Conserved Protein Domain Family
PBP1_ABC_ligand_binding_like_13

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cd06348: PBP1_ABC_ligand_binding_like_13 
Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions
This subgroup includes the type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine/isoleucine/valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.
Statistics
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PSSM-Id: 107343
View PSSM: cd06348
Aligned: 7 rows
Threshold Bit Score: 506.237
Threshold Setting Gi: 115423890
Created: 21-Mar-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     ###
gi 75906690   56 PIGIALAQTsnvalLGQEQVAGAKIAEkyfnd---kggvnGTPIKLIFQDTagdeaGTINAFQTLINKdKVVGIVGPTLS 132
gi 147678686  44 KIGVVATLSgdgadYGVSIKRGLETARdring---agginGRKISLVIEDShgdknEAINAVQKLINRdRVLAIIGPTNS 120
gi 22298422   33 PLGVALAQTgnaalYGQEQLQGVRVAEeffnq---sgqikGRTLRLVIQDTgsdeaGAVNVFQTLINGdRVIGIVGPTLS 109
gi 15807116   28 SLGVAVAQTsnvslFGQEQVAGAKLAEqlina---aggvnGTPIKLVYQDAggdenGAINAFQNLINKnRVLGIVGPTLS 104
gi 115423890  27 KLGVAEALSggaaqYGTSIRNGFQLAAdeinn---aggvnGDKLVLIIEDEqgkkeEAINVFKKLIFKdNVLMIFGPTLS 103
gi 15620554   42 PLGLAIAQTgnaslFGQEQLAGLQIAKavfe-----rpatGVPIDFRLQDSgsdeaSAINAFQTLINVnEVVAIIGPTLS 116
gi 87303364   42 PVGAVLSLTsnanaYGQDQQIGLKLAQtwfqqrqstnpqgGLELNLRLEDGggdeaTASQAFNLLIDA-GMVALIGPTLS 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            ###                                                #        
gi 75906690  133 QQafsanPIAERAKVPVVGPSNTAKGIPEIGdYVARVSAPVSVVAPNSVKAALkqnpnikKVAVFFAQNdaFSKSETEIF 212
gi 147678686 121 GEmfaagPVADKAGVVIMGTSNTARGIGEIGpYVFRNSLPEDNIIPITVRKSKekl-gfnRVALLYSSNndWAVSSAKTF 199
gi 22298422  110 QQafsadPIAEQAGVPVVAPSNTARGIPEMGaFISRVSAGVEVVAPTAIQAALeinpnirRVAVFFAQDdaFSRSETEIF 189
gi 15807116  105 QQafaadPIAERAKVPVLGISNTAKGVPQIGtYVARVSAPIAVIAPAAVKQALklnpkikKVAVMYAQNdaFSVSETETF 184
gi 115423890 104 NSaqaadPIAQAAKTVVFGTSNTADGITSIGnYVFRNSVTEADVLPATISTVKakt-glkNVAVLYGNDdvFTKSGYDNF 182
gi 15620554  117 QQafgadPIAERAGVPVLAASNTAKGIPELGqFIVRLSAPAAVVAPQAIAAARklnpqaqRVVVVYAQDd-AYSRSETEV 195
gi 87303364  121 QQafaadPIAQRRGVPVVAPSNTATGIPQIGsFISRVSAPSTEIAPLSIAKALqltpsirRAAVFYAQDdaYSTSETAIF 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                    #                       #           
gi 75906690  213 QQTVkd-qgLELVTVQKFqttdtdFQSQATNAINLkPDLVIISGLaadGGNLVRQLRELGYqGAIIGGNGlntsn-vfav 290
gi 147678686 200 EEALre-qgVAIVETQTFadgdtnFQAQLTRVAAAkPEALAVSALykeAALLLIQARQQGInLPVMGGNGfndpe-liki 277
gi 22298422  190 QKAIrehpkLELVTVQQTqttdtnFQAQINATLSLkPDLIVISGLaadGGNLIRQLRELGYqGLILGGNGvntvn-ifpv 268
gi 15807116  185 QSTLka-qgLNIVTVQKSlttdtdFTTQVTAVINSgADLVVVSALaadGGNIVKQLRQFGYkGLIVGGNGfntan-vfpv 262
gi 115423890 183 KKALed-qkIPVTATETFakgdvdFKAQLTKIKGSnPDALVLSALlaeGAPIMVQARQLGLnVPVIGGNGmnsvkifela 261
gi 15620554  196 FQKAvkdagLNLTLVQRYqvsdsdFQGLISQALQQkPDIIVLSSLaadGGNLVRQLRELGYgGLIVGGNGfntpn-vfpv 274
gi 87303364  201 QKALtd-kgLKPVTVQRTqlndqdFQNQITATLREtPDLIVISAQavdGGNLIRQLRELGYrGAIVVGNGmntpn-iypi 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 75906690  291 cKALCDGVLIAQAYspeytgeinKAFRQAYVDQyk-kePPQFSAQAFAAVQVYVESLkaldtknkvskiqlpelrtelnk 369
gi 147678686 278 aGEAAEGALVGSPWyagkddpavRDFVEEYKKRyh-tvPNQFAAQSYDALGIMAEALktegaaadrar--------frda 348
gi 22298422  269 cRRLCNGVLVAQAYnsenpdpmnVKFRNAFAAKys-qaPSQFSAQAFTAVQVFADSLarlsqaknlselpladlrqalnq 347
gi 15807116  263 cQKDCDGVLVAQAYsptqksavnQKFVSEYRKLyk-kdPPQFAAQAYAGIQVFVDALkvidkkkklstwdlaalrtelnk 341
gi 115423890 262 pGGASNNLWIGSPWsienktpqnTKFIEAYKAKfg-naPDQFSAQSYDALHIVAEALkhtklsgkiaed-----rtalrn 335
gi 15620554  275 cQQRCDGIIVAQTYspnfdspvnKDFRQRYEAQfg-kqPSQFSAQIFSAVQVIAESLnrvnqkqpvvdlplperrkallq 353
gi 87303364  279 cQAYCEGILIAQAYspeldtpvnRDFVALYQKAkggaiPPQLTAQAFTAYQVVAEALqrlnqrqpldkvplgearkalma 358
                        330       340       350
                 ....*....|....*....|....*....|
Feature 1                                      
gi 75906690  370 qlltgkYNTPLGEISFTPiGEVVqKDFYVA 399
gi 147678686 349 laaikdYRGVTGRFSFDEnGNPLmDAVVLQ 378
gi 22298422  348 eilkgvYETPLGEIRFTPqGEVLqRFFYVG 377
gi 15807116  342 qvlagqYDTPLGELRFDKdGEVNqKEFFVA 371
gi 115423890 336 alpsvqWTGATGPFKFRQaNDRAgKPAGYD 365
gi 15620554  354 amltgtYDTPLGRLSFTPgGEVNqEQFYVA 383
gi 87303364  359 ellsgrYDTPLGEISFSPdGEVVqQSFHVA 388

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