Conserved Protein Domain Family
PBP1_iGluR_N_LIVBP_like

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cd06351: PBP1_iGluR_N_LIVBP_like 
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NMDA, AMPA, and kainate receptor subtypes of ionotropic glutamate receptors (iGluRs)
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NMDA, AMPA, and kainate receptor subtypes of ionotropic glutamate receptors (iGluRs). While this N-terminal domain belongs to the periplasmic-binding fold type I superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type II. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. Glutamate mediates the majority of excitatory synaptic transmission in the central nervous system via two broad classes of ionotropic receptors characterized by their response to glutamate agonists: N-methyl-aspartate (NMDA) and non-NMDA receptors. NMDA receptors have intrinsically slow kinetics, are highly permeable to Ca2+, and are blocked by extracellular Mg2+ in a voltage-dependent manner. On the other hand, non-NMDA receptors have faster kinetics, are weakly permeable to Ca2+, and are not blocked by extracellular Mg2+. While non-NMDA receptors typically mediate excitatory synaptic responses at resting membrane potentials, NMDA receptors contribute to several forms of synaptic plasticity and are suggested to play an important role in the development of synaptic pathways.
Statistics
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PSSM-Id: 107346
View PSSM: cd06351
Aligned: 113 rows
Threshold Bit Score: 50.1997
Threshold Setting Gi: 71656801
Created: 8-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 17384613    37 RIGGIFeyadgpn-aqvmnaeEHAFRFSANIINRnrtll---------------------pnttLTYDIQRih------- 87
gi 31074387    44 GILPSKs--------------LPLSEAKSILTSLeden-----------------------itfSGVRLQEl-------- 78
gi 108874039    2 QISVFVnev----------gnDLAQVAVDVALNYirkn----------------------pslgLSVELLTveg------ 43
gi 24581733    18 LWIVFInev----------dnEPAAKAVEVVLTYlkkn----------------------irygLSVQLDSiea------ 59
gi 91093090    25 HVSGYGddkkmvndfanfrpgRLYFAIAASPSGQtysrafnktllnitqsylttkvhkdtfnftLETLVIElpe------ 98
gi 115934879    1 ALFGTEtg-----------yqDNYKTIIQDGVRYinrn-----------------------ttfLSEVHQLvfvdssi-n 45
gi 21358761    32 KINIFMtyd---------ednMLVKQSLDAAISYlek------------------------ntgEGAMVDGkhiya---- 74
gi 72112569    25 GAFYGMmtd----------kdDEYKRIIDDAVDYvtrqaw-------------------tnqntLRVTHFQpdtnalgep 75
gi 66500221    19 RYRVIInde----------anKVANQSITTALETikenyp------------------nhlgnvWSVQVNEs-------- 62
gi 46277636    38 RLGALMp-------------rAPLARARARAALAraalap-------------------rlphnLSLELVVaap------ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                # ##  ##                                     #                           
gi 17384613    88 ---fhDSFEATKKACDql--------alGVVAIFGPSqgsctna-vqsicnaLEVPHIQLRWkhhpldn--------kdt 147
gi 31074387    79 ----pDDDVIAIKTCLral------ralKPSAIIGPYsstya-----iatehLRIPYFVTSLtpasqs---------etp 134
gi 108874039   44 --nrtDSKGLLESLCSkytea--intnrPPHVIFDTTltgvssetvksisaaLGIPTVSASTgqegdlrqwrslsnvksn 119
