Conserved Protein Domain Family
PBP1_ABC_ligand_binding_like_14

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cd06349: PBP1_ABC_ligand_binding_like_14 
Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems
This subgroup includes the type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine/isoleucine/valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.
Statistics
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PSSM-Id: 107344
View PSSM: cd06349
Aligned: 9 rows
Threshold Bit Score: 493.441
Threshold Setting Gi: 160879406
Created: 21-Mar-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic Leu/Ile/Val-binding protein with bound valine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                    ### 
gi 91780164   47 WVGVTGPLSGqdaqYGEQWKRGFDLALEQINGSGgi--dGHPLNYDFEDSrsdprQAVQIAQKFVDDkRILLELGDLSSg 124
gi 42527862   39 YFAWYGPLTGdakqYGDTEKIAVELALKDINDAGngvlgGRKIIVDFYDDkndakEAVNIANKIVAEkKYLAVVGGFGSt 118
gi 83594205   42 LLGYELPLTGanaaYGRVFQEAARLQLDRFNAAGgv--gGRPVDILYADSrddadQARTIARAFVDDpRVVGVLGDFSSt 119
gi 160879406  42 KIAVAGPMTGdnaeYGIGFTNAAKMMADEWNKKGgv--lGKQIKIVQYDDknsseEAATIAQKIVSEgDIAGVIGHFSSg 119
gi 27382010   36 LLGVSGPLTGpnaqYGTQWKQGFDLALDEIQAAGgi--nGHKLAYSFEDSqsdprQSVAIAQKFVSDpRIVMELGDFSSp 113
gi 51893499   51 LIGVMGPLTGdsaeYGKIWRRGFDLALEEINAAGgv--qGRPLNYVFEDTqsdpkQSPAVAQKFVNDpRVVAVIGDFSSp 128
gi 91780159   44 LFGVSGPLSGpnaqYGAQWKAGFDLALDQINRDGgi--hGRPLQYVFEDSqsdprQAVTIAQKFVGDpRILIELGDFSSp 121
gi 124875558 101 VIGVSGPLTGqdaqYGEQWKRGFDLALDEINGSGgi--hGRPLAIDFQDSrsdprQAVAIAQKFVADpRIAIELGDFSSa 178
gi 150391810  34 KIAVAGPLTGdfaeYGTGFSNAAALMVEQWNEAGgv--lGQQIELVVFDDkntgeEAATIAERIAGDkDIKAVIGHFASg 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           ###                                              #           
gi 91780164  125 asMAASPVYQRGGLVQFGFTNSHpdftkggdymwSTAISQAEEQPMLAHYATtglgfkKIAVLYLNTDWGRTSKDIFAKA 204
gi 42527862  119 psMAAAPIYEKAKIINYSPTSSHadfsslgkfmfRNTPTQQIETTQYADYVYtklgikSVAILNVNDDWGNNIAKIFTNE 198
gi 83594205  120 vsMAAGSIYGKEGMPQLSPTAAHpdyikispwqfRAITTPAFEGPNNAAWMIgdg-ftSVAVIGVTTDWGLSSAQAFRKA 198
gi 160879406 120 vcLTAAPIYQENKLVEISPSASHpdyslvgdyifRNNTVISAEAAASIDIAVndlgkkKIGIISIKTDWGTNTSKIIKEL 199
gi 27382010  114 asMAASPIYQRGGLVQFGFTNSHpdftkggdfmwSTSVSQADEQPLLAAYAVkrlglkKLAILHLNTDWGRTSRDYFVKA 193
gi 51893499  129 asMAASPIFQRAGLVQLGITNSHpdftktgdfiwSNSTSQTDEAPFLARLAVeqlgrkRLAVLHQNTDWGKTTADLFVEQ 208
gi 91780159  122 asMAASPIYQRAGLVQLGFTNSHpdftkggdfiwSPSVSQADAQPLLAELAAkqg-fkRVAVLYQNTDWGRASKDVFVKA 200
gi 124875558 179 tsMAASPIYQRGQLIQFGFTNSHpdftkggdylwSTALSQAEEQPLLARYAVkelgfkRIAVLYLNTDWGRTSKDIFAKA 258
