 Geobacillus kau...
YP_001210627 189 IGLANYFKDNFtkggGEIVAFEAYskd-dkdFSAVLTNIARKNPDLLYLPDYHqkVSIIGKQAREKGi-kAIFLGGDGWd 266 Pelotomaculum t...
ZP_02091030  204 EGLAENFAKEFeakgGTVVDQESYseg-dvdFKTQLTSILGKNPEMVFCPNYYqeVGQILAQAESIGl-tVPFLGGDGWd 281 Faecalibacteriu...
EDK89843     185 DGVANAFVAEAekqgVQVVAREGYsdg-dkdFRAQLTKIAQQNPDVLFIPDYYeqDGLIAIQAREVGl-kSVIVGSDGWd 262 Fusobacterium n...
YP_001560624 195 TGVMQAFSEQVtlngGTIVASEAFakn-aidFNTQLTKIKATDAEVIFVPAYYndAAYITQQASDLGm-nLPFLGSDGWd 272 Clostridium phy...
NP_604326    184 DGVANAFVTEAekqgIQVVAREGYsdg-dkdFKAQLTKIAQQNPDILFIPDYYeqDGLIAIQAREVGl-kSVIVGSDGWd 261 Fusobacterium n...
EDM89044     182 SGVNDAFVAAAedngLEVVADEAYtadsntdFSVQLKKIKDSGAELLFLPNYYsdNALILQQAHDAGmddMKKFGVDGMd 261 Ruminococcus ob...
YP_521259    190 KGIYNTFVSKAkelnLEIVSTTTFtedsqtdFSVQLADAKKNGADLIFLPMYYtpASLIFQQAKSMDy-sPKYFGVDGMd 268 Desulfitobacter...
ZP_01771527  189 SGVADAFAEQAkaskLDIVDTETFkddsstsFTNQLTKAKEAGATLIFAPIYYtpASVLLKNAKDMGy-dMTLMGTDGMd 267 Collinsella aer...
EDK23504     187 SGVYQKFAERAktlgLDIVAAEAFtadsktdFSVQLQKAKDAGAELVFLPIYYqeASLILAQANKMGf-aPKWFGCDGMd 265 Ruminococcus to...
Feature 1                                                                                        
YP_148833    277 spkl-veiagKDALNNTYITNHYssgdpdpkiQEFVKAFKAKyn-kaPDAFNALGYDTAYFLAdaikragsa-------d 347 Geobacillus kau...
YP_001210627 267 sp-----dldFATMSGGYFTNHFsaddprpevKSFVEKYKAKyn-ttPEFCAALSYDATKLLLnaiakansd-------d 333 Pelotomaculum t...
ZP_02091030  282 gle---gyatADQLKDSYFCACYakg----ssTAFEDAYKAEygeayPNGFAPLGYDAAMTVVygikaaeeqgleagsde 354 Faecalibacteriu...
EDK89843     263 gvvktvdpssYAAIEDVYFANHYstkdsnekiQNFIKNYKEKyn-dePSAFSALSYDTAYLLKaaiekagt--------t 333 Fusobacterium n...
YP_001560624 273 gvla--qvkdPAVLEGAIFLSPFfasdeapvlKKFVETYQSNyn-avPDQFAADGYDSVYVIKaalekass--------v 341 Clostridium phy...
NP_604326    262 gvvktvdpssYAAIEDVYFANHYstkdsnekiQNFIKNYKEKyn-dePSAFSALSYDTAYLLKaaiekagt--------t 332 Fusobacterium n...
EDM89044     262 gilg-venfdTSLAEGVMLLTPFsatsddeksKAFVDAYEAAnkdevPNQFAADAYDVIYAMQlaandagitpdm-sned 339 Ruminococcus ob...
YP_521259    269 gilt-lenfdKSLAEGVMLLTPFsadatdertVNFVKKYQELfk-etPNQFAADGYDVVYAYKkaieaagitpdm-kaad 345 Desulfitobacter...
ZP_01771527  268 glls-vegfdTSLAEGVLLMTPFsadd--eknADFVKAYKDAyd-etPNQFAADAYDCVHAIAeaidragidisa-dgad 342 Collinsella aer...
EDK23504     266 glla-ldgfdAALAENLMFLTPFtadaedeatQKFVSDFEAAfk-gtPNQFAADAYDCVYVIKeaaekaeltpdm-svsd 342 Ruminococcus to...
Feature 1                                              
YP_148833    348 pvkikdaLAQTKDLQLVSGTMTLNEn-HDPVkSAAILE 384 Geobacillus kaustophilus HTA426
YP_001210627 334 ttkikdiLKDTKDFPAVSGKISFDKd-GNPTkAITILQ 370 Pelotomaculum thermopropionicum SI
ZP_02091030  355 ykqavidAIAGGTIEGITGTFTFDEh-HNPVkSTAILT 391 Faecalibacterium prausnitzii M21/2
EDK89843     334 dkeavtkAIKEIQFEGITGQLTFDEk-NNPVkSITVIR 370 Fusobacterium nucleatum subsp. polymorphum ATCC 10953
YP_001560624 342 dskdmisAMTQITVDGLTGSVSFTAd-GEPNkGAKYIE 378 Clostridium phytofermentans ISDg
NP_604326    333 dkeavtkAIKEIQFEGITGQLTFDEn-NNPVkSITIIK 369 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
EDM89044     340 isaamsaSMLNIELDGLTGKAKWTEd-GECDkEPKAFE 376 Ruminococcus obeum ATCC 29174
YP_521259    346 iceklvqVFPTISVDGLTGEKMTWAktGEVSkKPKGMV 383 Desulfitobacterium hafniense Y51
ZP_01771527  343 iagdlakAMRKIKIEGLTGELTWNDe-GQVEkPATAYV 379 Collinsella aerofaciens ATCC 25986
EDK23504     343 msdalkkAMTEIKVDRMTGKSITWSedGEPTkDPTVVI 380 Ruminococcus torques ATCC 27756

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