gi 24581733    60 --nksDAKVLLEAICNkyats--iekkqTPHLILDTTksgiasetvksftqaLGLPTISASYgqqgdlrqwrdldeakqk 135
gi 91093090    99 --ngsFSAALLRNLCNqfeg-----khvVAVLIVGDSpaaftv---sltakhAGIPVLWARGhsgflpglr---slessp 165
gi 115934879   46 srpsnSVYVALQEGCDhva------tsqVSALVLPKDrctasdd-iagvlshATNPVFSIDPgnlgs-----------gs 107
gi 21358761    75 ipkgnDVEVTVNKSCDlmdea--idagkPPHIVLDATttgmisetiksftraLTLPTFSASYgqegdirewrkltpseee 152
gi 72112569    76 evstnIFQAVQIEVCAdar------sssLRGIVLPHDicmdcnd-isgvigdAINPMVAIDLaggd-------------- 134
gi 66500221    63 -----DINNTLDRVCNnwdsavekggaeVPDLVIDTTtaglaakisnsftaaLGIPTLSAQYgqvgdlqywrklsadqqd 137
gi 46277636    80 --parDPASLTRGLCQalvp-----pgvAALLAFPEArpellql--hflaaaTETPVLSLLRrearaplga----pnpfh 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                        #  #             # #             
gi 17384613   148 fyvNLYPDYaSLSHAILDLVQylkwrSATVVYDDSt-----gLIRLQELIMAPsrynirLKIRQLPIDsd--dsRPLLKE 220
gi 31074387   135 yliQLFPSAhALARASVDMLSyyqlkRVAVIYDCEageiileRLAREPWLLVTgy---hVTNSSVGGVr-----EQLKVM 206
gi 108874039  120 yllQVMPPTdIIPEVIRAIVTymnitNAAILYDESfvmdhkyKALLQNFPTRHvi---tAIGNDRDRA------EQIEKL 190
gi 24581733   136 yllQVMPPAdIIPEAIRSIVIhmnitNAAILYDDSfvmdhkyKSLLQNIQTRHvi---tAIAKDGKREr----eEQIEKL 208
gi 91093090   166 levQLAPTGrELVQALRGLLLqahwhTFTLLVDPAss----tALRRPELWTTLtaqplhPTLITLSSPlr---aQSLFRK 238
gi 115934879  108 tafKMQPSPeDMTSFYIDILSyyswmNFTLLYDDGgaf--anMEGVMEYATMNkw---nISTVIIDEEf----gNNIPMI 178
gi 21358761   153 ylvQLMPPGdIIVQSIRDIVRtqnitNAGIIYDDTfvmehkyKSLLQNLPCRHim---tRVEATEKEVr-----RQTKRL 224
gi 72112569   135 ysiKLYPDVeDLVDMFAEVINytkwrDFLLIYDGDnaq-givEEMTAQANSRNqt---iQILPIGDDMm-----EMQKTI 205
gi 66500221   138 yliQVMPPTdLIPEVIRQLSIqlnitNAAILYDYNfvmdhkyKSLLLNVPTRHvi---nETSQQIIEMk-----RQLLRL 209
gi 46277636   147 lqlHWASPLeTLLDVLAAVLQahaweDVGLALCRTq------DPGGLVTLWTSra--grPPQLVLDLSrrdtgdAGLRAR 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 17384613   221 MKRGre--------frIIFDCsh-tmAAQILKQAMAMgmm--teyYHFIFTTLdlyal------------------dlep 271
gi 31074387   207 RNMYy----------tTFILVltpgrTRYVLDQALSLsmfskpnkWFLINVGLqey----------------------dl 254
gi 108874039  191 RNLDin---------nFFILGsf-asIKKVLESAKREffer-nfaWHAITQYQg-------------------------e 234
gi 24581733   209 RNLDin---------nFFILGtl-qsIRMVLESVKPAyfer-nfaWHAITQNEg-------------------------e 252
gi 91093090   239 LADIsrst-----rgvVVLLSdr-paAVRILEDAKRLnmmd-ghfVWLWVDTAanisisddggadkdkpppaaasedryk 311
gi 115934879  179 EERGsk---------nIFIYCsseiiLRNTIDQALLFgtmgpaytWMIGNMDMgid----------------------rq 227
gi 21358761   225 KDADiv---------nYFAVGsg-dtISRILDAATANdmfgrkyaWYALSKDNq-------------------------d 269
gi 72112569   206 EESSik---------nILLFCqyeeiCLDVVKMAIDEglmidgyhWFLGNIDLplt----------------------wd 254
gi 66500221   210 RDLDiv---------nYFILGne-ntISIALEAADALnftdkkygWFLLTPDIni------------------------w 255
gi 46277636   219 LAPMaapvggeapvpaAVLLGcdiarARRVLEAVPPG--------PHWLLGTPlppk--------------------alp 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 17384613   272 YRYSGVNLTGFRIlnvdnphvsaivekwsmerlqaaprsesglldgvmmtDAALLYDAVHIVsvcyqrapqmtvnslqch 351