gi 150391810 112 vaMVASPTYQEAGILNISPSASHpdfsgegdfifRNNTVIDIEAQVAVNLAIdtldkkNVGILSVRTDWGTSTADITKDL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                    #                       #           
gi 91780164  205 Ats---dGAQVVAAEGYqpn-ekdFRATLTRIRSAnPDSIVLISYYsdGAQIVRQARAAgvrEPIAAVGSVYspkFLELG 280
gi 42527862  199 Fvk---lGGKITDLQTYipnqtsdFTPMISKAKTTnPEAFFPVAYYqdSANIVRQAKNLdfnVQMILSSSTLkqeLIDLA 275
gi 83594205  199 Fel---rGGAVVVNEEVppg-nrrFDDVIDEIEDEaPQAIYLAMAYedAAPFLRALRARgsaLPVYGSSALYspkFIDLG 274
gi 160879406 200 VeklgidGVSIVAHEEVveg-sddYSPAITKLNQAgADVVICAGMYnlVAPVAKQYKQInpdIKVVGFSNSYsqqLIELG 278
gi 27382010  194 Ake---yGAEIAVTEGYiae-erdFRSTLVRVRDAsPDGLILISYYsdGALIARQARQVglkQTICAASSVYspkFLELG 269
gi 51893499  209 Ara---lGAEVVLQEAYllt-ekdFRPVLTKARDAqPDALVLISYYndGALIAQQIPAVgldVTVLAASSVYspqFLNLG 284
gi 91780159  201 Aas---rGIQVVASEGYqpt-dkdFRATLLRLRDAnPDALVLISYYsdGAQIVRQARGSglhTPIVAASSVYspkFMELG 276
gi 124875558 259 Vtg---lGAQVVAAEGYqpa-ekdFRSTLVRIGESkPDSIVLISYYadGAQIVRQARTSgvaLPIAAVGSVYspkFLELG 334
gi 150391810 192 Vek---aGGTVVDHQEVvdg-tidFSSNITRLHSAdADVIIVVGMYntLGPFASQYKAVnpeIELVGFSNAYsqqLINLA 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 91780164  281 GAAVNGVYTESNFfpgdprPEVQSFVTRYRAKyggd-pdtFAARAYDAMILAGEVIRRYGanrsavrdgfa-kidnvpsv 358
gi 42527862  276 GDIVEGAFIMNAYspdintPEFIRVIGEYTKRtgkq-gdaFVMQTYDVVKQLATAVDMAGsddpvvvret---lanmkgy 351
gi 83594205  275 GPAVEGVRLATAFvlgasdPVVVEFVSAYETLygai-ptlFAAHGYDAVGIMLAAVGRAGpevtreslrdalaatdryag 353
gi 160879406 279 GLAIEGVCFPVIFfseskdEKIKNYVSAFEKEfgnk-psaLTSQAYDSVGMLLSAIEKAGstdkeavrna--laevdyeg 355
gi 27382010  270 GEAVEDVHLGTRYfpedprPEVKKFITGFKAKyngqepdaFNAYAYDAMNMAAAVVRIGGtdrrairdafa-kvkdvssv 348
gi 51893499  285 GAAVEGVYTVSRFhpadprPEAQQFVERFRERygtd-pdtFAAGAYDGMKILAAVLNRVGvdrkalrdgle-qaehleti 362
gi 91780159  277 GDAVNGVTTNTSFfpddprPEVQHFVRTFEAKyhqq-pdaFNAFAYDAAIIAAYALRAGGldrrgvrdalp-rlrdvpsv 354
gi 124875558 335 GTAVEGVYTESNFfpaeprPEVQAFVQRYRAKfhad-pdsFVARAYDALILSAEVLRRYGttrqaahdgfa-kisdvpsv 412
gi 150391810 268 QENAENIHFPTIFfhgsveENVSSFVSAYEAKygss-pssLTAQAYDSAGIILKAIENAGtadrsaikde--vsklvydg 344
                        330       340       350
                 ....*....|....*....|....*....|
Feature 1                                      
gi 91780164  359 ifGKFKFDPq-tRRVAgaKNRELVVKDGKF 387
gi 42527862  352 naLSGPYNMnelGDAVr-SLVPMFIKNGKF 380
gi 83594205  354 vtGITRFDPe-tRETTk-ILTRLVVREGDF 381
gi 160879406 356 vtGQTKFDEn--GNVNk-QFVKVTIQGGKF 382
gi 27382010  349 ifGSATFDVe-sRRVKgaMNAELVVRKGQF 377
gi 51893499  363 lqGATAFGEd--RRLRnpRFVPLVVRGGAF 390
gi 91780159  355 vfGRATFDPa-tRRVIgvRSVNLVVDHGRW 383
gi 124875558 413 ifGKVRFDPq-tRRVAgaRTVYLVVKQGQW 441
gi 150391810 345 vtGETKFEDn--GDAIk-AFSLVKIENGQF 371

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