gi 31074387   255 DKYADSHANVTVLrlmmdynssfcglge-------nislsraafhdavrlYVHMYTTHALRLsmvgtgervsm------- 320
gi 108874039  235 LSSNIENATIMLLrpvsdskskdrlgv----------irttynmkqepqiTTVFYFDLALRTflaiknilqvgawppnmk 304
gi 24581733   253 ISSQRDNATIMFMkpmaytqyrdrlgl----------lrttynlneepqlSSAFYFDLALRSfltikemlqsgawpkdme 322
gi 91093090   312 RSVVKSDISDMHVnyllkndqfllfnrny------gvesskfkdrndrsqRLFSVVDGEFKGelpagllrlkplpvrvdr 385
gi 115934879  228 FLEDLEDSNGFVTrfnmnytre--------------------qqyalptaRNTPTGEWQFRErcafdaviavgh------ 281
gi 21358761   270 IQCGCENASIVYLrphtsadsrgriam----------lqrdygltstpeiDAVAYFEYFMRGilgaakmaaagkytdfey 339
gi 72112569   255 EVRQIRLDGAYITrlqmnkqan--------------------vnvrytttRPENQEEWPFRLknaydavvlfg------- 307
gi 66500221   256 PRCECRDISVLFMkpefdkrnnsd---------------svefslpkpilLSAFYYDMIRLAvlamksalddgewp---- 316
gi 46277636   271 TAGLPPGLLALGEvarppl--------------------------eaaihDIVQLVARALGSatqvqpkrallpapvncg 324
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 17384613   352 rhk-----------------------------------------------awrfggrfmnfikeaqweglTGRIVFNkt- 383
gi 31074387   321 ------------------------------------------------------------rrtvrklrmdGCTGHLMfsr 340
gi 108874039  305 yltcde-----------------------------------------ydgtnspnhtidlksafievtepTTYGPFEfpk 343
gi 24581733   323 ylncdd-----------------------------------------fqggntpqrnldlrdyftkitepTSYGTFDlvt 361
gi 91093090   386 hlvkgtvrlllatlklvlqrsplwmlqsiakgqlttscwktlgarefkfsdsfgrelktackdalagkkfSQEIGVDkvd 465
gi 115934879  282 ----------------------------------------------------------glrlyrkkrvadGNTGSSVlpg 303
gi 21358761   340 lrcee------------------------------------------fsednppvrndfdlrsalqsvsmTNTWASIswg 377
gi 72112569   308 ------------------------------------------------------------eafeshrartGSFPTKVaqc 327
gi 66500221   317 ---------------------------------------------------------meprhitcdeynnTNTPERKlnf 339
gi 46277636   325 xlqp--------------------------------------------agpespgrflarflantsfqgrTGPVWVTgs- 359
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               
gi 17384613   384 -----------------------sGLRt-DFDLDIIslk---------edgLEKVGVWs-----pADGLN 415
gi 31074387   341 fgirsesfl----qlmtlqgynldCSSgtWRSRPADvskrve---psksysTVASLSGnv---fgDRPLR 400
gi 108874039  344 gk------------------tpfnGHSfmKFDMDISavtirg----gasvsTKNLGKWea---slDNALY 388
gi 24581733   362 qs-----------------tqpfnGHSfmKFEMDINvlqirg----gssvnSKSIGKWis---glNSELI 407
gi 91093090   466 kslva-----------nfeilnlvPERs-TKDGDLFsnrsenvepstssvkWKRVGLVsgr-svrLDTII 522
gi 115934879  304 dssmpacpt---sslvvnendltyYLKevTFEGITGtvafdd----egnrvNYTITVRsg----qGETID 362
gi 21358761   378 sng---------------msypdvPLTmdKFKILAGrt-----------aeRKTLGEWsa---gmPGTLM 418
gi 72112569   328 ptasdt----------ftlssvmqDVKeiNFEGLSGhisfde----nyrrtNYSITVHqg----kGQTVY 379
gi 66500221   340 fgklkdayknitptyagikwgsrnGEHqaKFVMSVHlvtikd----gvvsnTVDSGSWna---siSSPLQ 402
gi 46277636   360 -----------------------sQVHm-SRHLKVWslrrdp----rgapaWATVGSWrdgqldlEPGGA 401

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